Publication date: Available online 28 August 2019Source: Radiotherapy and OncologyAuthor(s): Laura Toussaint, Daniel J. Indelicato, Ludvig P. Muren, Zuofeng Li, Yasmin Lassen-Ramshad, Kevin Kirby, Catia Pedro, Ronni Mikkelsen, Marcos Di Pinto, Morten Høyer, Camilla H. StokkevågAbstractBackground and purposeReducing radiation exposure to the temporal lobes could be beneficial to preserve cognitive function in paediatric brain tumour patients. The distribution of doses to brain substructures associated...
Thu Aug 29, 2019 18:42
Publication date: Available online 28 August 2019Source: Radiotherapy and OncologyAuthor(s): Angela Davey, Marcel van Herk, Corinne Faivre-Finn, Hitesh Mistry, Alan McWilliamAbstractBackground and purposeQuantitative tumour shape features extracted from radiotherapy planning scans have shown potential as prognostic markers. In this study, we investigated if sphericity of the gross tumour volume (GTV) on planning computed tomography (CT) is an independent predictor of overall survival (OS) in lung...
Thu Aug 29, 2019 18:42
Publication date: Available online 28 August 2019Source: Clinical TherapeuticsAuthor(s): Richard I. Shader
Thu Aug 29, 2019 18:21
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Xin Chen, Xiao-Feng Li, Yu Chen, Sai Zhu, Hai-Di Li, Si-Yu Chen, Jia-Nan Wang, Xue-Yin Pan, Fang-Tian Bu, Cheng Huang, Jun LiAbstractHepatic fibrosis, a common pathological feature and leading cause of various chronic liver diseases, still lacks effective therapy. Hesperetin derivative (HD) is a derivative of Traditional Chinese Medicine monomer isolated from the fruit peel of Citrusaurantium L. (Rutaceae)....
Thu Aug 29, 2019 14:22
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Jingnan Wang, Ruiru Li, Haobo Lin, Qian Qiu, Minxi Lao, Shan Zeng, Cuicui Wang, Siqi Xu, Yaoyao Zou, Maohua Shi, Liuqin Liang, Hanshi Xu, Youjun XiaoAbstractThe accumulation of cytosolic dsDNA plays important roles in the regulation of cellular processes. However, whether cytosolic dsDNA is involved in the pathogenesis of rheumatoid arthritis (RA) is not clear. Therefore, the present study investigated the...
Thu Aug 29, 2019 14:22
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Junling Gu, Wei Huang, Wenqian Zhang, Tingting Zhao, Chenlin Gao, Wenjun Gan, Mingyue Rao, Qing Chen, Man Guo, Yong Xu, You-Hua XuAbstractWe recently found that Sodium butyrate (NaB) possesses anti-inflammatory effects in diabetic nephropathy (DN) mouse model and in high-glucose induced mouse glomerular mesangial cells. Pyroptosis is a programmed cell death accompanied with the release of pro-inflammatory...
Thu Aug 29, 2019 14:22
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Tian Tang, Zhu-Ya Xiao, Guang Shan, Hong-Bo LeiAbstractLaryngeal squamous cell carcinoma (LSCC) is the major type of laryngeal carcinoma. SHIP2 plays a critical role in malignant tumors and is associated with activation of PI3K/Akt signaling pathway. Here, we aimed to explore the impacts of SHIP2 on LSCC Hep-2 cells and the relationship between SHIP2 and radiotherapy. SHIP2 knockdown impairs cell proliferation,...
Thu Aug 29, 2019 13:39
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Daliang Kong, Boda Ying, Jinrui Zhang, Hongliang YingAbstractBackgroundOsteosarcoma is one of malignant cancer. Histone phosphorylation is common in tumors. We explored the effects of p300-CBP-associated factor (PCAF) and phosphorylation of H3S28 in osteosarcoma cancer cell autophagy.MethodsOsteosarcoma cancer cell lines were collected and/or transfected with full length PCAF or interference miRNAs to mimic...
Thu Aug 29, 2019 13:39
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Chunbao Zang, Fangfang Zhao, Youguang PuAbstractObjectivesEsophageal cancer (EC) is one of the most difficult malignancies to cure. The radioresistance remains a major obstacle for effective treatment of EC.MethodsEsophageal cancer radioresistant cell lines were screened by the cumulative dose of radiation assays. qRT-PCR and Western blotting assays were used to detect the expression of LMXIB in EC. The...
Thu Aug 29, 2019 13:39
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Abdul Khalid Siraj, Rafia Begum, Roxanne Melosantos, Wafaa Albalawy, Jehan Abboud, Nabil Siraj, Khawla S. Al-KurayaAbstractBackgroundMany Muslims believe that water from the Zamzam well is the cure for every disease. Zamzam water (ZW) is naturally alkaline water consumed by millions of people worldwide. The current study investigated the effect of ZW on cell viability and apoptosis in breast, colorectal...
Thu Aug 29, 2019 13:39
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Guijun Zhang, Qinqin Wang, Xiaojuan Zhang, Zhaoyan Ding, Ronggui LiuAbstractTo explore the roles of long noncoding RNA (lncRNA) FOXF1 Adjacent Non-Coding Developmental Regulatory RNA (FENDRR) in human non-small cell lung cancer (NSCLC). The levels of FENDRR in NSCLC cells and tissues were analyzed using qRT-PCR assay. The growth and colony formation abilities of NSCLC cell were analyzed by the MTT and colony...
Thu Aug 29, 2019 13:39
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Hai-Yan Wang, Jin-Ge Zhao, Zheng-Guo Wei, Yu-Qing ZhangAbstractBackgroundDiabetic nephropathy (DN) is one of the major complications of diabetes. Sericin and flavonoids are two bioactive substances which have been demonstrated to have some therapeutical effect on diabetic nephropathy. The aim of this paper is to investigate the effect of ethanolic extract (EE) rich in quercetin and kaempferol and their glucosides...
Thu Aug 29, 2019 13:39
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xianbin Liu, Yikun Yang, Cong Xu, Hongli Yang, Shuangfeng Chen, Haiying ChenAbtractBackgroundZinc-finger protein 750 (ZNF750) is a potential tumor suppressor in oral squamous cell carcinoma (OSCC). However, the molecular mechanisms underlying its anti-tumor effect remain elusive in OSCC. This study aimed to elucidate the genes and pathways involved in tumor suppression following the ZNF750 over-expression...
Thu Aug 29, 2019 13:39
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