Abstract Traditionally, when antibody to the Hepatitis B core antigen (anti-HBc) and antibody to the Hepatitis B surface antigen (anti-HBs) are positive, the donor is considered suitable. However, the literature contains cases with this profile and circulating hepatitis B virus DNA. The aim of the study is to analyze the incidence of occult hepatitis B virus infection (OBI). Retrospective data were evaluated for deceased tissue donors in ten Tissue Establishments (Spain) during...
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Abstract The ultimate goal of any periodontal plastic surgery aimed to treat gingival recession is predictable recession coverage and esthetic outcome. Due to the post-operative morbidity and discomfort related to subepithelial connective tissue graft, various other methods have been introduced including the use of fetal membranes. The fetal membranes have shown promising results in medicine and recently in the field of regenerative dentistry and could possibly become a viable...
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Abstract Biomarkers are biological characteristic to measure and evaluate normal and pathological states. To define expression-based molecular biomarkers, high-quality tissue samples are a prerequisite for the preparation of standard RNA. It is already known that RIN number defines the RNA quality, however its relation with A260/280 ratio and Ct value is not defined clearly; therefore, understanding an association will provide a reliable method for describing...
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Related ArticlesPatterns of bone metastases from head and neck squamous cell carcinoma. Auris Nasus Larynx. 2019 Aug 21;: Authors: Suzuki A, Kashiwagi N, Doi H, Ishii K, Doi K, Kitano M, Kozuka T, Hyodo T, Tsurusaki M, Yagyu Y, Nakanishi K Abstract OBJECTIVE: To report clinical features of bone metastases (BM) from head and neck squamous cell carcinoma (HNSCC). METHODS: Among 772 patients with HNSCC diagnosed at our hospital over 9 years, 30...
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Related ArticlesHelicobacter pylori is associated with poor prognosis of laryngeal precancerous lesion. Auris Nasus Larynx. 2019 Aug 21;: Authors: Chen M, Fang Y, Cheng L, Wu H Abstract OBJECTIVES: Previous evidence suggested Helicobacter pylori (H. pylori) promoted tumorigenesis by inducing inflammation in gastric premalignant disease. Whether this organism affected the development of head and neck precancerous lesion remains unknown. We performed this...
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Related ArticlesPrevalence of potential candidates for electric-acoustic stimulation implant in a hearing-impaired population. Auris Nasus Larynx. 2019 Aug 19;: Authors: Saito K, Fujita T, Osaki Y, Koyama H, Shiraishi K, Kobayashi T, Sato M, Seo T, Doi K Abstract OBJECTIVE: To estimate the prevalence of potential electric-acoustic stimulation (EAS) implant candidates in a hearing-impaired population through a review of auditory examinations. ...
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Related ArticlesThe cheek expander enables tonsillectomy with a wide view and working space. Auris Nasus Larynx. 2019 Aug 19;: Authors: Anzai T, Tsunoda A, Tajima S, Ito S, Ikeda K Abstract OBJECTIVE: Tonsillectomy is the most commonly performed otolaryngological surgeries. Although a surgical method had been established, obtaining a clear surgical field still remains problematic, and injury to the corners of the mouth may occur. For safer tonsillectomy,...
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Related ArticlesInfluence of adhesives usage in complete dentures during adaptation period varying the degree of resorption of mandibular ridges. J Prosthodont Res. 2019 Aug 21;: Authors: Silva MDDD, Viotto HEDC, Policastro VB, Leite ARP, Cassiano AFB, Mendoza Marin DO, Santana TS, Mollo FA, Pero AC Abstract PURPOSE: This study evaluated the effect of the use of a powder-type adhesive on masticatory performance and oral health related quality of life...
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Related ArticlesChewing causes rapid changes in immunoreactive nerve patterns in rat molar teeth: Implications for dental proprioception and pain. Arch Oral Biol. 2019 Jul 31;107:104511 Authors: Byers MR Abstract OBJECTIVE: This study tests the hypothesis that normal use of teeth (chewing) causes changes in immunoreactive-(IR) patterns for endings of large Aβ and CGRP axons in rat molar cusps. DESIGN: First, a new paradigm to test chewing in...
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Related ArticlesLocking up of food between posterior teeth and its influence on chewing efficiency. Arch Oral Biol. 2019 Aug 12;107:104524 Authors: Zhang Y, Liu T, Wang X, Chen J, van der Glas HW Abstract OBJECTIVES: Food particles are intra-orally locked up between antagonistic posterior teeth, during each chewing cycle. Food locking up (FL) may enhance selection of particles for subsequent breakage, hence chewing efficiency (CE). The two aims were...
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Related ArticlesOptimizing a determination of chewing efficiency using a solid test food. J Texture Stud. 2019 Aug 23;: Authors: van der Glas HW, Liu T, Zhang Y, Wang X, Chen J Abstract A test using a solid food is relevant to measure chewing ability (CA) as (1) it includes an integrated functioning of all oral structures involved, (2) an impairment of chewing a solid food causes inevitably diet restrictions, and (3) chewing efficiency (CE) can easily...
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Related ArticlesEffects of stage II transport and food bolus sampling methods on the properties of food particles. J Oral Rehabil. 2019 Aug 23;: Authors: Tanaka Y, Sugimoto H, Kodama N, Minagi S Abstract BACKGROUND: During mastication, some portion of the food bolus is gradually transported to the oropharynx before deglutition, which is known as stage II transport (STII). Although the importance of STII in mastication and deglutition has been widely...
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Related ArticlesThe Quality of Life of Patients with Surgically Treated Mandibular Fractures and the Relationship of the Posttraumatic Pain and Trismus with the Postoperative Complications: A Prospective Study. Medicina (Kaunas). 2019 Apr 17;55(4): Authors: Boljevic T, Vukcevic B, Pesic Z, Boljevic A Abstract Background and objectives: Due to the fact that the mandible is the only movable bone in the face, it is often exposed to the influence of external...
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Related ArticlesLost in translation: confusion on resection and dissection planes hampers the interpretation of pathology reports for perihilar cholangiocarcinoma. Virchows Arch. 2019 Aug 24;: Authors: Roos E, Franken LC, Soer EC, van Hooft JE, Takkenberg RB, Klümpen HJ, Wilmink JW, van de Vijver MJ, van Gulik TM, Verheij J Abstract In perihilar cholangiocarcinoma (PHC), interpretation of the resection specimen is challenging for pathologists and clinicians...
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Related ArticlesIdentifying an optimal epoch length for spectral analysis of heart rate of critically-ill infants. Comput Biol Med. 2019 Aug 16;113:103391 Authors: Govindan RB, Massaro A, Vezina G, Chang T, du Plessis A Abstract BACKGROUND AND OBJECTIVE: To identify the optimal epoch length for power spectral analysis of cardiac beat-to-beat intervals (BBi) in critically ill newborns. MATERIALS AND METHOD: BBi of 49 term newborns undergoing...
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Related ArticlesCold-inducible protein RBM3 mediates hypothermic neuroprotection against neurotoxin rotenone via inhibition on MAPK signalling. J Cell Mol Med. 2019 Aug 22;: Authors: Yang HJ, Zhuang RJ, Li YB, Li T, Yuan X, Lei BB, Xie YF, Wang M Abstract Mild hypothermia and its key product, cold-inducible protein RBM3, possess robust neuroprotective effects against various neurotoxins. However, we previously showed that mild hypothermia fails to attenuate...
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Related ArticlesTargeted Temperature Management in Nursing Care. Ther Hypothermia Temp Manag. 2019 Aug 22;: Authors: Brophy GM, Hildebrandt DA, Moore EA, Van de Bussche TJ PMID: 31436496 [PubMed - as supplied by publisher]
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Related ArticlesIncidental Finding of Thrombus by Ultrasonography in a Trauma Patient with an Intravascular Cooling Device. Ther Hypothermia Temp Manag. 2019 Aug 22;: Authors: Piclet J, Meresse Z, Mathieu C, Duclos G, Antonini F, Zieleskiewicz L, Leone M Abstract In patients with traumatic brain injury, coagulation disorders may both cause bleeding and thrombosis. The addition of risk factors, including invasive devices, probably increases the risk of...
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Related ArticlesFall Is in the Air. Ther Hypothermia Temp Manag. 2019 Aug 22;: Authors: Dietrich WD PMID: 31436476 [PubMed - as supplied by publisher]
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Related ArticlesRisk factors for shivering during caesarean section under spinal anaesthesia. A prospective observational study. Acta Anaesthesiol Scand. 2019 Aug 22;: Authors: Wódarski B, Chutkowski R, Banasiewicz J, Moorthi K, Wójtowicz S, Malec-Milewska M, Iohom G Abstract BACKGROUND: Shivering during caesarean section under spinal anaesthesia is a common phenomenon. It could not only alter patient's physiology by increasing oxygen consumption but...
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Related ArticlesTreating murine inflammatory diseases with an anti-erythrocyte antibody. Sci Transl Med. 2019 Aug 21;11(506): Authors: Crow AR, Kapur R, Koernig S, Campbell IK, Jen CC, Mott PJ, Marjoram D, Khan R, Kim M, Brasseit J, Cruz-Leal Y, Amash A, Kahlon S, Yougbare I, Ni H, Zuercher AW, Käsermann F, Semple JW, Lazarus AH Abstract Treatment of autoimmune and inflammatory diseases typically involves immune suppression. In an opposite strategy,...
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How sport and exercise medicine research can protect athlete health and promote athlete performance.
Related ArticlesHow sport and exercise medicine research can protect athlete health and promote athlete performance. Br J Sports Med. 2019 Aug 21;: Authors: Mountjoy M, Engebretsen L PMID: 31434660 [PubMed - as supplied by publisher]
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Related Articles[Hypothermia therapy focuses on continuous improvement]. Zhonghua Yi Xue Za Zhi. 2019 Aug 20;99(31):2401-2403 Authors: Su YY PMID: 31434420 [PubMed - in process]
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CONCLUSION: Patients with non-cancer symptoms are frequently referred with suspected cancer. Patients with red flag symptoms are not aware of their significance and they have low expectations of healthcare. PMID: 31439066 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links...
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CONCLUSIONS: 1. LSCs were expressed in 63.41% of AML cases and were distributed among FAB subtypes without preference to any FAB subtype. 2. The expression of LSC phenotype was associated with poor response to induction therapy in AML patients. PMID: 31438833 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best...
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Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Moslem Afzali, Ali Mostafavi, Tayebeh ShamspurAbstractDespite its useful properties, imiquimod (IMQ), known as an anti-cancer drug, can be harmful to the skin at high concentrations. Therefore, we have developed a novel electrochemical sensor to determine IMQ, for the first time. A glassy carbon electrode (GCE) was modified by a new composite comprising of ionic liquid-based molecularly imprinted polymer...
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Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Jinyang Chen, Yan Wu, Cuicui Fu, Haiyan Cao, Xiaoping Tan, Wenbing Shi, Zhaoyang WuAbstractMicroRNAs (miRNAs) serve as significant regulators in a variety of diseases and have been emerging as a class of promising biomarkers for early cancer diagnosis. Herein, an enzyme-free surface-enhanced Raman scattering (SERS) platform was proposed for sensitive and reliable detection of target miRNA-21 using a corrective...
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Publication date: Available online 23 August 2019Source: MethodsAuthor(s): Jianji Chen, Cari Sagum, Mark T BedfordAbstractSignal transduction is driven by protein interactions that are controlled by posttranslational modifications (PTM). Usually, protein domains are responsible for “reading” the PTM signal deposited on the interacting partners. Protein domain microarrays have been developed as a high throughput platform to facilitate the rapid identification of protein-protein interactions, and this...
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Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Yu-Ying Tian, Zhi-Guo Xin, Hai-Feng Hou, Xiao-Chun Zhu, Qian Guo, Qin XiaoAbstractTwo new Cu(II)-containing coordination complexes with the chemical formulae of [Cu2(pydc)2(H2O)2]n (1, pydc = 3,5-pyridinedicarboxylate) and {[Cu(H2O)2(H3hmidc)2](H2O)}n (2, H4hmidc = 2-(hydroxymethyl)-1H-imidazole-4,5-dicarboxylic acid) have been successfully synthesized and characterized under solvothermal conditions. The...
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Publication date: Available online 24 August 2019Source: Journal of Molecular StructureAuthor(s): Javed Iqbal, Banzeer Ahsan Abbasi, Riaz Ahmad, Amir Shahbaz, Syeda Anber Zahra, Sobia Kanwal, Akhtar Munir, Atiya Rabbani, Tariq MahmoodAbstractThis present study for the first time reports a facile and ecofriendly route for synthesis of IONPs. The IONPs were simply synthesized using Rhamnella gilgitica leaves extract as both reducing and stabilizing agents. The color change of the reaction mixture from...
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In this study; spectroscopic, electronic and biological properties of Boc-D-Lys-OH (BDLO) molecule have been examined using quantum chemical calculations. First of all, the molecule was optimized and geometric structure parameters and vibrational wavenumbers were calculated by DFT/ B3LYP methods 6-311G++(d,p) basis set. The calculated wavenumbers were then compared with the experimental values of the FT-IR and FT-Raman spectra. Finally, the molecular docking was determined for anti apoptotic proteins...
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Publication date: Available online 23 August 2019Source: Journal of Molecular StructureAuthor(s): Rahman Abdizadeh, Farzin Hadizadeh, Tooba AbdizadehAbstractHistone deacetylases (HDACs) as the promising therapeutic targets for the treatment of cancer and other diseases, modify chromatin structure and contribute to aberrant gene expression in cancer. Inhibition of HDACs is emerging as an important strategy in human cancer therapy and HDAC inhibitors (HDACIs) enable histone to maintain a high degree...
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This study was done by collecting wild PU and cultivated PU and compared with a counterfeit which is commonly found in the market. Fourier Transform Infrared (FTIR) and Two-Dimension Infrared (2DIR) for the qualitative analysis are often regarded as green methods because the original resources of the test sample are preserved. The different spectral patterns of the counterfeit PU compared with the genuine PU were clearly indicated in 1D FTIR spectrum. The 2DIR spectrum of counterfeit PU showed more...
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Publication date: 5 January 2020Source: Journal of Molecular Structure, Volume 1199Author(s): Di Wu, Liang Guo, Si-Jie LiAbstractTwo Schiff base ligands 2-((ethylamino)methyl)-6-methoxyphenol (HL1) and (E)-2-(((2-(dimethylamino)ethyl)imino)methyl)-6-methoxyphenol (HL2) with bi-nucleating or tri-nucleating mode have been successfully prepared via an one step organic condensation reaction, which were further applied in the synthesis of three new Cu(II) and Ni(II)-based coordination complexes [Cu(L1)2](EtOH)...
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Publication date: Available online 23 August 2019Source: Journal of Molecular BiologyAuthor(s): Chrisovalantis Papadopoulos, Bojana Kravic, Hemmo MeyerAbstractLysosomal membrane permeabilization or full rupture of lysosomes is a common and severe stress condition that is relevant for degenerative disease, infection and cancer. If damage is limited, cells can repair lysosomes by means of the endosomal sorting complex required for transport (ESCRT) machinery. Presumably if repair fails, lysosomes are...
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ConclusionsKnock-down of Linc00483 inhibited the development of cervical cancer by regulating miR-508-3p/RGS17 axis. (Source: Life Sciences)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Publication date: Available online 23 August 2019Source: Journal of Photochemistry and Photobiology A: ChemistryAuthor(s): Gonzalo Ramírez-García, Miguel Ángel Honorato-Colin, Elder De la Rosa, Tzarara López-Luke, Sandeep S. Panikar, José de Jesús Ibarra-Sánchez, Valeria PiazzaAbstractThe multifunctional hybrid nanomaterials could bring alternative solutions to current public health problems like cancer diagnosis and treatment. In this work, the near-infrared-activated NaYF4:Yb,Er up-conversion nanoparticles...
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Publication date: 15 January 2020Source: Chemical Engineering Journal, Volume 380Author(s): Xiaojuan Zhang, Chuanchuan He, Ruicong Yan, Yan Chen, Pengxuan Zhao, Minsi Li, Ting Fan, Tan Yang, Yao Lu, Jun Luo, Xiang Ma, Guangya XiangAbstractThe clinical efficacy of cisplatin (DDP) treatment is largely limited by cisplatin resistance, which is related to the activation of hypoxia-inducible factor 1 (HIF-1). The HIF-1 activation can be induced by low oxygen availability as well as chemotherapeutics in...
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In this study, we developed a nucleus-targeting nanoparticle system for combining PTT/PDT and chemotherapy to treat breast cancer. IR780, a near-infrared (NIR) fluorescence dye that has potent anticancer efficacy of PTT and PDT, was firstly conjugated with TAT peptide through substitution reaction between chlorine atom and sulfhydryl group, thus obtained a conjugate TAT-IR780 with notably enhanced water solubility and optical stability. Next, chemotherapeutic drug doxorubicin (DOX) and TAT-IR780...
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In this study, first we determined toxic doses of this complex on NIH/3T3 normal fibroblast cells, SPC212 mesothelioma and ascertained anti-proliferative, apoptotic and morphological effects of these newly synthesized compounds on DU145 prostate cancer cells through cytotoxic and microscopic methods. A novel Copper(II)/1-(4-(trifluoromethyl)benzyl)-1H-benzimidazole/2,2’-bipyridyl complex, was synthesized, and mainly characterized by single crystal x-ray diffraction analysis. Anti-proliferative effect...
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(Source: Chemical and Engineering News)
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Publication date: 24 August 2019Source: New Scientist, Volume 243, Issue 3244Author(s): Clare Wilson (Source: New Scientist)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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In this report, a new method for rapid and sensitive detection of Mrp2 function was established via using mouse small intestinal organoids. Firstly, small intestinal crypts isolated from mouse intestine were induced by Noggin, R-spondin1 and EGF to develop three-dimensional (3D) organoids. Secondly, the 3D organoids were characterized by the physical and physiological structure of Mrp2-mediated drug transport. Finally, Mrp2 fluorescent substrate 5(6)-carboxyl- 2′, 7′-dichlorofluorescein (CDF) and...
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Authors: Benoit MF, Teoh D, Chandavarkar U, Hong L, Stevens E, Brockmeyer A PMID: 31441814 [PubMed - in process] (Source: Obstetrics and Gynecology)
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ConclusionsBoth PASS-RCs improved the balance between detecting reclassification and performing surveillance biopsies by reducing unnecessary biopsies. Recalibration to the local setting will increase their clinical usefulness and is therefore required before implementation.Patient summaryUnnecessary prostate biopsies while on active surveillance (AS) should be avoided as much as possible. The ability of two calculators to selectively identify men at risk of progression was tested in a large cohort...
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Publication date: Available online 23 August 2019Source: European Journal of Surgical OncologyAuthor(s): Youjin Oh, Min Seo Kim, Yoon Teak Lee, Chang Min Lee, Jong Han Kim, Sungsoo ParkAbstractAlthough laparoscopic total gastrectomy (LTG) compared to open total gastrectomy (OTG) has been widely used for advanced gastric cancer patients, its oncologic validity is yet to be proven. We performed systemic review and meta-analysis to compare LTG versus OTG for early and advanced stages of gastric cancer....
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Authors: Arora A, Javed A, Agarwal AK Abstract Primary malignant melanoma of the esophagus is an extremely rare neoplasm arising from the esophageal mucosal melanocytes. We herein describe a patient of primary malignant melanoma of the esophagus, who was managed by thoracolaparoscopic esophagectomy. PMID: 31435466 [PubMed] (Source: Oman Medical Journal)
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Authors: Al Elq AH Abstract Intravenous bisphosphonates are widely used in the management of solid tumors, metastatic bone disease, metabolic bone diseases and hypercalcemia of malignancies. Recently, yearly intravenous injections of zoledronic acid, one of the potent nitrogen-containing bisphosphonates, have also been approved for the prevention and treatment of osteoporosis. Although infrequently observed, asymptomatic hypocalcemia mainly due to intravenous bisphosphonates has been documented....
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ConclusionElevated AURKB expression was strongly correlated to TMZ resistant acquisition and poor prognosis, furthermore, targeting AURKB would be a potential therapeutic target for GBM patients. (Source: Pathology Research and Practice)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Conclusion: Misdiagnosis and inadvertent surgical intervention in cases of retinoblastoma in combination with delayed initiation of appropriate treatment is associated with poor prognosis. High index of suspicion for retinoblastoma is needed to avoid misdiagnosis and mismanagement. (Source: RETINA)
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The objective of this article is to document whether DIRT can accurately map the position of the perforators and measure their influence on the perfusion of the flap in order to select the best perforators to improve the outcome of breast reconstructions with free DIEP flaps. A systematic review of the literature published between January 1998 and November 23th 2018 was conducted regarding the possible benefit of dynamic infrared thermography (DIRT) in DIEP-flap breast reconstructions.The databases...
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Publication date: Available online 23 August 2019Source: European Journal of Obstetrics & Gynecology and Reproductive BiologyAuthor(s): Susie Brousse, Marine Joste, Franck Marie Leclère, Vincent Lavoué, Nicolas Bertheuil (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
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ConclusionDuring the observation period of>3 years, serum M2BP concentrations were increased in subjects who also exhibited increases in levels of metabolic parameters, especially LDL-C, and the oxidative stress marker d-ROM. These results support that serum M2BP reflects one of the contributors to the progression of silent atherosclerosis.Graphical abstract (Source: Nutrition, Metabolism and Cardiovascular Diseases)
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One woman's truly life-changing experience of caring for a mother with cancer. (Source: AJN)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Alpelisib (Piqray) is now approved to treat postmenopausal women or men who have hormone receptor–positive, human epidermal growth factor receptor 2–negative, PIK3CA-mutated, advanced or metastatic breast cancer that has progressed during or after endocrine-based therapy. (Source: AJN)
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Two studies explore outcomes for low-income, middle-aged adults. (Source: AJN)
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Authors: Kwon CI Abstract Pancreatic cancer is a major cause of cancer-related mortality and morbidity, and its incidence is increasing as the population is aging. On the other hand, significant improvement in the prognosis has not occurred. The absence of early diagnosis means that many patients are diagnosed only when they develop symptoms, such as jaundice, due to a biliary obstruction. The role of endoscopy in multidisciplinary care for patients with pancreatic cancer continues to evolve....
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