IJMS, Vol. 20, Pages 4150: Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies International Journal of Molecular Sciences doi: 10.3390/ijms20174150 Authors: Dina C. Simes Carla S. B. Viegas Nuna Araújo Catarina Marreiros Vitamin K is a multifunctional micronutrient implicated in age-related diseases such as cardiovascular diseases, osteoarthritis and osteoporosis. Although vitamin K-dependent proteins (VKDPs) are described...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4149: Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment
IJMS, Vol. 20, Pages 4149: Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment International Journal of Molecular Sciences doi: 10.3390/ijms20174149 Authors: Vo Van Giau Eva Bagyinszky Seong Soo A. An Mild cognitive impairment (MCI) is characterized by a level of cognitive impairment that is lower than normal for a person’s age, but a higher function than that that observed in a demented person. MCI represents a transitional state between normal...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4152: Diagnostic and Prognostic Role of Blood and Cerebrospinal Fluid and Blood Neurofilaments in Amyotrophic Lateral Sclerosis: A Review of the Literature International Journal of Molecular Sciences doi: 10.3390/ijms20174152 Authors: Delia Gagliardi Megi Meneri Domenica Saccomanno Nereo Bresolin Giacomo Pietro Comi Stefania Corti Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting upper and lower motor neurons (MNs)...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4148: Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity International Journal of Molecular Sciences doi: 10.3390/ijms20174148 Authors: Toshiaki Matsui Endang Nuryadi Shuichiro Komatsu Yuka Hirota Atsushi Shibata Takahiro Oike Takashi Nakano Photon radiation therapy is a major curative treatment for cancer. However, the lack of robust predictive biomarkers for radiosensitivity precludes personalized radiation therapy....
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4147: Radical Stress Is More Cytotoxic in the Nucleus than in Other Organelles International Journal of Molecular Sciences doi: 10.3390/ijms20174147 Authors: Laurent M. Paardekooper Ellen van Vroonhoven Martin ter Beest Geert van den Bogaart Cells are exposed to reactive oxygen species (ROS) as a by-product of mitochondrial metabolism, especially under hypoxia. ROS are also enzymatically generated at the plasma membrane during inflammation. Radicals cause...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4146: Oral Bacteria and Intestinal Dysbiosis in Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20174146 Authors: Ioannis Koliarakis Ippokratis Messaritakis Taxiarchis Konstantinos Nikolouzakis George Hamilos John Souglakos John Tsiaoussis The human organism coexists with its microbiota in a symbiotic relationship. These polymicrobial communities are involved in many crucial functions, such as immunity, protection against...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4145: The Clinical Link between Human Intestinal Microbiota and Systemic Cancer Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20174145 Authors: Romy Aarnoutse Janine Ziemons John Penders Sander S. Rensen Judith de Vos-Geelen Marjolein L. Smidt Clinical interest in the human intestinal microbiota has increased considerably. However, an overview of clinical studies investigating the link between the human intestinal microbiota...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4144: Cytosolic Copper Binding by a Bacterial Storage Protein and Interplay with Copper Efflux International Journal of Molecular Sciences doi: 10.3390/ijms20174144 Authors: Jaeick Lee Christopher Dennison Escherichia coli has a well-characterized copper (Cu) transporting ATPase (CopA) that removes this potentially toxic metal ion from the cytosol. Growth of the strain lacking CopA (ΔcopA) is inhibited above 0.5 mM Cu, whilst a similar effect does not...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4142: Molecular-Level Interactions between Engineered Materials and Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174142 Authors: Yoon-ha Jang Xuelin Jin Prabakaran Shankar Jung Heon Lee Kyubong Jo Kwang-il Lim Various recent experimental observations indicate that growing cells on engineered materials can alter their physiology, function, and fate. This finding suggests that better molecular-level understanding of the interactions...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4143: Nuclear Disposition of Alien Chromosome Introgressions into Wheat and Rye Using 3D-FISH International Journal of Molecular Sciences doi: 10.3390/ijms20174143 Authors: Veronika Koláčková Kateřina Perničková Jan Vrána Martin Duchoslav Glyn Jenkins Dylan Phillips Edina Turkosi Olga Šamajová Michaela Sedlářová Jozef Šamaj Jaroslav Doležel David Kopecký During interphase, the chromosomes of eukaryotes decondense and they occupy distinct...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4140: Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity International Journal of Molecular Sciences doi: 10.3390/ijms20174140 Authors: Yuki Narita Kana Hamamura Mami Kashiyama Sara Utsumi Yutaka Kakizoe Yuki Kondo Yoichi Ishitsuka Hirofumi Jono Tetsumi Irie Masashi Mukoyama Hideyuki Saito Daisuke Kadowaki Sumio Hirata Kenichiro Kitamura The interplay between oxidative stress, inflammation,...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4139: Development of Substrate Degradation Enzyme Therapy for Mucopolysaccharidosis IVA Murine Model International Journal of Molecular Sciences doi: 10.3390/ijms20174139 Authors: Kazuki Sawamoto Shunji Tomatsu Mucopolysaccharidosis IVA (MPS IVA) is caused by a deficiency of the lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS). Conventional enzyme replacement therapy (ERT) is approved for MPS IVA. However, the fact that the infused enzyme cannot...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4141: PtrARF2.1 Is Involved in Regulation of Leaf Development and Lignin Biosynthesis in Poplar Trees International Journal of Molecular Sciences doi: 10.3390/ijms20174141 Authors: Yongyao Fu Papa Win Huijuan Zhang Chaofeng Li Yun Shen Fu He Keming Luo Auxin response factors (ARFs) are important regulators modulating the expression of auxin-responsive genes in various biological processes in plants. In the Populus genome, a total of 39 ARF members...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4137: Mutual Enhancement of Opioid and Adrenergic Receptors by Combinations of Opioids and Adrenergic Ligands Is Reflected in Molecular Complementarity of Ligands: Drug Development Possibilities International Journal of Molecular Sciences doi: 10.3390/ijms20174137 Authors: Root-Bernstein Churchill Turke Subhramanyam Labahn Crosstalk between opioid and adrenergic receptors is well characterized and due to interactions between second messenger systems,...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4136: New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms20174136 Authors: Shang-Hung Chen Jang-Yang Chang Although cisplatin has been a pivotal chemotherapy drug in treating patients with various types of cancer for decades, drug resistance has been a major clinical impediment. In general, cisplatin exerts cytotoxic effects in tumor cells mainly through the generation...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4138: Phylogenetically Defined Isoforms of Listeria monocytogenes Invasion Factor InlB Differently Activate Intracellular Signaling Pathways and Interact with the Receptor gC1q-R International Journal of Molecular Sciences doi: 10.3390/ijms20174138 Authors: Chalenko Kalinin Marchenkov Sysolyatina Surin Sobyanin Ermolaeva The pathogenic Gram-positive bacterium Listeria monocytogenes has been evolving into a few phylogenetic lineages. Phylogenetically...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4134: Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis International Journal of Molecular Sciences doi: 10.3390/ijms20174134 Authors: Yeo Reum Jeon Hyun Roh Ji Hyuk Jung Hyo Min Ahn Ju Hee Lee Chae-Ok Yun Won Jai Lee Overabundance of extracellular matrix resulting from hyperproliferation of keloid fibroblasts (KFs)...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4132: Effect of Autophagy Regulated by Sirt1/FoxO1 Pathway on the Release of Factors Promoting Thrombosis from Vascular Endothelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174132 Authors: Qian Wu Yuting Hu Minrui Jiang Fanglei Wang Guoqing Gong Factors promoting thrombosis such as von Willebrand factor (vWF) and P-selectin are essential for the development of atherosclerosis (AS) and arterial thrombosis. The processing, maturation...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4135: Identification of Msp1-Induced Signaling Components in Rice Leaves by Integrated Proteomic and Phosphoproteomic Analysis International Journal of Molecular Sciences doi: 10.3390/ijms20174135 Authors: Ravi Gupta Cheol Woo Min Yu-Jin Kim Sun Tae Kim MSP1 is a Magnaporthe oryzae secreted protein that elicits defense responses in rice. However, the molecular mechanism of MSP1 action is largely elusive. Moreover, it is yet to be established whether MSP1...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4131: Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function International Journal of Molecular Sciences doi: 10.3390/ijms20174131 Authors: Julián Piñeiro Fernández Kimberly A. Luddy Cathal Harmon Cliona O’Farrelly The liver is a complex organ with critical physiological functions including metabolism, glucose storage, and drug detoxification. Its unique immune profile with large numbers of cytotoxic CD8+ T cells and significant innate...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4133: A Cell’s Fate: An Overview of the Molecular Biology and Genetics of Apoptosis International Journal of Molecular Sciences doi: 10.3390/ijms20174133 Authors: Giovanna C. Cavalcante Ana Paula Schaan Gleyce Fonseca Cabral Mayara Natália Santana-da-Silva Pablo Pinto Amanda F. Vidal Ândrea Ribeiro-dos-Santos Apoptosis is one of the main types of regulated cell death, a complex process that can be triggered by external or internal stimuli, which...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4130: Splicing Mutations Impairing CDKL5 Expression and Activity Can be Efficiently Rescued by U1snRNA-Based Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20174130 Authors: Dario Balestra Domenico Giorgio Matteo Bizzotto Maria Fazzari Bruria Ben Zeev Mirko Pinotti Nicoletta Landsberger Angelisa Frasca Mutations in the CDKL5 gene lead to an incurable rare neurological condition characterized by the onset of seizures in the...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4129: p53, miR-34a and EMP1—Newly Identified Targets of TFF3 Signaling in Y79 Retinoblastoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174129 Authors: Maike Busch Stefan Klein Jan Große-Kreul Oliver Scheiner Klaus Metz Harald Stephan Nicole Dünker Trefoil factor family peptide 3 (TFF3) is supposed to have tumor suppressive functions in retinoblastoma (RB), but the functional pathway is not completely understood. In the...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4127: Cortical Seizures in FoxG1+/− Mice are Accompanied by Akt/S6 Overactivation, Excitation/Inhibition Imbalance and Impaired Synaptic Transmission International Journal of Molecular Sciences doi: 10.3390/ijms20174127 Authors: Giovanna Testa Francesco Olimpico Laura Pancrazi Ugo Borello Antonino Cattaneo Matteo Caleo Mario Costa Marco Mainardi The correct morphofunctional shaping of the cerebral cortex requires a continuous interaction between...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4128: ZO-2 Is a Master Regulator of Gene Expression, Cell Proliferation, Cytoarchitecture, and Cell Size International Journal of Molecular Sciences doi: 10.3390/ijms20174128 Authors: Lorenza González-Mariscal Helios Gallego-Gutiérrez Laura González-González Christian Hernández-Guzmán ZO-2 is a cytoplasmic protein of tight junctions (TJs). Here, we describe ZO-2 involvement in the formation of the apical junctional complex during early development and in...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4126: Aggregation States of Aβ1–40, Aβ1–42 and Aβp3–42 Amyloid Beta Peptides: A SANS Study International Journal of Molecular Sciences doi: 10.3390/ijms20174126 Authors: Giulia Festa Francesco Mallamace Giulia Maria Sancesario Carmelo Corsaro Domenico Mallamace Enza Fazio Laura Arcidiacono Victoria Garcia Sakai Roberto Senesi Enrico Preziosi Giuseppe Sancesario Carla Andreani Aggregation states of amyloid beta peptides for amyloid...
Sat Aug 24, 2019 03:00
IJMS, Vol. 20, Pages 4124: Kainate Receptor-Mediated Depression of Glutamate Release Involves Protein Kinase A in the Cerebellum International Journal of Molecular Sciences doi: 10.3390/ijms20174124 Authors: Falcón-Moya Losada-Ruiz Rodríguez-Moreno Kainate (KA) receptors (KAR) have important modulatory roles of synaptic transmission. In the cerebellum, the action mechanisms of KAR-mediated glutamatergic depression are unknown. We studied these mechanisms by recording evoked...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4121: Probiotics for Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms20174121 Authors: Gazerani Parkinson’s disease (PD) is a complex neurological disorder classically characterized by impairments in motor system function associated with loss of dopaminergic neurons in the substantia nigra. After almost 200 years since the first description of PD by James Parkinson, unraveling the complexity of PD continues to evolve....
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4122: The Complex Phosphorylation Patterns that Regulate the Activity of Hsp70 and Its Cochaperones International Journal of Molecular Sciences doi: 10.3390/ijms20174122 Authors: Velasco Dublang Moro Muga Proteins must fold into their native structure and maintain it during their lifespan to display the desired activity. To ensure proper folding and stability, and avoid generation of misfolded conformations that can be potentially cytotoxic, cells synthesize...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4123: MicroRNA Signature in Human Normal and Tumoral Neural Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174123 Authors: Diana Gaido Murtas MicroRNAs, also called miRNAs or simply miR-, represent a unique class of non-coding RNAs that have gained exponential interest during recent years because of their determinant involvement in regulating the expression of several genes. Despite the increasing number of mature miRNAs recognized...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4125: Comprehensive Analysis of CRISPR/Cas9-Mediated Mutagenesis in Arabidopsis thaliana by Genome-wide Sequencing International Journal of Molecular Sciences doi: 10.3390/ijms20174125 Authors: Xu Fu Zhu Li Wang Wang Zhang Zhu The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) system has been widely applied in functional genomics research and plant breeding. In contrast to the off-target...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4119: Aberrant Methylation Status of Tumour Suppressor Genes in Ovarian Cancer Tissue and Paired Plasma Samples International Journal of Molecular Sciences doi: 10.3390/ijms20174119 Authors: Dana Dvorská Dušan Braný Bálint Nagy Marián Grendár Robert Poka Beáta Soltész Marianna Jagelková Katarína Zelinová Zora Lasabová Pavol Zubor Zuzana Danková Ovarian cancer is a highly heterogeneous disease and its formation is affected by many epidemiological...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4118: Modulation of Cardiovascular Function in Primary Hypertension in Rat by SKA-31, an Activator of KCa2.x and KCa3.1 Channels International Journal of Molecular Sciences doi: 10.3390/ijms20174118 Authors: Kloza Baranowska-Kuczko Toczek Kusaczuk Sadowska Kasacka Kozłowska The aim of this study was to investigate the hemodynamic effects of SKA-31, an activator of the small (KCa2.x) and intermediate (KCa3.1) conductance calcium-activated...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4120: Genome-Wide Analysis of the Growth-Regulating Factor Family in Peanut (Arachis hypogaea L.) International Journal of Molecular Sciences doi: 10.3390/ijms20174120 Authors: Kunkun Zhao Ke Li Longlong Ning Jialin He Xingli Ma Zhongfeng Li Xingguo Zhang Dongmei Yin Growth-regulating factors (GRFs) are plant-specific transcription factors that perform important functions in plant growth and development. Herein, we identified and characterised...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4117: Transcriptome Profiling Provides Insight into the Genes in Carotenoid Biosynthesis during the Mesocarp and Seed Developmental Stages of Avocado (Persea americana) International Journal of Molecular Sciences doi: 10.3390/ijms20174117 Authors: Yu Ge Zhihao Cheng Xiongyuan Si Weihong Ma Lin Tan Xiaoping Zang Bin Wu Zining Xu Nan Wang Zhaoxi Zhou Xinge Lin Xiangshu Dong Rulin Zhan Avocado (Persea americana Mill.) is an economically...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4114: The Acute Effects of Oral Administration of Phytic Acid-Chitosan-Magnetic Iron Oxide Nanoparticles in Mice International Journal of Molecular Sciences doi: 10.3390/ijms20174114 Authors: Norain Mohd Tamsir Norhaizan Mohd Esa Nurul Husna Shafie Mohd Zobir Hussein Hazilawati Hamzah Maizaton Atmadini Abdullah A nanocomposite, phytic acid-chitosan-magnetic iron oxide nanoparticles (IP6-CS-MNPs) has been used to treat colon cancer in vitro, previously....
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4115: Identification and in Silico Characterization of GT Factors Involved in Phytohormone and Abiotic Stresses Responses in Brachypodium distachyon International Journal of Molecular Sciences doi: 10.3390/ijms20174115 Authors: Feng Wen Liangwei Xu Yuebin Xie Liang Liao Tongjian Li Mingliang Jia Xinsheng Liu Xiaozhu Wu GT factors play critical roles in plant growth and development and in response to various environmental stimuli. Considering...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4116: 3dRNA v2.0: An Updated Web Server for RNA 3D Structure Prediction International Journal of Molecular Sciences doi: 10.3390/ijms20174116 Authors: Jun Wang Jian Wang Yanzhao Huang Yi Xiao 3D structures of RNAs are the basis for understanding their biological functions. However, experimentally solved RNA 3D structures are very limited in comparison with known RNA sequences up to now. Therefore, many computational methods have been proposed to solve this...
Fri Aug 23, 2019 03:00
IJMS, Vol. 20, Pages 4113: Emerging Role of Genetic Alterations Affecting Exosome Biology in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20174113 Authors: Paola Riva Cristina Battaglia Marco Venturin The abnormal deposition of proteins in brain tissue is a common feature of neurodegenerative diseases (NDs) often accompanied by the spread of mutated proteins, causing neuronal toxicity. Exosomes play a fundamental role on their releasing...
Fri Aug 23, 2019 03:00
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