Purpose: The aim of the present paper is to verify the long-term results in dental and skeletal stability in terms of symmetry, occlusion and functional balance by the association between the IS and the SF technique. Methods: In this paper, the authors described 12 cases of severe class III malocclusion treated by the association between the IS and the SF technique. Results: At 1 year of post-orthodontic follow up, the patients present an Angle class I occlusal relationship,...
Tue Jul 14, 2020 03:00
In addition to precautions taken with perioperative surgical techniques, nasal packing and external nasal splinting are frequently employed to ensure the stability of the nasal bones following osteotomies performed during rhinoplasty. However, despite these precautions, nasal bone fragments, generally caused by trauma or healing problems, can approach the midline, progress in a posterior direction and heal with malunion in an infractured manner. Since cavities on the infractured side can result in...
Tue Jul 14, 2020 03:00
Engineering creativity: Prior experience modulates electrophysiological responses to novel metaphors
Abstract Novel metaphorical language use exemplifies human creativity through production and comprehension of meaningful linguistic expressions that may have never been heard before. Available electrophysiological research demonstrates, however, that novel metaphor comprehension is cognitively costly, as it requires integrating information from distantly related concepts. Herein, we investigate if such cognitive cost may be reduced as a factor of prior domain knowledge. To this end, we asked engineering...
Thu Jul 16, 2020 18:49
Abstract Purpose To define based on expert opinion and practical experience using a systematic and scientific approach, (1) the perceived most effective exercise-based strategies to prevent muscle injury in elite footballers; and, (2) when and how these exercise programs are prescribed based on the number of days between games i.e. implementation strategy. Methods ...
Thu Jul 16, 2020 03:00
Publication date: October 2020Source: International Immunopharmacology, Volume 87Author(s): Guanghui Qian, Liyan Zhu, Chengcheng Huang, Ying Liu, Ying Ren, Yueyue Ding, Weiguo Qian, Qiuqin Xu, Hui Zheng, Haitao Lv
Thu Jul 16, 2020 18:44
Publication date: October 2020Source: International Immunopharmacology, Volume 87Author(s): Jun Xu, Liang Ma, Ping Fu
Thu Jul 16, 2020 18:44
Publication date: October 2020Source: International Immunopharmacology, Volume 87Author(s): Roghayeh Jafarpour, Salar Pashangzadeh, Saber Mehdizadeh, Hashem Bayatipoor, Zeinab Shojaei, Morteza Motallebnezhad
Thu Jul 16, 2020 18:44
Publication date: October 2020Source: International Immunopharmacology, Volume 87Author(s): Ying Chen, Chen-yang Wang, Liang Zhao, Yu-pu Hong, Xiao-yi Zhang, Fang-chao Mei, Yu Zhou, Wen-yi Guo, Qiao Shi, Kai-liang Zhao, Chen Chen, Jia Yu, Wei-xing Wang
Thu Jul 16, 2020 18:44
Publication date: Available online 15 July 2020Source: Pathology - Research and PracticeAuthor(s): Jin-lin Peng, Ji-zhou Wu, Guo-jian Li, Jian-lin Wu, Yu-mei Xi, Xiao-qing Li, Lei Wang
Thu Jul 16, 2020 18:40
Publication date: September 2020Source: Brain and Language, Volume 208Author(s): Lisa Tecoulesco, Erika Skoe, Letitia R. Naigles
Thu Jul 16, 2020 18:39
Publication date: Available online 16 July 2020Source: Journal of ProteomicsAuthor(s): Xiaoli Zhang, Baowen Zhang, Abolfazl Masoudi, Xiaoshuang Wang, Xiaomin Xue, Mengxue Li, Qi Xiao, Minjing Wang, Jingze Liu, Hui Wang
Thu Jul 16, 2020 18:25
Publication date: Available online 16 July 2020Source: Journal of ProteomicsAuthor(s): Yuan Gao, Yujun Liu, Fenglian Ma, Mengying Sun, Guangqing Mu, Yanfeng Tuo
Thu Jul 16, 2020 18:25
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Fakhry M. Dawoud, Ryan M. Naylor, Caterina Giannini, Amy A. Swanson, Fredric B. Meyer, Joon H. Uhm
Thu Jul 16, 2020 18:16
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Yan-fang Zhang, Nian Yu, Xing-jian Lin, Lingling Wang, Jingping Shi, Qiao-quan Zhang, Qing Di
Thu Jul 16, 2020 18:16
Publication date: September 2020Source: Clinical Neurology and Neurosurgery, Volume 196Author(s): Nida Fatima, Ashfaq Shuaib, Maher Saqqur
Thu Jul 16, 2020 18:16
Publication date: Available online 16 July 2020Source: Human PathologyAuthor(s): Sergei M. Hermelijn, Janina L. Wolf, T. Dorine den Toom, René M.H. Wijnen, Robbert J. Rottier, J. Marco Schnater, Jan H. von der Thüsen
Thu Jul 16, 2020 18:04
Publication date: Available online 15 July 2020Source: Human PathologyAuthor(s): Bryce Shawn Hatfield, Caleb Robert King, Aaron M. Udager, Sean R. Williamson, Jatin S. Gandhi, Mahul B. Amin, Laura Spruill, Kathryn Grace Lindsey, Raghavendra Pillappa, John Tyler Roseman, Mark Cameron Mochel, Steven Christopher Smith
Thu Jul 16, 2020 18:04
Publication date: Available online 15 July 2020Source: Human PathologyAuthor(s): Sounak Gupta, Chad M. Vanderbilt, Bradley C. Leibovich, Loren Herrera-Hernandez, Aditya Raghunathan, William R. Sukov, Jesse S. Voss, Emily G. Barr Fritcher, Katelyn A. Reed, Christine M. Lohse, Victor E. Reuter, Rafael E. Jimenez, R. Houston Thompson, John C. Cheville
Thu Jul 16, 2020 18:04
Publication date: Available online 16 July 2020Source: American Journal of Infection ControlAuthor(s): Jennifer Bayersdorfer, Sue Giboney, Rosemary Martin, Andria Moore, Rebecca Bartles
Thu Jul 16, 2020 18:01
Publication date: Available online 16 July 2020Source: American Journal of Infection ControlAuthor(s): Benjamin R. Hanisch, William Cohen, David Jacobsohn, Xiaoyan Song
Thu Jul 16, 2020 18:01
Publication date: Available online 15 July 2020Source: American Journal of Infection ControlAuthor(s): Daniel T Lammers, Ian F Jones, Christopher W Marenco, Kaitlin R Morte, John M McClellan, Matthew J Eckert, Jason R Bingham
Thu Jul 16, 2020 18:01
Publication date: Available online 15 July 2020Source: American Journal of Infection ControlAuthor(s): Patti E. Landerfelt, Apryl Lewis, Yin Li, Jeannie P. Cimiotti
Thu Jul 16, 2020 18:01
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Morteza Sadeh, Nauman S. Chaudhry, Ashley Selner, Mandana Behbahani, Tibor Valyi-Nagy, Gursant Atwal
Thu Jul 16, 2020 17:52
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Atsushi Nakayashiki, Tomohiro Kawaguchi, Kuniyasu Niizuma, Mika Watanabe, Miki Fujimura, Teiji Tominaga
Thu Jul 16, 2020 17:52
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Brian Fiani, Frank De Stefano, Athanasios Kondilis, Claudia Covarrubias, Louis Reier, Kasra Sarhadi
Thu Jul 16, 2020 17:52
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Kikutaro Tokairin, Ken Kazumata, Shuho Gotoh, Taku Sugiyama, Hiroyuki Kobayashi
Thu Jul 16, 2020 17:52
The decoy exon model has been proposed to regulate a subset of intron retention (IR) events involving predominantly larger introns (>1 kb). Splicing reporter studies have shown that decoy splice sites are essential for activity, suggesting that decoys act by engaging intron-terminal splice sites and competing with cross-intron interactions required for intron excision. The decoy model predicts that antisense oligonucleotides may be able to block decoy splice sites in endogenous pre-mRNA, thereby...
Thu Jul 16, 2020 16:30
In vitro selection combined with high-throughput sequencing is a powerful experimental approach with broad application in the engineering and characterization of RNA molecules. Diverse pools of starting sequences used for selection are often flanked by fixed sequences used as primer binding sites. These low diversity regions often lead to data loss from complications with Illumina image processing algorithms. A common method to alleviate this problem is the addition of fragmented bacteriophage PhiX...
Thu Jul 16, 2020 16:30
Nop9 is an essential factor in the processing of preribosomal RNA. Its absence in yeast is lethal, and defects in the human ortholog are associated with breast cancer, autoimmunity, and learning/language impairment. PUF family RNA-binding proteins are best known for sequence-specific RNA recognition, and most contain eight α-helical repeats that bind to the RNA bases of single-stranded RNA. Nop9 is an unusual member of this family in that it contains eleven repeats and recognizes both RNA structure...
Thu Jul 16, 2020 16:30
A major challenge for RNA-seq analysis of gene expression is to achieve sufficient coverage of informative nonribosomal transcripts. In eukaryotic samples, this is typically achieved by selective oligo(dT)-priming of messenger RNAs to exclude ribosomal RNA (rRNA) during cDNA synthesis. However, this strategy is not compatible with prokaryotes in which functional transcripts are generally not polyadenylated. To overcome this, we adopted DASH (depletion of abundant sequences by hybridization), initially...
Thu Jul 16, 2020 16:30
Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. However, most transcriptomic studies do not distinguish the relative contribution of transcription, RNA processing, and RNA degradation processes to cellular homeostasis. Here we used metabolic labeling followed by massive parallel sequencing of newly transcribed and preexisting RNA fractions to simultaneously analyze RNA synthesis and decay in primary endothelial...
Thu Jul 16, 2020 16:30
Recent findings in genome-wide transcriptomics revealed that RNAs are involved in almost every biological process, across all domains of life. The characterization of native RNAs of unknown function and structure is particularly challenging due to their typical low abundance in the cell and the inherent sensitivity toward ubiquitous RNA degrading enzymes. Therefore, robust in vitro synthesis and extensive work-up methods are often needed to obtain samples amenable for biochemical, biophysical, and...
Thu Jul 16, 2020 16:30
Many cellular noncoding RNAs contain chemically modified nucleotides that are essential for their function. The Epstein–Barr virus expresses two highly abundant noncoding RNAs called EBV-encoded RNA 1 (EBER1) and EBER2. To examine whether these viral RNAs contain modified nucleotides, we purified native EBERs from EBV-infected cells and performed mass spectrometry analysis. While EBER2 contains no modified nucleotides at stoichiometric amounts, EBER1 was found to carry 5-methylcytosine (m5C) modification....
Thu Jul 16, 2020 16:30
As the COVID-19 outbreak spreads, there is a growing need for a compilation of conserved RNA genome regions in the SARS-CoV-2 virus along with their structural propensities to guide development of antivirals and diagnostics. Here we present a first look at RNA sequence conservation and structural propensities in the SARS-CoV-2 genome. Using sequence alignments spanning a range of betacoronaviruses, we rank genomic regions by RNA sequence conservation, identifying 79 regions of length at least 15...
Thu Jul 16, 2020 16:30
Alternative polyadenylation (APA) determines stability, localization and translation potential of the majority of mRNA in eukaryotic cells. The heterodimeric mammalian cleavage factor II (CF IIm) is required for pre-mRNA 3' end cleavage and is composed of the RNA kinase hClp1 and the termination factor hPcf11; the latter protein binds to RNA and the RNA polymerase II carboxy-terminal domain. Here, we used siRNA mediated knockdown and poly(A) targeted RNA sequencing to analyze the role of CF IIm in...
Thu Jul 16, 2020 16:30
Dozens of candidate orphan riboswitch classes have been discovered previously by using comparative sequence analysis algorithms to search bacterial genomic sequence databases. Each orphan is classified by the presence of distinct conserved nucleotide sequences and secondary structure features, and by its association with particular types of genes. One previously reported orphan riboswitch candidate is the "NMT1 motif," which forms a hairpin structure with an internal bulge that includes numerous...
Thu Jul 16, 2020 16:30
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA 3D structure prediction. With agreement from crystallographers, the RNA structures are predicted by various groups before the publication of the crystal structures. We now report the prediction of 3D structures for six RNA sequences: four nucleolytic ribozymes and two riboswitches. Systematic protocols for comparing models and crystal structures are described and analyzed. In these six puzzles, we discuss (i)...
Thu Jul 16, 2020 16:30
The aminoacyl-tRNA synthetases are an essential and universally distributed family of enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate amino acids for decoding mRNAs according to the genetic code. Synthetases help to ensure accurate translation of the genetic code by using both highly accurate cognate substrate recognition and stringent proofreading of noncognate products. While alterations in the quality control mechanisms of synthetases are generally detrimental...
Thu Jul 16, 2020 16:30
In recent years, RNA-sequencing (RNA-seq) has emerged as a powerful technology for transcriptome profiling. For a given gene, the number of mapped reads is not only dependent on its expression level and gene length, but also the sequencing depth. To normalize these dependencies, RPKM (reads per kilobase of transcript per million reads mapped) and TPM (transcripts per million) are used to measure gene or transcript expression levels. A common misconception is that RPKM and TPM values are already normalized,...
Thu Jul 16, 2020 16:30
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