Related ArticlesPharyngeal Area Changes in Parkinson's Disease and Its Effect on Swallowing Safety, Efficiency, and Kinematics. Dysphagia. 2019 Aug 24;: Authors: Curtis JA, Molfenter SM, Troche MS Abstract Pharyngeal area can increase as a function of normal healthy aging and muscle atrophy. These increases in pharyngeal area can negatively affect swallowing function in healthy older adults (HOA). However, the presence of pharyngeal area changes and...
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Related ArticlesEffects of Verbal Cueing on Respiratory-Swallow Patterning, Lung Volume Initiation, and Swallow Apnea Duration in Parkinson's Disease. Dysphagia. 2019 Aug 22;: Authors: Curtis JA, Troche MS Abstract Respiratory-swallow coordination (RSC) is important for swallowing safety. Atypical RSC is common in Parkinson's disease (PD) and is associated with the presence of dysphagia and aspiration. Verbal cueing is known to affect RSC in healthy...
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Authors: Park HY Abstract Pancreatic cancer is associated with a poor prognosis and high mortality. Thus, distress that includes depression and anxiety is a relatively common comorbidity for patients suffering from pancreatic cancer. However, these psychological symptoms are likely to be under-detected and undertreated. Regarding high levels of unmet needs of psychological support for patients with pancreatic cancer, early screening for distress and adequate interventions should be considered...
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Authors: Jung MK Abstract Pancreatic cancer is the ninth common malignancy in South Korea. It has a dismal prognosis with a 5-year overall survival rate of less than 10%, and pancreatic cancer is associated with cancer cachexia, which is defined as the loss of muscle mass that is not reversible by conventional nutritional support. Cachexia is noted in over 85% of all pancreatic cancer patients and it is strongly related with the disease's mortality. Nearly 30% of pancreatic cancer deaths...
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Authors: Choe JW, Hyun JJ Abstract Pancreatic cancer is a dismal disease with a poor prognosis and is one of the most painful malignancies. Therefore, adequate pain control is essential to improving the patient's quality of life. Pain in pancreatic cancer has complex pathophysiologic mechanisms and different characteristics. The choice of pain management modalities should be individualized depending on the pain characteristics using a multidisciplinary approach. The treatment options available...
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Conclusions Vismodegib cannot replace complex reconstructions. However, in unresectable laBCC, Vismodegib can provide a bridge to surgery. Due to the possibility of persistent tumour cells, we recommend imaging-assisted surgery and an imaging-based follow-up. In case of complete clinical remission after Vismodegib in a neoadjuvant setting, we recommend that Vismodegib be continued as long as the adverse effects are tolerated and an imaging-based follow-up is advised. PMID: 31437079 [PubMed -...
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Prognostic factors for survival in patients with completely resected pN2 non-small-cell lung cancer.
Conclusions: The most significant prognostic factors associated with survival were pN2 status. Non-skip metastases (pN1N2) and positive lymph node count were not associated with prognosis. PMID: 31437115 [PubMed - as supplied by publisher] (Source: Acta Chirurgica Belgica)
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Conclusion: Considering the lower levels of CA-125 in patients with AA compared with NAA cases and also weak screening performance characteristics, it seems that it could not be considered as an accurate screening tool in this regard. PMID: 31432034 [PubMed] (Source: Accident and Emergency Nursing)
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ConclusionsRBBP4 was upregulated in the colon cancer. RBBP4 may be a novel predictor for poor prognosis of colon cancer and colon cancer hepatic metastasis. (Source: Hepatobiliary and Pancreatic Diseases International)
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ConclusionsBased on the MTNS the risk of malignancy in cases of hemithyroidectomy who required completion surgery was significantly higher than those who underwent hemithyroidectomy only. The MTNS can be of value to thyroid surgeon in the pre-operative decision-making when dealing with an indeterminate thyroid nodule on FNA biopsy. (Source: American Journal of Otolaryngology)
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Publication date: Available online 23 August 2019Source: Pharmacological ResearchAuthor(s): Qining Yang, Changyuan Wang, Yue Jin, Xiaodong Ma, Tianqi Xie, Jiaying Wang, Kexin Liu, Huijun SunAbstractAtherosclerosis (AS) is one of the major causes leading to mortality of dysfunctional cardiovascular events in the menopausal women, which has long-term deficiency of estrogen. At present, the primary treatment for postmenopausal AS is hormone replacement therapy (HRT). However, it can increase the risks...
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Publication date: Available online 23 August 2019Source: Pharmacological ResearchAuthor(s): Oh Yoen Kim, Ji Yeon Chung, Juhyun SongAbstractObesity is a globally widespread metabolic disorder, characterized by immoderate fat accumulation in the body. There are different types of body fats such as white adipose tissue (WAT), which stores surplus energy in the body, and brown adipose tissue (BAT) which utilize energy to produce heat during metabolism. BAT acts many beneficial functions in metabolic...
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Publication date: Available online 22 August 2019Source: International Journal of PharmaceuticsAuthor(s): Yuzhuo Bai, Yun Wang, Xudong Zhang, Jianhua Fu, Xiuli Xing, Chunlan Wang, Longlan Gao, Yu Liu, Li ShiAbstractIn recent years, researchers have made significant innovations in the field of tumor immunotherapy based on the knowledge of biology, oncology, and immunology. Tumor immunotherapy involves the use of immune checkpoint inhibitors and CAR (chimeric antigen receptor)-T cell therapy. As compared...
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In conclusion, GABRD expression might serve as a potential independent prognostic marker in patients with IDH WT LGG. Meanwhile, its expression was negatively correlated with the extent of TIM, which might help to explain the favorable survival outcome. Cg13916816 might be a critical CpG site influencing GABRD expression in IDH WT LGG. (Source: Biomedicine and Pharmacotherapy)
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Ling Gao, Jian-zhong Sang, Hua CaoAbstractThe inhibitory effects of limonin have been disclosed in various tumors, however, its roles in nasopharyngeal carcinoma (NPC) progression are never been revealed. In the current work, we collected NPC cells with a higher stemness compared with bulk cells through isolating the side population (SP) cells. It was found that limonin exhibited a stronger inhibitory effect...
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ConclusionThe cellular effects produced by SFN in NSCLC cells are largely mediated by SFN-induced production of ROS. Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels protect cells from SFN-induced apoptosis. Despite this, we found that SFN retained the ability to inhibit the growth of NSCLC tumors with high-level EGFR expression in vivo.Graphical abstractModel for the effects of different EGFR expression...
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Authors: Rutherford SC Abstract Although the role of imaging in the management of most lymphomas is well established at baseline, during treatment, and following treatment, surveillance imaging after complete response remains controversial despite the numerous studies that have investigated follow-up computed tomography, positron emission tomography, and magnetic resonance imaging over the past 20 years. Although robust data do not support an impact of this strategy on survival in Hodgkin...
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Authors: PMID: 31437136 [PubMed - in process] (Source: Clinical Advances in Hematology and Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Authors: Goldenberg NA PMID: 31437133 [PubMed - in process] (Source: Clinical Advances in Hematology and Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Authors: Emens LA PMID: 31437135 [PubMed - in process] (Source: Clinical Advances in Hematology and Oncology)
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Related ArticlesAtypical Michaelis-Menten kinetics in cytochrome P450 enzymes: a focus on substrate inhibition. Biochem Pharmacol. 2019 Aug 21;: Authors: Wen Hui Leow J, Chun Yong Chan E Abstract The widespread applications of the century-old Michaelis-Menten kinetics in the characterization of drug-metabolizing cytochrome P450 enzymes have persisted since their discovery in the 1950s. This is a concern given preceding reports of atypical Michaelis-Menten...
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Related ArticlesInhibition of human UDP-glucuronosyltransferase (UGT) enzymes by kinase inhibitors: Effects of dabrafenib, ibrutinib, nintedanib, trametinb and BIBF 1202. Biochem Pharmacol. 2019 Aug 21;: Authors: Korpraserttharworn P, Chau N, Nair PC, Rowland A, Miners JO Abstract We have demonstrated previously that the kinase inhibitors (KIs) lapatinib, pazopanib, regorafenib and sorafenib are potent inhibitors of UGT1A1 and UGTs 1A7-10. The present...
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Related ArticlesMicroglia-neuron interactions in the models of neuropathic pain. Biochem Pharmacol. 2019 Aug 21;: Authors: Tozaki-Saitoh H, Tsuda M Abstract Chronic pain is a debilitating condition that often emerges as a clinical symptom of inflammatory diseases. It has therefore been widely accepted that the immune system critically contributes to the pathology of chronic pain. Microglia, a type of immune cell in the central nervous system, has attracted...
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Related ArticlesM3 Muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway. Biochem Pharmacol. 2019 Aug 21;: Authors: Jadeja RN, Chu X, Wood C, Bartoli M, Khurana S Abstract Previously, we reported that hepatic muscarinic receptors modulate both acute and chronic liver injury, however, the role of muscarinic receptors in fatty liver disease is unclear. We observed in patients who underwent weight loss surgery, a decrease...
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Related ArticlesOrganic anion transport polypeptide 1b2 selectively affects the pharmacokinetic interaction between paclitaxel and sorafenib in rats. Biochem Pharmacol. 2019 Aug 19;: Authors: Ma X, Qin X, Shang X, Liu M, Wang X Abstract Paclitaxel, a broad-spectrum antitumor drug, is widely used as a cytotoxic drug, while sorafenib as a multi-kinase inhibitor is a classic targeted drug. A number of clinical trials have combined paclitaxel and sorafenib...
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Related ArticlesNovel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: comparison with geranylated flavonoids, mimulone and diplacone. Biochem Pharmacol. 2019 Aug 19;: Authors: Eggers C, Fujitani M, Kato R, Smid S Abstract BACKGROUND: Flavonoids form a diverse class of naturally occurring polyphenols ascribed various biological activities, including inhibition...
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Related ArticlesUsing Yoda-1 to mimic laminar flow in vitro: a tool to simplify drug testing. Biochem Pharmacol. 2019 Aug 19;: Authors: Davies JE, Lopresto D, Apta BHR, Lin Z, Ma W, Harper MT Abstract The endothelium is an attractive drug target and an important site of adverse drug reactions. Endothelial dysfunction is strongly associated with inflammation and contributes to drug-induced cardiovascular toxicity. Endothelial cells in the circulation...
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Related ArticlesRare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively. Biochem Pharmacol. 2019 Aug 14;: Authors: Matana A, Ziros PG, Chartoumpekis DV, Renaud C, Polašek O, Hayward C, Zemunik T, Sykiotis GP Abstract Nuclear factor, erythroid 2-like 2 (Nrf2) is a transcription factor that has been gaining attention in the field of pharmacology and especially...
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Related ArticlesModulation of Sirt1/NF-κB interaction of evogliptin is attributed to inhibition of vascular inflammatory response leading to attenuation of atherosclerotic plaque formation. Biochem Pharmacol. 2019 Aug 14;168:452-464 Authors: Nguyen PA, Won JS, Rahman MK, Bae EJ, Cho MK Abstract Evogliptin is a novel, potent and selective dipeptidyl peptidase 4 inhibitor that has received approval for use in the treatment of type 2 diabetes in South...
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Related ArticlesCystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis. Biochem Pharmacol. 2019 Aug 14;: Authors: Móodis K, Ramanujam VMS, Govar AA, Lopez E, Anderson KE, Wang R, Szabo C Abstract BACKGROUND: Hydrogen sulfide (H2S) is an endogenous gasotransmitter produced by mammalian cells. The...
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Related ArticlesThe regulatory roles of calcium channels in tumors. Biochem Pharmacol. 2019 Aug 12;: Authors: Zhong T, Pan X, Wang J, Yang B, Ding L Abstract Calcium (Ca2+) and its relevant transmembrane and intracellular calcium channels were previously thought to be chiefly associated with the regulation of cardiovascular and neuronal systems. Nowadays, an increasing evidence shows those calcium channels are also responsible for tumorigenesis and...
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Related ArticlesParkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on α-synuclein protein levels. Biochem Pharmacol. 2019 Aug 09;168:429-437 Authors: González-Barbosa E, García-Aguilar R, Vega L, Cabañas-Cortés MA, Gonzalez FJ, Segovia J, Morales-Lázaro SL, Cisneros B, Elizondo G Abstract Parkin (PRKN) is a ubiquitin E3 ligase that catalyzes the ubiquitination of several proteins. Mutations in the human Parkin gene, PRKN,...
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Related ArticlesDevelopmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice. Biochem Pharmacol. 2019 Aug 09;168:438-451 Authors: Buck JM, O'Neill HC, Stitzel JA Abstract Maternal smoking of conventional or vapor cigarettes during pregnancy, a form of developmental nicotine exposure (DNE), enhances the risk of neurodevelopmental...
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Related ArticlesWithaferin A: from Ayurvedic folk medicine to preclinical anti-cancer drug. Biochem Pharmacol. 2019 Aug 09;: Authors: Hassannia B, Logie E, Vandenabeele P, Vanden Berghe T, Berghe WV Abstract Despite the recent successes of targeted cancer immuno-therapies, drug resistance and disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed interest in natural product discovery to identify new pharmacophores...
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Related ArticlesThe tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. Bioorg Med Chem. 2019 Aug 08;:115044 Authors: Wang C, Engelke L, Bickel D, Hamacher A, Frank M, Proksch P, Gohlke H, Kassack MU Abstract Platinum compounds are the first-line therapy for many types of cancer. However, drug resistance has frequently been reported for and is a major limitation of platinum-based chemotherapy...
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Related ArticlesSafety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms. J Clin Med. 2019 Aug 15;8(8): Authors: Tafuto S, von Arx C, Capozzi M, Tatangelo F, Mura M, Modica R, Barretta ML, Di Sarno A, Tornesello ML, Colao A, Ottaiano A Abstract BACKGROUND: Platinum-based chemotherapy is the mainstay of front-line treatment of patients affected by pluri-metastatic intermediate/high grade NeuroEndocrine...
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Related ArticlesTaxanes during pregnancy in cervical cancer: A systematic review and pooled analysis. Cancer Treat Rev. 2019 Aug 06;79:101885 Authors: Zagouri F, Korakiti AM, Zakopoulou R, Kyriazoglou A, Zografos E, Haidopoulos D, Apostolidou K, Papatheodoridi MA, Dimopoulos MA Abstract BACKGROUND: Cervical cancer is one of the most common malignancies diagnosed during pregnancy. Taxanes administration has been established as theurapetic regimen in non...
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Related ArticlesOxaliplatin induces immunogenic cells death and enhances therapeutic efficacy of checkpoint inhibitor in a model of murine lung carcinoma. J Recept Signal Transduct Res. 2019 Aug 23;:1-7 Authors: Sun F, Cui L, Li T, Chen S, Song J, Li D Abstract Background: Platinum compounds are commonly used for lung cancer treatment. However, the severe side effects and relatively poor prognosis limit their therapeutic effect. Therefore, developing...
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Related ArticlesPrognostic and predictive value of histogram analysis in patients with non-small cell lung cancer refractory to platinum treated by nivolumab: A multicentre retrospective study. Eur J Radiol. 2019 Sep;118:251-256 Authors: Ravanelli M, Agazzi GM, Milanese G, Roca E, Silva M, Tiseo M, Rondi P, Baggi A, Ganeshan B, Muri M, Panni S, Botti C, Sverzellati N, Maroldi R, Berruti A, Farina D Abstract PURPOSE: The aim of this study was to assess...
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