Abstract Airway remodeling in asthma is characterized by the presence of increased airway smooth muscle (ASM), increased mucus producing cells (submucosal mucous glands and epithelial goblet cells), and subepithelial fibrosis (deposition of collagen and extracellular matrix proteins) which all contribute to increased airway wall thickness
Thu Jul 16, 2020 11:55
Abstract Although in Canada, hearing screening and early intervention are presented as a health need, we question whether young deaf and hard of hearing children’s access to language is adequately supported by public health and children’s services. The Ontario Infant Hearing Program has the stated mandate of supporting the language development of deaf and hard of hearing infants and young children. However, this program presents parents with early intervention service options...
Thu Jul 16, 2020 03:00
Publication date: Available online 16 July 2020Source: Clinical NeurophysiologyAuthor(s): Jongsuk Choi, Sejin Yang, Jun-Soon Kim, Jung Ho Han, Kyung Seok Park
Thu Jul 16, 2020 12:54
Publication date: Available online 15 July 2020Source: Clinical NeurophysiologyAuthor(s): G. Granata, G. Valle, R. Di Iorio, F. Iodice, F.M. Petrini, I. Strauss, E. D'anna, F. Iberite, L. Lauretti, E. Fernandez, R. Romanello, T. Stieglitz, S. Raspopovic, P. Calabresi, S. Micera, P.M. Rossini
Thu Jul 16, 2020 12:54
Publication date: Available online 15 July 2020Source: Clinical NeurophysiologyAuthor(s): K. Pacheco-Barrios, CB. Pinto, FG. Saleh Velez, D. Duarte, ME. Gunduz, M. Simis, AC. Lepesteur Gianlorenco, J. Leao Barouh, D. Crandell, M. Guidetti, L. Battistella, F. Fregni
Thu Jul 16, 2020 12:54
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020.
Thu Jul 16, 2020 12:39
Publication date: Available online 15 July 2020Source: Journal of VoiceAuthor(s): Soren Y. Lowell, Raymond H. Colton, Richard T. Kelley, Madeline Auld, Hanna Schmitz
Thu Jul 16, 2020 12:34
Allergen immunotherapy (AIT) vaccines are typically prepared in allergy practices following aseptic technique. Even though there's no evidence of contamination or infection, the US Pharmacopoeia (USP) recently proposed compounding guidelines requiring a change from aseptic to sterile technique. This study used social media data mining techniques to evaluate possible rare skin and soft tissue infections (SSTIs) associated with AIT. The analysis included US data from a range of social media platforms,...
Thu Jul 16, 2020 03:00
Little is known about the longitudinal course of adult atopic dermatitis (AD) lesional severity and extent in clinical practice.
Wed Jul 15, 2020 03:00
Pyridine‐substituted alkylidenecyclopropanes (Py‐ACPs) react with gold(III) salts under mild reaction conditions via an unprecedented, proximal ring‐opening pathway, to generate highly appealing, catalytically active pyridine alkenyl [C^N]‐gold(III) species. Mechanistic studies reveal that the activation of the C‐C bond in the cyclopropyl ring takes place through an unusual concerted, σ‐bond metathesis type‐process.
Thu Jul 16, 2020 11:28
Controlling the interaction of polarization light with an asymmetric nanostructure such as a metal/semiconductor heterostructure provides opportunities for tuning the surface plasmon excitation and near‐field spatial distribution. However, the effects of light polarization on interfacial charge transport and consequently the photocatalysis of plasmonic metal/semiconductor photocatalysts, remain unclear. Herein, we reveal the polarization dependence of plasmonic charge separation and spatial distribution...
Thu Jul 16, 2020 11:24
The unique and abundance of bacterial effectors have inspired us to explore their potential in rewiring malignant cell signaling. Their incapability for entering cells, however, hinders such application. Herein we developed a cationic lipid‐based high throughput library screening platform for effective intracellular delivery of bacterial effectors. As the misregulated MAPK signaling is a hallmark of many types of cancer, we turned our attention to the Shigella effector OspF which irreversibly inactivates...
Thu Jul 16, 2020 11:01
Coinage metals (Cu, Ag, Au)‐based catalysts have been widely used in organic synthesis chemistry, however, robust and heterogeneous silver‐based catalysts are hard to access due to its high photosensitivity and chemical instability. Herein, the unprecedented double S 2 − templated Ag 27 clusters have been stabilized by 5,10,15,20‐tetra(4‐pyridyl)porphyrin (TPyP‐H 2 ) ligands to afford a robust 2D metal‐organic framework ( Ag27‐MOF ). This silver cluster‐assembled material serves as a highly...
Thu Jul 16, 2020 11:00
Immunotherapy that harnesses the power of immune systems to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune‐related adverse events exist as two major issues for cancer immunotherapy. In parallel, a variety of electromagnetic nanomaterials that generate heat/reactive oxygen species triggered by electromagnetic energies have been applied for magnetic hyperthermia therapy, sonodynamic therapy, photothermal...
Wed Jul 15, 2020 18:30
We herein report a convenient method to specifically acylate phenolic hydroxyl groups through a radical pathway. When a mixture of an aldehyde and a phenol in ethyl acetate is irradiated with blue light in the presence of iridium and nickel bromide catalysts at ambient temperature, phenoxyl and acyl radicals are transiently generated in situ, and cross‐couple to furnish an ester. Aliphatic hydroxy groups remain untouched under the present reaction conditions.
Wed Jul 15, 2020 17:02
Fabrication of bio‐templated metallic structures is limited by differences in properties, processing condition, packing, and material state. Herein, we demonstrate that using undercooled metal particles, differences in modulus and processing temperatures can be overcome. Similarly, adoption of autonomous processes like self‐filtration, capillary pressure and evaporative concentration leads to enhanced packing, stabilization (jamming) and point sintering with phase change to create solid metal replicas...
Wed Jul 15, 2020 17:02
Photorelease of bioactive molecules has emerged as a valuable tool in biochemistry. Nevertheless, many important bioactive molecules, such as pyridine derivatives，cannot benefit from currently available organic photoremovable protecting groups (PPGs). We found that inefficient photorelease of pyridines is attributed to intramolecular photoinduced electron transfer (PET) from PPGs to pyridiniums. To alleviate PET, we rationally designed a strategy to drive excited state of PPG from S 1 to T 1 ...
Wed Jul 15, 2020 17:00
We present a very rare case of pure erythroid leukemia arising in a young patient with sickle cell disease being treated with hydroxyurea for almost 5 years. Diagnosing and managing this rare condition has been a challenge and the majority of patients with pure erythroid leukemia have a very poor prognosis with survival in months despite treatment. This form of leukemia could be therapy related and in our case, hydroxyurea may have been responsible for the development of this aggressive condition....
Thu Jul 16, 2020 10:47
Castleman disease is a rare cause of retroperitoneal mass in children. Clinical presentation and laboratory findings are usually nonspecific. Imaging shows features of a hypervascular or soft tissue mass. We present a 12-year-old boy who complained of frequent colds, fatigue, and failure to gain weight for the past 4 years who was referred to our hospital. Anemia and hypergammaglobulinemia were revealed in laboratory tests. Imaging showed a well-delineated retroperitoneal soft tissue mass with intense...
Thu Jul 16, 2020 10:44
Muscles of the feeding system are more orthogonally oriented and operate at relatively large moment arms and mechanical advantages. In contrast, the muscles of the locomotor system have almost parallel orientations and smaller mechanical advantages and muscle moment arms. These differences suggest that the feeding system is optimized for the application of high forces, while the locomotor system is optimized for large and rapid joint excursions for minimal energetic expenditure. Abstract Tetrapod...
Thu Jul 16, 2020 11:20
Cancer Informatics, Volume 19, Issue , January-December 2020. Genetic variations such as single nucleotide polymorphisms (SNPs) can cause susceptibility to cancer. Although thousands of genetic variants have been identified to be associated with different cancers, the molecular mechanisms of cancer remain unknown. There is not a particular dataset of relationships between cancer and SNPs, as a bipartite network, for computational analysis and prediction. Link prediction as a computational graph analysis...
Wed Jul 15, 2020 12:55
The Journal of Antibiotics, Published online: 16 July 2020; doi:10.1038/s41429-020-0345-yIn vitro activity of radezolid against Enterococcus faecium and compared with linezolid
Thu Jul 16, 2020 03:00
The Journal of Antibiotics, Published online: 16 July 2020; doi:10.1038/s41429-020-0349-7A lux-based Staphylococcus aureus bioluminescence screening assay for the detection/identification of antibiotics and prediction of antibiotic mechanisms
Thu Jul 16, 2020 03:00
Thu Jul 16, 2020 03:00
Thu Jul 16, 2020 03:00
Purpose: To report the surgical technique and outcomes for adjustable ptosis correction using a posterior levator advancement with minimal superior tarsectomy. Methods: A retrospective single-center study was conducted on patients who underwent adjustable ptosis repair via posterior levator advancement with minimal superior tarsectomy by a single surgeon from 2002 to 2018. Patients with greater than 1 mm asymmetry between eyes or contour abnormalities underwent nonsurgical adjustment...
Wed Jun 17, 2020 03:00
Purpose: To report female representation within the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) at all levels of career achievement over 50 years. Methods: Data were extrapolated from published ASOPRS directories and the 50th anniversary booklet. Fellowship, membership, leadership, and awards data were evaluated over 5 decades. Comparisons were made between the first and second 25 years, proportions of early and late career achievements, and time to career...
Wed Jun 17, 2020 03:00
The association between Henoch-Schönlein purpura (HSP) and neoplasia is rare and has been more commonly reported in cases of solid tumors rather than hemotological malignancies. To the authors’ knowledge, HSP in association with orbital lymphoma has not been previously reported. An 84-year-old man underwent anterior orbitotomy with biopsy for a rapidly growing orbital mass. Immediately following this procedure, he developed petechial rash, flash pulmonary edema, and kidney dysfunction with hematuria...
Wed Jun 17, 2020 03:00
IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition characterized by lymphoplasmacytic infiltrates rich in IgG4-positive plasma cells, often with elevated serum IgG4. Multiple organs may be affected. Coronary arteritis may be one form of fatal involvement in IgG4-RD. IgG4-RD can manifest as periocular lesions, called IgG4-related ophthalmic disease (IgG4-ROD). Here, the authors describe a patient with asymptomatic coronary arteritis detected after the diagnosis of IgG4-ROD. A 58-year-old...
Wed Jun 17, 2020 03:00
Purpose: A previously published predictive model based on threshold parameters for erythrocyte sedimentation rate, c-reactive protein, and platelet count demonstrated that 40% of patients who underwent biopsy may not have required it. The current study was performed to evaluate the model’s performance on an independent data set. Methods: This is a retrospective consecutive series of patients undergoing temporal artery biopsy (TAB) in a single health region in Canada. The model was applied...
Wed Jun 17, 2020 03:00
No abstract available
Wed Jun 17, 2020 03:00
Intramuscular choristomatous cystic lesions within the orbit are rare but may require removal due to their volume effects. The authors describe 2 such cases of intramuscular cysts in adult patients. Both patients presented with symptoms due to local mass effects with swelling, proptosis and diplopia. Imaging confirmed cystic intramuscular masses. Surgical removal involved intraoperative decompression of the cyst to aid dissection with excision of some muscle fibers. Histology confirmed a keratinized...
Wed Jun 17, 2020 03:00
Wed Jul 15, 2020 16:29
Molecules, Vol. 25, Pages 3255: In Vitro Evaluation of Antimicrobial Peptide Tridecaptin M in Combination with Other Antibiotics against Multidrug Resistant Acinetobacter baumannii Molecules doi: 10.3390/molecules25143255 Authors: Manoj Jangra Vrushali Raka Hemraj Nandanwar The rapid emergence of antimicrobial resistance in Acinetobacter baumannii coupled with the dried pipeline of novel treatments has driven the search for new therapeutic modalities. Gram-negative bacteria have...
03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου