Periodontal status of children with primary immunodeficiencies: a systematic reviewAbstractObjective
The aim of this systematic review was to appraise the existing literature on periodontal disease in children affected by different types of neutrophil-associated primary immunodeficiencies (PIDs).
Methods
A PRESS-validated search strategy was developed to search through databases MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, LILACS, Google Scholar and Open Grey. All included studies were assessed for methodological quality and risk of bias.
Results
One hundred eighteen articles reporting on 160 PID patients were included for qualitative analysis. The majority (70%) were individual case reports. Clinical and radiographic manifestations of the periodontal disease included poor oral hygiene, generalised alveolar bone loss, severe gingival inflammation, increased pocket depths, tooth mobility and gingival recession. For most studies, the primary intervention was periodontal treatment in the form of scaling and root planing or dental extractions. Stabilisation of the periodontal condition varied between different PIDs. In severe congenital neutropenia (SCN), 61% of cases reported stabilisation of the periodontal condition, while for all other PIDs, ‘stability’ was reported in less than 43% of cases.
Conclusion
The published literature suggests that patients with PIDs can present with severe periodontitis and that conventional treatment approaches have limited benefits.
|
Toothpaste factors related to dentine tubule occlusion and dentine protection against erosion and abrasionAbstractObjectives
To investigate the effect of toothpastes on dentine surface loss and tubule occlusion, and the association of toothpaste-related factors to each of the outcomes.
Materials and methods
One hundred and sixty human dentine specimens were randomly distributed into 10 groups, according to different toothpastes. The specimens were submitted to artificial saliva (60 min), citric acid (3 min), and brushing abrasion (25 s; totalizing 2 min in toothpaste slurries). This was repeated five times and two outcome variables were analyzed: dentine surface loss (dSL; μm) and tubule occlusion by measurement of the total area of open tubules (Area-OT; μm2). Data were analyzed with Kruskal-Wallis and Mann-Whitney tests (α = 0.05); bivariate and multivariate regressions were used to model the association of the chemical (pH, concentration of F−, Ca2+, and PO43− and presence of Sn2+) and physical (% weight of solid particles, particle size, and wettability) factors of the toothpastes to both outcome variables.
Results
Toothpastes caused different degrees of dSL and did not differ in Area-OT. All chemical and physical factors, except the presence of Sn2+, were associated with dSL (p < 0.001). Area-OT was associated only with the presence of Sn2+ (p = 0.033).
Conclusion
Greater dSL was associated with lower pH, lower concentration of F−, higher concentration of Ca2+ and PO43−, greater % weight of solid particles, smaller particle size, and lesser wettability, whereas tubule occlusion was associated with the presence of Sn2+.
Clinical relevance
Depending on their chemical and physical composition, toothpastes will cause different degrees of dentine tubule occlusion and dentine surface loss. This could, in turn, modulate dentine hypersensitivity.
|
Correction to: Effect of Er:YAG laser etching on topography, microstructure, compressive strength, and bond strength of a universal adhesive to calcium silicate cements
Figure 2 was incorrect in the original published version of this article. Correct figure in presented here. The original article has been corrected.
|
Clinical efficacy of Lactobacillus reuteri -containing lozenges in the supportive therapy of generalized periodontitis stage III and IV, grade C: 1-year results of a double-blind randomized placebo-controlled pilot studyAbstractObjective
The aim of this 12-month mono-centre double-blind randomized placebo-controlled clinical study was to evaluate the efficacy of Lactobacillus reuteri-containing lozenges during the supportive therapy of generalized periodontitis stage III and IV, grade C (GPIII-IVC) patients.
Material and methods
Twenty treated GPIII-IVC patients were randomly divided into 2 groups. The test group received two 3-month-long administrations of L. reuteri (2 lozenges/day after brushing) with a 3-month washout period, while the control one received a placebo. Outcome measures were tooth survival, complications and adverse events, change in probing pockets depth (PPD), change in probing attachment level (PAL), presence of bleeding on probing (BOP) and patient’s evaluation of treatment. Measurements were collected at 3, 6, 9 and 12 months.
Results
At 1 year, no dropout, tooth loss, complications or adverse event were recorded. Mean PPD and mean PAL and percentages of sites with BOP were statistically improved (p < 0.05) compared with baseline in both groups, while more PPD reduction at all time points (p < 0.05) and more PAL gain at 6 months and more BOP reduction at 6 and 9 months were found in the probiotic group (p < 0.05).
Conclusions
Within the limitation of the study, the use of L. reuteri probiotics lozenges improved some clinical outcomes in treated GPIII-IVC patients during maintenance therapy. Studies with a larger number of patients are needed to confirm these data.
Clinical relevance
The use of L. reuteri probiotic lozenges could be considered as an adjunct in the maintenance therapy of GPIII-IVC patients.
|
Pain and quality of life after endodontic surgery with or without advanced platelet-rich fibrin membrane application: a randomized clinical trialAbstractBackground
Clinical evidence of the autologous platelet concentrates effects on the patient-reported outcome measures (PROMs) after endodontic surgery is still limited.
Objectives
To investigate the effect of the advanced platelet-rich fibrin (A-PRF+) membrane application upon patient postoperative pain, and quality of life in endodontic surgery.
Materials and methods
A two-parallel-arm randomized clinical trial was made comparing endodontic surgery with or without A-PRF+ as adjunctive treatment. Fifty individuals comprehending 50 apical lesions (second premolar to the second premolar) of upper maxilla were included. Pain perception and quality of life (functional limitations and other symptoms) were assessed 1 week after surgery using a visual analog scale and a Likert scale-based questionnaire. Descriptive analysis was done using χ2 and t test. Binary logistic regression, ANOVA-type statistic, and GEE analysis were used for inferential analysis.
Results
Pain perception was mild in both groups [A-PRF+ 12.7 ± 8.5] versus [no A-PRF+ 20.7 ± 16.3]; it proved less variable during the first 4 days in test group, showing lower extreme pain values (p = 0.096). Analgesic use was similar in both groups. Controls reported significantly worse sleep and speech functions (p < 0.05). Bleeding and bad taste/breath were the most discriminative symptoms.
Conclusions
Postoperative pain perception was mild in endodontic surgery of the upper anterior maxilla. Differences in pain perception were not statistically significant. The use of A-PRF+ afforded less variable pain perception than in the controls. Altered quality of life parameters were more prevalent in the control group and prove significant for speech and sleep functions.
Clinical relevance
Patient-related outcomes are of utmost importance in clinical practice. The use of A-PRF+ provides an affordable and safe alternative to improve postoperative quality of life in endodontic surgery.
|
Expression of concern |
Correlation of magnetic resonance imaging grades with cytokine levels of synovial fluid of patients with temporomandibular joint disorders: a cross-sectional studyAbstractObjectives
Magnetic resonance imaging (MRI) is a standardized method for assisting joint diagnosis. To validate the reliability of different imaging-based grading systems, this study examined (1) the associations between grading systems for osseous change, joint effusion, and the Wilkes classification of temporomandibular joint (TMJ) disorders and (2) the correlation between cytokines in synovial fluid and imaging-based joint scores.
Materials and methods
Twenty-seven patients, who routinely received numeric rating scale (NRS) and MRI assessment before TMJ arthrocentesis, were enrolled. Each joint was evaluated through the grading criteria for severity of osseous change and joint effusion by blinded observers using MRI. ImageJ was employed for classifying joint effusion. Joint synovial fluid, collected through arthrocentesis, was examined for cytokine expression by using a Luminex multiplex assay. All data were analyzed using the Pearson correlation analysis.
Results
The Wilkes classification was strongly correlated with osseous change scores, but not with joint effusion scores. Joint effusion scores significantly correlated with NRS scores, but not with the Wilkes classification and osseous change scores. Compared with osseous change scores, joint effusion scores had a higher correlation with the levels of inflammatory cytokines (interleukin (IL)-8 and soluble IL-6 receptor (sIL-6R)) and with anti-inflammatory cytokines (soluble tumor necrosis factor receptors I and II (sTNF-RI/II)).
Conclusions
In patients with TMJ disorders, MRI grades are strongly correlated with NRS scores and levels of cytokines (IL-8, sIL-6R, and sTNF-RI/II) in the synovial fluid.
Clinical relevance
Joint effusion scoring can be a reliable and valid indicator for pathological assessment of TMJ disorders.
|
Atraumatic restorative treatment—ART in early childhood caries in babies: 4 years of randomized clinical trialAbstractObjective
To assess the effectiveness of atraumatic restorative treatment (ART) performed 4 years ago in babies suffering from early childhood caries (ECC), and to compare the clinical performance of ART atraumatic restorations performed with two different high-viscosity glass ionomer cements (GIC).
Materials and methods
This was a longitudinal follow-up of a randomized, double-blind, split-mouth-type clinical trial. The initial sample was composed of 100 deciduous molars with occlusal lesions in 25 children with ages between 18 and 36 months who received ART with two different GICs: Ketac Molar Easymix® (3 M ESPE) and Vitro Molar® (DFL). The clinical assessments were performed by a trained, blind examiner gauged by the parameters assessed in 1, 2, and 4 years (ART and USPHS criteria).
Results
For the analysis of the clinical performance of ARTs between the different GICs, the chi-square and Mann–Whitney tests were applied (p < 0.05). In the 4 years of evaluation, the sample was composed by 76 ARTs and 19 children, with 94.7% of the treatments having inactivated the cavity process. The total success percentage of the ARTs was 94%, 87.5%, and 82.9%, in 1, 2, and 4 years of follow-up, respectively. Moreover, among the GICs studied, this difference was not statistically significant (p > 0.05) (ClinicalTrials.gov NCT03756025).
Conclusion
ART was effective in handling ECC, with an excellent clinical performance of ART restorations, for both GICs, during the 4 years of follow-up.
Clinical relevance
ART, with both GIC studied, is an alternative therapy for ECC.
|
Effectiveness of the ozone application in two-visit indirect pulp therapy of permanent molars with deep carious lesion: a randomized clinical trialAbstractObjectives
The aim of this randomized, three-arm parallel, single-blinded clinical trial was to evaluate the clinical and microbiological effectiveness of the ozone application in two-visit indirect pulp therapy.
Materials and methods
One hundred five lower first molar teeth with deep caries lesion were included and randomly assigned three groups to apply the two-visit indirect pulp therapy. Treatment procedure was applied without any disinfectant (control), with 60-s 2% chlorhexidine digluconate (CHX) or 60-s ozone application. In four different stages (after initial excavation, ozone/CHX application before the temporary restoration, 4 months later immediately after removing temporary restoration, and final excavation), dentin humidity, consistency, and color properties were recorded to evaluate the clinical characteristics of the tissue, and standard dentin samples were collected for the microbiological analysis of mutans streptococci, lactobacilli, and the total number of colony-forming units. The data were analyzed by using Mann-Whitney U test for multiple comparisons.
Results
The remaining dentin became harder, drier, and darker after 4 months in all groups. However, CHX and ozone application were statistically better than the control group (p < 0.05). There was a gradual decrease in the total number of microorganisms in all groups. While cavity disinfectant applications were improved the antibacterial efficacy (control, 79.11%; CHX, 98.39%; ozone, 93.33%), CHX application exhibited a greater significant reduction than both groups (p = 0.000).
Conclusion
The two-visit indirect pulp therapy yielded successful results for all study groups. However, CHX would be conveniently preferable due to improving the treatment success.
Clinical relevance
The two-visit indirect pulp therapy applied with cavity disinfectant is a proper alternative treatment procedure in deep carious lesions, instead of conventional technique.
|
Experimental mucositis/gingivitis in persons aged 70 or over: microbiological findings and prediction of clinical outcomeAbstractObjectives
To assess in persons aged 70 years or older the microbiological alterations occurring around implants and natural teeth during and after 3 weeks of undisturbed plaque accumulation. Furthermore, to test the predictive value of several markers at baseline for the extent of inflammation around implants and teeth after this period.
Materials and methods
Twenty partially edentulous participants with titanium implants refrained from oral hygiene practices while being clinically monitored in weekly intervals for 21 days. Teeth and implants were then cleaned, oral hygiene resumed, and the participants were further monitored. Levels of six subgingival plaque microorganisms, the plaque index (PI), and the gingival index (GI) were assessed before (baseline), during (days 0, 7, 14, 21), and after plaque accumulation (days 28, 42). Six microorganisms; demographic and clinical variables at day 0 were further evaluated as potential predictors for presence of GI > 1 at days 21 and 28.
Results
The detection frequency of the selected bacteria did not differ between implants and teeth at any time point. Bacteria counts decreased in the preparatory phase and increased in the plaque accumulation phase. Patterns observed at implants and teeth were similar. Only Parvimonas micra at day 21 reached significantly higher counts at implants than teeth. For the prediction of clinical outcome at day 21, in the multivariable model, only implant vs. tooth was significant indicator for the primary outcome (p = 0.01).
Conclusions
Overall, the analysis of subgingival/submucosal samples revealed only minor differences between implants and teeth during the development and resolution of inflammation.
Clinical relevance
Within the limitations of our study, with plaque accumulation, elders develop more inflammation around implants than around teeth, in spite of similar bacterial profiles.
|
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
Translate
Ετικέτες
Κυριακή 20 Οκτωβρίου 2019
Αναρτήθηκε από
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
στις
1:33 π.μ.
Ετικέτες
00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
Telephone consultation 11855 int 1193
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(278)
- ► Φεβρουαρίου (139)
- ► Ιανουαρίου (139)
-
►
2022
(1962)
- ► Δεκεμβρίου (107)
- ► Σεπτεμβρίου (158)
- ► Φεβρουαρίου (165)
- ► Ιανουαρίου (163)
-
►
2021
(3614)
- ► Δεκεμβρίου (152)
- ► Σεπτεμβρίου (271)
- ► Φεβρουαρίου (64)
- ► Ιανουαρίου (357)
-
►
2020
(3279)
- ► Δεκεμβρίου (396)
- ► Σεπτεμβρίου (157)
- ► Φεβρουαρίου (382)
- ► Ιανουαρίου (84)
-
▼
2019
(11718)
- ► Δεκεμβρίου (265)
-
▼
Οκτωβρίου
(562)
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Associations between Folate Metabolism Enzym...
- Five-year breast cancer survival rates at a ...
- Ομιλία του ομοτ. Καθηγητή Παθολογίας Παν/μίο...
- Protein Kinase Cα Mediates Recovery of Renal...
- Relationship between tongue muscle quality a...
- Antioxidants, Vol. 8, Pages 523: Exploring t...
- 30. PLoS One. 2019 Oct 29;14(10):e0224355. do...
- 1. PLoS One. 2019 Oct 29;14(10):e0224490. doi...
- Latest Results for Child's Nervous System,
- Pregnancy Loss Is Not Associated With Late C...
- Medgadget,
- Diagnostic Cytopathology,
- Latest Results for Current Epidemiology Repor...
- Hindawi Publishing Corporation,
- Mediators of Inflammation,
- Latest Results for Oral and Maxillofacial Surg...
- MedWorm Cancer & Oncology Research,
- Journal of Medical Virology,
- Onapristone as Preoperative Treatment for Po...
- Help Parents of Children With Feeding Disord...
- 21. Cell Commun Signal. 2019 Oct 28;17(1):137...
- 1. Food Addit Contam Part A Chem Anal Control...
- US Medical Trainees' Knowledge of Human Papi...
- Qualitative, Exploratory, and Multidimension...
- In vivo measurement of esophageal hiatus sur...
- Antioxidants, Vol. 8, Pages 523: Exploring t...
- Foods, Vol. 8, Pages 532: Broccoli (Brassica...
- Molecules, Vol. 24, Pages 3913: Guanidine-Co...
- Latest Results for Evolving Systems
- Latest Results for International Journal of C...
- 3DPrint.com
- Latest Results for Abdominal Radiology,
- Wiley: Pediatric Dermatology:
- Vitamin D in chronic obstructive pulmonary disea...
- The Ethics of Cranial Nerve ImplantsPublication ...
- Addressing the health, safety, welfare, and dign...
- The Use of Older Versus Newer Data in the Nation...
- Acromioclavicular and Coracoclavicular Ligament ...
- Short-Term Clinical and Quality Outcomes Have In...
- Epidemiological Impact of Expedited Partner Ther...
- Systematic Review on Therapeutic Strategies to M...
- Pelvic Organ ProlapsePelvic organ prolapse (POP)...
- Submental flap practice patterns and perceived ou...
- Absolute Obstetric Anesthesia Review: The Compl...
- Treatment of nevus of Ota by Q switched Nd : YA...
- ATM whole gene deletion in an Italian family wit...
- Hemodynamic Changes in the Sigmoid Sinus of Pati...
- Adolescent sex education: Prevalence, sources an...
- Metastatic Nasopharyngeal Carcinoma Treated With...
- A Novel Patient-Specific Model for Predicting Se...
- Quantitative structure–activity relationship ana...
- Should pyridoxine be given to breastfed infants ...
- Chitosan Hydrogel Enhances the Therapeutic Effic...
- Contact Sensitization in Patients with Chronic L...
- Psychocardiology concern for the management of t...
- Improving Trip and Slip-Resisting Skills in Olde...
- Addressing the unmet needs in medical training f...
- Should pneumatic compression be used in conjunct...
- Vestibular Implantation and the Feasibility of F...
- Multilocus Sequence Typing (MLST) of Campylobac...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Indibulin dampens microtubule dynamics and p...
- Different patterns of epileptiform-like acti...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Predictors for failure of supraglottic superi...
- p16 status and choice of chemotherapy in the...
- Outcome of surgical treatment for carotid bod...
- Closed–suction compared with Penrose drainag...
- ► Σεπτεμβρίου (545)
- ► Φεβρουαρίου (1143)
- ► Ιανουαρίου (744)
-
►
2017
(2)
- ► Φεβρουαρίου (1)
- ► Ιανουαρίου (1)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου