• Allergologia et Immunopathologia,
• Frequency and clinical features of pollen-food syndrome in children

  Publication date: Available online 8 October 2019Source: Allergologia et ImmunopathologiaAuthor(s): H. Guvenir, E. Dibek Misirlioglu, B. Buyuktiryaki, M.M. Zabun, M. Capanoglu, M. Toyran, E. Civelek, C.N. KocabasAbstractBackgroundPollen-food syndrome (PFS) is an allergic reaction to fresh fruits, vegetables and/or nuts that can occur in patients who are allergic to pollen. The prevalence of PFS in children is not clearly known.ObjectiveThe object

  Allergologia et Immunopathologia

  Wed Oct 09, 2019 04:12
• Association between skin prick test and serum specific immunoglobulin E to American cockroach allergens in allergic rhinitis patients

  Publication date: Available online 8 October 2019Source: Allergologia et ImmunopathologiaAuthor(s): W. Srisuwatchari, P. Kwanthong, C. Bunnag, P. Pacharn, O. Jirapongsananuruk, N. VisitsunthornAbstractIntroduction and objectivesAmerican cockroach is a common aeroallergen sensitization in allergic rhinitis (AR) patients. Association between skin prick test (SPT) and specific immunoglobulin E (sIgE) to American cockroach allergen remains uncertain.

  Allergologia et Immunopathologia

  Wed Oct 09, 2019 04:12
• Airborne pollen calendar of Portugal: a 15-year survey (2002–2017)

  Publication date: Available online 7 October 2019Source: Allergologia et ImmunopathologiaAuthor(s): Irene Camacho, Elsa Caeiro, Carlos Nunes, Mário Morais-AlmeidaAbstractIntroductionData about the occurrence of airborne pollen enables the creation of pollen calendars with an approximation of flowering periods for the most common allergenic plant species in a specific area. The aim of this work is to provide pollen calendar for each of the seven m

  Allergologia et Immunopathologia

  Wed Oct 09, 2019 04:12
• Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents

  Publication date: Available online 7 October 2019Source: Allergologia et ImmunopathologiaAuthor(s): Felipe Faria Pierotti, Carolina Sanchez Aranda, Renata Rodrigues Cocco, Emanuel Sarinho, Flávio Sano, Arnaldo Porto, Nelson Rosário, Herberto José Chong Neto, Ekaterini Goudouris, Lilian Sanches Moraes, Neusa Falbo Wandalsen, Márcia Carvalho Mallozi, Antônio Carlos Pastorino, Jackeline Motta Franco, Maria Letícia Chavarria, Magnus P. Borres, Dirceu

  Allergologia et Immunopathologia

  Wed Oct 09, 2019 04:12
• Angewandte Chemie International Edition
• Loss of Single Domain Function in Modular Assembly Line Alters Size and Shape of Complex Polyketide

  The structural wealth of complex polyketide metabolites produced by bacteria results from intricate, highly evolved biosynthetic programs of modular assembly lines, in which the number of modules defines the size of the backbone, and the domain composition controls the degree of functionalization. We report a remarkable case where polyketide chain length and scaffold depend on the function of a single b‐keto processing domain: A ketoreductase dom

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 08:31
• A Single Thermoresponsive Diblock Copolymer Can Form Spheres, Worms or Vesicles in Aqueous Solution

  It is well‐known that the self‐assembly of AB diblock copolymers in solution can produce various morphologies depending on the relative volume fraction of each block. Recently, polymerization‐induced self‐assembly (PISA) has become widely recognized as a powerful platform technology for the rational design and efficient synthesis of a wide range of block copolymer nano‐objects. In this study, PISA is used to prepare a new thermoresponsive poly(N‐

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 07:43
• Shining new light on multifunctional lanthanide single‐molecule magnets

  Single‐molecule magnets (SMMs) are at the forefront of new technological advances in quantum information processing and spintronics. Despite the recent impressive breakthroughs in extending the magnetic blocking temperatures beyond liquid nitrogen temperatures, significant challenges await in terms of integrating and addressing such compounds in devices. With this ultimate goal in mind, the design of multifunctional SMMs not only allows to imbue

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 06:42
• Interplay between J‐ and H‐type coupling in aggregates of π‐conjugated polymers: a single‐molecule perspective

  Strong dipole‐dipole coupling within and between π‐conjugated segments shifts electronic transitions, and modifies vibronic coupling and excited‐state lifetimes. Since J‐type coupling between monomers along the chain and H‐type coupling of chromophores between chains compete, a superposition of the spectral modifications arising from each type of coupling emerges, making the two couplings hard to discern in the ensemble. We introduce a single‐mol

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 06:14
• Cyclic (alkyl)(boryl)germylene derived from cyclic (alkyl)(amino)germylene

  Cyclic (alkyl)(amino)germylene 1 undergoes a ring expansion reaction with dibromomesitylborane (MesBBr 2 ) to afford a six‐membered dibromogermane derivative 2 . In the presence of Lewis bases (PMe 3 or Me NHC), reduction of 2 with two equivalents of potassium graphite (KC 8 ) gives rise to cyclic (alkyl)(boryl)germylene‐base adducts 3 and 4 , respectively. Upon heating, compound 3 reacts with H 2 to yield the germane 6 ,

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 03:43
• Copernicium is a Relativistic Noble Liquid

  The chemical nature and aggregate state of copernicium (Cn) have been subject of speculation for many years. While strong relativistic effects render Cn chemically inert, which led Pitzer to suggest a noble‐gas‐like behavior in 1975, Eichler and coworkers in 2008 reported substantial interactions with a gold surface and suggested a metallic character with a solid aggregate state based on atom‐at‐a‐time experiments. Here, we explore the physicoche

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 03:21
• Arene Trifunctionalization with Highly Fused Ring Systems through Domino Aryne Nucleophilic, Diels‐Alder Cascade

  A convenient and efficient domino aryne process was developed under transition metal‐free conditions, featuring a group of tetra‐ and pentacyclic ring systems. This transformation was realized by a 1,2‐benzdiyne‐involved nucleophilic, Diels‐Alder reaction cascade using styrene as diene moiety. Three new chemical bonds, namely one C‐N and two C‐C bonds, and two benzofused rings could be concomitantly constructed, which was made possible by distinc

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 03:20
• Nitride Spinel: An Ultraincompressible High‐Pressure Form of BeP2N4

  Owing to its outstanding elastic properties, the nitride spinel γ‐Si3 N4 is of considered interest for materials scientists and chemists. DFT calculations suggest that Si 3 N 4 ‐analog beryllium phosphorus nitride BeP2 N4 adopts the spinel structure at elevated pressures as well and shows outstanding elastic properties. Herein, we investigate phenakite‐type BeP2 N4 by single‐crystal synchrotron X‐ray diffraction and report the phase tra

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 03:19
• Visible‐Light‐Driven N‐Heterocyclic Carbene‐catalyzed γ‐ and ε‐Alkylation with Alkyl Radicals

  The merging of photoredox catalysis and N‐heterocyclic carbene (NHC) catalysis for γ‐ and ε‐alkylation of enals with alkyl radicals was developed. The alkylation reaction of γ‐oxidized enals with alkyl halides worked well for the synthesis γ‐multisubstituted‐α,β‐unsaturated esters, including those with challenging vicinal all‐carbon quaternary centers. The synthesis of ε‐multisubstituted‐α,β‐γ,δ‐diunsaturated esters via unprecedented NHC‐catalyz

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 02:00
• Enhancing biocompatible stability of DNA nanostructures using dendritic oligonucleotides and brick motifs

  The use of DNA‐based nanomaterials in biomedical applications is continuing to grow, yet more emphasis is being put on the need for guaranteed structural stability of DNA nanostructures in physiological conditions. Various methods have been developed to stabilize DNA origami against low concentrations of divalent cations and presence of nucleases. However, most strategies require a complete encapsulation of nanostructures, which makes accessing t

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 02:00
• Bioactive Peptide Brush Polymers via Photoinduced Reversible‐Deactivation Radical Polymerization

  Harnessing metal‐free photoinduced reversible‐deactivation radical polymerization (photo‐RDRP) in organic and aqueous phases, we report a synthetic approach to enzyme‐responsive and pro‐apoptotic peptide brush polymers. Thermolysin‐responsive peptide based polymeric amphiphiles assembled into spherical micellar nanoparticles that undergo a morphology transition to worm‐like micelles upon enzyme‐triggered cleavage of coronal peptide sidechains. Mo

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:59
• Carboxyl as a Remote‐selective Chelating Group for C−H Activation of Arenes

  The first example of carboxyl group assisted, remote‐selective C(sp 2 )−H activation with a Pd II ‐catalyst has been developed via possible  κ 2 coordination of the carboxyl, suppressing the ortho‐C−H activation via the κ 1 coordination. Besides meta ‐C−H olefination, direct meta ‐arylation of hydrocinnamic acid derivatives with low‐cost aryl iodides has been achieved for the first time. These findings may stimulate the exploration

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:59
• Quantification of the charge consuming phenomena under high voltage hold of carbon/carbon supercapacitors by coupling operando and post‐mortem analyses

  Enhancing the operating voltage of supercapacitors (SCs), hence their specific energy, is an important research objective. However, long‐term hold at high voltage entails loss of capacitance, increase of resistance and internal pressure. Such detrimental effects could be reduced by obtaining quantitative information on the relative impact of the various mechanisms leading to the worsening of the SCs performance. Here, on the example of a carbon/c

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:58
• Asymmetric hybrid polyoxometalates: a new platform for multifunctional redox‐active nanomaterials

  Access to asymmetrically functionalised polyoxometalates is a grand challenge as it could lead to new molecular nanomaterials with multiple or modular functionality. Here, a simple “one‐pot” synthetic approach to the isolation of an asymmetrically functionalised organic‐inorganic hybrid Wells‐Dawson polyoxometalate in good yield is presented. The cluster bears two organophosphonate moieties with contrasting physical properties: a chelating metal‐

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:58
• Surface Capping Agents and Their Roles in Shape‐Controlled Synthesis of Colloidal Metal Nanocrystals

  Controlling the shapes and related properties of colloidal metal nanocrystals are key to the realization of their vast applications. Surface capping agents, including neutral molecules, ionic species, macromolecules, and biomolecules, have been extensively used to control the evolution of seeds into nanocrystals with diverse but well‐controlled shapes. Here we offer a comprehensive review of these agents, with a focus on the mechanistic understan

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:57
• Selective Late‐Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry‐BF4

  Here we report a simple and practical functionalization of primary sulfonamides by means of a pyrylium salt (Pyry‐BF 4 ) with nucleophiles. This simple reagent is capable of activating the poorly nucleophilic NH 2 group in a sulfonamide thus enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Due to the great variety of primary sulfonamides in pharmaceutical contexts, special attention has been p

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:56
• Rb4Li2TiOGe4O12: A Titanyl Nonlinear Optical Material with Widest Transparency Range

  Practical mid‐infrared (MIR) coherent light beams generated by frequency conversion in nonlinear optical (NLO) crystals are indispensable in time‐resolved infrared vibrational spectroscopy, remote light detection and ranging, and free space communications. Herein, a new titanyl germanate Rb4Li2TiOGe4O12 (RLTG) MIR NLO crystal was obtained by heavier element substitution. It features a complicated structure network composed of the compressed TiO5

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:56
• Thiophenylazobenzene – an alternative photoisomerization controlled by lone pair∙∙∙π interaction

  Azoheteroarene photoswitches have attracted attention due to their unique properties. We present here the stationary photochromism and the ultrafast photoisomerization mechanism of thiophenylazobenzene (TphAB) – an alternative sulfur‐based azoheteroarene design. TphAB demonstrates impressive fatigue resistance and photoisomerization efficiency, and shows favorably separated (E)‐ and (Z)‐isomer absorption bands, allowing for highly selective photo

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:56
• Novel Umpolung Strategy for α‐Functionalization of Aldehydes for the Addition of Thiols and other Nucleophiles

  Nucleophile‐nucleophile coupling is a challenging transformation in organic chemistry. Herein we present a novel umpolung strategy for α‐functionalization of aldehydes with nucleophiles. The strategy uses organocatalytic enamine activation and quinone‐promoted oxidation to access O ‐bound quinol‐intermediates that undergo nucleophilic substitution reactions. These quinol‐intermediates react with different classes of nucleophiles. The focus is o

  Angewandte Chemie International Edition

  Wed Oct 09, 2019 01:54
• Dual‐Ligand Porous Coordination Polymer Chemiresistor with Modulated Conductivity and Porosity

  Single‐ligand‐based electronically conductive porous coordination polymers / metal organic frameworks (EC‐PCPs/MOFs) fail to meet the requirements in numerous electronic applications due to their limited turnabilities in terms of both conductivity and topology. In this work, a new 2D π‐conjugated EC‐MOFs containing mixed trigonal‐liganded copper units was developed: Cu3(HHTP)(THQ) (HHTP = 2,3,6,7,10,11‐hexahydrotriphenylene, THQ = tetrahydroxy‐1,

  Angewandte Chemie International Edition

  Tue Oct 08, 2019 11:14
• A Logical DNA‐controlled Receptor Assembly for Programmable Modulation of Cellular Signal Transduction

  Programming cells to sense multiple‐inputs and activate cellular signal transduction cascades is of great interest. Albeit it has been achieved via engineering of genetic circuits using synthetic biology tools, a nongenetic and generic approach remains highly demanded. Herein, we propose the design of aptamer‐controlled logic receptor assembly for modulating cellular signal transduction. In this design, aptamers were engineered like “robotic arm”

  Angewandte Chemie International Edition

  Tue Oct 08, 2019 10:45
• Copper‐Catalyzed Enantioselective Allylboration of Alkynes: Synthesis of Highly Versatile Multifunctional Building Blocks

  The first copper‐catalyzed enantioselective allylboration of alkynes is reported. The method employs a multitasking chiral NHC‐Cu catalyst and provides access to densely functionalized molecules from simple starting materials with excellent levels of chemo‐, regio‐ and enantioselectivity. These multifunctional products display a highly versatile reactivity as shown by the synthesis of a variety of non‐racemic molecular scaffolds. DFT calculations

  Angewandte Chemie International Edition

  Tue Oct 08, 2019 10:43
• Recent Advance in Interfacial Assembly Growth of Mesoporous Silica on Magnetite Particles

  Interfacing magnetic particles with ordered mesoporous materials is an effective direction for the development of functional porous composite materials with rationally designed core‐shell structure. Due to the combined properties of magnetic nanoparticles and mesoporous silica (high surface area, large pore volume, porosity, and biocompatibility), core‐shell magnetic mesoporous silica materials have emerged as a research hotspot and attracted tre

  Angewandte Chemie International Edition

  Tue Oct 08, 2019 09:39
• Flexible Amalgam Film Enables Stable Lithium Metal Anodes with High Capacities

  Dendrite formation is considered a critical challenge for the applications of lithium (Li) metal anodes. In this work, we demonstrate a new strategy to address this issue by fabricating an Li amalgam film on its surface. This protective film serves as a flexible buffer that affords repeated Li plating/stripping. In symmetric cells, these protected Li electrodes exhibit stable cycling over 750 hrs at high plating current and capacity of 8 mA cm ‐

  Angewandte Chemie International Edition

  Tue Oct 08, 2019 09:13
• Li‐N2 Batteries: A Reversible Energy Storage System?

  Tremendous energy consumption is required for traditional artificial N 2 fixation, leading to additional environmental pollution. Recently, new Li‐N 2 batteries have inextricably integrated the energy storage system with N 2 fixation. In this work, we introduced graphene into Li‐N 2 batteries and enhanced the cyclic stability. However, the instability and hygroscopicity of the discharge product Li 3 N lead to a rechargeable but irrevers

  Angewandte Chemie International Edition

  Tue Oct 08, 2019 08:12
• Convergent Total Syntheses of (–)‐Rubriflordilactone B and (–)‐pseudo‐Rubriflordilactone B

  A highly convergent strategy for the synthesis of the natural product (–)‐rubriflordilactone B, and the proposed structure of (–)‐pseudo‐rubriflordilactone B, is described. Late stage coupling of diynes containing the respective natural product FG rings with a common AB ring aldehyde precedes rhodium‐catalyzed [2+2+2] alkyne cyclotrimerization to form the natural product skeleton, with the syntheses completed in just one further operation. This w

  Angewandte Chemie International Edition

  Tue Oct 08, 2019 06:48
• Reversible Transformation between Amorphous and Crystalline States of Unsaturated Polyesters by Cis‐Trans Isomerization

  The development of smart materials that reversibly transform between amorphous and crystalline state in response to the external stimuli is a challenging issue. Herein, we report such an aliphatic polyester from ethylene oxide and maleic anhydride, which exhibits reversible transformation between amorphous (a T g of 18 °C) and crystalline (a T m of 124 °C) states controlled by cis‐trans isomerization of C=C bonds in the polymer backbone w

  Angewandte Chemie International Edition

  Tue Oct 08, 2019 06:44
• Anthropology-News
• What Did the Moon Landing Do for Archaeology?

  By now, with all of the retrospectives, books, and stories that have appeared attendant upon the 50th anniversary of Apollo 11’s landing on the moon, you’d think we’d know better. NASA (National Aeronautics and Space Administration, created in 1958) did not invent Tang and Velcro for the Apollo missions. It is true that the moon landing has created many products that have found places in our scholarly and personal lives today. I’ve used a space b

  Anthropology-News

  Wed Oct 09, 2019 06:00