Related Articles Collagen Matrix With Mucoperiosteum Graft as an Effective Fatless Flapless Reconstruction After Endoscopic Pituitary Adenoma Resection. Oper Neurosurg (Hagerstown). 2020 Jul 25;: Authors: Shahein M, Montaser AS, Barbero JMR, Maza G, Todeschini AB, Otto BA, Carrau RL, Prevedello DM Abstract BACKGROUND: Proper skull base reconstruction after endoscopic endonasal pituitary surgery is of great importance to decrease the rate of...
Tue Jul 28, 2020 14:53
Related Articles Multifocal Gorham-Stout disease associated with Chiari I malformation and recurrent aseptic meningitis: Case report and review of literature. J Clin Neurosci. 2020 Feb;72:486-492 Authors: Stephens S, Squires L, Campbell R, Davies J, Chaseling R Abstract Gorham-Stout disease is a rare condition of uncertain aetiology characterised by lymphatic proliferation within osseous structures and subsequent massive osteolysis. This report...
Tue Jul 28, 2020 14:53
Related Articles Determination of cerebrospinal fluid leakage by selective deletion of transferrin glycoform using an immunochromatographic assay. Theranostics. 2019;9(14):4182-4191 Authors: Oh J, Kwon SJ, Dordick JS, Sonstein WJ, Linhardt RJ, Kim MG Abstract Cerebrospinal fluid (CSF) leakage can lead to brain and spine pathologies and there is an urgent need for a rapid diagnostic method for determining CSF leakage. Beta-2 transferrin (β2TF),...
Tue Jul 28, 2020 14:53
Related Articles A snapshot survey of antimicrobial susceptibility among respiratory Staphylococcus aureus isolates: focus on ceftaroline. J Chemother. 2020 Jul 27;:1-3 Authors: Oliveira DS, Carniel E, Perez LRR PMID: 32715970 [PubMed - as supplied by publisher]
Tue Jul 28, 2020 16:10
Related Articles Optimal vancomycin dose in the treatment of Clostridium difficile infection, antimicrobial stewardship initiative. J Chemother. 2020 Jul 27;:1-9 Authors: Ereshefsky BJ, Alrahmany D, El Nekidy WS, Pontiggia L, Ghazi IM Abstract C. difficile infections (CDI) are increasingly recognized as a leading cause of infectious diarrhea, with increasing morbidity and mortality. Treatment primarily centers around oral vancomycin treatment....
Tue Jul 28, 2020 16:10
Related Articles Optimal Pipette Resistance, Seal Resistance, and Zero-Current Membrane Potential for Loose Patch or Breakthrough Whole-Cell Recording in vivo. Front Neural Circuits. 2020;14:34 Authors: Yan L, Fang Q, Zhang X, Huang B Abstract In vivo loose patch and breakthrough whole-cell recordings are useful tools for investigating the intrinsic and synaptic properties of neurons. However, the correlation among pipette resistance, seal condition,...
Tue Jul 28, 2020 13:13
Anaplastic Astrocytoma: State of the art and future directions. Crit Rev Oncol Hematol. 2020 Jul 17;153:103062 Authors: Caccese M, Padovan M, D'Avella D, Chioffi F, Gardiman MP, Berti F, Busato F, Bellu L, Bergo E, Zoccarato M, Fassan M, Zagonel V, Lombardi G Abstract Anaplastic Astrocytoma(AA) is a malignant, diffusely infiltrating, primary brain tumor. According to the WHO 2016 classification of central-nervous-system tumors, AA has been...
Tue Jul 28, 2020 13:50
Utilization and cost implications of hematopoietic progenitor cells stored for a future salvage autologous transplantation or stem cell boost in myeloma patients. Biol Blood Marrow Transplant. 2020 Jul 24;: Authors: Chhabra S, Thapa B, Szabo A, Konings S, D'Souza A, Dhakal B, Jerkins JH, Pasquini MC, Johnson BD, Hari PN, Hamadani M Abstract Autologous hematopoietic cell transplantation (autoHCT) is a standard initial treatment for myeloma....
Tue Jul 28, 2020 13:50
Toxicity in combination immune checkpoint inhibitor and radiation therapy: a systematic review and meta-analysis. Radiother Oncol. 2020 Jul 24;: Authors: Sha CM, Lehrer EJ, Hwang C, Trifiletti DM, Mackley HB, Drabick JJ, Zaorsky NG Abstract BACKGROUND AND PURPOSE: Immune checkpoint inhibitor with radiation therapy (ICI + RT) is under investigation for improved patient outcome, so we performed a systematic review/meta-analysis of toxicities...
Tue Jul 28, 2020 13:50
A Critical Appraisal of the ACS "Medically-Necessary, Time-Sensitive Procedures" (MeNTS) Scoring System, Urology Consensus Recommendations, and Individual Surgeon Case Prioritization for Resumption of Elective Urologic Surgery During the COVID-19 Pandemic. J Urol. 2020 Jul 27;:101097JU0000000000001315 Authors: Cohn JA, Ghiraldi EM, Uzzo RG, Simhan J Abstract PURPOSE: Resumption of elective urology cases postponed due to the Covid-19 pandemic...
Tue Jul 28, 2020 13:50
Related Articles Blood-based RAS mutation testing: concordance with tissue-based RAS testing and mutational changes on progression. Future Oncol. 2020 Jul 27;: Authors: Germetaki T, Nicholls C, Adams RA, Braun M, Rogan J, Moghadam S, Lenfert E, Lukas A, Edelstein DL, Jones FS, Saunders MP Abstract Aim: To determine the concordance between plasma and tissue RAS mutation status in metastatic colorectal cancer patients to gauge whether blood-based...
Tue Jul 28, 2020 13:50
Related Articles Small molecules as antagonists of co-inhibitory pathways for cancer immunotherapy: a patent review (2018-2019). Expert Opin Ther Pat. 2020 Jul 27;: Authors: Geng Q, Rohondia SO, Khan HJ, Jiao P, Dou QP Abstract INTRODUCTION: Therapeutic antibodies blocking co-inhibitory pathways do not attack tumor cells directly, but instead bind to their targeted proteins and mobilize the immune system to eradicate tumors. However, only a...
Tue Jul 28, 2020 13:50
Related Articles Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic. Future Oncol. 2020 Jul 27;: Authors: Elghazawy H, Bakkach J, Zaghloul MS, Abusanad A, Hussein MM, Alorabi M, Eldin NB, Helal T, Zaghloul TM, Venkatesulu BP, Elghazaly H, Al-Sukhun S Abstract Breast cancer is the most common malignancy among women worldwide. The current COVID-19 pandemic represents an unprecedented...
Tue Jul 28, 2020 13:50
Related Articles Targeting the B-cell lymphoma 2 anti-apoptotic proteins for cervical cancer treatment. Future Oncol. 2020 Jul 26;: Authors: Abdul Rahman SF, Xiang Lian BS, Mohana-Kumaran N Abstract The B-cell lymphoma 2 (BCL-2) anti-apoptotic proteins have become attractive therapeutic targets especially with the development of BH3-mimetics which selectively target these proteins. However, it is important to note that expression levels of the...
Tue Jul 28, 2020 13:50
Related Articles Mutational Portrait of Lung Adenocarcinoma in Brazilian Patients: Past, Present, and Future of Molecular Profiling in the Clinic. Front Oncol. 2020;10:1068 Authors: Freitas HC, Torrezan GT, da Cunha IW, Macedo MP, Karen de Sá V, Corassa M, Ferreira ENE, Saito AO, Dal Molin GZ, Cordeiro de Lima VC, Carraro DM Abstract Objectives: Approximately 60% of lung adenocarcinomas (LAs) carry mutations that can guide treatment with tyrosine-kinase...
Tue Jul 28, 2020 13:50
Related Articles Prognostic Role of Tumor Budding in Carcinoma Tongue: A Systemic Review and Meta-Analysis. Cureus. 2020 Jul 21;12(7):e9316 Authors: Karjol U, Jonnada P, Annavarjula V, Cherukuru S, Chandranath A, Anwar A Abstract Introduction Tumor budding is defined as a cluster of cells that invade the stroma. This has recently been studied to be associated with lymph node metastasis (LNM) and poor overall survival (OS) rate. The reliability...
Tue Jul 28, 2020 13:50
Related Articles Correlation between salivary and serum CA15-3 concentrations in patients with breast cancer. Mol Clin Oncol. 2020 Aug;13(2):155-161 Authors: Assad DX, Mascarenhas ECP, Normando AGC, Chardin H, Barra GB, Pratesi R, Nóbrega YKM, Acevedo AC, Guerra ENS Abstract The early detection of breast cancer enables the use of less aggressive treatment and increases patient survival. The transmembrane glycoprotein mucin 1, which is also known...
Tue Jul 28, 2020 13:50
Related Articles Mean Platelet Volume/Lymphocyte Ratio as a Prognostic Indicator for HBV-Related Decompensated Cirrhosis. Gastroenterol Res Pract. 2020;2020:4107219 Authors: Wu J, Mao W, Li X Abstract Aim: To evaluate the prognostic role of the mean platelet volume/lymphocyte ratio (MPVLR) for mortality in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi). Methods: The medical records of 101 patients with HBV-DeCi...
Tue Jul 28, 2020 13:50
Related Articles Intratumoural immunotherapies for unresectable and metastatic melanoma: current status and future perspectives. Br J Cancer. 2020 Jul 27;: Authors: Middleton MR, Hoeller C, Michielin O, Robert C, Caramella C, Öhrling K, Hauschild A Abstract The emergence of human intratumoural immunotherapy (HIT-IT) is a major step forward in the management of unresectable melanoma. The direct injection of treatments into melanoma lesions can...
Tue Jul 28, 2020 13:50
Related Articles Clinical burden of immune checkpoint inhibitor-induced pneumonitis. Respir Investig. 2020 Jul 23;: Authors: Sakamoto K, Fukihara J, Morise M, Hashimoto N Abstract Immune checkpoint inhibitors (ICIs) have been a breakthrough in medical oncology. However, many patients experience a novel type of adverse drug reaction that has a unique clinical presentation, called immune-related adverse events (irAEs). A breakdown of self-tolerance...
Tue Jul 28, 2020 13:50
Related Articles The evaluation of a surgery and the short-term benefits of a new active bone conduction hearing implant - the Osia®. Braz J Otorhinolaryngol. 2020 Jul 04;: Authors: Gawęcki W, Gibasiewicz R, Marszał J, Błaszczyk M, Gawłowska M, Wierzbicka M Abstract INTRODUCTION: Modern medicine offers a wide spectrum of different hearing devices, and bone conduction implants can be found among them. OBJECTIVE: The presentation of the...
Tue Jul 28, 2020 13:50
Related Articles Proposal of a novel subclassification of pN3b for improvement the prognostic discrimination ability of gastric cancer patients. Eur J Surg Oncol. 2020 Jul 04;: Authors: Wang P, Deng J, Sun Z, Wang W, Wang Z, Xu H, Zhou Z, Liang H Abstract INTRODUCTION: In the recent edition of TNM staging system, pN3b gastric cancer were separated into the staging system for better prognosis accuracy. The definition of pN3b contains a large...
Tue Jul 28, 2020 13:50
Related Articles Effect of primary colorectal cancer tumor location on survival after pulmonary metastasectomy. J Thorac Cardiovasc Surg. 2020 Jun 22;: Authors: Corsini EM, Mitchell KG, Correa A, Morris VK, Antonoff MB, MD Anderson Pulmonary Metastasectomy Working Group Abstract OBJECTIVES: Although colorectal cancer bowel segment location has been shown to independently predict the outcomes in early stage disease, it has not been previously...
Tue Jul 28, 2020 13:50
Related Articles Cardio-Oncology in Era of the COVID-19 Pandemic and Beyond. J Am Heart Assoc. 2020 Jul 27;:e05456 Authors: Addison D, Campbell CM, Guha A, Ghosh AK, Dent SF, Jneid H Abstract Coronavirus 2019 (COVID-19) has emerged as a global pandemic and public health crisis. Increasing waves of intermittent infectious outbreaks have dramatically influenced care among broad populations. Over the last two decades, there has been a rapid increase...
Tue Jul 28, 2020 13:50
Related Articles Antibody-drug conjugates to treat gastric cancers. Expert Opin Biol Ther. 2020 Jul 25;: Authors: Koganemaru S, Shitara K Abstract INTRODUCTION: Despite new treatment options, the long-term prognosis of recurrent or inoperable gastric cancer remains poor. Antibody-drug conjugates (ADCs) are a new class of drugs and have shown promising results in clinical trials. AREAS COVERED: This review focuses on recent clinical...
Tue Jul 28, 2020 13:50
Related Articles Future directions in advanced penile cancer - mechanisms of carcinogenesis and a search for targeted therapy. Future Oncol. 2020 Jul 26;: Authors: Teh J, O'Connor E, O'Brien J, Lim WM, Taylor M, Heriot A, Ramsay R, Lawrentschuk N Abstract Penile squamous cell carcinoma (SCC) is a rare and aggressive urological malignancy. Advanced penile SCC requires multimodal management, including surgery and systemic therapy. Given its rarity,...
Tue Jul 28, 2020 13:50
Related Articles Impairment of endoxifen formation in tamoxifen-treated premenopausal breast cancer patients carrying reduced-function CYP2D6 alleles. Br J Clin Pharmacol. 2020 Jul 26;: Authors: Thorén L, Lindh JD, Ackehed G, Kringen MK, Hall P, Bergh J, Molden E, Margolin S, Eliasson E Abstract AIMS: Tamoxifen is bioactivated to endoxifen by polymorphic CYP2D6-dependent metabolism. Here, endoxifen levels were compared to CYP2D6 diplotypes,...
Tue Jul 28, 2020 13:50
Related Articles Sleep disturbance in people with brain tumours and caregivers: a survey of healthcare professionals' views and current practice. Support Care Cancer. 2020 Jul 25;: Authors: Jeon MS, Dhillon HM, Koh ES, Nowak AK, Hovey E, Agar MR Abstract PURPOSE: Sleep disturbance is easily overlooked in subspecialty consultations and may remain untreated during and after initial treatment of malignant brain tumours (BT). This study aimed to...
Tue Jul 28, 2020 13:50
Related Articles Event-free survival at 24 months is a robust surrogate endpoint for long-term survival in pediatric, adolescent, and adult T cell lymphoblastic lymphoma. Ann Hematol. 2020 Jul 25;: Authors: Chen H, Qin Y, Yang J, Liu P, Zhang C, He X, Zhou S, Yang S, Gui L, Zhou L, Sun Y, Shi Y Abstract T cell lymphoblastic lymphoma (T-LBL) has an aggressive clinical behavior. To date, powerful and consistent prognostic factors have not been...
Tue Jul 28, 2020 13:50
Related Articles Modelling human embryogenesis: embryo-like structures spark ethical and policy debate. Hum Reprod Update. 2020 Jul 26;: Authors: Pereira Daoud AM, Popovic M, Dondorp WJ, Trani Bustos M, Bredenoord AL, Chuva de Sousa Lopes SM, van den Brink SC, Roelen BAJ, de Wert GMWR, Heindryckx B Abstract BACKGROUND: Studying the human peri-implantation period remains hindered by the limited accessibility of the in vivo environment and scarcity...
Tue Jul 28, 2020 13:50
Related Articles Synthesis of Sub-30 nm Lanthanide-Doped KLu₂F7 Nanorods with Multicolor Upconversion Luminescence. J Nanosci Nanotechnol. 2020 Dec 01;20(12):7694-7697 Authors: Liu N, Chen X, Ma X Abstract Sub-30 nm lanthanide-doped KLu₂F7 upconversion (UC) nanorods were synthesized using a hightemperature coprecipitation method. Highly uniform morphologies, a small size distribution and the desirable orthorhombic crystalline phase was achieved...
Tue Jul 28, 2020 13:50
Related Articles Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes. Stem Cell Res Ther. 2020 Jul 25;11(1):319 Authors: Chen L, Wang CT, Forsyth NR, Wu P Abstract BACKGROUND: Gestational diabetes (GDM) is a common complication of pregnancy. The impact of pregnancy complications on placental function suggests that extraembryonic stem cells in the placenta may also...
Tue Jul 28, 2020 13:50
Related Articles KRAS: From undruggable to a druggable Cancer Target. Cancer Treat Rev. 2020 Jul 15;89:102070 Authors: Uprety D, Adjei AA Abstract RAS is the most frequently mutated oncogene in human cancers, with mutations in about 30% of all cancers. RAS exists in three different isoforms (K-RAS, H-RAS and N-RAS) with high sequence homology. K-RAS is the most commonly mutated RAS isoform. The Ras protein is a membrane bound protein with inherent...
Tue Jul 28, 2020 13:50
Related Articles Clinical development of therapies targeting TGFβ: current knowledge and future perspectives. Ann Oncol. 2020 Jul 22;: Authors: Ciardiello D, Elez E, Tabernero J, Seoane J Abstract Transforming growth factor beta (TGFβ) is a pleiotropic cytokine that plays a key role in both physiologic and pathologic conditions, including cancer. Importantly, TGFβ can exhibit both tumor suppressive and oncogenic functions. In normal epithelial...
Tue Jul 28, 2020 13:50
Related Articles Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study. Lancet Glob Health. 2020 Aug;8(8):e1027-e1037 Authors: Heer E, Harper A, Escandor N, Sung H, McCormack V, Fidler-Benaoudia MM Abstract BACKGROUND: Breast cancer has distinct causes, prognoses, and outcomes and effects in patients at premenopausal and postmenopausal ages. We sought to assess the global burden and trends in breast...
Tue Jul 28, 2020 13:50
Related Articles Current clinical trials on breast cancer in China: A systematic literature review. Cancer. 2020 Aug 15;126 Suppl 16:3811-3818 Authors: Fan Y, Xu B Abstract With rapid advancement in clinical research, clinical trials on breast cancer in China have made great progress and are increasingly receiving worldwide recognition. Oncologists have been provided with an unprecedented opportunity to conduct clinical trials that offer both...
Tue Jul 28, 2020 13:50
Related Articles Accurate method for evaluating the duration of the entire radiotherapy process. J Appl Clin Med Phys. 2020 Jul 25;: Authors: Guo C, Huang P, Li Y, Dai J Abstract BACKGROUND AND PURPOSE: Along with the increasing demand for high-quality radiotherapy and the growing number of high-precision radiotherapy devices, precise radiotherapy workflow management and accurate time evaluation of the entire radiotherapy process are crucial...
Tue Jul 28, 2020 13:50
Related Articles Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells. Cell Death Dis. 2020 Jul 24;11(7):577 Authors: Zhai B, Li Y, Kotapalli SS, Bacha J, Brown D, Steinø A, Daugaard M Abstract 1,2:5,6-Dianhydrogalactitol (DAG) is a bi-functional DNA-targeting agent currently in phase II clinical trial for treatment of temozolomide-resistant glioblastoma (GBM). In the present study, we investigated...
Tue Jul 28, 2020 13:50
Related Articles Baseline metabolic tumor volume as a strong predictive and prognostic biomarker in patients with non-small cell lung cancer treated with PD1 inhibitors: a prospective study. J Immunother Cancer. 2020 Jul;8(2): Authors: Chardin D, Paquet M, Schiappa R, Darcourt J, Bailleux C, Poudenx M, Sciazza A, Ilie M, Benzaquen J, Martin N, Otto J, Humbert O Abstract BACKGROUND: Reliable predictive and prognostic markers are still lacking...
Tue Jul 28, 2020 13:50
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