A facile strategy is developed for the preparation of a bovine serum albumin (BSA) –polyaniline (PANI) assemblies with tumor pH ‐responsivity for amplified photoacoustic imaging and augmented photothermal therapy, through intermolecular acid–base reactions between carboxyl groups of BSA and imine moieties of PANI. AbstractTumor ‐microenvironment‐responsive theranostics have great potential for precision diagnosis and effective treatment of cancer. Polyaniline (PANI) is the first reported pH‐responsive...
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Publication date: September 2019Source: Clinical Lymphoma Myeloma and Leukemia, Volume 19, Issue 9Author(s): (Source: Clinical Lymphoma Myeloma and Leukemia)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Publication date: September 2019Source: Clinical Lymphoma Myeloma and Leukemia, Volume 19, Issue 9Author(s): (Source: Clinical Lymphoma Myeloma and Leukemia)
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Authors: Bax Lotesoriere Sironi Capelli Cancer is one of the major causes of mortality worldwide and its already large burden is projected to increase significantly in the near future with a predicted 22 million new cancer cases and 13 million cancer-related deaths occurring annually by 2030. Unfortunately, current procedures for diagnosis are characterized by low diagnostic accuracies. Given the proved correlation between cancer presence and alterations of biological fluid...
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The publisher regrets that the Conflict of Interests statements provided by the author were not added as supplementary items. Please see below a summary statement of the conflicts of interest for this manuscript: (Source: Lung Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Authors: Mongre Mishra Prakash Jung Lee Kumari Hong Lee Lung cancer is a type of deadly cancer and a leading cause of cancer associated death worldwide. BCL-2 protein is considered as an imperative target for the treatment of cancer due to their significant involvement in cell survival and death. A carbazole-piperazine hybrid molecule ECPU-0001 was designed and synthesized as a potent BCL-2 targeting agent with effective anticancer cancer activity. Interaction...
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In this study, human serum albumin (HSA) complexed with 5BMF (5BMF@HSA) has been developed to further improve its solubility (from 1.61 to 5.41 mg/mL), and the fluorescent intensity of 5BMF@HSA was improved over 2 times. Nearly 10-fold 5BMF was released from 5BMF@HSA complex in acidic condition when compared with neutral/basic environment. Intracellular distribution of 5BMF was altered by HSA as its signals were observed in lysosomes where free 5BMF barely localized. Both 5BMF@HSA and 5BMF showed...
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Publication date: Available online 24 August 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Maha Hafsi, Sandra Preveral, Christopher Hoog, Joel Hérault, Géraldine Adryanczyk Perrier, Christopher T Lefèvre, Hervé Michel, David Pignol, Jérôme Doyen, Thierry Pourcher, Olivier Humbert, Juliette Thariat, Béatrice CambienAbstractAlthough chemically synthesized ferro/ferrimagnetic nanoparticles have attracted great attention in cancer theranostics, they lack radio-enhancement efficacy...
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Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Mohamed Gaber, Mark Hany, Sarah Mokhtar, Maged W. Helmy, Kadria A. Elkodairy, Ahmed O. ElzoghbyAbstractMulti-modality strategies of albumin-mediated drug accumulation in tumor, boronate-based active tumor targeting and synergistic cancer therapy were combined together for effective treatment of breast cancer. Herein we report the development of albumin-shell oily-core nanocapsules (NCs), loaded with...
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Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Sushma Havanur, Inayat Batish, Sri Pragnya Cheruku, Karthik Gourishetti, JagadeeshBabu P.E., Nitesh KumarAbstractCancer has emanated as a daunting menace to human-kind even though medicine, science, and technology has reached its zenith. Subsequent scarcity in the revelation of new drugs, the exigency of salvaging formerly discovered toxic drugs such as doxorubicin has emerged. The invention of drug...
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Publication date: Available online 24 August 2019Source: NeuroscienceAuthor(s): Roger D. Madison, Grant A. RobinsonAbstractExtracellular vesicles are lipid bilayer-enclosed extracellular structures. Although the term extracellular vesicles is quite inclusive, it generally refers to exosomes (< 200 nm), and microvesicles (~ 100–1000 nm). Such vesicles are resistant to degradation and can contain proteins, lipids, and nucleic acids. Although it was previously thought that the primary purpose of...
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Conclusions: Neurocutaneous syndromes are clinically heterogeneous and the surveillance of potential clinical complications is challenging. The availability of genetic diagnosis and novel imaging methods in this group of disorders is likely to further expand their clinical spectrum. Guidelines for assessment and management will need to be modified based on new available data. PMID: 31443616 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
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Publication date: Available online 25 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Huseyin Bilgin Bilgic, Selin Hacilarlioglu, Serkan Bakirci, Onur Kose, Ahmet Hakan Unlu, Ayca Aksulu, Metin Pekagirbas, Jabbar Ahmed, Christina Deschermeier, Gordon Langley, Tulin KaragencAbstractBabesiosis is a disease complex caused by unicellular Babesia parasites and among them, malignant ovine babesiosis caused by B. ovis has a devastating economical impact on the small ruminant industry. The control...
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In this study, a library of P450BM3 mutants was produced using site-directed mutagenesis and the enzymes screened for metabolism of the opium poppy alkaloid noscapine, a drug with anticancer activity. Of the 18 enzyme mutants screened, 12 showed an ability to metabolise noscapine that was not present in the wild-type enzyme. Five noscapine metabolites were detected by LC-MS/MS, with the major metabolite for all mutants being N-demethylated noscapine. The highest observed regioselectivity for N-demethylation...
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Publication date: Available online 24 August 2019Source: Inorganica Chimica ActaAuthor(s): I.I. Ozturk, C.N. Banti, S.K. Hadjikakou, N. Panagiotou, A.J. TasiopoulosAbstractA series of mononuclear, dinuclear and polynuclear bismuth(III) iodide complexes (1-5) bearing heterocyclic thioamide ligands, 2-mercapto-3,4,5,6-tetrahydro-pyrimidine (tHPMT), 2-mercapto-benzimidazole (MBZIM), 2-mercapto-1-methylimidazole (MMI), 2-mercaptobenzothiazole (MBZT) and 2-mercaptopyridine (PYT), have been synthesized...
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Authors: Andrey Smolobochkin Almir Gazizov Marina Sazykina Nurgali Akylbekov Elena Chugunova Ivan Sazykin Anastasiya Gildebrant Julia Voronina Alexander Burilov Shorena Karchava Maria Klimova Alexandra Voloshina Anastasia Sapunova Elena Klimanova Tatyana Sashenkova Ugulzhan Allayarova Anastasiya Balakina Denis Mishchenko A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular...
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Authors: Moacă Pavel Danciu Crăiniceanu Minda Ardelean Antal Ghiulai Cioca Derban Simu Chioibaş Szuhanek Dehelean Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory...
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In this study, the chemical composition, antioxidant and cytotoxic activities of extracts of the leaves, bark, twigs and oleo-resin from D. alatus are investigated. Cytotoxicity was measured by the neutral red (NR) assay against HCT116, SKLU1, SK-MEL2, SiHa and U937 cancer cell lines and antioxidant capacity was evaluated by DPPH, ABTS radical scavenging, and ferric reducing antioxidant power (FRAP) assays. The chemical composition was analyzed by gas chromatography–mass spectrometry (GC-MS). Leaf,...
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Conclusions: The study documented the low level of BC knowledge among male partners. There is an urgent need to pay more consideration to disseminating awareness among men, as they are associates, and they must be armed with proper awareness. There is an urgent demand for establishing a national program and educational campaigns towards BC. Stressing the advantages and access to free mammography is necessary. (Source: International Journal of Environmental Research and Public Health)
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Conclusions. The BENECA mHealth lifestyle application with a supervised rehabilitation program had a statistically and clinically significant effect on QoL and upper-limb functionality in breast cancer survivors and is a unique and important promising new approach. (Source: Annals of Physical and Rehabilitation Medicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Related ArticlesRenal cell tumors with an entrapped papillary component: a collision with predilection for oncocytic tumors. Virchows Arch. 2019 Aug 23;: Authors: Williamson SR, Cheng L, Gadde R, Giannico GA, Wasco MJ, Taylor Smith PJ, Gupta NS, Grignon DJ, Jorda M, Kryvenko ON Abstract Renal cell tumors with mixed morphology resembling multiple renal cell carcinoma (RCC) subtypes are generally regarded as unclassified RCC. However, occasionally, papillary...
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Related ArticlesAbstracts : 31 st European Congress of Pathology. Virchows Arch. 2019 Aug 22;: Authors: PMID: 31440833 [PubMed - as supplied by publisher]
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Related ArticlesClinico-pathological features of gynecological myopericytoma: a challenging diagnosis in an exceptional location. Virchows Arch. 2019 Aug 13;: Authors: Borella F, Lucchino F, Bertero L, Ribotta M, Castellano I, Carosso A, Cosma S, Katsaros D, Benedetto C Abstract Myopericytomas (MPC) are rare mesenchymal tumors, originating from the perivascular myoid cells. They predominantly occur in the skin and superficial soft tissues of the extremities,...
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Hemiarch Reconstruction Versus Clamped Aortic Anastomosis for Concomitant Ascending Aortic Aneurysm.
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