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Παρασκευή 30 Αυγούστου 2019


Distinct immunology of the placenta
Science: Current Issue
Thu Aug 29, 2019 20:34
Protecting elections from social media manipulation
Science: Current Issue
Thu Aug 29, 2019 20:34
Breaking the species barrier
Science: Current Issue
Thu Aug 29, 2019 20:34
The immunological code of pregnancy
Science: Current Issue
Thu Aug 29, 2019 20:34
Born in the ribosomal tunnel
Science: Current Issue
Thu Aug 29, 2019 20:34
AI surpasses humans at six-player poker
Science: Current Issue
Thu Aug 29, 2019 20:34
Late Upper Paleolithic occupation at Coopers Ferry, Idaho, USA, ~16,000 years ago
Radiocarbon dating of the earliest occupational phases at the Cooper’s Ferry site in western Idaho indicates that people repeatedly occupied the Columbia River basin, starting between 16,560 and 15,280 calibrated years before the present (cal yr B.P.). Artifacts from these early occupations indicate the use of unfluted stemmed projectile point technologies before the appearance of the Clovis Paleoindian tradition and support early cultural connections with northeastern Asian Upper Paleolithic archaeological...
Science: Current Issue
Thu Aug 29, 2019 20:34
How humans changed the face of Earth
Science: Current Issue
Thu Aug 29, 2019 20:34
Redox-neutral organocatalytic Mitsunobu reactions
Nucleophilic substitution reactions of alcohols are among the most fundamental and strategically important transformations in organic chemistry. For over half a century, these reactions have been achieved by using stoichiometric, and often hazardous, reagents to activate the otherwise unreactive alcohols. Here, we demonstrate that a specially designed phosphine oxide promotes nucleophilic substitution reactions of primary and secondary alcohols in a redox-neutral catalysis manifold that produces...
Science: Current Issue
Thu Aug 29, 2019 20:34
The Mitsunobu reaction, reimagined
Science: Current Issue
Thu Aug 29, 2019 20:34
Solar System chaos and the Paleocene-Eocene boundary age constrained by geology and astronomy
Astronomical calculations reveal the Solar System’s dynamical evolution, including its chaoticity, and represent the backbone of cyclostratigraphy and astrochronology. An absolute, fully calibrated astronomical time scale has hitherto been hampered beyond ~50 million years before the present (Ma) because orbital calculations disagree before that age. Here, we present geologic data and a new astronomical solution (ZB18a) showing exceptional agreement from ~58 to 53 Ma. We provide a new absolute astrochronology...
Science: Current Issue
Thu Aug 29, 2019 20:34
Bacteria send messages to colonize plant roots
Science: Current Issue
Thu Aug 29, 2019 20:34
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
The requirement for next-generation antimalarials to be both curative and transmission-blocking necessitates the identification of previously undiscovered druggable molecular pathways. We identified a selective inhibitor of the Plasmodium falciparum protein kinase PfCLK3, which we used in combination with chemogenetics to validate PfCLK3 as a drug target acting at multiple parasite life stages. Consistent with a role for PfCLK3 in RNA splicing, inhibition resulted in the down-regulation of more than...
Science: Current Issue
Thu Aug 29, 2019 20:34
How do genes affect same-sex behavior?
Science: Current Issue
Thu Aug 29, 2019 20:34
Evidence lights the way
Science: Current Issue
Thu Aug 29, 2019 20:34
Lessons in black excellence
Science: Current Issue
Thu Aug 29, 2019 20:34
The genetics of sexual orientation
Science: Current Issue
Thu Aug 29, 2019 20:34
Changing conception
Science: Current Issue
Thu Aug 29, 2019 20:34
Targeting parasite's protein kinase
Science: Current Issue
Thu Aug 29, 2019 20:34
Recursion: A Novel
Science: Current Issue
Thu Aug 29, 2019 20:34
A dynamic signaling scaffold
Science: Current Issue
Thu Aug 29, 2019 20:34
Making olive oil sustainable
Science: Current Issue
Thu Aug 29, 2019 20:34
Resurrecting sentinels in the skin
Science: Current Issue
Thu Aug 29, 2019 20:34
Will DNA barcoding meet taxonomic needs?
Science: Current Issue
Thu Aug 29, 2019 20:34
Skyrmions in a frustrated magnet
Science: Current Issue
Thu Aug 29, 2019 20:34
Trophy hunting bans imperil biodiversity
Science: Current Issue
Thu Aug 29, 2019 20:34
Twisted multilayer graphene
Science: Current Issue
Thu Aug 29, 2019 20:34
Science diplomacy leverages alliances to build global bridges
Science: Current Issue
Thu Aug 29, 2019 20:34
Building psychoactives with purpose
Science: Current Issue
Thu Aug 29, 2019 20:34
Interactive early education builds STEM literacy in children
Science: Current Issue
Thu Aug 29, 2019 20:34
Controlling exciton lifetimes
Science: Current Issue
Thu Aug 29, 2019 20:34
A synthetic history of human land use
Science: Current Issue
Thu Aug 29, 2019 20:34
Superhuman AI for multiplayer poker
In recent years there have been great strides in artificial intelligence (AI), with games often serving as challenge problems, benchmarks, and milestones for progress. Poker has served for decades as such a challenge problem. Past successes in such benchmarks, including poker, have been limited to two-player games. However, poker in particular is traditionally played with more than two players. Multiplayer games present fundamental additional issues beyond those in two-player games, and multiplayer...
Science: Current Issue
Thu Aug 29, 2019 20:34
AI now masters six-player poker
Science: Current Issue
Thu Aug 29, 2019 20:34
Archaeological assessment reveals Earths early transformation through land use
Environmentally transformative human use of land accelerated with the emergence of agriculture, but the extent, trajectory, and implications of these early changes are not well understood. An empirical global assessment of land use from 10,000 years before the present (yr B.P.) to 1850 CE reveals a planet largely transformed by hunter-gatherers, farmers, and pastoralists by 3000 years ago, considerably earlier than the dates in the land-use reconstructions commonly used by Earth scientists. Synthesis...
Science: Current Issue
Thu Aug 29, 2019 20:34
Displacing OH groups catalytically
Science: Current Issue
Thu Aug 29, 2019 20:34
Dynamical charge density fluctuations pervading the phase diagram of a Cu-based high-Tc superconductor
Charge density modulations have been observed in all families of high–critical temperature (Tc) superconducting cuprates. Although they are consistently found in the underdoped region of the phase diagram and at relatively low temperatures, it is still unclear to what extent they influence the unusual properties of these systems. Using resonant x-ray scattering, we carefully determined the temperature dependence of charge density modulations in YBa2Cu3O7– and Nd1+xBa2–xCu3O7– for several doping levels....
Science: Current Issue
Thu Aug 29, 2019 20:34
Deep divide in fate of iron
Science: Current Issue
Thu Aug 29, 2019 20:34
Skyrmion lattice with a giant topological Hall effect in a frustrated triangular-lattice magnet
Geometrically frustrated magnets can host complex spin textures, leading to unconventional electromagnetic responses. Magnetic frustration may also promote topologically nontrivial spin states such as magnetic skyrmions. Experimentally, however, skyrmions have largely been observed in noncentrosymmetric lattice structures or interfacial symmetry-breaking heterostructures. Here, we report the emergence of a Bloch-type skyrmion state in the frustrated centrosymmetric triangular-lattice magnet Gd2PdSi3....
Science: Current Issue
Thu Aug 29, 2019 20:34

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