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Abstract Total fertilization failure (TFF), which is the failure of fertilization in all oocytes, occurs in 1‐3% of intracytoplasmic sperm injection (ICSI) cycles. However, the sperm‐related factors that cause fertilization failure in humans are still largely unknown. Here, we identified three novel homozygous variations in the PLCZ1 gene in a recessive inheritance pattern in three consanguineous families, which all located in a key catalytic domain, and predicted to modify its secondary...
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Publication date: Available online 29 August 2019Source: Sleep MedicineAuthor(s): Abhishek Goyal, Abhijit Pakhare, Ishan Raj Tiwari, Alkesh Khurana, Poonam ChaudharyAbstractBackgroundRecently new classification criteria for obesity hypoventilation syndrome (OHS) have been described. OHS prevalence according to new criteria has not been reported in obstructive sleep apnea (OSA). Prevalence of OHS has not been previously reported from India.MethodsRetrospective study was carried out in OSA patients...
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Abstract Purpose Failed needle-tip positioning in an ultrasound-guided infraclavicular block can be due to improper needle insertion point and steep needle insertion angle. Needle pre-curving enables the user to pass the needle with different curved trajectories on approaching the brachial plexus. Aim of the study was to compare curved and non-curved needles as regards the time needed to perform the lateral sagittal infra-clavicular block....
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Related ArticlesDifferences in comminution progress during mastication in healthy dentate and denture-wearing elderly people. J Prosthodont Res. 2019 Aug 24;: Authors: Sugimoto H, Tanaka Y, Kodama N, Minagi S Abstract PURPOSE: This study aimed to investigate the effect of removable denture prostheses on the comminution progress in elderly people. METHODS: Twenty-two denture wearers of Eichner's classification B and C (75.1±5.3 years old) and...
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Publication date: Available online 29 August 2019Source: Medical HypothesesAuthor(s): Avinoam Rabinovitch, Ira Aviram, Yaacov Biton, Doron BraunsteinAbstractAlthough epilepsy afflicts numerous people worldwide, its dynamics are still controversial. Especially seizure termination is relatively unidentified. Here we suggest a coherent explanation to all stages of epilepsy, its genesis, seizure initiation and termination. We present biophysical features that could account for the phenomenon: all phases...
Publication date: Available online 29 August 2019Source: Medical HypothesesAuthor(s): Bindu MenonAbstractWith progress in neurosciences, neuroimaging and brain stimulation techniques, mental illnesses are now being seen as development anomalies at the molecular- structural level of synapses, resulting in abnormal cross wiring in areas responsible for complex cognitive and emotional processing. These include the multimodal association cortices situated in the prefrontal lobes, the insula in the temporal...
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This study sought to determine whether swallowing speed for water is a useful screening test to predict aspiration in Parkinson’s disease patients. Despite a wide range of potential cutoff values, swallowing speed turned out to be insufficiently reliable. Abstract Background There is still a lack of a clinical test to reliably identify patients with Parkinson's disease (PD) being at risk for aspiration. Methods In this prospective, controlled, cross‐sectional study, we assessed if swallowing...
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Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
Congenital hypothyroidism in preterm infants: a 3- to 8-year longitudinal study in southern Thailand
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
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Publication date: Available online 28 August 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Dominika Högberg, Martin Björck
Thu Aug 29, 2019 14:59
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Publication date: Available online 29 August 2019Source: Journal of VoiceAuthor(s): Ricardo Cardoso, José Lumini-Oliveira, Rute F. MenesesSummaryObjectiveThe study aimed to verify the relation between autonomic nervous system (ANS) dysfunctions, voice, and dysphonia.Study DesignThe study is a systematic review.MethodsAccording to the PRISMA flowchart, a search on Pubmed/Medline, SciELO, RCAAP, LILACS, Cochrane Library, PEDro, and Isi Web of Knowledge was performed up to April 2019 using the following...
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Publication date: Available online 28 August 2019Source: Gait & PostureAuthor(s): Stuart J. Warden, Allie C. Kemp, Ziyue Liu, Sharon M. MoeAbstractBackgroundThere is a clinical need to be able to reliably detect meaningful changes (0.1 to 0.2 m/s) in usual gait speed (UGS) considering reduced gait speed is associated with morbidity and mortality.Research questionWhat is the impact of tester on UGS assessment, and the influence of test repetition (trial 1 vs. 2), timing method (manual stopwatch...
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AbstractMalignant triton tumor (MTT) is a rare subtype of malignant peripheral nerve sheath tumors with rhabdomyoblastic differentiation. Although the condition may manifest sporadically, it typically affects adult patients with neurofibromatosis type 1. In this article, an extremely rare case of MTT with chest wall origin, which expanded into the left thoracic cavity, is reported. A 64-year-old male was admitted to the institution with sudden shortness of breath. Radiological examination revealed...
AbstractGallstone ileus is an uncommon presentation among acute surgical patients. Its diagnosis is often delayed due to its non-specific clinical presentation. We report the case of an 81-year-old gentleman with a 2-day history of small bowel obstruction (SBO). He had a history of gallstone disease and no past surgical history. Plain abdominal radiography was consistent with SBO. A computed tomography (CT) abdomen scan would be warranted given the presentation of SBO in a virgin abdomen. However,...
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Publication date: September–October 2019Source: Journal of Surgical Education, Volume 76, Issue 5Author(s):
Publication date: September–October 2019Source: Journal of Surgical Education, Volume 76, Issue 5Author(s):
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Abstract Recently, the incidence of inflammatory bowel diseases, especially the Crohn's disease (CD) and gastrointestinal luminal tuberculosis (ITB), has grown rapidly worldwide. Currently there is no general gold standard to distinguish between CD and ITB tissues, which both have tuberculosis and surrounding fibrous structures. Mueller matrix imaging technique is suitable for describing the location, density and distribution behavior of such fibrous structures. In this study, we apply the Mueller...
Abstract As the most abundant structural mammalian protein, collagen has been implicated in the pathogenesis of numerous diseases such as osteogenesis imperfecta and cancer. In the case of cornea, abnormal cornea development can lead to conditions such as agenesis, megalocornea, microcornea, and cornea plana. Therefore, understanding the mechanisms of collagen assembly during development may contribute to the prevention or treatment of corneal diseases. In this study, we applied fast Fourier transform...
Abstract The optical immersion clearing technique has been successfully applied through the last 30 years in the visible to NIR spectral range, and has proven to be a promising method to promote the application of optical technologies in clinical practice. To investigate its potential in the ultraviolet range, collimated transmittance spectra from 200 to 1000 nm were measured from colorectal muscle samples under treatment with glycerol‐water solutions. The treatments created two new optical windows...
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Abstract The vagal afferent nerves regulate swallowing and esophageal motor reflexes. However, there are still gaps in the understanding of vagal afferent innervation of the esophageal mucosa. Anatomical studies found that the vagal afferent mucosal innervation is dense in the upper esophageal sphincter area but rare in more distal segments of the esophagus. In contrast, electrophysiological studies concluded that the vagal afferent nerve fibers also densely innervate mucosa in...
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This case series evaluates masseteric-to-facial nerve transfer with selective neurectomy in rehabilitation of the synkinetic smile.
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RESUMO Objetivo Realizar equivalência cultural da versão brasileira do protocolo The Levels of Speech Usage (LSU), por meio de adaptação linguística e cultural. Método Inicialmente realizou-se a tradução do LSU para o Português brasileiro por três fonoaudiólogos fluentes na língua inglesa, retrotradução para o inglês por um quarto fonoaudiólogo, comparação com o protocolo original e aprovação de um comitê de fonoaudiólogas não participantes das etapas anteriores; chegou-se ao protocolo LSU-Br....
Measurement of listening effort using of a dual-task paradigm of Brazilian Portuguese: a pilot study
RESUMO Objetivo Mensurar o esforço auditivo com o uso de um paradigma de tarefa dupla de memória operacional e analisar a significância clínica do desempenho de indivíduos normo-ouvintes. Método Participaram 10 adultos jovens, entre 18 e 30 anos, de ambos os gêneros, normo-ouvintes classificados segundo a média quadritonal (500, 1000, 2000 e 4000Hz) e com nível sociocultural similar. Os participantes foram submetidos à anamnese audiológica, meatoscopia e audiometria tonal limiar. Para a mensuração...
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An accurate estimation of leaf area index (LAI) is crucial for many models of material and energy fluxes within plant ecosystems and between an ecosystem and the atmospheric boundary layer. Therefore, three methods (litter traps, needle technique, and PCA) for taking precise LAI measurements were in the presented protocol.
We demonstrate a method to determine successful or failed fertilization on the basis of sperm nuclear morphology in Arabidopsis double fertilization using an epifluorescence microscope.
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Due to limited therapeutic options, vancomycin-resistant Enterococcus faecium (VREF) is of great clinical significance. Recently, rising proportions of vancomycin resistance in enterococcal infections have been r...
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A Program Director's Guide to Cultivating Diversity and Inclusion in Radiology Residency Recruitment
Publication date: Available online 28 August 2019Source: Academic RadiologyAuthor(s): Carolynn M. DeBenedectis, Darel E. Heitkamp, Eric England, Glenn C. Gaviola, Joshua A. Hirsch, Christopher P. Ho, Ann K. Jay, Nolan Kagetsu, Vivek Kalia, James Milburn, Seng Ong, Angelisa M. Paladin, Maitray D. Patel, Jonathan Swanson, David S. Sarkany
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Hypothyroidism is a common medical disorder which results in many metabolic effects, such as dyslipidemia, hypertension, accelerated atherosclerosis, and coronary artery disease. Hypothyroidism affects the ren...
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Hereditary angioedema (HAE) is a debilitating disorder resulting from C1-esterase inhibitor (C1-INH) deficiency. In the COMPACT phase 3 study the prophylactic use of a subcutaneous C1 inhibitor (C1-INH [SC], H...
There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial activat...
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The study aimed to verify the relation between autonomic nervous system (ANS) dysfunctions, voice, and dysphonia.
Multiparametric indexes provide a more robust acoustic analysis of voice quality considering more than one acoustic parameter in the evaluation of sustained phonation and continuous speech. However, once the continuous speech is considered, differences among languages must be addressed.
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The increasing amount of available biological information on the markers can be used to inform the models applied for genomic selection to improve predictions. The objective of this study was to propose a general model for genomic selection using a link function approach within the hierarchical generalized linear model framework (hglm) that can include external information on the markers. These models can be fitted using the well-established hglm package in R. We also present an R package (CodataGS)...
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Presentation of Case. Dr. Hung M. Le (Pediatrics): A 16-year-old girl was seen in the sports concussion clinic at this hospital because of headache, dizziness, balance problems, fatigue, irritability, and difficulties with sleep and concentration after she had head trauma during a sailboat race.…
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Surgical Infections, Ahead of Print.
Surgical Infections, Ahead of Print.
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Abstract Background Abnormal posterior pituitary development including ectopic location has been associated with endocrine manifestations of anterior pituitary dysfunction. Objective We describe an unreported clinical and radiologic entity we call partial ectopic posterior pituitary for which associated endocrine consequences are not known. ...
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This course will review the benefits and use of Widex Remote Care, a tele-health approach to virtual hearing aid follow-up services. After taking this course, clinicians will understand how to implement Widex Remote Care and describe the benefits of this value added service for their practice and for their patients.
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Abstract Developmental and epileptic encephalopathies are genetic disorders in which both the developmental disability and the frequent epileptic activity are the effect of a specific gene variant. While heterozygous variants in SCN1B have been described in families with generalized epilepsy with febrile seizures plus, Type 1, only three cases of homozygous, missense variants in SCN1B have been reported in association with autosomal recessive inheritance of a severe developmental and epileptic encephalopathy....
Abstract Dental anomalies occur frequently in a number of genetic disorders and act as major signs in diagnosing these disorders. We present definitions of the most common dental signs and propose a classification usable as a diagnostic tool by dentists, clinical geneticists, and other health care providers. The definitions are part of the series Elements of Morphology and have been established after careful discussions within an international group of experienced dentists and geneticists. The classification...
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Objectives Increased intracranial pressure (ICP) in neonates and infants is a severe disease state that requires adequate diagnosis and, depending on the clinical situation and whether it is increasing, a rapid and efficient therapy. Clinical evaluation, B-mode ultrasound, and Doppler ultrasound give rise to a basic noninvasive diagnosis of increased ICP. The purpose of this prospective study was 2-fold: first, to analyze the technical feasibility of obtaining shear wave elastography (SWE) measurements...
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Oticon introduced new power hearing aids for children and adults, and a new CROS/BiCROS hearing solution, which is part of the Oticon Velox S™ family of hearing solutions. The new Oticon Xceed gives adults with severe-to-profound hearing loss 360° access to more speech than ever before. Oticon Xceed Play enables children with severe-to-profound hearing loss to enjoy the open sound experience and provides access to clear speech. A third new hearing solution, Oticon CROS, is the world's first CROS/BiCROS...
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Variation in the fusion sequence of primary and secondary ossification centers in the human skeleton
Abstract Objectives One of the biggest challenges for biological anthropologists is determining the minimum number of individuals in commingled skeletal samples in forensic or bioarcheological contexts. The fusion sequence of primary and secondary ossification centers is a promising, yet under‐explored, process to improve identification of associated remains of subadults and young adults, but is limited by the lack of understanding of population variation in this aspect of human development....
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Abstract Background We investigated the impact of level I lymph node involvement (LNI) on survival for patients with oropharyngeal squamous cell carcinoma (OPSCC). Methods We performed a cohort study of patients with OPSCC who underwent resection with known human papillomavirus (HPV) status in the National Cancer Database (2010‐2014). Results Among 5591 patients with OPSCC, 599 (10.7%) had level I LNI. Predictors of level I LNI included pT classification (pT3 vs pT1; odds ratio [OR],...
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The most common sites of IgG4-related ocular disease are the lacrimal glands, infraorbital nerve, and extraocular muscles. Other ocular adnexal sites are relatively rare. We report a rare case of an 83-year-old man who developed palpebral conjunctivitis following bilateral hypertrophic ectropion of the eyelid. Tissue immunostaining revealed many IgG4-positive plasma cells (67 IgG4/74 IgG cells/high-power field). The serum IgG4 level was 76.9 mg/dL, which was within the normal range. The diagnosis...
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Background Neuropeptides exert their activity through binding to G protein-coupled receptors (GPCRs). GPCRs are well-known drug targets in the pharmaceutical industry and are currently discussed as targets to control pest insects. Here, we investigate the neuropeptide adipokinetic hormone (AKH) system of the desert locust Schistocerca gregaria. The desert locust is known for its high reproduction, and for forming devastating swarms consisting of billions of individual insects. It is also known...
Jerusalem artichoke (Helianthus tuberosus L.) is widely cultivated in Northwest China, and it has become an emerging economic crop that is rapidly developing. Because of its elevated inulin content and high resistance, it is widely used in functional food, inulin processing, feed, and ecological management. In this study, Illumina sequencing technology was utilized to assemble and annotate the complete chloroplast genome sequences of Jerusalem artichoke. The total length was 151,431 bp, including...
The Brazilian-endemic greenbeack parrotfish, Scarus trispinosus Valenciennes, 1840, is the largest herbivorous reef fish in the South Atlantic. Following the sharp decline of large carnivorous reef fishes, parrotfishes (Labridae: Scarinae) were progressively targeted by commercial fisheries in Brazil, resulting in a global population decline of 50% for S. trispinosus. Most of its remnant population is concentrated in the Abrolhos Bank, where the present study was conducted. We present novel information...
Aim Historically, the distribution of Sandhill Cranes included much of North America and extending in summer into northeast Russia. In recent years, observations of sandhill cranes in Asia during the non-breeding period have been frequently reported. However, the distribution and abundance of sandhill cranes during the non-breeding period in Asia have rarely been summarized and studied. Our study aimed to analyze the status of sandhill cranes that have spread south into East Asia...
The end-Permian mass extinction (∼252 Ma) was responsible for high rates of extinction and evolutionary bottlenecks in a number of animal groups. Echinoids, or sea urchins, were no exception, and the Permian to Triassic represents one of the most significant intervals of time in their macroevolutionary history. The extinction event was responsible for significant turnover, with the Permian–Triassic representing the transition from stem group echinoid-dominated faunas in the Palaeozoic to Mesozoic...
Background Fledglings of many mature forest-dependent Neotropical songbirds move from mature forest habitats into areas of thick vegetation such as regenerating clearcuts. The Cerulean Warbler (Setophaga cerulea), a Neotropical migratory songbird, is a species of conservation concern across its range and it is listed as endangered in Indiana. This species has declined faster than any other species of wood-warbler in North America. Most prior research on Cerulean Warblers has examined...
Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets. Several studies provided functional and structural data about human serpins. By comparison, only little knowledge regarding bacterial serpins exists. Through the emergence of metagenomic studies, many bacterial serpins were identified from numerous ecological niches including...
The arrival of large masses of drifting Sargassum since 2011 has caused changes in the natural dynamics of Caribbean coastal ecosystems. In the summer of 2015, unprecedented and massive mats of S. fluitans and S. natans have been observed throughout the Mexican Caribbean including exceptional accumulations ashore. This study uses stable isotopes to assess the impact of Sargassum blooms on the trophic dynamics of the Diadema antillarum sea urchin, a keystone herbivore on many Caribbean reefs. Bayesian...
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Abstract Chicken fat and fructose are added into food-processing to reduce costs and enhance acceptability; however, these additives turn food into unhealthy and hypercaloric meals. Herein we have hypothesized that chronic feeding with chicken fat and fructose, together or by separate, can cause pulmonary redox and inflammatory changes. These changes are particularly related to neutrophils and myeloperoxidase, with consequent changes...
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