Abstract Purpose Experimental studies suggested that green tea may have an anticancer effect on hematologic neoplasms. However, few prospective studies have been conducted. Methods A total of 65,042 individuals aged 40–79 years participated in this study and completed a self-administered questionnaire about their lifestyle and medical history at baseline...
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AbstractPurpose of the ReviewThis review paper is a comprehensive look at the cardiovascular disease (CVD) risk that is associated with the use of androgen deprivation therapy in prostate cancer. It summarizes when certain cancer therapies are indicated and should guide physicians in identifying patients at increased risk for CVD during prostate cancer therapy.Recent FindingsGnRH agonist use and maximal androgen blockade (MAB) are associated with increased CVD. This association is not observed in...
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Authors: Cheng X, Yan K, Ma J, Chen Z, Zhao L, Wang X, Wu R Abstract The treatment of severe chronic immune thrombocytopenia (SCITP) in pediatric patients is challenging. We evaluated the clinical efficacy and safety of eltrombopag in children with SCITP in China. This observational study was carried out at the Hematology Oncology Center, Beijing Children's Hospital between April 2017 and July 2018. Patients with SCITP who had at least 12 weeks of eltrombopag treatment and follow-up data...
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Publication date: Available online 23 August 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Alexandra G. Pershina, Olga Ya. Brikunova, Alexander M. Demin, Oleg B. Shevelev, Ivan A. Razumov, Evgenii L. Zavjalov, Dina Malkeyeva, Elena Kiseleva, Nadezhda V. Krakhmal’, Sergey V. Vtorushin, Vasily L. Yarnykh, Vladimir V. Ivanov, Raisa I. Pleshko, Victor P. Krasnov, Ludmila M. OgorodovaAbstractNowadays there is growing recognition of the fact that biological systems have a greater...
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We report a rare case of a primary intraventricular CNS classical HL-PTLD in a male patient, 18 years following renal transplantation. The location allowed for safe neurosurgical intervention which resolved the symptom of elevated intracranial pressure and allowed for induction of a Rituximab-based chemotherapy regimen. Both the ventricular location of the PTLD and Hodgkin Lymphoma PTLD are themselves individually quite rare and have not previously been reported together. The unique location allowed...
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Authors: Inaba H, Ariyasu H, Takeshima K, Iwakura H, Akamizu T Abstract Various thyroid diseases are associated with autoimmunity. Major autoimmune thyroid diseases are Graves' disease (GD) and Hashimoto's thyroiditis (HT). Thyrotropin receptor is an autoantigen in GD, and its immunogenicity has been examined. Immune-checkpoint inhibitor (ICI) is recently widely used for treatment of malignant tumors, but cases of thyroid diseases during ICI treatment have been increasing. Thyroid diseases...
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CONCLUSION: More than 50% of low-risk PTMC are on AS in Japan. However, the indication and recommendation for AS vary significantly between institutions. To improve the implementation of this management modality, physicians and patients should be further educated, and the socio-medical environment should be improved. PMID: 31441377 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
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Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncol Rep. 2019 Aug 22;: Authors: Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H, Luo YQ Abstract Oxaliplatin (Oxa)‑based chemotherapy is widely used as the first‑line treatment for colorectal cancer (CRC). However, Oxa‑resistance is common for many postoperative CRC patients. To...
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In this study, the WT1 and CCNA1 mRNA levels were found to be elevated in bone marrow samples from pediatric acute promyelocytic leukemia (APL or AML‑M3) patients, and to be quite varied in pediatric acute lymphocytic leukemia (ALL) patients, compared to non‑leukemic bone marrow controls. Consistent with the observed upregulation of both WT1 and CCNA1 in APL, WT1 overexpression elevated the CCNA1 mRNA levels in K562 leukemia cells. Treatment with curcumin decreased the WT1 levels in K562 cells, and...
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Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment. Oncol Rep. 2019 Aug 21;: Authors: Kwon YM, Je JY, Cha SH, Oh Y, Cho WH Abstract Chemo‑photothermal therapy for cancer treatment has received increasing attention due to its selective therapeutic effects. In the present study, the anticancer effects of drug‑loaded Fe3O4 magnetic nanoparticles (MNPs) by chemo‑photothermal therapy on U‑87 MG human...
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Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells. Oncol Rep. 2019 Aug 21;: Authors: Aedo-Aguilera V, Carrillo-Beltrán D, Calaf GM, Muñoz JP, Guerrero N, Osorio JC, Tapia JC, León O, Contreras HR, Aguayo F Abstract Curcumin is a natural antioxidant polyphenol, which decreases epithelial‑mesenchymal transition (EMT) and cell migration in cervical cancer cells. However, the mechanism by which such a decrease occurs...
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Authors: Li F, Guo H, Yang Y, Feng M, Liu B, Ren X, Zhou H Abstract Bladder cancer (BC) is a potentially life‑threatening malignancy. Due to a high recurrence rate, frequent surveillance strategies and intravesical drug therapies, BC is considered one of the most expensive tumors to treat. As a fundamental evolutionary catabolic process, autophagy plays an important role in the maintenance of cellular environmental homeostasis by degrading and recycling damaged cytoplasmic components, including...
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Emetine exhibits anticancer activity in breast cancer cells as an antagonist of Wnt/β‑catenin signaling. Oncol Rep. 2019 Aug 22;: Authors: Sun Q, Fu Q, Li S, Li J, Liu S, Wang Z, Su Z, Song J, Lu D Abstract Emetine, an amoebicidal drug, exerts potent anticancer activity against various solid tumors, however, the underlying molecular mechanism remains unclear. In the present study, the effects of emetine were investigated on various proteins involved in the Wnt/β‑catenin signaling...
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Publication date: Available online 23 August 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Paula Santos-Otte, Hanne Leysen, Jaana van Gastel, Jhana O. Hendrickx, Bronwen Martin, Stuart MaudsleyAbstractAging is a complex biological process that is inevitable for nearly all organisms. Aging is the strongest risk factor for development of multiple neurodegenerative disorders, cancer and cardiovascular disorders. Age-related disease conditions are mainly caused by the progressive...
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CONCLUSIONS: These data suggest that the need for a palliative care consult identifies inpatients at very high risk for early deterioration and underlines the critical importance of advance care planning/goals-of-care discussions by the oncology and palliative care teams to ensure patients and families understand their disease process and have the opportunity to direct their care decisions. PMID: 31438769 [PubMed - as supplied by publisher] (Source: Journal of Palliative Care)
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This report provides estimates of the percentage of total grains intake consumed from whole grains sources, for adults aged 20 and over who reported consumption of grains (98.6%) on a given day during 2013-2016. PMID: 31442194 [PubMed - in process] (Source: NCHS data brief)
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Publication date: 1 November 2019Source: Journal of Molecular Liquids, Volume 293Author(s): Ganeshlenin Kandasamy, Atul Sudame, Dipak Maity, Shalini Soni, Kumari Sushmita, Naga Suresh Veerapu, Suryasarathi Bose, C.V. TomyAbstractIn this work, we have developed novel multifunctional magnetic-polymeric nanoparticles (MMPNs) based ferrofluids by encapsulating oleylamine (OM)-coated hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) inside the poly(lactic-co-glycolic acid) (PLGA) nanoparticles...
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CONCLUSION: Our experience shows that patients with diagnoses of acute retinal necrosis or progressive outer retinal necrosis have a poor visual prognosis. The occurrence of cytomegalovirus retinitis signifies a very unfavorable survival prognosis in patients who underwent hematopoietic stem cell transplantation; the patients in our study died within 1 year from cytomegalovirus retinitis diagnosis. PMID: 31435074 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty...
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CONCLUSION: CRS/HIPEC performed is a safe method with low perioperative mortality. PMID: 31435073 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
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Authors: Michalek J, Brychtova S, Pink R, Dvorak Z Abstract Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue....
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Related ArticlesA rare case of rectal cancer with perianal metastasis: a case report. World J Surg Oncol. 2019 Aug 20;17(1):149 Authors: Ikeda T, Nanashima A, Ichihara A, Kitamura E, Nagatomo K, Tanaka H Abstract BACKGROUND: Cancer metastasis from colon cancer to an anal fistula is very rare. We herein reported a rare case in which local excision was performed for metastatic anal fistula cancer originating from rectal cancer. CASE PRESENTATION:...
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Related ArticlesPerioperative chemotherapy versus neoadjuvant chemoradiation for patients with adenocarcinoma of the distal esophagus in Austria: a retrospective analysis. World J Surg Oncol. 2019 Aug 19;17(1):146 Authors: Koch OO, Weitzendorfer M, Varga M, Tschoner A, Partl R, Perathoner A, Gehwolf P, Kapp KS, Függer R, Öfner D, Emmanuel K Abstract BACKGROUND: The aim of this study was to compare the outcome of patients with adenocarcinoma of the distal...
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Related ArticlesAn extremely rare primary sarcoma of the lung with peritoneal and small bowel metastases: a case report. World J Surg Oncol. 2019 Aug 19;17(1):147 Authors: Pleština S, Librenjak N, Marušić A, Batelja Vuletić L, Janevski Z, Jakopović M Abstract BACKGROUND: Primary sarcoma of the lung is a very rare malignant tumor accounting for less than 0.5% of all lung tumors and presenting diagnostic and treatment challenge. We describe a case of...
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Related ArticlesUnusual synchronous double primary treatment-naïve lung adenocarcinoma harboring T790M and L858R mutations in early-stage lung cancer. World J Surg Oncol. 2019 Aug 19;17(1):148 Authors: Weng CF, Chen PJ, Tseng AH, Huang SH, Lee HH Abstract BACKGROUND: Concurrent mutations of synchronous multiple primary non-small cell lung cancer (SMPNSCLC) is rare, and only a few cases have been reported. Herein, we present a case of early-stage SMPNSCLC...
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Conclusion: 11-DGA-3-O-Gal-CTD-lip represent a promising nanocarrier for the liver-targeted delivery of antitumor drugs to treat hepatocellular carcinoma. (Source: Molecules)
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Authors: Bo Cao Xi-Chuan Wei Xiao-Rong Xu Hai-Zhu Zhang Chuan-Hong Luo Bi Feng Run-Chun Xu Sheng-Yu Zhao Xiao-Juan Du Li Han Ding-Kun Zhang For the treatment of diseases, especially chronic diseases, traditional natural drugs have more effective therapeutic advantages because of their multi-target and multi-channel characteristics. Among many traditional natural medicines, resins frankincense and myrrh have been proven to be effective in the treatment of inflammation...
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Conclusion: LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients. (Source: Chinese Journal of Integrative Medicine)
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Authors: Anna Michaelidesová Jana Konířová Petr Bartůněk Martina Zíková Brain and nervous system cancers in children represent the second most common neoplasia after leukemia. Radiotherapy plays a significant role in cancer treatment; however, the use of such therapy is not without devastating side effects. The impact of radiation-induced damage to the brain is multifactorial, but the damage to neural stem cell populations seems to play a key role. The brain contains pools of regenerative...
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(Source: European Journal of Epidemiology)
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The management of patients with prostate cancer, in contrast to that of most other neoplasms is somewhat unique in that care of patients is typically overseen to a variable degree by a variety of different clinicians including urologists, radiation, and medical oncologists over a disease course that may extend over many years. (Source: Urology)
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For men with localized prostate cancer (CaP), radical prostatectomy (RP) as well as radiotherapy (RT) was associated with lower incidences of progression and metastases than was active monitoring.1 Meanwhile, prospective trial showed these patients with a long life expectancy would benefit from surgical intervention with a mean gain of almost 3-year of life.2 Unfortunately, when localized CaP progressed to incurable metastatic disease ancestral subclones and stromal micro-environment evolved dynamically...
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We agree that the wide variability in postoperative chemotherapy use observed in our study underscores the need to increase guideline-consistent care for nonmuscle invasive bladder cancer. The physician factors we examined – including physician age, years employed at our institution, specialty training in oncology, and experience treating bladder cancer – did not explain the treatment variability. As Dr. Schroeck noted, other physician factors, such as the level of concern about side effects or awareness...
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The authors report on a retrospective cohort study of 5386 patients diagnosed with nonmuscle-invasive bladder cancer (NMIBC) at Kaiser Permanente Southern California between 2001 and 2015. They find that 41% of patients received any intravesical therapy. Use of postoperative intravesical chemotherapy was rarer (given to 17%), but increased over time. There was substantial variation in use of intravesical therapy across urologists. The variation was greatest for use of postoperative intravesical chemotherapy,...
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Retrospective evaluations of the treatment of the primary tumor in the setting of metastatic hormone sensitive prostate cancer (mHSPC) are prevalent in the recent literature. The majority of these reports have favored the addition of local therapy1 and form the hypothesis generating support for recently completed and ongoing prospective randomized studies.2,3 Interestingly, in the present retrospective study, cancer-specific survival was not improved with local therapy. This is intriguing since the...
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Conclusions: 3D semiautomatic quantification of PPV is feasible and reproducible using CT in patients with occupational exposure to asbestos. PPV measurement may be useful to correlate with other asbestos-related disease outcomes and prognosis. (Source: Journal of Thoracic Imaging)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Purpose: A common diagnostic dilemma in the assessment of small pulmonary nodules on computed tomography (CT) is in distinguishing benign intrapulmonary lymph nodes (IPLNs) from small primary pulmonary malignancies. Several CT features have been described of IPLNs, including attachment to a pleural surface. We had observed that IPLNs were often connected to a pulmonary vein and sought to evaluate the utility of this sign in discriminating IPLNs from lung adenocarcinomas. The frequency of other...
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(Source: American Journal of Health Behavior)
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Contributor : Tsuyoshi OsawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe conditions of the tumor microenvironment, such as nutrient starvation, play critical roles in cancer progression. However, the role of glutamine deprivation in cancer progression is not studied as extensively as that of hypoxia. Here, we show that glutamine starvation triggered down-regulation of PCYT2 by stimulating accumulation of PEtn. Interestingly, glutamine upregulated series...
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Contributors : Luis Arturo Baiza Gutman ; Araceli Rub í Vietma RodriguezSeries Type : Expression profiling by arrayOrganism : Homo sapiensDiabetes and breast cancer are common diseases with a major impact on the health sector in Mexico and worldwide. Epidemiological and experimental works support the link between type 2 diabetes and breast cancer; these data support that insulin resistance, hyperglycemia, hyperinsulinemia, and elevated levels of IGF-1 in patients with type II diabetes mellitus promote...
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