Translational Research , 

Macrophage Migration Inhibitory Factor Increases Atrial Arrhythmogenesis through CD74 Signaling

Publication date: Available online 5 October 2019Source: Translational ResearchAuthor(s): Wan-Li Cheng, Yu-Hsun Kao, Yao-Chang Chen, Yung-Kuo Lin, Shih-Ann Chen, Yi-Jen ChenAbstractMacrophage migration inhibitory factor (MIF), a pleiotropic inflammatory cytokine, is highly expressed in patients with atrial fibrillation (AF). CD74 (major histocompatibility complex, class II invariant chain) is the main receptor for MIF. However, the role of the MIF/CD74 axis in atrial arrhythmogenesis is unclear....

Translational Research

Sun Oct 06, 2019 17:08

A Telomerase-derived Peptide Vaccine Inhibits Laser-induced Choroidal Neovascularization in a Rat Model

Publication date: Available online 5 October 2019Source: Translational ResearchAuthor(s): Eun Kyoung Lee, Young Joo Kim, Won-Jun Shon, Hyeong Gon YuAbstractGV1001, a novel peptide derived from human telomerase reverse transcriptase, reportedly has anti-cancer and anti-inflammatory effects. Choroidal neovascularization (CNV) is a complex pathogenic process that involves angiogenesis, inflammation, cellular immunity, and other factors. This study was aimed at investigating the effect of GV1001 on laser-induced...

Translational Research

Sun Oct 06, 2019 17:08