Related ArticlesMicroRNAs hsa-miR-495-3p and hsa-miR-486-5p Suppress Basal and Rifampicin-induced Expression of Human Sulfotransferase 2A1 (SULT2A1) by Facilitating mRNA Degradation. Biochem Pharmacol. 2019 Aug 22;: Authors: Li D, Knox B, Chen S, Wu L, Tolleson WH, Liu Z, Yu D, Guo L, Tong W, Ning B Abstract Drug metabolizing enzymes mediate biotransformation of drugs and play an essential role in drug efficacy and toxicity. Human sulfotransferases are...
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Related ArticlesEfficacy and safety of neoadjuvant chemotherapy regimens for triple-negative breast cancer: a network meta-analysis. Aging (Albany NY). 2019 Aug 24;11: Authors: Li Y, Yang D, Chen P, Yin X, Sun J, Li H, Ren G Abstract Different neoadjuvant chemotherapies are available for triple-negative breast cancer (TNBC). Here, we performed a network meta-analysis to evaluate the pathological complete response (pCR) benefit and safety of treatment...
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Related ArticlesCurrent evidence and future perspectives for curcumin and its analogues as promising adjuncts to oxaliplatin: state-of-the-art. Pharmacol Res. 2019 03;141:343-356 Authors: Zangui M, Atkin SL, Majeed M, Sahebkar A Abstract Curcumin is a multifunctional phytochemical that has documented anti-oxidant, anti-inflammatory and anti-tumor properties. The anti-tumor effect of curcumin has been widely investigated, both as a single ingredient...
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Related ArticlesOutcomes to first-line pembrolizumab in patients with non-small cell lung cancer and very high PD-L1 expression. Ann Oncol. 2019 Aug 21;: Authors: Aguilar EJ, Ricciuti B, Gainor JF, Kehl KL, Kravets S, Dahlberg S, Nishino M, Sholl LM, Adeni A, Subegdjo S, Khosrowjerdi S, Peterson RI, Digumarthy S, Liu C, Sauter J, Rizvi H, Arbour KC, Carter BW, Heymach JV, Altan M, Hellmann MD, Awad MM Abstract PURPOSE: In non-small cell lung cancers...
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Related ArticlesFXYD5 (Dysadherin) upregulation predicts shorter survival and reveals platinum resistance in high-grade serous ovarian cancer patients. Br J Cancer. 2019 Aug 22;: Authors: Tassi RA, Gambino A, Ardighieri L, Bignotti E, Todeschini P, Romani C, Zanotti L, Bugatti M, Borella F, Katsaros D, Tognon G, Sartori E, Odicino F, Romualdi C, Ravaggi A Abstract BACKGROUND: High-grade serous ovarian carcinoma (HGSOC) is generally associated with a...
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Authors: Jain N PMID: 31437134 [PubMed - in process] (Source: Clinical Advances in Hematology and Oncology)
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Authors: Gertz MA PMID: 31437137 [PubMed - in process] (Source: Clinical Advances in Hematology and Oncology)
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Authors: Levis MJ PMID: 31437132 [PubMed - in process] (Source: Clinical Advances in Hematology and Oncology)
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Authors: Kizilocak H, Young G Abstract Hemophilia A and B are inherited bleeding disorders characterized by deficiency or dysfunction of coagulation protein factors VIII and IX, respectively. Recurrent joint and muscle bleeds are the major clinical manifestations. Replacement therapy with clotting factors, either at the time of bleeding or as part of a prophylactic regimen, is adapted to individual patient needs. The major complication of therapy is the development of neutralizing antibodies....
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Conclusions: Cesium-131 interstitial brachytherapy is feasible and does not pose major radiation safety concerns; it should be considered as a treatment option for previously irradiated patients with recurrent, resectable HNC. PMID: 31435429 [PubMed] (Source: Journal of Contemporary Brachytherapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps...
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Conclusions: The hybrid inverse optimization method achieved high conformity in the clinical practice. The non-coplanar needle can help to achieve a better dose distribution than the coplanar needle. PMID: 31435434 [PubMed] (Source: Journal of Contemporary Brachytherapy)
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Conclusions: For patients with inoperable GBM, IRT HDR BRT alone or in combination with EBRT is a safe and effective irradiation method providing palliation without excessive toxicity. PMID: 31435428 [PubMed] (Source: Journal of Contemporary Brachytherapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Conclusions: We found that the use of the hybrid applicator allowed for adequate target coverage in a patient with unusual anatomy. The patient tolerated treatment well and demonstrated favorable response on follow-up exam and imaging. The long-term curative result needs to be further evaluated. PMID: 31435436 [PubMed] (Source: Journal of Contemporary Brachytherapy)
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Conclusions: 3D-PIT based on the CT-MRI fusion images can result in good accuracy for positioning and dose distribution in radioactive seed implantation for treatment of rHGG. PMID: 31435430 [PubMed] (Source: Journal of Contemporary Brachytherapy)
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Authors: Chicheł A PMID: 31435424 [PubMed] (Source: Journal of Contemporary Brachytherapy)
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Conclusions: During the first 4 years after BT, more than half of patients maintained an IIEF-5 > 16, and EF results remained stable. Severe erectile dysfunction (ED) was very rare. PMID: 31435425 [PubMed] (Source: Journal of Contemporary Brachytherapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Conclusions: Fluoroscopy and 3D CT image-guided interstitial brachytherapy is feasible and appears to be a suitable treatment technique for patients with clinically localized prostate cancer after previous rectal resection and external beam radiation therapy. PMID: 31435432 [PubMed] (Source: Journal of Contemporary Brachytherapy)
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Conclusions: Whole-gland salvage BT is an effective treatment with an acceptable toxicity profile. The pathology findings from RARP imply that there is a room for improvement in diagnoses made by MRI in the pre-salvage setting. PMID: 31435426 [PubMed] (Source: Journal of Contemporary Brachytherapy)
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Conclusions: Assuming a static geometry, statistically significant degradation of plan quality can result from restricting the dwell time homogeneity in min/max-based optimization of cervix HDR brachytherapy plans using SagiPlan. Therefore, setting DTHEW to zero is indicated for the type of patient plans considered in this study. PMID: 31435433 [PubMed] (Source: Journal of Contemporary Brachytherapy)
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Conclusions: Good agreement exists for overall cosmetic outcomes measured by subjective and objective methods. Location of the NAC, breast size and shape are the most important parameters determining cosmetic outcomes irrespective of the method of assessment. PMID: 31435427 [PubMed] (Source: Journal of Contemporary Brachytherapy)
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By Travis J. BristolThe Higher Education Act Ongoing negotiations in Congress about the reauthorization of the Higher Education Act (HEA) have direct implications for increasing the ethnoracial diversity of our country’s educator workforce. Initially signed by President Lyndon Johnson in 1965 as part of his larger Great Society initiatives and most recently reauthorized in 2008 by President Barack Obama, one of HEA’s primary goals was to increase access and opportunity to higher education for...
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Authors: Miguel D, de Frutos JM, López-Lara F, Alonso P, Diezhandino P, Saornil MA, García C Abstract Effective cancer brachytherapy requires a treatment plan that delivers high-dose to tumor, while minimizing the dose to critical normal tissues. Therefore, an accurate knowledge of the sources and magnitude of the techniques is essential for producing robust and well optimized-plans. The purpose of this technical note is to establish general procedures and strategies for optimization and...
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Conclusions: Fibre-optic endoscope-guided 3D HDR ISBT boost could be an additional treatment strategy for locoregional residual NPC after radical EBRT, especially for deep invasive lesion. PMID: 31435431 [PubMed] (Source: Journal of Contemporary Brachytherapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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We describe Dr. Hurria's early efforts toward meeting these calls though the implementation of the GA in oncology research. We then summarize some of the seminal studies constituting the evidence base supporting GA's implementation. Finally, we lay out the evolution of cancer-focused guidelines recommending the GA, concluding with future needs to advance the next steps toward more widespread implementation in routine cancer care. Throughout, we describe Dr. Hurria's vision and its execution in driving...
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Publication date: November 2019Source: Cancer Genetics, Volume 239Author(s): Nicoletta Coccaro, Luisa Anelli, Paola Orsini, Antonella Zagaria, Angela Minervini, Luciana Impera, Giuseppina Tota, Crescenzio Francesco Minervini, Cosimo Cumbo, Elisa Parciante, Maria Rosa Coserva, Immacolata Attolico, Giorgina Specchia, Francesco AlbanoAbstractMyeloid neoplasms with eosinophilia and abnormalities of the PDGFRA gene can benefit from therapy with tyrosine kinase inhibitors, therefore revealing the PDGFRA...
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Publication date: Available online 23 August 2019Source: Cancer GeneticsAuthor(s): Abdelkareem A. Ahmed, Mohammed Elmujtba Adam EssaAbstractThyroid cancer remains the highest prevailing endocrine malignancy, and its incidence rate has progressively increased in the previous years. Above 95% of thyroid tumor are follicular cells types of carcinoma in which are considered invasive type of tumor. The pathogenesis and molecular mechanism of thyroid tumors are yet remains elucidated, in spite of activating...
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ConclusionOur findings implicate serum IgM in the pathogenesis of bladder cancer and suggest that the concept of humoral immune surveillance against cancer warrants further mechanistic investigation. (Source: Cancer Epidemiology)
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ConclusionIn this large nationwide cohort of ovarian cancer patients, β-blocker users had reduced survival. (Source: Cancer Epidemiology)
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Publication date: Available online 23 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ji Cheng, Jianping Guo, Brian J. North, Bin Wang, Chun-Ping Cui, Hongchang Li, Kaixiong Tao, Lingqiang Zhang, Wenyi WeiAbstractDeubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases. Currently, DUBs have been found to play critical roles in the regulation of various...
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In the original publication, the 6th author ’s first name and the last name was inverted and incorrectly published. The correct author name is Letizia Ferella. (Source: Journal of Cancer Research and Clinical Oncology)
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(Source: Journal of Cancer Research and Clinical Oncology)
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Conclusion: The 'Cancer Treatment at Home' service has improved the patient experience for cancer care and has been recognized nationally for its achievements. PMID: 31441319 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
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ConclusionsElevated patient costs for BCS with lymphedema are for more than lymphedema itself, suggesting that financial coverage for lymphedema treatment alone may not eliminate cost disparities.Implications for Cancer SurvivorsThe economic challenges examined in this paper have long been a concern of BCS and advocates, with only recent attention by policy makers, researchers, and providers. BCS identified potential policy and programmatic solutions, including expanding insurance coverage and financial...
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AbstractUreteral metastases from other primary cancers are very rare. Treatment of these metastases is difficult and outcomes are poor. A thorough literature review was done with the aim of finding characteristics that may influence survival rates of patients with ureteral metastases. Systematic literature searches of PubMed and Web of Science were performed in Jan 2019. A total of 79 papers that included 265 patients with cancer metastases to their ureters were finally considered for evidence synthesis....
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ConclusionsEating problems after treatment have substantial effects on the everyday life of HNC survivors. A multidisciplinary residential rehabilitation program may be beneficial to meet their rehabilitation needs.Implications for Cancer SurvivorsThe results are useful for future planning of rehabilitation services and clinical studies that may contribute to improving current clinical practice and benefit HNC survivors. (Source: Journal of Cancer Survivorship)
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Authors: Vasudeva Bhat Alison L. Allan Afshin Raouf The epithelial cells in an adult woman’s breast tissue are continuously replaced throughout their reproductive life during pregnancy and estrus cycles. Such extensive epithelial cell turnover is governed by the primitive mammary stem cells (MaSCs) that proliferate and differentiate into bipotential and lineage-restricted progenitors that ultimately generate the mature breast epithelial cells. These cellular processes are orchestrated...
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Authors: Tyler S. Keeley Shengyu Yang Eric Lau Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling...
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Cancers, Vol. 11, Pages 1242: The PI3K/AKT/mTOR and CDK4/6 Pathways in Endocrine Resistant HR+/HER2− Metastatic Breast Cancer: Biological Mechanisms and New Treatments Cancers doi: 10.3390/cancers11091242 Authors: Daniele Presti Erica Quaquarini Endocrine-based treatments are the normal standard-of-care in women with hormone receptor-positive/Human Epidermal growth factor Receptor 2-negative metastatic breast cancer. Despite the well-known efficacy of these drugs as first-line therapies,...
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Conclusions: Plasmatic LDH and its variation during first-line treatment predict PFS and OS in MBC, providing independent prognostic information. It would be worthwhile to prospectively evaluate the association between LDH variation and therapeutic benefit in MBC, and explore how it may affect treatment strategies. (Source: Cancers)
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