Prognostic Significance of Sarcopenia in Patients with Unresectable Advanced Esophageal Cancer

JCM, Vol. 8, Pages 1647: Prognostic Significance of Sarcopenia in Patients with Unresectable Advanced Esophageal Cancer:
JCM, Vol. 8, Pages 1647: Prognostic Significance of Sarcopenia in Patients with Unresectable Advanced Esophageal Cancer
Journal of Clinical Medicine doi: 10.3390/jcm8101647
Authors: Sachiyo Onishi Masahiro Tajika Tsutomu Tanaka Yutaka Hirayama Kazuo Hara Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Yoshitaka Inaba Takeshi Kodaira Tetsuya Abe Kei Muro Masahito Shimizu Yasumasa Niwa
The prognostic significance of sarcopenia in unresectable advanced esophageal cancer remains unclear. Our study retrospectively evaluated 176 consecutive Japanese patients with esophageal squamous cell carcinoma who had been diagnosed with unresectable advanced cancer in Aichi Cancer Center Hospital between January 2007 and December 2014. Skeletal muscle mass was calculated from abdominal computed tomography (CT) scans before treatment, and patients were divided into sarcopenic and non-sarcopenic groups. Sarcopenia was present in 101 patients (57.4%). Eighty-two patients in the sarcopenic group and 63 patients in the non-sarcopenic group died during follow-up (mean: 20.3 months). The overall survival (OS) rate was significantly lower in the sarcopenic group compared to the non-sarcopenic group (2-year OS: 9.8% vs. 23.7%, p < 0.01). Cox regression analysis revealed only pretreatment sarcopenia as an independent prognostic factor (hazard ratio (HR): 1.48, 95% confidence interval (CI): 1.04–2.10, p = 0.03). In the sarcopenic group, withdrawn cases, for whom the planned treatment was discontinued for some reason, showed a significantly lower OS rate compared to complete cases (1-year OS: 11.0% vs. 59.9%, p < 0.01). The most common reason for discontinuation was aspiration pneumonia (64.5%). Presence of sarcopenia was an independent prognostic factor for unresectable advanced esophageal cancer. Identifying the presence of sarcopenia prior to treatment may improve the prognosis.