Cancers, Vol. 12, Pages 2093: Head and Neck Cancer Metastasis and the Effect of the Local Soluble Factors, from the Microenvironment, on Signalling Pathways: Is It All about the Akt? Cancers doi: 10.3390/cancers12082093 Authors: Hanan Ahmed Arpa Ghoshal Sarah Jones Ian Ellis Mohammad Islam The signalling pathways involved in metastasis of oral adenoid cancer cells (TYS) in response to cancer-associated fibroblasts (COM D24) and normal oral mucosal fibroblasts (MM1) was examined....
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2092: Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer Cancers doi: 10.3390/cancers12082092 Authors: Mona Kafka Fabian Mayr Veronika Temml Gabriele Möller Jerzy Adamski Julia Höfer Stefan Schwaiger Isabel Heidegger Barbara Matuszczak Daniela Schuster Helmut Klocker Jasmin Bektic Hermann Stuppner Iris E. Eder...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2091: Protein Arginine Methyltransferase 5 as a Therapeutic Target for KRAS Mutated Colorectal Cancer Cancers doi: 10.3390/cancers12082091 Authors: David Shifteh Tzuriel Sapir Moshe Pahmer Adam Haimowitz Sanjay Goel Radhashree Maitra Nearly 45% of colorectal cancer (CRC) patients harbor a mutation in their KRAS gene for which, despite many years of research, there are still no targeted therapies available. Protein Arginine Methyltransferase 5 (PRMT5)...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2087: Innovative CAT-T Cell Therapy for Solid Tumor; Current Duel between CAR-T Spear and Tumor Shield Cancers doi: 10.3390/cancers12082087 Authors: Yuna Jo Laraib Amir Ali Ju A Shim Byung Ha Lee Changwan Hong Novel engineered T cells containing chimeric antigen receptors (CAR-T cells) that combine the benefits of antigen recognition and T cell response have been developed, and their effect in the anti-tumor immunotherapy of patients with relapsed/refractory...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2089: Comprehensive Cohort Analysis of Mutational Spectrum in Early Onset Breast Cancer Patients Cancers doi: 10.3390/cancers12082089 Authors: Mohit K. Midha Yu-Feng Huang Hsiao-Hsiang Yang Tan-Chi Fan Nai-Chuan Chang Tzu-Han Chen Yu-Tai Wang Wen-Hung Kuo King-Jen Chang Chen-Yang Shen Alice L. Yu Kuo-Ping Chiu Chien-Jen Chen Early onset breast cancer (EOBC), diagnosed at age ~40 or younger, is associated with a poorer prognosis...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2088: The Perceived Impact of Length of the Diagnostic Pathway Is Associated with Health-Related Quality of Life of Sarcoma Survivors: Results from the Dutch Nationwide SURVSARC Study Cancers doi: 10.3390/cancers12082088 Authors: Vicky L. M. N. Soomers Ingrid M. E. Desar Lonneke V. van de Poll-Franse Michiel A. J. van de van de Sande Jacco J. de Haan Cornelis Verhoef Ingeborg J. H. Vriens Winan J. van Houdt Johannes J. Bonenkamp Winette T....
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2085: Plasmacytoid Dendritic Cell Impairment in Metastatic Melanoma by Lactic Acidosis Cancers doi: 10.3390/cancers12082085 Authors: Matilde Monti Raffaella Vescovi Francesca Consoli Davide Farina Daniele Moratto Alfredo Berruti Claudia Specchia William Vermi The introduction of targeted therapies and immunotherapies has significantly improved the outcome of metastatic melanoma (MM) patients. These approaches rely on immune functions for their...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2081: The Changing Paradigm for the Treatment of HER2-Positive Breast Cancer
Cancers, Vol. 12, Pages 2081: The Changing Paradigm for the Treatment of HER2-Positive Breast Cancer Cancers doi: 10.3390/cancers12082081 Authors: Aena Patel Nisha Unni Yan Peng For decades, HER2-positive breast cancer was associated with poor outcomes and higher mortality rates than other breast cancer subtypes. However, the advent of Trastuzumab (Herceptin) has significantly changed the treatment paradigm of patients afflicted with HER2-positive breast cancer. The discovery of...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2084: Anti-Proliferative Effect of Statins Is Mediated by DNMT1 Inhibition and p21 Expression in OSCC Cells Cancers doi: 10.3390/cancers12082084 Authors: Rachmad Anres Dongoran Kai-Hung Wang Tsung-Jen Lin Ta-Chun Yuan Chin-Hung Liu Statins, also known as HMG-CoA reductase inhibitors, are a class of cholesterol-lowering drugs and their anti-cancer effects have been studied in different types of malignant diseases. In the present study, we investigated...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2086: Computational Identification of Gene Networks as a Biomarker of Neuroblastoma Risk Cancers doi: 10.3390/cancers12082086 Authors: Lidan Sun Libo Jiang Christa N. Grant Hong-Gang Wang Claudia Gragnoli Zhenqiu Liu Rongling Wu Neuroblastoma is a common cancer in children, affected by a number of genes that interact with each other through intricate but coordinated networks. Traditional approaches can only reconstruct a single regulatory network...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2090: Mapping and Quantification of Non-Coding RNA Originating from the rDNA in Human Glioma Cells Cancers doi: 10.3390/cancers12082090 Authors: Anastasia A. Sadova Natalia S. Kupriyanova Galina V. Pavlova Ribosomal DNA is one of the most conserved parts of the genome, especially in its rRNA coding regions, but some puzzling pieces of its noncoding repetitive sequences harbor secrets of cell growth and development machinery. Disruptions in the neat mechanisms...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2082: Study of the Female Sex Survival Advantage in Melanoma—A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts Cancers doi: 10.3390/cancers12082082 Authors: Abdullah Al Emran Jérémie Nsengimana Gaya Punnia-Moorthy Ulf Schmitz Stuart J. Gallagher Julia Newton-Bishop Jessamy C. Tiffen Peter Hersey Background: Survival from melanoma is strongly related to patient sex, with females having a survival rate almost twice...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2083: Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells Cancers doi: 10.3390/cancers12082083 Authors: Genevra Kuziel Victoria Thompson Joseph V. D’Amato Lisa M. Arendt Obesity is correlated with breast tumor desmoplasia, leading to diminished chemotherapy response and disease-free survival. Obesity causes chronic, macrophage-driven inflammation within breast tissue, initiated by chemokine ligand 2 (CCL2)...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2080: LncRNA DLG2-AS1 as a Novel Biomarker in Lung Adenocarcinoma Cancers doi: 10.3390/cancers12082080 Authors: Alberto M. Arenas Marta Cuadros Alvaro Andrades Daniel J. García Isabel F. Coira María Isabel Rodríguez Carlos Baliñas-Gavira Paola Peinado Juan Carlos Álvarez-Pérez Pedro P. Medina Long non-coding RNAs (lncRNAs) are a heterogeneous class of non-coding RNAs whose biological roles are still poorly understood. LncRNAs serve as...
Tue Jul 28, 2020 03:00
Cancers, Vol. 12, Pages 2079: Survival from Cervical Cancer Diagnosed Aged 20–29 Years by Age at First Invitation to Screening in England: Population-Based Study Cancers doi: 10.3390/cancers12082079 Authors: Alejandra Castanon Daniela Tataru Peter Sasieni Age at which women are first invited to attend cervical screening in England has changed twice: in 2004, women under 25 years were no longer invited; and in 2012, first invitations were sent six months earlier (at age 24.5 years)....
Tue Jul 28, 2020 03:00
Cells, Vol. 9, Pages 1795: Evidence Supporting an Antimicrobial Origin of Targeting Peptides to Endosymbiotic Organelles Cells doi: 10.3390/cells9081795 Authors: Clotilde Garrido Oliver D. Caspari Yves Choquet Francis-André Wollman Ingrid Lafontaine Mitochondria and chloroplasts emerged from primary endosymbiosis. Most proteins of the endosymbiont were subsequently expressed in the nucleo-cytosol of the host and organelle-targeted via the acquisition of N-terminal presequences,...
Tue Jul 28, 2020 03:00
Cells, Vol. 9, Pages 1794: Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review Cells doi: 10.3390/cells9081794 Authors: Seung-Woo Kim Ja-Kyeong Lee Neutrophil extracellular traps (NETs) comprise decondensed chromatin, histones and neutrophil granular proteins and are involved in the response to infectious as well as non-infectious diseases. The prothrombotic activity of NETs has been reported in various thrombus-related diseases; this activity...
Tue Jul 28, 2020 03:00
Cells, Vol. 9, Pages 1793: Molecular Changes in the Non-Inflamed Terminal Ileum of Patients with Ulcerative Colitis Cells doi: 10.3390/cells9081793 Authors: Ho-Su Lee Maaike Vancamelbeke Sare Verstockt Tom Wilms Bram Verstockt João Sabino Marc Ferrante Séverine Vermeire Isabelle Cleynen Ulcerative colitis is a chronic inflammatory disease confined to the colon. Although the etiopathogenesis remains unknown, small bowel dysfunctions like histological and permeability...
Tue Jul 28, 2020 03:00
Cells, Vol. 9, Pages 1792: The Emerging Role of Galectins and O-GlcNAc Homeostasis in Processes of Cellular Differentiation Cells doi: 10.3390/cells9081792 Authors: Rada Tazhitdinova Alexander V. Timoshenko Galectins are a family of soluble β-galactoside-binding proteins with diverse glycan-dependent and glycan-independent functions outside and inside the cell. Human cells express twelve out of sixteen recognized mammalian galectin genes and their expression profiles are...
Tue Jul 28, 2020 03:00
Cells, Vol. 9, Pages 1791: The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation Cells doi: 10.3390/cells9081791 Authors: Ana Bajc Česnik Helena Motaln Boris Rogelj Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder, characterized by cytoplasmic inclusions of RNA-binding protein TDP-43. Despite decades of research and identification of more than 50 genes associated with amyotrophic lateral sclerosis (ALS),...
Tue Jul 28, 2020 03:00
Cells, Vol. 9, Pages 1790: miRNAs in Health and Disease: A Focus on the Breast Cancer Metastatic Cascade towards the Brain Cells doi: 10.3390/cells9081790 Authors: Marta Sereno Mafalda Videira Imola Wilhelm István A. Krizbai Maria Alexandra Brito MicroRNAs (miRNAs) are small non-coding RNAs that mainly act by binding to target genes to regulate their expression. Due to the multitude of genes regulated by miRNAs they have been subject of extensive research in the past few...
Tue Jul 28, 2020 03:00
Chemosensors, Vol. 8, Pages 58: Electrochemical Sodium Ion Sensor Based on Silver Nanoparticles/Graphene Oxide Nanocomposite for Food Application Chemosensors doi: 10.3390/chemosensors8030058 Authors: Pranlekha Traiwatcharanon Wilai Siriwatcharapiboon Chatchawal Wongchoosuk High sodium ion (Na+) consumption leads to high blood pressure which causes many health issues. Real-time determination of Na+ content in food is still important to limit Na+ intake and control the taste of...
Tue Jul 28, 2020 03:00
Chemosensors, Vol. 8, Pages 57: On-Line Gaseous Formaldehyde Detection Based on a Closed-Microfluidic-Circuit Analysis Chemosensors doi: 10.3390/chemosensors8030057 Authors: Anaïs Becker Christina Andrikopoulou Pierre Bernhardt Claire Trocquet Stéphane Le Calvé This paper describes a compact microfluidic analytical device in a closed-circuit developed for the detection of low airborne formaldehyde levels. The detection is based on the passive trapping of gaseous formaldehyde...
Tue Jul 28, 2020 03:00
Cosmetics, Vol. 7, Pages 60: Tyrosinase and Melanogenesis Inhibition by Indigenous African Plants: A Review Cosmetics doi: 10.3390/cosmetics7030060 Authors: Laurentia Opperman Maryna De Kock Jeremy Klaasen Farzana Rahiman The indiscriminate use of non-regulated skin lighteners among African populations has raised health concerns due to the negative effects associated with skin lightener toxicity. For this reason, there is a growing interest in the cosmetic development of plants...
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Diagnostics, Vol. 10, Pages 525: Predictive Biomarkers and Patient Outcome in Platinum-Resistant (PLD-Treated) Ovarian Cancer Diagnostics doi: 10.3390/diagnostics10080525 Authors: Dionísio de Sousa Marques Príncipe Portugal Canberk Prazeres Lopes Gimba Lima Soares Identification of predictive biomarkers for ovarian cancer (OC) treatment, particularly in the platinum-resistant/refractory setting, is highly relevant for clinical management. E-cadherin,...
Tue Jul 28, 2020 03:00
Diagnostics, Vol. 10, Pages 524: Ciliary Feature Counter: A program for the Quantitative Assessment of Cilia to Diagnose Primary Ciliary Dyskinesia Diagnostics doi: 10.3390/diagnostics10080524 Authors: Andreia L. Pinto Ranjit K. Rai Claire Hogg Thomas Burgoyne Primary ciliary dyskinesia (PCD) is a disorder that affects motile cilia in the airway that are required for the removal of mucus, debris, and pathogens. It is important to diagnose PCD in early childhood to preserve lung...
Tue Jul 28, 2020 03:00
Diagnostics, Vol. 10, Pages 522: Long-Term Effects of Angiotensin Receptor–Neprilysin Inhibitors on Myocardial Function in Chronic Heart Failure Patients with Reduced Ejection Fraction Diagnostics doi: 10.3390/diagnostics10080522 Authors: Gregor Poglajen Ajda Anžič-Drofenik Gregor Zemljič Sabina Frljak Andraž Cerar Renata Okrajšek Miran Šebeštjen Bojan Vrtovec Background. We sought to evaluate the long-term effects of angiotensin receptor blocker–neprilysin...
Tue Jul 28, 2020 03:00
Diagnostics, Vol. 10, Pages 523: Limited Practical Utility of Liquid Biopsy in the Treated Patients with Advanced Breast Cancer Diagnostics doi: 10.3390/diagnostics10080523 Authors: Anna Niwinska Aneta Bałabas Maria Kulecka Anna Kluska Magdalena Piątkowska Agnieszka Paziewska Kazimiera Pyśniak Wojciech Olszewski Michał Mikula Jerzy Ostrowski Recently, liquid biopsy has emerged as a tool to monitor oncologic disease progression and the effects of treatment....
Tue Jul 28, 2020 03:00
Diversity, Vol. 12, Pages 296: The Influence of Human Interference on Zooplankton and Fungal Diversity in Poyang Lake Watershed in China Diversity doi: 10.3390/d12080296 Authors: Haiming Qin Xinyi Cao Lanyue Cui Qian Lv Tingtao Chen The Poyang water system in Jiangxi Province, China, is important for floodwater storage, diversity maintenance, and the economy of the Poyang Lake watershed. In recent years, pollution has destroyed the ecosystem and impacted human health and...
Tue Jul 28, 2020 03:00
Diversity, Vol. 12, Pages 295: A Trait-Based Clustering for Phytoplankton Biomass Modeling and Prediction Diversity doi: 10.3390/d12080295 Authors: Crispin M. Mutshinda Zoe V. Finkel Claire E. Widdicombe Andrew J. Irwin When designing models for predicting phytoplankton biomass or characterizing traits, it is useful to aggregate the myriad of species into a few biologically meaningful groups and focus on group-level attributes, the common practice being to combine phytoplankton...
Tue Jul 28, 2020 03:00
Diversity, Vol. 12, Pages 294: Lichen Distribution Patterns in the Ecoregions of Italy Diversity doi: 10.3390/d12080294 Authors: Stefano Martellos Marco d’Agostino Alessandro Chiarucci Pier Luigi Nimis Juri Nascimbene An outline of the main distribution patterns of lichens in the ecoregions of Italy, accounting for their climatic, geographic, and environmental features, is still missing. On the basis of a GIS-based analysis, we summarized: (1) the main features (e.g., surface,...
Tue Jul 28, 2020 03:00
Fermentation, Vol. 6, Pages 74: Microbial and Sensory Analysis of Soy and Cow Milk-Based Yogurt as a Probiotic Matrix for Lactobacillus rhamnosus GR-1 Fermentation doi: 10.3390/fermentation6030074 Authors: Syeda Maria Fatima Sharareh Hekmat Plant-based milk alternatives represent a growing sector of the functional food industry due to consumer demand for more nutritious and sustainable options. Soymilk is abundant in fibre, phytosterols, and isoflavones. In contrast, cow milk has...
Tue Jul 28, 2020 03:00
Foods, Vol. 9, Pages 1014: Bioactive Compounds and Quality of Extra Virgin Olive Oil Foods doi: 10.3390/foods9081014 Authors: Cecilia Jimenez-Lopez Maria Carpena Catarina Lourenço-Lopes Maria Gallardo-Gomez Jose M. Lorenzo Francisco J. Barba Miguel A. Prieto Jesus Simal-Gandara (1) Background: Extra virgin olive oil (EVOO) is responsible for a large part of many health benefits associated to Mediterranean diet as it is a fundamental ingredient of this diet. The peculiarities...
Tue Jul 28, 2020 03:00
Foods, Vol. 9, Pages 1013: The Efficiency of Atmospheric Dielectric Barrier Discharge Plasma against Escherichia coli and Bacillus cereus on Dried Laver (Porphyra tenera) Foods doi: 10.3390/foods9081013 Authors: Ji Yoon Kim Eun Bi Jeon Man-Seok Choi Eun Ha Choi Jun Sup Lim Jinsung Choi Shin Young Park This study investigated the effects of atmospheric dielectric barrier discharge (DBD) plasma (1.1 kV, 43 kHz, 5–30 min, N2: 1.5 L/m) on the reduction of Escherichia...
Tue Jul 28, 2020 03:00
Humanities, Vol. 9, Pages 69: Native Apocalypse in Claire G. Coleman’s The Old Lie Humanities doi: 10.3390/h9030069 Authors: Iva Polak Claire G. Coleman’s science fiction novel The Old Lie (2019) evokes the blemished chapters of Australia’s history as the basis of a dystopian futuristic Earth. By using the metaphor of a secular apocalypse (Weaver) wrapped in the form of a space opera, she interrogates historical colonialism on a much larger scale to bring to the fore...
Tue Jul 28, 2020 03:00
IJERPH, Vol. 17, Pages 5442: Experiential Learning Program to Strengthen Self-Reflection and Critical Thinking in Freshmen Nursing Students during COVID-19: A Quasi-Experimental Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17155442 Authors: Yi-Chuan Cheng Li-Chi Huang Chi-Hsuan Yang Hsing-Chi Chang This article focuses on the unique needs and concerns of nursing educators and nursing students in the face of the COVID-19 pandemic....
Tue Jul 28, 2020 03:00
IJERPH, Vol. 17, Pages 5443: Association between Compliance with the 24-Hour Movement Guidelines and Fundamental Movement Skills in Preschoolers: A Network Perspective International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17155443 Authors: Clarice Maria de Lucena Martins Cain Craig Truman Clark Paulo Felipe Ribeiro Bandeira Jorge Mota Michael Joseph Duncan The present study aimed to analyze the compliance with the 24-h movement guidelines and...
Tue Jul 28, 2020 03:00
IJERPH, Vol. 17, Pages 5444: Lifestyle Medicine and Psychological Well-Being Toward Health Promotion: A Cross-Sectional Study on Palermo (Southern Italy) Undergraduates International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17155444 Authors: Domenica Matranga Vincenzo Restivo Laura Maniscalco Filippa Bono Giuseppe Pizzo Giuseppe Lanza Valerio Gaglio Walter Mazzucco Silvana Miceli (1) Aim: To assess the attitude toward Lifestyle Medicine...
Tue Jul 28, 2020 03:00
IJERPH, Vol. 17, Pages 5447: Long-Term Assessment of Air Quality and Identification of Aerosol Sources at Setúbal, Portugal International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17155447 Authors: Alexandra Viana Silva Cristina M. Oliveira Nuno Canha Ana Isabel Miranda Susana Marta Almeida Understanding air pollution in urban areas is crucial to identify mitigation actions that may improve air quality and, consequently, minimize human exposure...
Tue Jul 28, 2020 03:00
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