European Journal of Neuroscience
- The use of the orbitofrontal H‐sulcus as a reference frame for value signalsAbstract Understanding the factors that drive organization and function of the brain is an enduring question in neuroscience. Using functional magnetic resonance imaging (fMRI), structure and function have been mapped in primary sensory cortices based on knowledge of the organizational principles that likely drive a given region (e.g. aspects of visual form in primary visual cortex and sound frequency in primary auditory cortex) as well as knowl
- Functional Implications of Cav2.3 R‐Type Voltage‐Gated Calcium Channels in the Murine Auditory System ‐ Novel Vistas from Brainstem‐Evoked Response AudiometryAbstract Voltage‐gated Ca2+ channels (VGCCs) are considered to play a key role in auditory perception and information processing within the murine inner ear and brainstem. In the past, Cav1.3 L‐type VGCCs gathered most attention as their ablation causes congenital deafness. However, isolated patch‐clamp investigation and localisation studies repetitively suggested that Cav2.3 R‐type VGCCs are also expressed in the cochlea and further components
- The human central nervous system transmits common synaptic inputs to distinct motor neuron pools during non‐synergistic digit actionsKey points •Neural connectivity between distinct motor neuronal modules in the spinal cord is classically studied through electrical stimulation or multi‐muscle EMG recordings. •We quantified the strength of correlation in the activity of two distinct populations of motor neurons innervating the thenar and first dorsal interosseous muscles during tasks that required the two hand muscles to exert matched or un‐matched forces in different direc
ScienceDirect Publication: Pathology - Research and Practice
- Limited clinical significance of tissue calprotectin levels in bowel mucosa for the prediction of complicated course of the disease in children with ulcerative colitisPublication date: Available online 11 October 2019Source: Pathology - Research and PracticeAuthor(s): Ondrej Fabian, Ondrej Hradsky, Tereza Lerchova, Filip Mikus, Josef Zamecnik, Jiri BronskyAbstractBackgroundFecal calprotectin (F-CPT) represents one of the most widely used biomarkers for intestinal inflammation. However, the levels may be false negative or false positive in some situations.AimsTo evaluate the usefulness of immunohistochemical (I
Annals of Intensive Care - Latest Articles
- Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre studyDynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variations and stroke volume variations, has been proposed to assess functional arterial load. We evaluated the evolution of Eady...
- Evaluation of least significant changes of pulse contour analysis-derived parametersMany maneuvers assessing fluid responsiveness (minifluid challenge, lung recruitment maneuver, end-expiratory occlusion test, passive leg raising) are considered as positive when small variations in cardiac in...
- A multicenter study of oral sarcomas in BrazilAbstract Objectives The aim of this study was to investigate the prevalence of oral sarcomas from geographic regions of Brazil. Materials and methods A cross‐sectional study was conducted on biopsies obtained from January 2007 to December 2016 at twelve Brazilian oral and maxillofacial pathology centres. Gender, age, evolution time, clinical aspects, tumour location, tumour size at diagnosis, radiographic aspects and histopathological d
- The significance of PA28γ and U2AF1 in oral mucosal carcinogenesisAbstract Objective Proteasome activator 28γ (PA28γ) upregulation plays a critical role in the carcinogenesis of many malignancies, including oral cancer. We aim to screen the related genes of PA28γ and investigate their function in oral mucosa carcinogenesis. Materials and Methods Bioinformatics analysis was performed to screen the related genes of PA28γ. Immunohistochemical analysis was carried out to validate their correlation in oral
- Localization of PD‐L1 on single cancer cells by iSERS microscopy with Au/Au core/satellite nanoparticlesProgrammed cell death‐ligand 1 (PD‐L1) is an important predictive biomarker. The detection of PD‐L1 can be crucial for patients with advanced cancer where the use of immunotherapy is considered. Here, we demonstrate the use of immuno‐SERS microscopy (iSERS) for localizing PD‐L1 on single cancer SkBr‐3 cells. A central advantage of iSERS is that the disturbing autofluorescence from cells and tissues can be efficiently minimized by red to near‐infr
- A mutant KRAS‐induced factor REG4 Promotes Cancer Stem Cell Properties via Wnt/β‐catenin SignalingMutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through microarray analyses of genes specifically induced in CRC spheroids harboring both KRAS and APC mutations. Among them, REG4 was ide
- Genomic profiling of the residual disease of advanced high‐grade serous ovarian cancer after neoadjuvant chemotherapyThe goal of this study was to demonstrate the spectrum of genomic alterations present in the residual disease of patients with advanced high‐grade serous ovarian cancer (HGSOC) after neoadjuvant chemotherapy (NAC), including matched pretreatment biopsies. During the study period between 2006 and 2017, we collected pre‐ and post‐NAC tumor tissue samples from patients with advanced HGSOC. We performed combined next‐generation sequencing and immunoh
- HIV‐1, HAART and cancer: a complex relationshipHIV infected people are at higher risk of developing cancer, although it is globally diminished in the era of highly active antiretroviral treatment (HAART). Recently, antioncogenic properties of some HAART drugs were discovered. We discuss the role of HAART in the prevention and improvement of treatment outcomes of cancers in HIV‐infected people. We describe different trends in HAART‐cancer relationships: cancer‐predisposing as well as cancer‐pr
- Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and ApoptosisSummary The malignant growth of human papillomavirus (HPV)‐positive cancer cells is dependent on the continuous expression of the viral E6/E7 oncogenes. Here, we examined the effects of iron deprivation on the phenotype of HPV‐positive cervical cancer cells. We found that iron chelators, such as the topical antifungal agent ciclopirox (CPX), strongly repress HPV E6/E7 oncogene expression, both at the transcript and protein level. CPX efficiently
- Endoscopic Ear Surgery; Does It Have An Impact On Quality Of Life?; Our Experience Of 152 CasesAbstract Objective Transcanal endoscopic ear surgery (TEES) is a relatively new method of treatment for otological conditions. Although there are studies on TEES outcomes, none of the studies have assessed the quality of life (QoL) of patients following surgery. This study uses the validated Glasgow Benefit Inventory (GBI) to quantify quality of life outcomes following TEES. Design Retrospective questionnaire‐based study Setting S
- Synthetic enhancer compounds, besides acting on biogenic amine system, influence the glutamate transmission and stress responsePublication date: Available online 11 October 2019Source: Behavioural Brain ResearchAuthor(s): Joseph Knoll, Ildiko MiklyaGraphical abstractThree weeks treatment with specific doses of enhancer drugs increased the protein level of phosphorylated glutamatergic receptor subunits in the prefrontal cortex and reduced the resting corticosterone level during the active period in male rats. *p < 0.05, **p < 0.01 vs Control
- Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndromePublication date: Available online 11 October 2019Source: Behavioural Brain ResearchAuthor(s): Hui Liu, Zhi-Zhi LiuAbstractColoboma, heart defects, choanal atresia, restricted growth and development, genital hypoplasia, ear abnormalities and/or hearing loss (CHARGE) syndrome is a congenital disorder that is mainly caused by mutations within chromodomain helicase DNA-binding protein 7 (chd7). Behavioral abnormalities have been addressed in CHARGE
Systematic Reviews - Latest Articles
- Long-term efficacy of interventions for actinic keratosis: protocol for a systematic review and network meta-analysisActinic keratoses (AK) are common precancerous lesions of the skin due to cumulative sun exposure. A variety of interventions are available for the treatment; however, the majority of randomised controlled tri...
- Quantitative label-free proteomic analysis reveals differentially expressed proteins in the digestive juice of resistant versus susceptible silkworm strains and their predicted impacts on BmNPV infectionPublication date: Available online 11 October 2019Source: Journal of ProteomicsAuthor(s): Shang-zhi Zhang, Jie Wang, Lin-bao Zhu, Shahzad Toufeeq, Xin Xu, Ling-ling You, Bing Li, Pei Hu, Jia-ping XuAbstractBombyx mori nucleopolyhedrovirus (BmNPV) is a major pathogen causing severe economic loss. Previous studies have revealed that some proteins in silkworm digestive juice show antiviral activity. In this study, antiviral activity examination of d
- Peripheral Immune Biomarkers and Neurodegenerative Diseases: A Prospective Cohort Study with 20 Years of Follow‐upAbstract Objective To assess the associations of several blood immune biomarkers with the future risks of amyotrophic lateral sclerosis and Parkinson disease in a prospective cohort study with 20 years of follow‐up. Methods The Swedish Apolipoprotein‐Related Mortality Risk study is a longitudinal cohort study including 812,073 participants with repeated blood biomarker measurements between 1985 and 1996 and a follow‐up until 2011. Using
- Low‐Frequency Brain Oscillations Track Motor Recovery in Human StrokeAbstract Objective The majority of patients with stroke survive the acute episode and live with enduring disability. Effective therapies to support recovery of motor function after stroke are yet to be developed. Key to this development is the identification of neurophysiologic signals that mark recovery and are suitable and susceptible to interventional therapies. Movement preparatory low‐frequency oscillations (LFOs) play a key role in cort
- Association between periodontitis and medication‐related osteonecrosis of the jaw: a systematic review and meta‐analysisAbstract Consensus has yet to be reached about the prevention and treatment of medication‐related osteonecrosis of the jaw (MRONJ), which is a treatment sequela of several antiresorptive therapies and other pharmaceutical interventions. Several epidemiologic studies have identified periodontal disease (PD) as a risk factor for this outcome. Thus, the objective of this systematic review and meta‐analysis was to investigate this association and it
- Development and validation of a short version of Chronic Oral Mucosal Disease Questionnaire (COMDQ‐15)Abstract Background The adoption of the Chronic Oral Mucosal Disease Questionnaire (COMDQ) into clinical practice has been low, despite its rigorous development process. A potential limitation of the COMDQ is the high response burden to patients. Therefore, the aim of the present study was to develop and validate a short version of the 26‐item COMDQ. Methods The COMDQ data of 520 patients with chronic oral mucosal diseases were randomly
- Safety and efficacy of surgery combined with bleomycin irrigation for complex cervical–facial lymphatic malformations of childrenPublication date: Available online 12 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Ying Wang, Weiqing Tang, Xiaoyan LiAbstractBackgroundIn this retrospective study, we compare the safety and efficacy of surgery combined with bleomycin intra-operatively with intralesional sclerotherapy alone for the management of head and neck lymphatic malformations in children.Materials and MethodsThe patients with cervica
- Parents’ views about factors facilitating their involvement in the oral early intervention services provided for their children with hearing loss in KuwaitPublication date: Available online 11 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Alyaa Alduhaim, Alison Purcell, Steven Cumming, Maree DobleAbstractObjectivesDeveloped countries (such as the Unites States of America, the United Kingdom, and Australia) provide high-quality services to children with hearing loss and their parents, including universal newborn hearing screening, early fitting of hearing devic
Oral and Maxillofacial Surgery
- Management of regional metastatic disease in cutaneous malignancy of the head and neck. 3. Merkel cell carcinomaThis is the third of three articles that give an overview of the current evidence for management of the neck and parotid in patients with cutaneous cancers of the head and neck. In this paper we discuss Merkel cell carcinoma (MCC) and review the latest evidence for management of the regional nodes.
- Incidence, timing, presentation, treatment, and outcomes of second primary head and neck squamous cell carcinoma after oral cancerAfter their initial presentation of oral squamous cell carcinoma (SCC), patients have a lifelong risk of developing another new SCC of the head and neck. The aim of this study was to establish second primary rates, baseline characteristics (site, clinical or pathological stage, and smoking and alcohol history), timing, presentation, treatment, and outcomes. From the regional unit we analysed records of patients treated with curative intent for th
Oral & Maxillofacial Surgery
- Opioid guidelines for common dental surgical procedures: a multidisciplinary panel consensusOne in 16 patients prescribed opioids after a surgical procedure will become a long-term user. The lack of procedure-specific guidelines after common dental procedures contributes to the opioid overprescribing problem. We convened a multidisciplinary panel to develop consensus recommendations for opioid prescribing after common dental procedures. We used a three-step modified Delphi method to develop a consensus recommendation for outpatient opio
Plastic, Reconstructive & Aesthetic Surgery
- Prediction of Late Enophthalmos using Quantitative Measures in Isolated Medial Orbital Wall Fracture: Multiple Regression AnalysisEnophthalmos is one of the most distressing complications of orbital fracture and when faced with a blow-out fracture, plastic surgeons often find it difficult to determine the need for surgical correction. Although a number of studies have been conducted on this topic, no study has yet been performed using a set of measurable parameters.
rhinol allergy
- Concha Bullosa Affects Baseline and Postoperative Quality-of-Life Measures in Surgically Managed Chronic Rhinosinusitis.Related ArticlesConcha Bullosa Affects Baseline and Postoperative Quality-of-Life Measures in Surgically Managed Chronic Rhinosinusitis. Am J Rhinol Allergy. 2019 Oct 11;:1945892419881836 Authors: Qualliotine JR, Jafari A, Shen S, Bernstein JD, DeConde AS PMID: 31603344 [PubMed - as supplied by publisher]
- Characterization of Sinus Disease in Patients with Yellow Nail Syndrome.Related ArticlesCharacterization of Sinus Disease in Patients with Yellow Nail Syndrome. Am J Rhinol Allergy. 2019 Oct 11;:1945892419881253 Authors: Gutierrez CN, Low CM, Stokken JK, Choby G, O'Brien EK PMID: 31603343 [PubMed - as supplied by publisher]
- <sup>11</sup>C-Methionine Integrated PET/MRI-Based Texture Analysis Features May Have a Potential Ability to Distinguish Oligodendroglioma (IDH-Mutant and 1p/19q-Codeleted) From Varied GliomasPublication date: Available online 11 October 2019Source: Academic RadiologyAuthor(s): Kai Zhao, Peng Yu, Zhe Xue, Jiajin Liu, Anhui Yao, Yue Zhao, Fuxing Yang, Jiahe Tian, Bainan XuRationale and ObjectivesDifferent histology and gene status of gliomas results in different natural history, treatment, and prognosis in different subgroups. Low-grade gliomas (LGGs) with isocitrate dehydrogenase (IDH) mutant and 1p/19q-codeleted are kind of gliomas w
- PET-MR Imaging and MR Texture Analysis in the Diagnosis of Pancreatic Cysts: A Prospective Preliminary StudyPublication date: Available online 9 October 2019Source: Academic RadiologyAuthor(s): Si-Hang Cheng, Dong Liu, Bo Hou, Ya Hu, Li Huo, Haiqun Xing, Zheng-Yu Jin, Hua-Dan XueRationale and ObjectivesOur aim was to evaluate the capability of textural and metabolic parameters measured at pretreatment 18F-fluorodeoxyglucose Positron emission tomography (PET)-MR in differentiating malignant from benign pancreatic cystic lesions.Materials and MethodForty
- The presence of Aspergillus fumigatus in asthmatic airways is not clearly related to clinical disease severityAbstract Background It is suggested that airway fungi, in particular Aspergillus may impinge on clinical phenotype in asthma. Indeed the term severe asthma with fungal sensitisation (SAFS) has been coined. We aimed to ascertain whether the presence of fungi, in particular Aspergillus fumigatus, in the airway correlated with asthma severity and control. Furthermore, we aimed to determine if traditional markers of Aspergillus sensitisation rela
- New insights into the sensitization to non‐related nsLTPs from pollen and food: new role of the allergen Ole e 7Abstract Background Ole e 7 is a non‐specific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7‐sensitized patients exhibit a co‐sensitization to the peach nsLTP, Pru p 3. However, there is no evidence of cross‐reactivity which explains this observed co‐sensitization. Therefore,
- Deviance detection in sound frequency in simple and complex sounds in urethane-anesthetized ratsPublication date: Available online 11 October 2019Source: Hearing ResearchAuthor(s): Tiantian Yang, Jarmo Hämäläinen, Kaisa Lohvansuu, Arto Lipponen, Markku Penttonen, Piia AstikainenAbstractMismatch negativity (MMN), which is an electrophysiological response demonstrated in humans and animals, reflects memory-based deviance detection in a series of sounds. However, only a few studies on rodents have used control conditions that were sufficient i
Cancers
- Cancers, Vol. 11, Pages 1549: High Expression of MicroRNA-196a is Associated with Progression of Hepatocellular Carcinoma in Younger PatientsCancers, Vol. 11, Pages 1549: High Expression of MicroRNA-196a is Associated with Progression of Hepatocellular Carcinoma in Younger Patients Cancers doi: 10.3390/cancers11101549 Authors: Shen-Yung Wang Chih-Li Chen Yu-Chen Hu Yi Chi Yen-Hua Huang Chien-Wei Su Wen-Juei Jeng Yuh-Jin Liang Jaw-Ching Wu MicroRNAs are small RNAs involved in various biological processes and cancer metastasis. miR-196a was associate
- Cancers, Vol. 11, Pages 1548: Inherited Variants in BLM and the Risk and Clinical Characteristics of Breast CancerCancers, Vol. 11, Pages 1548: Inherited Variants in BLM and the Risk and Clinical Characteristics of Breast Cancer Cancers doi: 10.3390/cancers11101548 Authors: Wojciech Kluźniak Dominika Wokołorczyk Bogna Rusak Tomasz Huzarski Aniruddh Kashyap Klaudia Stempa Helena Rudnicka Anna Jakubowska Marek Szwiec Sylwia Morawska Katarzyna Gliniewicz Karina Mordak Małgorzata Stawicka Joanna Jarkiewicz-Tretyn
- Cancers, Vol. 11, Pages 1547: Is There a Standard Adjuvant Therapy for Resected Pancreatic Cancer?Cancers, Vol. 11, Pages 1547: Is There a Standard Adjuvant Therapy for Resected Pancreatic Cancer? Cancers doi: 10.3390/cancers11101547 Authors: Fenocchio Filippi Lombardi Quarà Milanesio Aimar Leone Aglietta Surgical resection remains the only treatment that offers a potential chance of long-term survival. Unfortunately, about 80% of patients treated with curative intent will develop recurrence. Since 20
- Cancers, Vol. 11, Pages 1543: Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics AlgorithmsCancers, Vol. 11, Pages 1543: Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms Cancers doi: 10.3390/cancers11101543 Authors: Elizabeth Gensterblum-Miller J. Chad Brenner Recent developments in bioinformatics technologies have led to advances in our understanding of how oncogenic viruses such as the human papilloma virus drive cancer progression and evade t
- Cancers, Vol. 11, Pages 1545: Translational Potential of MicroRNAs for Preoperative Staging and Prediction of Chemoradiotherapy Response in Rectal CancerCancers, Vol. 11, Pages 1545: Translational Potential of MicroRNAs for Preoperative Staging and Prediction of Chemoradiotherapy Response in Rectal Cancer Cancers doi: 10.3390/cancers11101545 Authors: Machackova Prochazka Kala Slaby Abstract: Colorectal cancer is the third most common cancer and the second cause of cancer-related deaths. Rectal cancer presents roughly one-third of all colorectal cancer cases and differs f
- Cancers, Vol. 11, Pages 1546: Cerebrospinal Fluid MicroRNA Signatures as Diagnostic Biomarkers in Brain TumorsCancers, Vol. 11, Pages 1546: Cerebrospinal Fluid MicroRNA Signatures as Diagnostic Biomarkers in Brain Tumors Cancers doi: 10.3390/cancers11101546 Authors: Alena Kopkova Jiri Sana Tana Machackova Marek Vecera Lenka Radova Karolina Trachtova Vaclav Vybihal Martin Smrcka Tomas Kazda Ondrej Slaby Pavel Fadrus Central nervous system (CNS) malignancies include primary tumors that originate within the CNS as
- Cancers, Vol. 11, Pages 1544: Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia CellsCancers, Vol. 11, Pages 1544: Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells Cancers doi: 10.3390/cancers11101544 Authors: Sylwia Flis Ewelina Bratek Tomasz Chojnacki Marlena Piskorek Tomasz Skorski Tyrosine kinase inhibitors (TKIs) revolutionized the treatment of chronic myeloid leukemia in the chronic phase (CML-CP).
- Cancers, Vol. 11, Pages 1542: Analysis of A 6-Mirna Signature in Serum from Colorectal Cancer Screening Participants as Non-Invasive Biomarkers for Advanced Adenoma and Colorectal Cancer DetectionCancers, Vol. 11, Pages 1542: Analysis of A 6-Mirna Signature in Serum from Colorectal Cancer Screening Participants as Non-Invasive Biomarkers for Advanced Adenoma and Colorectal Cancer Detection Cancers doi: 10.3390/cancers11101542 Authors: María Marcuello Saray Duran-Sanchon Lorena Moreno Juan José Lozano Luis Bujanda Antoni Castells Meritxell Gironella Early detection of colorectal cancer (CRC) and its precancer
- Cancers, Vol. 11, Pages 1541: Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in MiceCancers, Vol. 11, Pages 1541: Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice Cancers doi: 10.3390/cancers11101541 Authors: Andrea D. Re Cecconi Mara Forti Michela Chiappa Zhiyong Zhu Leonid V. Zingman Luigi Cervo Luca Beltrame Sergio Marchini Rosanna Piccirillo Physical activity improves the prognosis of cancer patients, partly by contrasting the associate
- Pure word deafness revealing ischemic stroke in a Tunisian patientPublication date: Available online 11 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Thouraya Ben Younes, Mariem Messelmani, Malek Mansour, Jamel Zaouali, Ridha Mrissa
- Non-traumatic cervical artery dissection and ischemic stroke: A narrative review of recent researchPublication date: Available online 11 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Michał Marciniec, Klaudia Sapko, Marcin Kulczyński, Sylwia Popek-Marciniec, Anna Szczepańska-Szerej, Konrad RejdakAbstractCervical artery dissection (CAD) is a leading cause of ischaemic stroke (IS) in young and middle-aged adults. Despite well characterized clinical presentation, the diagnosis of CAD can be quite challenging due to a wide vari
- Gamma Knife radiosurgery for pituitary spindle cell oncocytomas: Case series and literature reviewPublication date: Available online 11 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Göktuğ Akyoldaş, Ömer Batu Hergünsel, İnan Erdem Özdemir, Meriç Şengöz, Selçuk PekerAbstractObjectivesSpindle cell oncocytomas (SCOs) are benign lesions of the posterior portion of the pituitary gland that typically come to neurosurgical attention due to compression of the sellar or parasellar structures, and headaches. Initial treatment option
- Age Predicts Outcomes Better than Frailty Following Aneurysmal Subarachnoid Hemorrhage: A Retrospective Cohort AnalysisPublication date: Available online 11 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Matthew McIntyre, Chirag Gandhi, Andrew Long, Alex Vonhoof, Boyi Li, Vikas Patel, Adil Afridi, Mohamed Halabi, Meic Schmidt, Chad Cole, Justin Santarelli, Fawaz Al-Mufti, Christian BowersAbstractObjectiveIncreasing age has been associated with worse outcomes following aneurysmal subarachnoid hemorrhage (aSAH), yet frailty’s effect on aSAH outco
- Inter-rater reliability of primitive signs in dementiaPublication date: Available online 11 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Andrea Plutino, Sara Baldinelli, Chiara Fiori, Valentina Ranaldi, Mauro Silvestrini, Simona LuzziAbstractObjectivesThe aim of the present study is to explore inter-rater reliability of primitive signs in a group of patients assessed for dementia.Patients and methods97 patients admitted to our University Hospital for cognitive impairment were en
- Supervised I-vector Modeling for Language and Accent RecognitionPublication date: Available online 11 October 2019Source: Computer Speech & LanguageAuthor(s): Shreyas Ramoji, Sriram GanapathyAbstractThe conventional i-vector approach to speaker and language recognition constitutes an unsupervised learning paradigm where a variable length speech utterance is converted into a fixed dimensional feature vector (termed as i-vector). The i-vector approach belongs to the broader family of factor analysis models wher
- Immune cell infiltration as a biomarker for the diagnosis and prognosis of digestive system cancerAbstract The digestive system cancers are aggressive cancers with the highest mortality worldwide. In this study, we performed a systematic investigation of the tumor immune microenvironment to identify diagnostic and prognostic biomarkers. The fraction of 22 immune cell types of patients were estimated using CIBERSORT. The least absolute shrinkage and selection operator (LASSO) analysis was performed to identify important immune predictors. By
Journal of Cancer Research and Clinical Oncology
- 18 F-FDG PET/CT versus CT/MR imaging for detection of neck lymph node metastasis in palpably node-negative oral cavity cancerAbstract Purpose Subclinical lymph node (LN) metastasis is associated with poor survival outcome in oral cavity squamous cell carcinoma (OCC), which alleges elective neck LN dissection. Preoperative detection of metastatic LNs may improve prognosis and proper management of OCC. We examined the clinical usefulness of fluorine 18-fluorodeoxyglucose (18F-FDG) positron emission tomography
- A nomogram for predicting the presence of germline mutations in pheochromocytomas and paragangliomasAbstract Purpose Up to 40% of patients with pheochromocytomas or paragangliomas (PPGLs) carry a germline mutation. This study aimed to build a nomogram using clinical information to predict the probability of germline mutation in PPGLs. Methods The data were collected from 563 patients who were diagnosed
- CRISPR/Cas9 facilitates genomic editing for large-scale functional studies in pluripotent stem cell culturesAbstract Pluripotent stem cell (PSC) cultures form an integral part of biomedical and medical research due to their capacity to rapidly proliferate and differentiate into hundreds of highly specialized cell types. This makes them a highly useful tool in exploring human physiology and disease. Genomic editing of PSC cultures is an essential method of attaining answers to basic physiological functions, developing in vitro models
- Impact of adjuvant fractionated stereotactic radiotherapy dose on local control of brain metastasesAbstract Purpose The aim of this study was to determine whether a higher biological effective dose (BED) would result in improved local control in patients treated with fractionated stereotactic radiotherapy (FSRT) for their resected brain metastases. Methods Patients with newly diagnosed brain metastases
- Rutin protects human periodontal ligament stem cells from TNF-α induced damage to osteogenic differentiation through suppressing mTOR signaling pathway in inflammatory environmentPublication date: Available online 11 October 2019Source: Archives of Oral BiologyAuthor(s): Bin Zhao, Wenjing Zhang, Yixuan Xiong, Yunpeng Zhang, Linglu Jia, Xin XuAbstractObjectivesTo investigate whether rutin could protect human periodontal ligament stem cells (hPDLSCs) from TNF-α induced damage to osteogenic differentiation in inflammatory environment and detect the underlying mechanism.Materials and methodshPDLSCs were identified by flow cyt
- Assessment of of Submucosal Injection of Dexmedetomidine on Postoperative Symptoms After Surgical Molar ExtractionPublication date: Available online 10 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Burcu Gursoytrak, Özlem Kocaturk, Mahmut Koparal, Belgin GulsunPurposeEmbedded third molar surgery is the most frequent procedure performed in oral-maxillofacial surgery (OMS). The purpose of this study was to assess the clinical effect of submucosal dexmedetomidine (dex) for the decreasing of postoperative edema, trismus and pain followi
- Does Early Repair of Orbital Fractures Result in Superior Patient Outcomes? A Systematic Review and Meta AnalysisPublication date: Available online 10 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Hossein E. Jazayeri, Nima Khavanin, Jason W. Yu, Joseph Lopez, Karan P. Ganjawalla, Tatyana Shamliyan, R. John Tannyhill, Amir H. DorafsharAbstractPurposeTo date, no clear evidence-based guidelines exist pertaining to the ideal timing to surgical treatment of orbital fractures. The purpose of this study was to determine if early treatment
- Incidence, timing, presentation, treatment, and outcomes of second primary head and neck squamous cell carcinoma after oral cancerPublication date: Available online 12 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S.N. Rogers, A. Swain, C. Carroll, D. LoweAbstractAfter their initial presentation of oral squamous cell carcinoma (SCC), patients have a lifelong risk of developing another new SCC of the head and neck. The aim of this study was to establish second primary rates, baseline characteristics (site, clinical or pathological stage, and
- Opioid guidelines for common dental surgical procedures: a multidisciplinary panel consensusPublication date: Available online 12 October 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): O.A. Farooqi, W.E. Bruhn, M.K. Lecholop, D. Velasquez-Plata, J.G. Maloney, S. Rizwi, R.B. Templeton, A. Goerig, C. Hezkial, C.M. Novince, M.T. Zieman, A.M.N. Lotesto, M.A. MakaryAbstractOne in 16 patients prescribed opioids after a surgical procedure will become a long-term user. The lack of procedure-specific guidelines aft
Κυριακή 13 Οκτωβρίου 2019
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