Related ArticlesThoracic psammomatous meningioma with osseous metaplasia: a controversial diagnosis of a case report and literature review. World J Surg Oncol. 2019 Aug 24;17(1):150 Authors: Wang C, Chen Y, Zhang L, Ma X, Chen B, Li S Abstract BACKGROUND: Spinal psammomatous meningioma with calcification is commonly observed, but distinctive osseous differentiation rarely occurs. CASE PRESENTATION: Here, we described a 52-year-old female complaining...
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Contributors : Isha Sengupta ; Dipanwita Das ; Shivaram P Singh ; Runu Chakravarty ; Chandrima DasSeries Type : Expression profiling by arrayOrganism : Homo sapiensHepatitis B virus (HBV), belonging to Hepadnaviridae family, remains undetected in early infection and is known to be the cause of several hepatic diseases leading to cirrhosis and hepatocellular carcinoma. We have found that PML-Nuclear Body Speckled 110kDa (Sp110), is hyper-expressed upon HBV infection and intriguingly, Sp110 knock-down...
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ConclusionMindfulness was previously shown to be a promising intervention for chronic pain treatment. Our study demonstrates that higher pre-operative dispositional mindfulness is associated with more favorable post-operative pain outcomes, including lower pain scores, but not lower opioid consumption. This relationship provides an opportunity to target the modifiable personality characteristic of mindfulness, to improve post-operative pain for patients planning gynecologic surgery. (Source: Journal...
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This study demonstrates that pathology reporting of PHC is challenging. Reports are frequently incomplete and often do not incorporate assessment of all resection planes and the dissection plane. The periductal dissection plane is frequently overlooked, but is a major cause of residual disease. (Source: Virchows Archiv)
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ConclusionsHepatectomy is a safe and effective way of treating breast cancer liver metastasis at experienced centers where multidisciplinary adjuvant treatments are available. It can be considered more frequently as part of the multidisciplinary care for this patient population. (Source: Hepatobiliary and Pancreatic Diseases International)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any...
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Publication date: 5 October 2019Source: International Journal of Pharmaceutics, Volume 569Author(s): Mohammed H. Qusa, Abu Bakar Siddique, Sami Nazzal, Khalid A. El SayedAbstractEpidemiological studies have compellingly documented the ability of the Mediterranean diet rich in extra-virgin olive oil to reduce the incidence of certain malignancies, and cardiovascular diseases, and slow the Alzheimer’s disease progression. S-(-)-Oleocanthal (OC) was identified as the most bioactive olive oil phenolic...
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This study suggests that the DOX-PIO combination could be used in the clinic for osteosarcoma patients who develop DOX-resistance. (Source: Biomedicine and Pharmacotherapy)
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We reported that HePTP was overexpressed in TNBC, where it acted to drive migration and invasion of tumor cells. We showed that knockdown of HePTP significantly suppressed metastatic capacity of TNBC cells. Moreover, HePTP promoted cells migration and invasion by dephosphorylating glycogen synthase kinase 3 beta (GSK3β), thereby activating Wnt/β-catenin signaling. Additionally, we demonstrated that overexpression of HePTP in HePTP lowly expressed cells could effectively promote the migration and...
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Publication date: Available online 23 August 2019Source: Journal of Cardiology CasesAuthor(s): Shohei Moriyama, Taku Yokoyama, Kei Irie, Mamoru Ito, Kenji Tsuchihashi, Mitsuhiro Fukata, Hitoshi Kusaba, Toru Maruyama, Koichi AkashiAbstractFluorouracil (5-FU), a commonly used anticancer agent, has potent cardiotoxicity that is mediated by vascular endothelial injury and vasospasm. Here, we report a patient demonstrating atrial fibrillation (AF), which was most likely induced by vasospasm mediated by...
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Publication date: Available online 22 August 2019Source: Seminars in Cancer BiologyAuthor(s): Sergey G. Klochkov, Margarita E. Neganova, Vladimir N. Nikolenko, Kuo Chen, Siva G. Somasundaram, Cecil E. Kirkland, Gjumrakch AlievAbstractThe use of nanoparticles dramatically increases the safety and efficacy of the most common anticancer drugs. The main advantages of nano-drugs and delivery systems based on nano-technology are effective targeting, delayed release, increased half-life, and less systemic...
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Publication date: Available online 22 August 2019Source: Practical Radiation OncologyAuthor(s): Jacqueline Wu, Josephine Wu, Åse Ballangrud, Jim Mechalakos, Josh Yamada, D. Michael LovelockAbstractSpine stereotactic body radiation therapy frequently involves the delivery of high doses to targets in proximity to the spinal cord, thus the radiation must be delivered with great spatial accuracy. Monitoring for large shifts in target and cord position that might occur during dose delivery is a challenge...
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CONCLUSIONSCoverage guidelines for IMRT, SRS, SABR, and PBT vary across 5 major insurance providers and may be substantially discordant when compared to ASTRO coverage guidelines. There remain several specific areas where ongoing and future dialogue between ASTRO, payers, and policymakers remains essential. (Source: Practical Radiation Oncology)
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ConclusionA decision tree based on the JDH metrics that can quickly determine the necessity of online replanning based on the image of the day without segmentation has been determined using a machine learning process. The process can be automated and completed within a minute, allowing users to quickly decide which fractions require OLAR. (Source: Practical Radiation Oncology)
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ConclusionsEvaluation of 193 bone tumours of the scapula revealed a high incidence of malignancy in this series, while increased patient age was identified as a potential risk factor for the development of a malignant lesion of the scapula. These findings highlight the importance of early diagnosis and treatment of suspicious lesions of the scapula to improve patient outcome. (Source: Journal of Bone Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before....
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Publication date: Available online 22 August 2019Source: Journal of Bone OncologyAuthor(s): Matthew Lockwood, Rajesh Banderudrappagari, Larry J. Suva, Issam MakhoulAbstractBisphosphonates are commonly used in patients with metastatic bone disease to prevent skeletal related events. Atypical femur fracture is a known complication of long-term bisphosphonate use but the incidence in cancer patients and pathogenesis are not well known. Several mechanisms of pathogenesis have been proposed including...
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In this study, by structural modification of a retrograde transport blocker Retro-2cycl, a series of novel compounds were obtained. The primary screen revealed that compound 27 has an improved anti-ricin activity compare to positive control. In vitro pre-exposure evaluation in Madin–Darby Canine Kidney (MDCK) cells demonstrated that 27 is a powerful anti-ricin compound with an EC50 of 41.05 nmol/L against one LC (lethal concentration, 5.56 ng/mL) of ricin. Further studies surprisingly indicated that...
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Authors: Gokhale P, Chauhan APS, Arora A, Khandekar N, Nayarisseri A, Singh SK Abstract Acute Myeloid Leukaemia (AML) is a blood cancer, which affects the red blood cells in the bone marrow. Of the possible proteins that are affected in AML, fms-like tyrosine kinase 3 (FLT3) has long been recognized as a potential therapeutic target as it affects the other signaling pathways and leads to a cascade of events. First-generation inhibitors sorafenib and midostaurin, as well as secondgeneration...
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Authors: Shukla P, Khandelwal R, Sharma D, Dhar A, Nayarisseri A, Singh SK Abstract Juvenile idiopathic arthritis (JIA) is a heterogeneous disease characterized by the arthritis of unknown origin and IL6 is a known target for JIA. 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. The similarity searching with this compound gave 269 virtual screened compounds. The said screening presented 269...
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Authors: Udhwani T, Mukherjee S, Sharma K, Sweta J, Khandekar N, Nayarisseri A, Singh SK Abstract The progression of lung cancer is associated with inactivation of programmed cell death protein 1, abbreviated as PD- 1 which regulates the suppression of the body's immune system by suppressing T- cell inflammatory activity and is responsible for preventing cancer cell growth. It is of interest to identify inhibitors for PD-L1 dimeric structure through molecular docking and virtual screening....
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Authors: Nakamura S, Kanda M, Kodera Y Abstract Introduction: Gastric cancer is one of the most common causes of cancer-related mortality worldwide. To improve clinical outcomes, it is critical to develop appropriate approaches to diagnosis and treatment. Biomarkers have numerous potential clinical applications, including screening, assessing risk, determining prognosis, monitoring recurrence, and predicting response to treatment. Furthermore, biomarkers may contribute to the development...
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Publication date: Available online 24 August 2019Source: Materials & DesignAuthor(s): D. Andre, T. Burlet, F. Körkemeyer, G. Gerstein, J.S.K.-L. Gibson, S. Sandlöbes-Haut, S. Korte-KerzelAbstractA promising approach to deform metallic-intermetallic composite materials is the application of electric current pulses during the deformation process to achieve a lower yield strength and enhanced elongation to fracture. This is known as the electroplastic effect. In this work, a novel setup to study...
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Publication date: Available online 24 August 2019Source: Materials & DesignAuthor(s): Mohammad Karzar Jeddi, Ossi Laitinen, Henrikki LiimatainenAbstractSuperabsorbent aerogels are fascinating materials for oil and chemical spillage cleanup. However, the development of an economic and efficient superabsorbent is still highly challenging. In this study, we introduce a novel approach to prepare very low density (0.005 g/cm3), highly porous (>99.6%), economic, reusable, hydrophobic, and magnetic...
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Publication date: Available online 24 August 2019Source: Materials & DesignAuthor(s): Jian Wang, Christian Hopmann, Mauritius Schmitz, Tobias Hohlweck, Jens WipperfürthAbstractThe absence of the influence of cooling rate in the pressure–specific volume–temperature (pvT) models makes them inadequate in the process simulation of injection molding. This work derived new equations of state (EoS) from the traditional two-domain Tait model that describes the pvT behavior of semi-crystalline polymers...
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Publication date: Available online 24 August 2019Source: Materials & DesignAuthor(s): Cui E. Seow, Harry E. Coules, Guiyi Wu, Raja H.U. Khan, Xiangfang Xu, Stewart WilliamsAbstractWire + Arc Additive Manufacturing (WAAM) can be used to create large free-form components out of specialist materials such as nickel-base superalloys. Inconel (IN) 718 is well suited for the WAAM process due to its excellent weldability. However, during deposition, WAAM IN718 is susceptible to micro-segregation, leading...
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Publication date: Available online 24 August 2019Source: Materials & DesignAuthor(s): Óscar Santiago, Miguel A. Raso, Emilio Navarro, Teresa J. LeoAbstractThe use of polymers in direct methanol fuel cells (DMFCs) would reduce their density and cost, thereby enhancing their commercialization. This work aims to select the most appropriate materials among seven thermoplastic polymers (ABS, CPE, CPE+, Nylon, PC, PLA and TPU 95A) for use as bipolar plates (BPs) for different applications of DMFCs....
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Publication date: Available online 23 August 2019Source: Materials & DesignAuthor(s): Pengrong Ouyang, Hui Dong, Xijing He, Xuan Cai, Yibin Wang, Jialiang Li, Haopeng Li, Zhongmin JinAbstractThe pore size of porous scaffold plays a critical role in bone regeneration, but its mechanism and optimal value remain unclear. This study investigated the effect of pore size on hydromechanical properties of porous scaffold and its correlation with cellular response and bone regeneration. Porous titanium...
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Publication date: Available online 23 August 2019Source: Materials & DesignAuthor(s): Xuewu Li, Tian Shi, Ben Li, Xinchun Chen, Chuanwei Zhang, Zhiguang Guo, Qiaoxin ZhangAbstractPreparing super-hydrophobic surfaces with additive manufacturing (AM) and multi-step processes improves corrosion resistance of Al alloys. But the incorporation of dissimilar metals accelerates matrix corrosion, additive polymers cannot offer a long-term structural stability, and multi-step methods are complicated and...
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Publication date: Available online 23 August 2019Source: Materials & DesignAuthor(s): Haoran Tu, Yu Yan, Dong Cai, Jingxue Wang, Xiaoyun Shang, Hui Tian, Feng Su, Xiaobo DuAbstractNanocrystalline Nd2 (Fe, Co)14C materials were synthesized by a mechanochemical method. Ball milling in organic solvent (hydrocarbon), Nd15Fe80.6Co4B0.4 alloy disproportionated into NdH2+δ, α-Fe (Co) and Fe7C3 phases. H2 was released from the NdH2+δ and Nd2 (Fe, Co)14C hard magnetic powders were obtained during the...
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Publication date: Available online 22 August 2019Source: Materials & DesignAuthor(s): Anna Pazniak, Pavel Bazhin, Nikolay Shplis, Evgeniy Kolesnikov, Igor Shchetinin, Alexander Komissarov, Josef Polcak, Alexander Stolin, Denis KuznetsovAbstractMXenes are an emerging family of two-dimensional (2D) early transition metal carbides/nitrides that are produced by selective A-element chemical etching from 3D MAX phase counterpart. Herein we report a low-cost method combining self-propagation high-temperature...
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Publication date: Available online 22 August 2019Source: Materials & DesignAuthor(s): Hao Jiang, Song Gao, Guangyao Li, Junjia CuiAbstractElectromagnetic self-piercing riveting (E-SPR) as a new riveting method is attracting more and more attentions due to its superiority in joining dissimilar materials. In this paper, nine sets of half hollow rivets with different blade angles, inner diameters and leg lengths were designed for E-SPR process. The section quality and mechanical properties of the...
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Publication date: Available online 22 August 2019Source: Materials & DesignAuthor(s): Kaiming Han, Yingmin Wang, Jianbing Qiang, Hongbin Zhang, Shengxue Qin, Hui Jiang, Shuang Zhang, Chuang DongAbstractComposition rule of binary and some ternary bulk metallic glasses (BMGs) has been empirically solved by using the composition formulas of the cluster-plus-glue-atom model. However, multi-component BMGs such as Zr-Al-Ni-Cu with exceptionally high glass-forming abilities cannot be well understood...
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Publication date: Available online 22 August 2019Source: Materials & DesignAuthor(s): Yu-An Shen, Shiqi Zhou, Jiahui Li, Chih-han Yang, Sijie Huang, Shih-kang Lin, Hiroshi NishikawaAbstractPackage-on-Package (PoP) is a popular technology for fabricating chipsets of accelerated processing units. However, the coefficient of thermal expansion mismatch between Si chips and polymer substrates induces thermal warpage during the reflow process. As such, the reflow temperature and reliability of solder...
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Conclusions: Patients undergoing sublobar/lobar resections had higher survival rate. PMID: 31437020 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
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Authors: Jain KK Abstract This chapter is a brief overview of use of nanobiotechnology in drug delivery. Several types of nanoparticles are available. Nanoparticulate formulations of normally used drugs have increased efficacy due to improved absorption and require lower dosage with less side effects than standard formulations. Nanobiotechnology also facilitates targeted drug delivery of anticancer drugs, which is important for the management of cancer. Nanoparticles also facilitate crossing...
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Authors: Jain KK Abstract This is an overview of the current drug delivery systems (DDSs) starting with various routes of drug administration. Various drug formulations are then described as well as devices used for drug delivery and targeted drug delivery. There has been a considerable increase in the number of new biotechnology-based therapeutics. Most of these are proteins and peptides, and their delivery present special challenges. Cell and gene therapies are sophisticated methods of...
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Authors: Kandil R, Xie Y, Mehta A, Merkel O Abstract Small interfering RNA (siRNA)-based therapy has been subject of intense research since the discovery of RNA interference (RNAi), providing a tool to potentially silence any chosen gene. Nevertheless, efficient delivery still presents a major hurdle to translating this promising technology into medical practice. Here, we describe a straightforward method to prepare and characterize an effective delivery system consisting of low-molecular-weight...
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Authors: Martins C, Sarmento B Abstract Taxane chemotherapeutics have played a key role in the treatment of various types of cancer throughout the past years. However, the drawbacks inherent to the pharmaceutical formulation of taxanes are still a reality and mainly due to the low aqueous solubility of these medicines, as well as to the nontargeted therapy and consequent side effects. Nanoparticles (NPs) of poly(lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) have sparked...
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Letter to the editor submitted in response to "Efficacy and safety of imiquimod 5% cream for basal cell carcinoma: a meta-analysis of randomized controlled trial." J Dermatolog Treat. 2019 Aug 22;:1-4 Authors: Axon E, Grindlay DJ PMID: 31437067 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
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Publication date: Available online 22 August 2019Source: Stem Cell ResearchAuthor(s): Masayuki Takahashi, Satoshi YamazakiAbstractReprograming human primary cancer cells remains technically challenging, and leukemia-specific human induced pluripotent stem cell (hiPSC) lines have not yet been generated from tissues of patients with acute leukemia (Muñoz-López et al., 2016). Here, we developed an hiPSC line with a doxycycline-inducible expression system with the fusion gene ETV6-RUNX1 integrated into...
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