• Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation—A Systematic Review

  To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper airways (UA). Recently, topical administration of ectoine has just been recognized as adjuvant treatment in the Allergic Rhinitis (AR) and Rhinosinusitis (ARS). The aim of this work is to review the published literature regarding all the potential therapeutic effects of ectoine in the acute and chronic inflammatory dise

  BioMed Research International

  Mon Aug 26, 2019 02:05
• Albicidin, a potent DNA gyrase inhibitor with clinical potential

  The Journal of Antibiotics - Issue - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Structurally diverse metabolites from the rare actinobacterium <i>Saccharothrix xinjiangensis</i>

  The Journal of Antibiotics - Issue - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Έμφραγμα: Ποια εποχή είναι συχνότερο και γιατί

  Οι περιοχές με αυξημένη ατμοσφαιρική ρύπανση έχουν υψηλότερα ποσοστά αγγειοπλαστικής, της θεραπευτικής δηλαδή πρακτικής για την απόφραξη των αρτηριών λόγω αθηροσκλήρωσης, συγκριτικά με περιοχές που δεν υποφέρουν από ρύπανση. Επίσης, η αγγειοπλαστική είναι συχνότερη τον χειμώνα, συγκριτικά με άλλες εποχές του έτους, σύμφωνα με πολωνική μελέτη που παρουσιάζεται στο ετήσιο Ευρωπαϊκό Συνέδριο Καρδιολογίας στο Παρίσι. Η αθηροσκλήρωση θεωρείται παράγο

  Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία

  Sun Aug 25, 2019 23:10
• Common genetic variations of deiodinase genes and prognosis of brain tumor patients

  Abstract Background Thyroid hormone (TH) metabolism can have prognostic significance in brain tumors. We studied the association of common variations in three deiodinase gene single-nucleotide polymorphisms (SNPs) with circulating TH concentrations and prognosis of brain tumor patients. Methods Patients a

  International journal of basic and clinical endocrinology

  Sun Aug 25, 2019 17:00
• Radiotherapy after skin-sparing mastectomy with immediate breast reconstruction in intermediate-risk breast cancer

  Abstract Background Skin-sparing (SSME) and nipple-sparing mastectomy (NSME) were developed to improve the cosmetic results for breast cancer (BC) patients, both allowing for immediate breast reconstruction. Recommendations for post-mastectomy radiotherapy (PMRT) are primarily derived from trials where patients were treated by standard mastectomies. Due to their more conservative chara

  Strahlentherapie und Onkologie

  Sun Aug 25, 2019 17:00
• Assortative mating in hybrid zones is remarkably ineffective in promoting speciation [NEW RESULTS]

  Assortative mating and other forms of partial prezygotic isolation are often viewed as being more important than partial postzygotic isolation (low fitness of hybrids) early in the process of speciation. Here I simulate secondary contact between two populations ( species) to examine effects of pre- and postzygotic isolation in preventing blending. A small reduction in hybrid fitness (e.g., 10%) produces a narrower hybrid zone than a strong but im

  bioRxiv Subject Collection: Evolutionary Biology

  Sun Aug 25, 2019 17:00
• Inhibitory protein puts a lid on an epigenetic marker

  Nature - Issue - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Lithium: the gripping history of a psychiatric success story

  Nature - Issue - nature.com science feeds

  Sun Aug 25, 2019 17:00
• A conserved regulatory program initiates lateral plate mesoderm emergence across chordates

  Nature Communications - current - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Carbon dioxide electroreduction to C₂ products over copper-cuprous oxide derived from electrosynthesized copper complex

  Nature Communications - current - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria

  Nature Communications - current - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Quantum localization and delocalization of charge carriers in organic semiconducting crystals

  Nature Communications - current - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Author Correction: The role of energy storage in deep decarbonization of electricity production

  Nature Communications - current - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences

  Nature Communications - current - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Profiling surface proteins on individual exosomes using a proximity barcoding assay

  Nature Communications - current - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Fermi level-tuned optics of graphene for attocoulomb-scale quantification of electron transfer at single gold nanoparticles

  Nature Communications - current - nature.com science feeds

  Sun Aug 25, 2019 17:00
• Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis

  Abstract Objective To define the impact of hyperlipidemia as a coexisting factor on the prognosis of Idiopathic Sudden sensorineural hearing loss (ISSHL), we prospectively analyzed the Lipid‐lowering therapy Group (LLTG) data compared with Control Group (CG) data to determine the effects of Lipid intervention on the prognosis of sudden hearing loss. Design A prospective, non‐randomized study. Main outcome measures From January 201

  Wiley: Clinical Otolaryngology: Table of Contents

  Mon Aug 26, 2019 02:04
• SerenoCemTM Granules in mastoid obliteration surgery: a 2 year follow up case series of 55 patients to determine the risk of progressive bone resorption

  Abstract SerenoCemTM granules (Corinthian Medical Ltd, Nottingham, UK) are a pre‐set version of SerenoCemTM ionomeric cement, which is a bone‐bonding and bioactive material marketed since 1999; and have been used in mastoid obliteration surgery. Our previous work had revealed a propensity for the granules to cause resorption of bone adjacent to the site of implantation,[1] leading to the Medicines and Healthcare products Regulatory Agency (MHRA)

  Wiley: Clinical Otolaryngology: Table of Contents

  Sun Aug 25, 2019 03:08
• Development and accuracy of an artificial intelligence algorithm for acne grading from smartphone photographs

  Abstract We developed an artificial intelligence algorithm (AIA) for smartphones to determine the severity of facial acne using the GEA scale and to identify different types of acne lesion (comedonal, inflammatory) as well as post‐inflammatory hyperpigmentation (PIHP) or residual hyperpigmentation. Overall, 5972 images (face, right and left profiles) obtained with smartphones (IOS and/or Android) from 1072 acne patients were collected. Three tr

  Experimental Dermatology

  Sun Aug 25, 2019 02:18
• The activating p.Ser466Arg change in STAT1 causes a peculiar phenotype with features of interferonopathies

  ABSTRACT STAT1 is a DNA‐binding signal transducer that regulates transcription of specific genes in response to IFNγ and IFNα/β stimulation. Loss‐of‐function mutations impairing STAT1 activity are known to confer susceptibility to intracellular bacterial and viral diseases. Conversely, the few known activating mutations of STAT1 allow predisposition to chronic mucocutaneous candidiasis disease (CMCD)

  Clinical Genetics

  Sun Aug 25, 2019 10:54
• The Genome Empowerment Scale (GEmS): An Assessment of Parental Empowerment in Families with Undiagnosed Disease

  Abstract While genomic sequencing (ES/GS) has the potential to diagnose children with difficult to diagnose phenotypes, the goal should be not only a diagnosis, but also to empower parents to seek next steps for their children and to emotionally manage the outcome, whether or not a diagnosis is secured. To help achieve this goal, objective measures are needed to assess the process of parental empowerment related to genome sequencing.

  Clinical Genetics

  Sun Aug 25, 2019 09:03
• Precapillary pulmonary gas exchange is similar for oxygen and inert gases

  Key points Precapillary gas exchange for oxygen has been documented in both humans and animals. It has been suggested that, if precapillary gas exchange occurs to a greater extent for inert gases than for oxygen, shunt and its effects on arterial oxygenation may be underestimated by the multiple inert gas elimination technique (MIGET). We evaluated fractional precapillary gas exchange in canines for O2 and two inert gases, sulphur hexafluori

  The Journal of Physiology

  Sun Aug 25, 2019 07:13
• Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis

  Abstract Objective To define the impact of hyperlipidemia as a coexisting factor on the prognosis of Idiopathic Sudden sensorineural hearing loss (ISSHL), we prospectively analyzed the Lipid‐lowering therapy Group (LLTG) data compared with Control Group (CG) data to determine the effects of Lipid intervention on the prognosis of sudden hearing loss. Design A prospective, non‐randomized study. Main outcome measures From January 201

  Clinical Otolaryngology

  Mon Aug 26, 2019 01:23
• SerenoCemTM Granules in mastoid obliteration surgery: a 2 year follow up case series of 55 patients to determine the risk of progressive bone resorption

  Abstract SerenoCemTM granules (Corinthian Medical Ltd, Nottingham, UK) are a pre‐set version of SerenoCemTM ionomeric cement, which is a bone‐bonding and bioactive material marketed since 1999; and have been used in mastoid obliteration surgery. Our previous work had revealed a propensity for the granules to cause resorption of bone adjacent to the site of implantation,[1] leading to the Medicines and Healthcare products Regulatory Agency (MHRA)

  Clinical Otolaryngology

  Sun Aug 25, 2019 03:08
• SHR‐A1403, a novel c‐Met antibody‐drug conjugate, overcomes AZD9291 resistance in NSCLC cells overexpressing c‐Met

  Abstract EGFR tyrosine kinase inhibitors (TKIs) have been used as the first‐line treatment of non‐small cell lung cancers (NSCLCs) harboring EGFR‐activating mutations, while acquired resistance is ubiquitous and needs to be solved urgently. Here, we introduce an effective approach for overcoming resistance to the EGFR‐TKI, AZD9291, in NSCLC cells using SHR‐A1403, a novel c‐Met‐targeting antibody‐drug conjugate (ADC) consisting of an anti‐c‐Met m

  Cancer Science

  Sun Aug 25, 2019 04:43
• Cell-free supernatants from cultures of lactic acid bacteria isolated from fermented grape as biocontrol against Salmonella Typhi and Salmonella Typhimurium virulence via autoinducer-2 and biofilm interference

  Background Salmonella Typhi and Salmonella Typhimurium are the causative pathogens of salmonellosis, and they are mostly found in animal source foods (ASF). The inappropriate use of antibiotics enhances the possibility for the emergence of antibiotic resistance in pathogens and antibiotic residue in ASF. One promising alternative to antibiotics in animal farming is the use of lactic acid bacteria (LAB).

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• Filter feeding in Late Jurassic pterosaurs supported by coprolite contents

  Diets of pterosaurs have mainly been inferred from indirect evidence such as comparative anatomy, associations of co-occurring fossils, and functional morphology. Gut contents are rare, and until now there is only a single coprolite (fossil dropping), with unidentified inclusions, known. Here we describe three coprolites collected from a palaeosurface with numerous pterosaur tracks found in early Kimmeridgian (Hypselocyclum Zone) intertidal depo

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• The RIPper, a web-based tool for genome-wide quantification of Repeat-Induced Point (RIP) mutations

  Background The RIPper (http://theripper.hawk.rocks) is a set of web-based tools designed for analyses of Repeat-Induced Point (RIP) mutations in the genome sequences of Ascomycota. The RIP pathway is a fungal genome defense mechanism that is aimed at identifying repeated and duplicated motifs, into which it then introduces cytosine to thymine transition mutations. RIP thus serves to deactivate and counteract the deleterious cons

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• A rare case of sinonasal glomangiopericytoma post operative accidental diagnosis and managment-A...

  A rare case of sinonasal glomangiopericytoma post operative accidental diagnosis and managment-A case report.Related ArticlesA rare case of sinonasal glomangiopericytoma post operative accidental diagnosis and managment-A case report. Int J Surg Case Rep. 2019 Aug 09;62:54-57 Authors: Sharma N, Mandlik D, Patel P, Patel P, Joshipura A, Patel M, Mankiwala S, Vatsyayan A, Dubey T, Sanghvi K, Shah D, Kanhere S, Talati S, Patel K Abstract INTRODUCTI

  Αλέξανδρος Γ. Σφακιανάκης

  Mon Aug 26, 2019 23:48
• Bridging the TB data gap: in silico extraction of rifampicin-resistant tuberculosis diagnostic test results from whole genome sequence data

  Background Mycobacterium tuberculosis rapid diagnostic tests (RDTs) are widely employed in routine laboratories and national surveys for detection of rifampicin-resistant (RR)-TB. However, as next-generation sequencing technologies have become more commonplace in research and surveillance programs, RDTs are being increasingly complemented by whole genome sequencing (WGS). While comparison between RDTs is difficult, all RDT results can be deriv

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• Profiling the lncRNA-miRNA-mRNA ceRNA network to reveal potential crosstalk between inflammatory bowel disease and colorectal cancer

  Background Because of the increasing dysplasia rate in the lifelong course of inflammatory bowel disease (IBD) patients, it is imperative to characterize the crosstalk between IBD and colorectal cancer (CRC). However, there have been no reports revealing the occurrence of the ceRNA network in IBD-related CRC. Methods In this study, we conducted gene expression profile stu

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• Three new species, one new genus and subfamily of Dorylaimida (de Man, 1876) Pearse, 1942, and revisions on the families Tylencholaimellidae Jairajpuri, 1964 and Mydonomidae Thorne, 1964 (Nematoda: Dorylaimida)

  Three new species of the order Dorylaimida (de Man, 1876) Pearse, 1942 were identified and described. Paratylencholaimus sanshaensis gen. nov. sp. nov. from Hainan is proposed as a new member of the family Tylencholaimellidae Jairajpuri, 1964. Paratylencholaimus gen. nov. is close to Phellonema Thorne, 1964 and Goferus Jairajpuri & Ahmad, 1992 but can be differentiated mainly by having basal part of odontophore rod-like and without knobs, an

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• Effectiveness of small road tunnels and fences in reducing amphibian roadkill and barrier effects at retrofitted roads in Sweden

  Schemes to reduce road impacts on amphibians have been implemented for decades in Europe, yet, several aspects on the effectiveness of such schemes remain poorly understood. Particularly in northern Europe, including Sweden, there is a lack of available information on road mitigation for amphibians, which is hampering implementation progress and cost-effectiveness analyses of mitigation options. Here, we present data derived from systematic coun

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus

  Background To investigate whether SUA is associated with NAFLD in men and women with T2DM. Methods This cross-sectional study enrolled patients with T2DM at Shanxi High-Tech Development Zone Central Hospital (June 2011 to September 2017). Patients were stratified according to gender and presence/absence of NAFLD. Parameters associated with NAFLD were identified usin

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• Detecting the impact of land cover change on observed rainfall

  Analysis of observational data to pinpoint impact of land cover change on local rainfall is difficult due to multiple environmental factors that cannot be strictly controlled. In this study we use a statistical approach to identify the relationship between removal of tree cover and rainfall with data from best available sources for two large areas in Australia. Gridded rainfall data between 1979 and 2015 was used for the areas, while large scale

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• The association between evidence of a predator threat and responsiveness to alarm calls in Western Australian magpies (Cracticus tibicen dorsalis)

  Alarm calls are a widespread form of antipredator defence and being alerted to the presence of predators by the alarm calls of conspecifics is considered one of the benefits of group living. However, while social information can allow an individual to gain additional information, it can also at times be inaccurate or irrelevant. Such variation in the accuracy of social information is predicted to select for receivers to discriminate between sour

  PeerJ Computer Science

  Sun Aug 25, 2019 17:00
• Intrinsic Self‐Trapped Emission in 0D Lead‐Free (C4H14N2)2In2Br10 Single Crystal

  Low‐dimensional lead halide perovskite materials recently have drawn much attention owing to the intriguing broadband emissions, however, the toxicity of lead will hinder their future development. Herein we report a novel lead‐free (C 4 H 14 N 2 ) 2 In 2 Br 10 single crystal with a unique zero‐dimensional (0D) structure constituted by [InBr 6 ] 3‐ octahedral and [InBr 4 ] ‐ tetrahedral units. The single crystal exhibits broadb

  Angewandte Chemie International Edition

  Sun Aug 25, 2019 07:09
• Ρευματοειδής Αρθρίτιδα: Αυτά τα φάρμακα αυξάνουν τον κίνδυνο

  Μια νέα μελέτη που δημοσιεύθηκε στο BMC Medicine παρέχει επαρκή στοιχεία ότι η χρήση αντιβιοτικών σχετίζεται με αυξημένο κίνδυνο εκδήλωσης ρευματοειδούς αρθρίτιδας. Ερευνητές του Πανεπιστημίου Keele και του Ινστιτούτου Quadram, στην Αγγλία, ανέλυσαν στοιχεία από ιατρικά αρχεία πρωτοβάθμιας φροντίδας και παρατήρησαν ότι οι πιθανότητες εκδήλωσης ρευματοειδούς αρθρίτιδας ήταν 60% υψηλότερες στα άτομα που είχαν εκτεθεί σε αντιβιοτικά, συγκριτικά με

  Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία

  Sun Aug 25, 2019 22:15
• Καρκίνος: Το εμβόλιο που προλαμβάνει το 92% των κρουσμάτων

  Το 92% των καρκίνων που οφείλονται στον ιό των ανθρώπινων θηλωμάτων (HPV) θεωρείται ότι θα μπορούσε να αποφευχθεί μέσω του εμβολιασμού, σύμφωνα με το Κέντρο Ελέγχου και Πρόληψης Νοσημάτων (CDC) των ΗΠΑ, αναγάγοντας σε ζήτημα προτεραιότητας την προώθηση της ανοσοποίησης. Ο ιός των ανθρώπινων θηλωμάτων ευθυνόταν κατά μέσο όρο για 34.800 περιστατικά καρκίνου ετησίως μεταξύ 2012 και 2016, όπως υποστηρίζει η νέα μελέτη του CDC στην οποία τονίζεται ότ

  Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία

  Sun Aug 25, 2019 22:04
• Supervision: Walking Alongside AuD Students

  The educational journey an AuD student walks through is more than the didactic or clinical rotation exercise. If approached with creative forethought, the educational experience can encompass multiple opportunities for the student to exercise and grow positive personality traits leading to future leadership in audiology.

  Audiology

  Sun Aug 25, 2019 21:00
• The Power of the Demo: An Innovative Field Study Offers a New Perspective

  Hearing care professionals can gain valuable insights to what their patients’ initial listening experiences might be like simply by listening to the hearing aids. In a novel experiment designed to put Hearing Care Professionals in the shoes of their patients and to illustrate how sound quality can positively color the initial experience trying hearing aids, ReSound field representatives were trained to demo ReSound LiNX Quattro hearing aid

  Audiology

  Sun Aug 25, 2019 21:00
• A neurophysiological investigation of anticipation to pain in Parkinson's disease

  Abstract Chronic pain is common in people with Parkinson's disease, and is often considered to be caused by the motor impairments associated with the disease. Altered top‐down processing of pain characterises several chronic pain conditions and occurs when the cortex modifies nociceptive processing in the brain and spinal cord. This contrasts with bottom‐up modulation of pain whereby nociceptive processing is modified on its way up to the brain.

  European Journal of Neuroscience

  Sun Aug 25, 2019 03:12
• Use of the Er,Cr:YSGG laser for removing remnant adhesive from the enamel surface in rebonding of orthodontic brackets

  Abstract The aim of this study was to compare the use of the Er,Cr:YSGG laser with the use of adhesive-removing pliers for removing remnant adhesive from the enamel surface. A total of 54 sound premolars were divided into two groups of 27. Each group was assigned one of two adhesive removal systems: the Er,Cr:YSGG laser, and adhesive-removing pliers. Shear bond strength was measured 24 h after bracket bonding, with the bracket

  Odontology

  Sun Aug 25, 2019 17:00
• Cancers, Vol. 11, Pages 1246: A Multi-Center Study of BRCA1 and BRCA2 Germline Mutations in Mexican-Mestizo Breast Cancer Families Reveals Mutations Unreported in Latin American Population

  Cancers, Vol. 11, Pages 1246: A Multi-Center Study of BRCA1 and BRCA2 Germline Mutations in Mexican-Mestizo Breast Cancer Families Reveals Mutations Unreported in Latin American Population Cancers doi: 10.3390/cancers11091246 Authors: Oliver Millan Catalan Alma D. Campos-Parra Rafael Vázquez-Romo David Cantú de León Nadia Jacobo-Herrera Fermín Morales-González César López-Camarillo Mauricio Rodríguez-Dorantes Eduard

  Cancers

  Sun Aug 25, 2019 17:00