IJMS, Vol. 20, Pages 4187: Homology Modeling-Based in Silico Affinity Maturation Improves the Affinity of a Nanobody International Journal of Molecular Sciences doi: 10.3390/ijms20174187 Authors: Xin Cheng Jiewen Wang Guangbo Kang Min Hu Bo Yuan Yingtian Zhang He Huang Affinity maturation and rational design have a raised importance in the application of nanobody (VHH), and its unique structure guaranteed these processes quickly done in vitro. An anti-CD47 nanobody,...
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IJMS, Vol. 20, Pages 4190: Correlation of Autophagosome Formation with Degradation and Endocytosis Arabidopsis Regulator of G-Protein Signaling (RGS1) through ATG8a International Journal of Molecular Sciences doi: 10.3390/ijms20174190 Authors: Yue Jiao Miroslav Srba Jingchun Wang Wenli Chen Damaged or unwanted cellular proteins are degraded by either autophagy or the ubiquitin/proteasome pathway. In Arabidopsis thaliana, sensing of D-glucose is achieved by the heterotrimeric...
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IJMS, Vol. 20, Pages 4188: Inhibition of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Hampers the Vasopressin-dependent Stimulation of Myogenic Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms20174188 Authors: Silvia Sorrentino Alessandra Barbiera Gabriella Proietti Gigliola Sica Sergio Adamo Bianca Maria Scicchitano Arginine-vasopressin (AVP) promotes muscle differentiation, hypertrophy, and regeneration through the combined activation...
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IJMS, Vol. 20, Pages 4186: Structure Determination by Single-Particle Cryo-Electron Microscopy: Only the Sky (and Intrinsic Disorder) is the Limit International Journal of Molecular Sciences doi: 10.3390/ijms20174186 Authors: Emeka Nwanochie Vladimir N. Uversky Traditionally, X-ray crystallography and NMR spectroscopy represent major workhorses of structural biologists, with the lion share of protein structures reported in protein data bank (PDB) being generated by these powerful...
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IJMS, Vol. 20, Pages 4189: Hypoxic Regulation of Neutrophils in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20174189 Authors: Daniel Triner Yatrik M. Shah Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating...
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IJMS, Vol. 20, Pages 4185: Role of NF-κB in Platelet Function International Journal of Molecular Sciences doi: 10.3390/ijms20174185 Authors: Kevin Kojok Abed El-Hakim El-Kadiry Yahye Merhi Platelets are megakaryocyte-derived fragments lacking nuclei and prepped to maintain primary hemostasis by initiating blood clots on injured vascular endothelia. Pathologically, platelets undergo the same physiological processes of activation, secretion, and aggregation yet with such pronouncedness...
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IJMS, Vol. 20, Pages 4182: Building a Bridge between Chemotherapy and Immunotherapy in Malignant Pleural Mesothelioma: Investigating the Effect of Chemotherapy on Immune Checkpoint Expression International Journal of Molecular Sciences doi: 10.3390/ijms20174182 Authors: Marcq Audenaerde Waele Jacobs Loenhout Cavents Pauwels Meerbeeck Smits In light of the promising results of immune checkpoint blockade (ICPB) in malignant pleural mesothelioma (MPM), we...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4184: Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties International Journal of Molecular Sciences doi: 10.3390/ijms20174184 Authors: Felicitas Vernen Peta J. Harvey Susana A. Dias Ana Salomé Veiga Yen-Hua Huang David J. Craik Nicole Lawrence Sónia Troeira Henriques Tachyplesin I, II and III are host defense peptides from horseshoe crab species with antimicrobial and anticancer...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4180: L1 Cell Adhesion Molecule in Cancer, a Systematic Review on Domain-Specific Functions International Journal of Molecular Sciences doi: 10.3390/ijms20174180 Authors: Maten Reijnen Pijnenborg Zegers L1 cell adhesion molecule (L1CAM) is a glycoprotein involved in cancer development and is associated with metastases and poor prognosis. Cellular processing of L1CAM results in expression of either full-length or cleaved forms of the protein. The different...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4181: Positive Effects of Ger-Gen-Chyn-Lian-Tang on Cholestatic Liver Fibrosis in Bile Duct Ligation-Challenged Mice International Journal of Molecular Sciences doi: 10.3390/ijms20174181 Authors: Zi-Yu Chang Chin-Chang Chen Hsuan-Miao Liu Yuan-Chieh Yeh Tung-Yi Lin Tzung-Yan Lee Tse-Hung Huang The purpose of this study was to investigate whether Ger-Gen-Chyn-Lian-Tang (GGCLT) suppresses oxidative stress, inflammation, and angiogenesis during experimental...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4183: Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D International Journal of Molecular Sciences doi: 10.3390/ijms20174183 Authors: Klaudia Berkowska Aoife Corcoran Małgorzata Grudzień Agnieszka Jakuszak Michał Chodyński Andrzej Kutner Ewa Marcinkowska 1,25-dihydroxyvitamin D3 (1,25D3) is implicated in many cellular functions, including cell proliferation and differentiation, thus...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4179: Zebrafish and Medaka: Two Teleost Models of T-Cell and Thymic Development
IJMS, Vol. 20, Pages 4179: Zebrafish and Medaka: Two Teleost Models of T-Cell and Thymic Development International Journal of Molecular Sciences doi: 10.3390/ijms20174179 Authors: Baubak Bajoghli Advaita M. Dick Annisa Claasen Larissa Doll Narges Aghaallaei Over the past two decades, studies have demonstrated that several features of T-cell and thymic development are conserved from teleosts to mammals. In particular, works using zebrafish (Danio rerio) and medaka (Oryzias...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4178: Correction: Huang, H.-M., et al. Effects of Sapindus mukorossi Seed Oil on Skin Wound Healing: In Vivo and In Vitro Testing. Int. J. Mol. Sci. 2019, 20, 2579 International Journal of Molecular Sciences doi: 10.3390/ijms20174178 Authors: Chang-Chih Chen Chia-Jen Nien Lih-Geeng Chen Kuen-Yu Huang Wei-Jen Chang Haw-Ming Huang The authors are sorry to report that some of the HPLC data reported in their recently published paper [...]
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4176: FOXG1-Related Syndrome: From Clinical to Molecular Genetics and Pathogenic Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms20174176 Authors: Lee-Chin Wong Shekhar Singh Hsin-Pei Wang Chia-Jui Hsu Su-Ching Hu Wang-Tso Lee Individuals with mutations in forkhead box G1 (FOXG1) belong to a distinct clinical entity, termed “FOXG1-related encephalopathy”. There are two clinical phenotypes/syndromes identified...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4177: Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription International Journal of Molecular Sciences doi: 10.3390/ijms20174177 Authors: Ming-Chun Hsieh Hsien-Yu Peng Yu-Cheng Ho Cheng-Yuan Lai Jen-Kun Cheng Gin-Den Chen Tzer-Bin Lin Diverse transcriptional controls in the dorsal horn have been observed in pain hypersensitivity. However, the understanding of the...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4174: Identification of a Potential Founder Effect of a Novel PDZD7 Variant Involved in Moderate-to-Severe Sensorineural Hearing Loss in Koreans International Journal of Molecular Sciences doi: 10.3390/ijms20174174 Authors: Sang-Yeon Lee Jin Hee Han Bong Jik Kim Seung Ha Oh Seungmin Lee Doo-Yi Oh Byung Yoon Choi PDZD7, a PDZ domain-containing scaffold protein, is critical for the organization of Usher syndrome type 2 (USH2) interactome. Recently,...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4173: Biopolymeric Films of Amphiphilic Derivatives of Chitosan: A Physicochemical Characterization and Antifungal Study International Journal of Molecular Sciences doi: 10.3390/ijms20174173 Authors: Anna Carolina Rodrigues Santos Alves Aline Margarete Furuyama Lima Marcio José Tiera Vera Aparecida de Oliveira Tiera The chemical modification of chitosan has been an active subject of research in order to improve the physicochemical and antifungal properties...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4175: FKRR-MVSF: A Fuzzy Kernel Ridge Regression Model for Identifying DNA-Binding Proteins by Multi-View Sequence Features via Chou’s Five-Step Rule International Journal of Molecular Sciences doi: 10.3390/ijms20174175 Authors: Yi Zou Yijie Ding Jijun Tang Fei Guo Li Peng DNA-binding proteins play an important role in cell metabolism. In biological laboratories, the detection methods of DNA-binding proteins includes yeast one-hybrid methods, bacterial...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4172: Structural Analysis and Dynamic Processes of the Transmembrane Segment Inside Different Micellar Environments—Implications for the TM4 Fragment of the Bilitranslocase Protein International Journal of Molecular Sciences doi: 10.3390/ijms20174172 Authors: Kosma Szutkowski Emilia Sikorska Iulia Bakanovych Amrita Roy Choudhury Andrej Perdih Stefan Jurga Marjana Novič Igor Zhukov The transmembrane (TM) proteins are gateways for molecular transport...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4171: Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions International Journal of Molecular Sciences doi: 10.3390/ijms20174171 Authors: Tadayuki Shimada Shin Yasuda Hiroko Sugiura Kanato Yamagata Syntenin is an adaptor-like molecule that has two adjacent tandem postsynaptic density protein 95/Discs large protein/Zonula occludens 1 (PDZ) domains. The PDZ domains of syntenin recognize multiple peptide motifs with low to moderate affinity....
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4170: Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses International Journal of Molecular Sciences doi: 10.3390/ijms20174170 Authors: Yue Gao Zhengying Bian Wenyao Xue Qianwen Li Yu Zeng Yimeng Wang Lei Tang Tiejun Tang Xiangdong Gao Wei Guo Interleukin (IL)-23 is considered an effective therapeutic target for the treatment of psoriasis because...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4168: Wnt Binding Affinity Prediction for Putative Frizzled-Type Cysteine-Rich Domains International Journal of Molecular Sciences doi: 10.3390/ijms20174168 Authors: Mark Agostino Sebastian Öther-Gee Pohl Several proteins other than the frizzled receptors (Fzd) and the secreted Frizzled-related proteins (sFRP) contain Fzd-type cysteine-rich domains (CRD). We have termed these domains “putative Fzd-type CRDs”, as the relevance of Wnt signalling...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4167: Use of the Secreted Proteome of Trametes versicolor for Controlling the Cereal Pathogen Fusarium langsethiae International Journal of Molecular Sciences doi: 10.3390/ijms20174167 Authors: Alessia Parroni Agnese Bellabarba Marzia Beccaccioli Marzia Scarpari Massimo Reverberi Alessandro Infantino Fusarium langsethiae is amongst the most recently discovered pathogens of small grains cereals. F. langsethiae is the main producer, in Europe, of T2...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4165: Reaction of 1-propanol with Ozone in Aqueous Media International Journal of Molecular Sciences doi: 10.3390/ijms20174165 Authors: Erika Reisz Agnes Tekle-Röttering Sergej Naumov Winfried Schmidt Torsten C. Schmidt The main aim of this work is to substantiate the mechanism of 1-propanol oxidation by ozone in aqueous solution when the substrate is present in large excess. Further goals are assessment of the products, their formation yields as well...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4166: Identifying Common Features in the Activation of Melanocortin-2 Receptors: Studies on the Xenopus tropicalis Melanocortin-2 Receptor International Journal of Molecular Sciences doi: 10.3390/ijms20174166 Authors: Perry E. Davis Emily C. Wilkinson Robert M. Dores The interaction between the pituitary hormone, adrenocorticotropin (ACTH), and melanocortin-2 receptor (MC2R) orthologs involves the H6 F7 R8 W9 and R/K15 K16 R17 R18 motifs in ACTH making contact...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4169: Epigenetics and Neurological Disorders in ART International Journal of Molecular Sciences doi: 10.3390/ijms20174169 Authors: Marina La Rovere Marica Franzago Liborio Stuppia About 1–4% of children are currently generated by Assisted Reproductive Technologies (ART) in developed countries. These babies show only a slightly increased risk of neonatal malformations. However, follow-up studies have suggested a higher susceptibility to multifactorial,...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4163: Sex, Age, and Bodyweight as Determinants of Extracellular DNA in the Plasma of Mice: A Cross-Sectional Study International Journal of Molecular Sciences doi: 10.3390/ijms20174163 Authors: Ľubica Janovičová Barbora Konečná Lenka Vokálová Lucia Lauková Barbora Vlková Peter Celec Extracellular DNA (ecDNA) is studied as a possible biomarker, but also as a trigger of the immune responses important for the pathogenesis of several diseases. Extracellular...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4164: β-Glucose-1,6-Bisphosphate Stabilizes Pathological Phophomannomutase2 Mutants In Vitro and Represents a Lead Compound to Develop Pharmacological Chaperones for the Most Common Disorder of Glycosylation, PMM2-CDG International Journal of Molecular Sciences doi: 10.3390/ijms20174164 Authors: Maria Monticelli Ludovica Liguori Mariateresa Allocca Giuseppina Andreotti Maria Vittoria Cubellis A large number of mutations causing PMM2-CDG, which is the...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4159: Discovery of Novel Angiotensin-Converting Enzyme Inhibitory Peptides from Todarodes pacificus and Their Inhibitory Mechanism: In Silico and In Vitro Studies International Journal of Molecular Sciences doi: 10.3390/ijms20174159 Authors: Dingyi Yu Cong Wang Yufeng Song Junxiang Zhu Xiaojun Zhang In order to rapidly and efficiently excavate antihypertensive ingredients in Todarodes pacificus, its myosin heavy chain was hydrolyzed in silico and the...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4158: Tumor Metabolism as a Regulator of Tumor–Host Interactions in the B-Cell Lymphoma Microenvironment—Fueling Progression and Novel Brakes for Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20174158 Authors: Anna C. Beielstein Christian P. Pallasch Tumor metabolism and its specific alterations have become an integral part of understanding functional alterations leading to malignant transformation and maintaining cancer progression. Here,...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4161: Glucobrassicin Metabolites Ameliorate the Development of Portal Hypertension and Cirrhosis in Bile Duct-Ligated Rats International Journal of Molecular Sciences doi: 10.3390/ijms20174161 Authors: Ting Chang Hsin-Ling Ho Shao-Jung Hsu Ching-Chih Chang Ming-Hung Tsai Teh-Ia Huo Hui-Chun Huang Fa-Yauh Lee Ming-Chih Hou Shou-Dong Lee Patients suffering from liver cirrhosis are often complicated with the formation of portosystemic collateral...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4160: Rett Syndrome and Other Neurodevelopmental Disorders Share Common Changes in Gut Microbial Community: A Descriptive Review International Journal of Molecular Sciences doi: 10.3390/ijms20174160 Authors: Elisa Borghi Aglaia Vignoli In this narrative review, we summarize recent pieces of evidence of the role of microbiota alterations in Rett syndrome (RTT). Neurological problems are prominent features of the syndrome, but the pathogenic mechanisms modulating...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4162: SILAC-Based Quantification of TGFBR2-Regulated Protein Expression in Extracellular Vesicles of Microsatellite Unstable Colorectal Cancers International Journal of Molecular Sciences doi: 10.3390/ijms20174162 Authors: Fabia Fricke Malwina Michalak Uwe Warnken Ingrid Hausser Martina Schnölzer Jürgen Kopitz Johannes Gebert Microsatellite unstable (MSI) colorectal cancers (CRCs) are characterized by mutational inactivation of Transforming Growth...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4157: Local Growth Hormone Therapy for Pressure Ulcer Healing on a Human Skin Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms20174157 Authors: Lara Cristóbal Nerea de los Reyes Miguel A. Ortega Melchor Álvarez-Mon Natalio García-Honduvilla Julia Buján Andrés A. Maldonado The growth hormone is involved in skin homeostasis and wound healing. We hypothesize whether it is possible to improve pressure ulcer (PU) healing by locally...
Mon Aug 26, 2019 03:00
IJMS, Vol. 20, Pages 4155: Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20174155 Authors: Sally Temraz Farah Nassar Rihab Nasr Maya Charafeddine Deborah Mukherji Ali Shamseddine Research has been driven towards finding therapy predictive biomarkers for colorectal cancer (CRC) with a special interest in studying the gut microbiome. Gut microbiome acts not only as a barrier to prevent...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4156: The Role of SATB1 in Tumour Progression and Metastasis International Journal of Molecular Sciences doi: 10.3390/ijms20174156 Authors: Glatzel-Plucińska Piotrowska Dzięgiel Podhorska-Okołów Carcinogenesis is a long-drawn, multistep process, in which metastatic spread is an unequivocal hallmark of a poor prognosis. The progression and dissemination of epithelial cancers is commonly thought to rely on the epidermal-mesenchymal transition (EMT) process....
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4154: Role of Cancer Stem Cells in Cholangiocarcinoma and Therapeutic Implications International Journal of Molecular Sciences doi: 10.3390/ijms20174154 Authors: Hsing-Ju Wu Pei-Yi Chu Cholangiocarcinoma (CCA) is the second most common type of liver cancer, and is highly aggressive with very poor prognosis. CCA is classified into intrahepatic cholangiocarcinoma (iCCA) and extra-hepatic cholangiocarcinoma (eCCA), which is further stratified into perihilar (pCCA)...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4151: Formation of α-Farnesene in Tea (Camellia sinensis) Leaves Induced by Herbivore-Derived Wounding and Its Effect on Neighboring Tea Plants International Journal of Molecular Sciences doi: 10.3390/ijms20174151 Authors: Xuewen Wang Lanting Zeng Yinyin Liao Jianlong Li Jinchi Tang Ziyin Yang Herbivore-induced plant volatiles (HIPVs) play important ecological roles in defense against stresses. In contrast to model plants, reports on HIPV formation...
Sun Aug 25, 2019 03:00
IJMS, Vol. 20, Pages 4153: ERK1,2 Signalling Pathway along the Nephron and Its Role in Acid-base and Electrolytes Balance International Journal of Molecular Sciences doi: 10.3390/ijms20174153 Authors: Giovanna Capolongo Yoko Suzumoto Mariavittoria D’Acierno Mariadelina Simeoni Giovambattista Capasso Miriam Zacchia Mitogen-activated protein kinases (MAPKs) are intracellular molecules regulating a wide range of cellular functions, including proliferation, differentiation,...
Sun Aug 25, 2019 03:00
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