Publication date: Available online 14 October 2019Source: Sleep MedicineAuthor(s): Alex A. MacDonald, Phavalan Rajendram, Maneesha Kamra, Brian J. Murray, Penny A. MacDonald, Mark I. BoulosAbstractStudy ObjectivesAfter cerebrovascular events, obstructive sleep apnea (OSA) is associated with poor functional outcomes, an increased risk of recurrent stroke, and mortality. Although the significant under-diagnosis of OSA is likely multifactorial in nature, factors associated with attendance at in-laboratory...
Tue Oct 15, 2019 15:04
Singer EV, Shelton AR, Malow BA. Can we predict which children with autism will have obstructive sleep apnea? J Clin Sleep Med. 2019;15(10):1389–1390.
Mon Oct 14, 2019 23:02
Castriotta RJ, Chung P. Cutting for cures: bariatric surgery and obstructive sleep apnea. J Clin Sleep Med. 2019;15(10):1391–1392.
Mon Oct 14, 2019 23:02
Earl DC, Brown LK. On not knowing what we don’t know to knowing what we don’t know: obstructive sleep apnea in the transgender community. J Clin Sleep Med. 2019;15(10):1393–1395.
Mon Oct 14, 2019 23:02
Study Objectives:The aim of the current study was to test the hypothesis that there is a temporal correlation between reflux episodes and respiratory events in patients with laryngopharyngeal reflux and obstructive sleep apnea.Methods:Adults with clinically diagnosed laryngopharyngeal reflux confirmed by two validated instruments (reflux symptom index ≥ 13 and reflux finding score ≥ 7) and obstructive sleep apnea (OSA) underwent full polysomnography with concomitant and synchronized multichannel...
Mon Oct 14, 2019 23:02
Study Objectives:Natriuretic peptides have been identified as biomarkers of increased myocardial wall stress in the context of obstructive sleep apnea (OSA) in the general population. However, the relationship between N-terminal pro B-type natriuretic peptide (NT-proBNP) and OSA remains unclear in patients with coronary artery disease (CAD). Hence, we aimed to investigate the clinical value of NT-proBNP in evaluating OSA in a large population of patients with CAD.Methods:Consecutive patients with...
Mon Oct 14, 2019 23:02
Study Objectives:Reliable sleep staging is difficult to obtain from home sleep testing for diagnosis of obstructive sleep apnea (OSA), especially when it is self-applied. Hence, the current study aimed to develop a single frontal electroencephalography-based automatic sleep staging system (ASSS).Methods:The ASSS system was developed on a clinical dataset, with a high percentage of participants with OSA. The F4-M1 signal extracted from 62 participants (62.9% having OSA) was used to build a four-stage...
Mon Oct 14, 2019 23:02
Study Objectives:To explore knowledge and experiences of women with narcolepsy on pregnancy and contraception issues and their relationships with narcolepsy pharmacotherapy.Methods:An 18-item survey was administered through the Narcolepsy Network website for 8 weeks during the fall of 2012. The survey ascertained demographic information; prescription narcolepsy medication use and discontinuation during pregnancy; physician counseling regarding pregnancy, contraception, and medication usage; and pregnancy...
Mon Oct 14, 2019 23:02
Study Objectives:Currently, there are no universally accepted guidelines for diagnosis and management of sleep-disordered breathing (SDB) in infants. The purpose of this study was to survey pediatric sleep medicine providers regarding their current practice patterns for diagnosis and management of SDB in infants.Methods:An anonymous, web-based survey with 71 questions was distributed via the PEDSLEEP and Ped-Lung listserv, which serve as a hub of communication for pediatric sleep and pulmonary medicine...
Mon Oct 14, 2019 23:02
Study Objectives:Despite high prevalence rates of both psychopathology and sleep problems during adolescence, as well as frequent co-occurrence, little is known about the mental health of adolescents presenting for insomnia evaluation and treatment. This study describes (1) rates of mental health symptoms and (2) associations of mental health symptoms with sleep behaviors and schedules in adolescents presenting to a behavioral sleep medicine clinic within an accredited sleep disorders center.Methods:As...
Mon Oct 14, 2019 23:02
Study Objectives:Lead exposure has been linked to adverse cognitive outcomes among children, and sleep disturbances could potentially mediate these relationships. As a first step, whether childhood lead levels are linked to sleep disturbances must be ascertained. Prior studies of lead and sleep are scarce and rely on parent-reported sleep data.Methods:The study population included 395 participants from the Early Life Exposure in Mexico to Environmental Toxicants project, a group of sequentially enrolled...
Mon Oct 14, 2019 23:02
Study Objectives:Although respiratory abnormalities occurring during wakefulness are well recognized in patients with Rett syndrome (RS), less has been reported regarding sleep-disordered breathing (SDB) in this population. This study aims to characterize the presenting complaints, types and severity of SDB, and treatment modalities of patients with RS and sleep concerns.Methods:Retrospective chart review of pediatric patients with RS referred to our academic tertiary care institution from January...
Mon Oct 14, 2019 23:02
Study Objectives:A strong association between sleep-disordered breathing (SDB) and atrial fibrillation and/or atrial flutter (AF) has consistently been observed in epidemiologic and interventional studies. The effect of positive airway pressure (PAP) on AF recurrence is inconclusive. This study sought to evaluate the effectiveness of PAP therapy for SDB on AF recurrence.Methods:This was a single-center, retrospective study conducted at a tertiary referral center. All adult patients who had SDB on...
Mon Oct 14, 2019 23:02
Study Objectives:To describe the demographic and clinical characteristics of children with autism spectrum disorder (ASD) referred for polysomnography (PSG) and to look for predictors of obstructive sleep apnea (OSA) and severe OSA in these children.Methods:This is a retrospective case series of children ages 2 to 18 years who underwent PSG between January 2009 and February 2015. Children were excluded if they had major comorbidities, prior tonsillectomy, or missing data. The following information...
Mon Oct 14, 2019 23:02
Study Objectives:Limited evidence exists on the cost-effectiveness of mandibular advancement device (MAD) compared to continuous positive airway pressure (CPAP) therapy in moderate obstructive sleep apnea (OSA). Therefore, this study compares the clinical and cost-effectiveness of MAD therapy with CPAP therapy in moderate OSA.Methods:In a multicentre randomized controlled trial, patients with an apnea-hypopnea index (AHI) of 15 to 30 events/h were randomized to either MAD or CPAP. Incremental cost-effectiveness...
Mon Oct 14, 2019 23:02
Study Objectives:Children with craniopharyngioma are at risk for excessive daytime sleepiness (EDS). Multiple Sleep Latency Testing (MSLT) is the gold standard for objective evaluation of EDS; however, it is time and resource intensive. We compared the reliability, sensitivity, and specificity of the modified Epworth Sleepiness Scale (M-ESS) and MSLT in monitoring EDS in children with craniopharyngioma.Methods:Seventy patients (ages 6 to 20 years) with craniopharyngioma completed the M-ESS and were...
Mon Oct 14, 2019 23:02
Study Objectives:To compare the secular trends of sleep/wake patterns in school-aged children in Hong Kong and Shanghai, two major metropolitan cities in China with two different policies that school start time was delayed in Shanghai, but advanced in Hong Kong in 10 years’ time.Methods:Participants were from two waves of cross-sectional school-based surveys of children aged 6 to 11 years. In Shanghai, 4,339 and 13,795 children participated in the 2005 and 2014 surveys, respectively. In Hong Kong,...
Mon Oct 14, 2019 23:02
Study Objectives:The modified jaw-thrust maneuver (MJTM) during drug-induced sleep endoscopy (DISE) is known to predict the treatment effect of mandibular advancement devices. However, its effect on the depth of sedation and potential to provoke arousal by awakening patients during the maneuver has not been studied so far. This study investigated the effect of the MJTM on the depth of sedation during DISE.Methods:Forty patients on whom the MJTM was performed during DISE were included. The effect...
Mon Oct 14, 2019 23:02
Study Objectives:Our objectives were to determine in an obese population (body mass index > 35 kg/m2) the number of patients, after gastric bypass (GBP), who no longer met French Ministry of Health criteria for utilizing positive airway pressure (PAP), and the predictive factors of obstructive sleep apnea (OSA) improvement.Methods:Between June 2012 and August 2014 we diagnosed OSA in 129 incident patients requiring PAP therapy before GBP. A postoperative sleep recording was undertaken for 44 of...
Mon Oct 14, 2019 23:02
Introduction:Obstructive sleep apnea (OSA) and systemic hypertension (SH) are common and interrelated diseases. It is estimated that approximately 75% of treatment-resistant hypertension cases have an underlying OSA. Exploration of the gut microbiome is a new advance in medicine that has been linked to many comorbid illnesses, including SH and OSA. Here, we will review the literature in SH and gut dysbiosis, OSA and gut dysbiosis, and whether gut dysbiosis is common in both conditions.Methods:We...
Mon Oct 14, 2019 23:02
The effect of hormone therapy on sleep-disordered breathing in transgender patients has not been described. We present three cases of patients undergoing gender reassignment and treated with hormone replacement. The first case was a transgender woman (assigned male at birth) with a prolonged history of severe obstructive sleep apnea (OSA) that resolved following initiation of female sex hormones. The second and third cases both address transgender males (assigned female at birth) in whom OSA developed...
Mon Oct 14, 2019 23:02
Continuous positive airway pressure (CPAP) is a first-line treatment for obstructive sleep apnea (OSA). However, the adherence to CPAP can be difficult for patients due to several reasons. In this case report we describe a patient with severe OSA who initially was treated successfully with CPAP, but after a few months adherence problems developed because of macroglossia. This was caused by amyloidosis due to multiple myeloma. During treatment with chemotherapy and stem cell transplantation, the size...
Mon Oct 14, 2019 23:02
We present the case of a 12-year-old girl with medically refractory epilepsy and a vagal nerve stimulator (VNS), who experienced severe obstructive sleep apnea (OSA) with respiratory events closely matching her VNS settings. We demonstrated a real-time decrease in OSA through an in-laboratory VNS titration study, decreasing her VNS frequency from 20 Hz to 10 Hz. We were able to demonstrate a baseline level of OSA by turning off the VNS. We then effectively treated her residual OSA with continuous...
Mon Oct 14, 2019 23:02
Palen BN, He K, Redinger J, Parsons EC. A change of heart. J Clin Sleep Med. 2019;15(10):1543–1545.
Mon Oct 14, 2019 23:02
Upchurch A, Sharma S, Hadigal S, Wagner M, Berry R. Persistent hypoxemia in a teen with down syndrome. J Clin Sleep Med. 2019;15(10):1547–1549.
Mon Oct 14, 2019 23:02
DelRosso LM, Lehnert D, Chen ML.When sleeping with eyes closed is optional. J Clin Sleep Med. 2019;15(10):1551–1553.
Mon Oct 14, 2019 23:02
Gupta MA. Effect of varying definitions of hypopnea on the calculation of the apnea-hypopnea index may depend upon the level of sympathetic activation: results from a patient with posttraumatic stress disorder. J Clin Sleep Med. 2019;15(10):1555.
Mon Oct 14, 2019 23:02
Publication date: October 2019Source: Sleep Medicine, Volume 62Author(s):
Mon Oct 14, 2019 15:29
Publication date: Available online 11 October 2019Source: Sleep MedicineAuthor(s): Pablo E. Brockmann, Oliviero Bruni, Leila Kheirandish-Gozal, David GozalAbstractBackgroundHabitually snoring children are at risk of manifesting disease-related problems even if their sleep studies are overall within normal limits.Study objectivesTo compare sleep spindle activity in children with primary snoring and healthy controls.MethodsSleep spindle activity including analysis of fast and slow spindles (ie, >13...
Sun Oct 13, 2019 15:45
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