Related ArticlesLeucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1. Mol Genet Genomics. 2019 Aug 27;: Authors: Ohtsuka H, Kato T, Sato T, Shimasaki T, Kojima T, Aiba H Abstract Many studies show that lifespans of various model organisms can be extended by limiting the quantities of nutrients that are necessary for proliferation. In Schizosaccharomyces pombe, the...
Thu Aug 29, 2019 13:48
Related ArticlesTargeting Glioblastoma Stem Cells through Disruption of the Circadian Clock. Cancer Discov. 2019 Aug 27;: Authors: Dong Z, Zhang G, Qu M, Gimple RC, Wu Q, Qiu Z, Prager BC, Wang X, Kim LJY, Morton AR, Dixit D, Zhou W, Huang H, Li B, Zhu Z, Bao S, Mack SC, Chavez L, Kay SA, Rich JN Abstract Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSCs). Here, we show that GSCs, differentiated glioblastoma...
Thu Aug 29, 2019 13:48
Related ArticlesMetformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells. J Exp Clin Cancer Res. 2019 Aug 27;38(1):376 Authors: Wu Y, Zheng Q, Li Y, Wang G, Gao S, Zhang X, Yan X, Zhang X, Xie J, Wang Y, Sun X, Meng X, Yin B, Wang B Abstract BACKGROUND: Metformin has been reported to function as the anti-tumor inhibiting the growth of different types of cancers, including bladder cancer. But there are few reports on...
Thu Aug 29, 2019 13:48
Related ArticlesUsefulness of preschool and school versions of the Behavioral Rating Inventory of Executive Functions in the evaluation of the daily life executive function in myoclonic-atonic epilepsy. Epilepsy Behav. 2019 Aug 25;99:106482 Authors: Breuillard D, Jambaqué I, Laschet J, Nabbout R Abstract PURPOSE: Executive functions (EF) are high-order cognitive skills that have a major influence on quality of life, social skills, and school achievement....
Thu Aug 29, 2019 15:00
Related ArticlesCoupling of Nanofiltration and Thermal Fenton Reaction for the Abatement of Carbamazepine in Wastewater. ACS Omega. 2018 Aug 31;3(8):9407-9418 Authors: Minella M, De Bellis N, Gallo A, Giagnorio M, Minero C, Bertinetti S, Sethi R, Tiraferri A, Vione D Abstract The complete removal of biorecalcitrant xenobiotics, including most notably the pharmaceutical pollutants, by advanced oxidation processes is often difficult to be reached in urban...
Thu Aug 29, 2019 15:00
Related ArticlesPhotobiomodulation as a treatment for neurodegenerative disorders: current and future trends. Biomed Eng Lett. 2019 Aug;9(3):359-366 Authors: Hong N Abstract Photobiomodulation (PBM) is a rapidly growing as an innovative therapeutic modality for various types of diseases in recent years. Neuronal degeneration is irreversible process and it is proven to be difficult to slow down or stop the progression. Pharmacologic approaches to slow...
Thu Aug 29, 2019 15:00
Related ArticlesReigning in Excitatory Signaling in CDKL5 Deficiency. Epilepsy Curr. 2019 Aug 28;:1535759719869919 Authors: Forcelli PA Abstract AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder Yennawar M, White RS, Jensen FE. J Neurosci. 2019;39(24):4814-4828. Pathogenic mutations in cyclin-dependent kinase-like 5 (CDKL5) result in CDKL5 deficiency disorder (CDD), a rare disease marked by early-life...
Thu Aug 29, 2019 15:00
Related ArticlesThe Winner by a Nose: Intranasal Midazolam. Epilepsy Curr. 2019 Aug 28;:1535759719870508 Authors: Faught E Abstract Safety and Efficacy of Midazolam Nasal Spray in the Outpatient Treatment of Patients With Seizure Clusters-A Randomized, Double-Blind, Placebo-Controlled Trial. Detyniecki K, Van Ess PJ, Sequeira DJ, Wheless JW, Meng TC, Pullmnaan WE. Epilepsia. 2019. doi:10.1111/epi.15159. Epub ahead of print. OBJECTIVE: To evaluate...
Thu Aug 29, 2019 15:00
Related ArticlesEvidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors. BMC Genomics. 2019 Aug 28;20(1):677 Authors: Hixson KM, Cogswell M, Brooks-Kayal AR, Russek SJ Abstract BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a major signaling molecule that the brain uses to control a vast network of intracellular cascades fundamental to properties of learning and...
Thu Aug 29, 2019 13:22
Related ArticlesMorphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations. Phytomedicine. 2019 Jun;59:152756 Authors: Huang NK, Lin CC, Lin YL, Huang CL, Chiou CT, Lee YC, Lee SY, Huang HT, Yang YC Abstract BACKGROUND: According to Compendium of Materia Medica, Gastrodia elata (GE) Blume as a top grade and frequently prescribed herbal medicine has been used in treating...
Thu Aug 29, 2019 13:22
Related ArticlesEpilepsy in Pregnancy. Neurol Clin. 2019 02;37(1):53-62 Authors: Harden C, Lu C Abstract Epilepsy is a prevalent, chronic, and serious neurologic disease affecting many women of childbearing age. Specific concerns, including contraception, fertility, teratogenic risk of antiepileptic drugs, delivery, and breastfeeding, are addressed in this article. Evidence-based counseling and management strategies are provided to help clinicians...
Thu Aug 29, 2019 13:22
Related ArticlesNocturnal supervision and SUDEP risk at different epilepsy care settings. Neurology. 2018 10 16;91(16):e1508-e1518 Authors: van der Lende M, Hesdorffer DC, Sander JW, Thijs RD Abstract OBJECTIVE: To estimate the incidence of sudden unexpected death in epilepsy (SUDEP) in people with intellectual disabilities in residential care settings and to ascertain the effects of nocturnal seizures and nocturnal supervision on SUDEP risk. ...
Thu Aug 29, 2019 13:22
Related ArticlesChanges in subjective experience elicited by direct stimulation of the human orbitofrontal cortex. Neurology. 2018 10 16;91(16):e1519-e1527 Authors: Fox KCR, Yih J, Raccah O, Pendekanti SL, Limbach LE, Maydan DD, Parvizi J Abstract OBJECTIVE: We applied direct cortical stimulation (DCS) to the orbitofrontal cortex (OFC) in neurosurgical patients implanted with intracranial electrodes to probe, with high anatomic precision, the causal...
Thu Aug 29, 2019 13:22
Related ArticlesMonitoring cognition during awake brain surgery in adults: A systematic review. J Clin Exp Neuropsychol. 2018 12;40(10):1081-1104 Authors: Ruis C Abstract INTRODUCTION: Historically, most studies about awake brain surgery have focused on language or motor functions. More recently, other cognitive functions have also been assessed. However, a clear overview of the neuropsychological tests or test paradigms that are used during such procedures...
Thu Aug 29, 2019 13:22
Related ArticlesNREM sleep parasomnias as disorders of sleep-state dissociation. Nat Rev Neurol. 2018 08;14(8):470-481 Authors: Castelnovo A, Lopez R, Proserpio P, Nobili L, Dauvilliers Y Abstract Non-rapid eye movement (NREM) sleep parasomnias (or NREM parasomnias) are fascinating disorders with mysterious neurobiological substrates. These conditions are common and often severe, with social, personal and forensic implications. The NREM parasomnias...
Thu Aug 29, 2019 13:22
Related Articles[Drug reaction with eosinophilia and systemic symptoms due to carbamazepine. Pediatric case]. Arch Argent Pediatr. 2018 06 01;116(3):e433-e436 Authors: Pereira-Ospina RDP, Bejarano-Quintero AM, Suescún-Vargas JM, Pinzón-Salamanca JY Abstract Severe skin reactions include Stevens-Johnson Syndrome, toxic epidermal necrolysis and Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, which are uncommon in the pediatric population...
Thu Aug 29, 2019 13:22
Related ArticlesA Review of Women's Neurology. Am J Med. 2018 07;131(7):735-744 Authors: O'Neal MA Abstract Concern about what is best practice when caring for women with neurologic disease is a common clinical scenario. Therefore, knowledge about women's health issues and their intersection with neurologic disorders is imperative. This review will discuss the appropriate gender-based considerations in epilepsy, multiple sclerosis, migraine, autoimmune...
Thu Aug 29, 2019 13:22
Related ArticlesA Swarm Optimization Solver Based on Ferroelectric Spiking Neural Networks. Front Neurosci. 2019;13:855 Authors: Fang Y, Wang Z, Gomez J, Datta S, Khan AI, Raychowdhury A Abstract As computational models inspired by the biological neural system, spiking neural networks (SNN) continue to demonstrate great potential in the landscape of artificial intelligence, particularly in tasks such as recognition, inference, and learning. While SNN...
Thu Aug 29, 2019 15:24
Related ArticlesFully Synthetic Longitudinal Real-World Data From Hearing Aid Wearers for Public Health Policy Modeling. Front Neurosci. 2019;13:850 Authors: Christensen JH, Pontoppidan NH, Rossing R, Anisetti M, Bamiou DE, Spanoudakis G, Murdin L, Bibas T, Kikidiks D, Dimakopoulos N, Giotis G, Ecomomou A PMID: 31456658 [PubMed]
Thu Aug 29, 2019 15:24
Related ArticlesEFhd2 Affects Tau Liquid-Liquid Phase Separation. Front Neurosci. 2019;13:845 Authors: Vega IE, Umstead A, Kanaan NM Abstract The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer's disease and related dementias, is poorly understood. Therefore, understanding the process that modulates the formation of toxic tau oligomers and their conversion to putative neuroprotective...
Thu Aug 29, 2019 15:24
Related ArticlesResting State fMRI: Going Through the Motions. Front Neurosci. 2019;13:825 Authors: Maknojia S, Churchill NW, Schweizer TA, Graham SJ Abstract Resting state functional magnetic resonance imaging (rs-fMRI) has become an indispensable tool in neuroscience research. Despite this, rs-fMRI signals are easily contaminated by artifacts arising from movement of the head during data collection. The artifacts can be problematic even for motions...
Thu Aug 29, 2019 15:24
Related ArticlesNo Relationships Between the Within-Subjects' Variability of Pain Intensity Reports and Variability of Other Bodily Sensations Reports. Front Neurosci. 2019;13:774 Authors: Agostinho M, Canaipa R, Honigman L, Treister R Abstract Purpose: The subjective nature of pain assessment and its large variance negatively affect patient-health care provider communication and reduce the assay sensitivity of pain clinical trials. Given the lack of...
Thu Aug 29, 2019 15:24
Related ArticlesHigh Density, Double-Sided, Flexible Optoelectronic Neural Probes With Embedded μLEDs. Front Neurosci. 2019;13:745 Authors: Reddy JW, Kimukin I, Stewart LT, Ahmed Z, Barth AL, Towe E, Chamanzar M Abstract Optical stimulation and imaging of neurons deep in the brain require implantable optical neural probes. External optical access to deeper regions of the brain is limited by scattering and absorption of light as it propagates through...
Thu Aug 29, 2019 15:24
Related ArticlesImmunotherapy for non-small cell lung cancer. JAAPA. 2019 Sep;32(9):37-42 Authors: Vafadar S Abstract Immunotherapy is a new genre of treatment for patients with advanced cancer. Initially approved for use in metastatic melanoma, immunotherapy has found a significant place in treating non-small cell lung cancer (NSCLC). Clinical trials using several combinations of immunotherapy are underway to help to determine the best treatment for...
Thu Aug 29, 2019 15:04
Related ArticlesCasting A Wide Net On Surgery: The Central Role of Neutrophil Extracellular Traps. Ann Surg. 2019 Aug 27;: Authors: Eustache JH, Tohme S, Milette S, Rayes RF, Tsung A, Spicer JD Abstract : Since their discovery, neutrophil extracellular traps (NETs) have been implicated in a broad array of functions, both beneficial and detrimental to the host. Indeed, NETs have roles in infection, sepsis, wound healing, thrombotic disease, and cancer...
Thu Aug 29, 2019 15:04
Related ArticlesOptimized modification of the eighth edition of AJCC TNM staging system for resected pancreatic ductal adenocarcinoma. Future Oncol. 2019 Aug 28;: Authors: Pu N, Yin L, Habib JR, Gao S, Hu H, Zhu Y, Wu Y, Yu J, Lou W Abstract Aim: To reassess the prognostic performance of the American Joint Committee on Cancer (AJCC) 8th edition for Pancreatic ductal adenocarcinoma (PDAC) and optimize the categorization of PDAC staging. Patients &...
Thu Aug 29, 2019 15:04
Related ArticlesElective Node Irradiation With Integrated Boost to the Prostate Using Helical IMRT-Clinical Outcome of the Prospective PLATIN-1 Trial. Front Oncol. 2019;9:751 Authors: Koerber SA, Winter E, Katayama S, Slynko A, Haefner MF, Uhl M, Sterzing F, Habl G, Schubert K, Debus J, Herfarth K Abstract Introduction: This prospective, non-randomized phase II trial aimed to investigate the role of additional irradiation of the pelvic nodes for patients...
Thu Aug 29, 2019 15:04
Related ArticlesApplication of Bayesian predictive probability for interim futility analysis in single-arm phase II trial. Transl Cancer Res. 2019 Jul;8(Suppl 4):S404-S420 Authors: Chen DT, Schell MJ, Fulp WJ, Pettersson F, Kim S, Gray JE, Haura EB Abstract Background: Bayesian predictive probability design, with a binary endpoint, is gaining attention for the phase II trial due to its innovative strategy. To make the Bayesian design more accessible,...
Thu Aug 29, 2019 15:04
Related ArticlesIndividual Based Model Links Thermodynamics, Chemical Speciation and Environmental Conditions to Microbial Growth. Front Microbiol. 2019;10:1871 Authors: Gogulancea V, González-Cabaleiro R, Li B, Taniguchi D, Jayathilake PG, Chen J, Wilkinson D, Swailes D, McGough AS, Zuliani P, Ofiteru ID, Curtis TP Abstract Individual based Models (IbM) must transition from research tools to engineering tools. To make the transition we must aspire to...
Thu Aug 29, 2019 15:04
Related ArticlesPembrolizumab for the treatment of diffuse large B-cell lymphoma. Expert Opin Biol Ther. 2019 Aug 28;:1-8 Authors: Sheikh S, Kuruvilla J Abstract Introduction: Pembrolizumab is a novel monoclonal antibody that targets the interaction between programmed cell death protein 1 (PD-1) and its ligand (PD-L1). Pembrolizumab has shown significant clinical efficacy in Hodgkin Lymphoma (HL), but results in non Hodgkin Lymphoma (NHL) are mixed....
Thu Aug 29, 2019 15:04
Related ArticlesBone Metastasis of Breast Cancer. Adv Exp Med Biol. 2019;1152:105-129 Authors: Tahara RK, Brewer TM, Theriault RL, Ueno NT Abstract Bone is the most common site of metastasis for breast cancer. Bone metastasis significantly affects both quality of life and survival of the breast cancer patient. Clinically, complications secondary to bone metastasis include pain, pathologic fractures, spinal cord compression, and hypercalcemia of malignancy....
Thu Aug 29, 2019 13:03
Related ArticlesAn analysis of genetic heterogeneity in untreated cancers. Nat Rev Cancer. 2019 Aug 27;: Authors: Reiter JG, Baretti M, Gerold JM, Makohon-Moore AP, Daud A, Iacobuzio-Donahue CA, Azad NS, Kinzler KW, Nowak MA, Vogelstein B Abstract Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication. Any two randomly selected cells, whether normal or cancerous, are therefore genetically different. Here, we review...
Thu Aug 29, 2019 13:03
Related ArticlesChallenges and potential solutions to the evaluation, monitoring, and regulation of surgical innovations. BMC Surg. 2019 Aug 27;19(1):119 Authors: Roberts DJ, Zygun DA, Ball CG, Kirkpatrick AW, Faris PD, James MT, Mrklas KJ, Hemmelgarn BD, Manns B, Stelfox HT Abstract BACKGROUND: As it may be argued that many surgical interventions provide obvious patient benefits, formal, staged assessment of the efficacy and safety of surgical procedures...
Thu Aug 29, 2019 13:03
Related ArticlesPost-conization follow-up of patients with CIN 2/3 with different amount of distance to negative cone biopsy margin: a retrospective cohort study. J Obstet Gynaecol. 2019 Aug 28;:1-5 Authors: Giray B, Kabaca-Kocakusak C, Guray-Uzun M, Akis S Abstract The aim of this study was to investigate whether patients with CIN 2/3 with different amount of distance to negative cone biopsy margin differ in terms of post-conization follow-up results....
Thu Aug 29, 2019 13:03
Related ArticlesAdvances in the therapy of BRAFV600E metastatic colorectal cancer. Expert Rev Anticancer Ther. 2019 Aug 27;: Authors: Jin Z, Sinicrope FA Abstract Introduction: BRAFV600E metastatic colorectal cancer (CRC) is an aggressive tumor subset with an approximate 8% incidence. In these patients, standard chemotherapy has limited efficacy, and the recent development of novel targeted treatment regimens may significantly improve clinical outcome....
Thu Aug 29, 2019 13:03
Related ArticlesUse of the Secreted Proteome of Trametes versicolor for Controlling the Cereal Pathogen Fusarium langsethiae. Int J Mol Sci. 2019 Aug 26;20(17): Authors: Parroni A, Bellabarba A, Beccaccioli M, Scarpari M, Reverberi M, Infantino A Abstract Fusarium langsethiae is amongst the most recently discovered pathogens of small grains cereals. F. langsethiae is the main producer, in Europe, of T2 and HT-toxins in small grain cereals, albeit often...
Thu Aug 29, 2019 13:03
Related ArticlesThe HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes. Diagnostics (Basel). 2019 Aug 26;9(3): Authors: Kołodziej M, Waszczykowska A, Korzeniewska-Dyl I, Pyziak-Skupien A, Walczak K, Moczulski D, Jurowski P, Młynarski W, Szadkowska A, Zmysłowska A Abstract The aim of the study was to analyze the thickness of individual retinal layers in patients with type 1...
Thu Aug 29, 2019 13:03
Related ArticlesREG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. J Cancer Res Clin Oncol. 2019 Sep;145(9):2273-2283 Authors: Sun S, Hu Z, Huang S, Ye X, Wang J, Chang J, Wu X, Wang Q, Zhang L, Hu X, Yu H Abstract OBJECTIVES: Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation...
Thu Aug 29, 2019 13:03
Related ArticlesRadiation Therapy in Ovarian Cancer: An Overview and Future Directions. Clin Oncol (R Coll Radiol). 2018 08;30(8):504-506 Authors: McCormack M Abstract Clear cell cancer of the ovary is a rare and aggressive subtype. There is a general paucity of data from randomised trials to inform the most appropriate approach to adjuvant therapy. Retrospective data has highlighted an improvement in disease free survival with the addition of whole...
Thu Aug 29, 2019 13:03
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