Related ArticlesThe Synchronization Manifesto: A critique of whole-culture synchronization. FEBS J. 2019 Aug 25;: Authors: Cooper S Abstract The field of cell cycle studies is dominated by the incorrect idea that one can treat an entire culture to produce a synchronized culture. If this predominant method cannot work, at all, then an enormous amount of work on the cell cycle must be re-evaluated. Here, criteria are presented for determining whether a...
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Related ArticlesPynA is a pyrimidine 5'-nucleotidase that functions as an antimutator protein in Streptococcus pneumoniae. FEBS J. 2019 Aug 22;: Authors: Ulrych A, Petráčková D, Goldová J, Buriánková K, Doubravová L, Branny P Abstract Streptococcus pneumoniae is a gram-positive bacterium that is a major agent of community acquired bacterial pneumonia, meningitis and sepsis. Although the mismatch repair function of S. pneumoniae has been assigned to...
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Related ArticlesA synthetic glycerol assimilation pathway demonstrates biochemical constraints of cellular metabolism. FEBS J. 2019 Aug 22;: Authors: Lindner SN, Aslan S, Müller A, Hoffart E, Behrens P, Edlich-Muth C, Blombach B, Bar-Even A Abstract The engineering of synthetic metabolic routes can provide valuable lessons on the roles of different biochemical constraints in shaping pathway activity. In this study, we designed and engineered a novel...
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Related ArticlesLong noncoding RNA KCNQ1OT1 promotes apoptosis in neuroblastoma cells by regulating miR-296-5p/Bax axis. FEBS J. 2019 Aug 21;: Authors: Li MM, Liu XH, Zhao YC, Ma XY, Zhou YC, Zhao YX, Liu XY Abstract Long noncoding RNAs (lncRNAs) are emerging as important regulators of multiple cellular processes such as cell invasion, growth, apoptosis, and differentiation. LncRNAs can function as competing endogenous RNAs (ceRNAs) which sponge and...
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Related ArticlesPPARγ induces NEDD4 gene expression to promote autophagy and insulin action. FEBS J. 2019 Aug 18;: Authors: Liu J, Yao Q, Xiao L, Ma W, Li F, Lai B, Wang N Abstract The E3 ubiquitin ligase neural precursor cell-expressed developmentally down-regulated protein 4 (NEDD4) plays a crucial role in governing a number of signaling pathways, including insulin and autophagy signaling. However, the molecular mechanism by which NEDD4 gene is transcriptionally...
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Related ArticlesInter-domain communication suppressing high intrinsic ATPase activity of Sse1 is essential for its co-dissaggregase activity with Ssa1. FEBS J. 2019 Aug 18;: Authors: Kumar V, Peter JJ, Sagar A, Ray A, Jha MP, Rebeaud ME, Tiwari S, Goloubinoff P, Ashish, Mapa K Abstract In eukaryotes, Hsp110s are unambiguous cognates of the Hsp70 chaperones, in primary sequence, domain organization and structure. Hsp110s function as nucleotide exchange...
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CONCLUSIONS In gastric cancer, increased expression of miR-205-5p was associated with tumor stage, and in SGC-7901 cells PTEN was a target gene for miR-205-5p. PMID: 31444971 [PubMed - in process] (Source: Medical Science Monitor)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Lymph node involvement is an important determinant of treatment and prognosis in non-small cell lung cancer (NSCLC) and must be determined via surgical lymph node (LN) evaluation. However, lymphadenectomy is associated with multiple significant morbidities. Recent studies have suggested LN evaluation can be foregone in some or all patients with NSCLC ≤ 2.0 cm. Our objective was to identify if these patients may be safely spared the morbidity of lymphadenectomy. (Source: The Journal of Thoracic and...
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Authors: Cheng Z Abstract Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence has revealed that FoxO (forkhead box class O) transcription factors have a multifaceted role in autophagy regulation and dysregulation. Nuclear FoxOs transactivate genes that control the formation of autophagosomes and their fusion...
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Publication date: Available online 24 August 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Nandini Pathak, Kaneez Fatima, Sneha Singh, Divya Mishra, Amit Chand Gupta, Yogesh Kumar, Debabrata Chanda, D.U. Baw.ule, Karuna Shanker, Feroz Khan, Atul Gupta, Suaib Luqman, Arvind S. NegiAbstractBreast cancer is the most prevalent cancer in women affecting about 12% of world’s female population. It is a multifactorial disease, mostly invasive in nature. Diosgenin and related...
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ConclusionsOur study provides the characterization of circRNAs in cancer cell lines and explored the potential mechanism of circRNA biogenesis as well as its therapeutic implications. We also provide a data portal to facilitate the related biomedical researches. (Source: Genome Medicine)
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To elucidate the effect of the biallelic somatic TSC2 mutations, identified in one adolescent patient, in renal cell carcinoma (RCC). (Source: Urology)
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Results are reported from a matched case-control analysis assessing toxicity related to radiation therapy in a large sample of U.S. veterans afflicted with inflammatory bowel disease (IBD) and rectal cancer. When comparing IBD and non-IBD rectal cancer patients treated with radiation therapy, patients with IBD experienced similar rates of toxicity and thus should be considered for neoadjuvant radiation therapy when otherwise indicated. (Source: International Journal of Radiation Oncology * Biology...
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We initially aimed to ascertain the application value of inflammatory indexes in predicting severe acute radiation pneumonitis (SARP). Furthermore, a novel nomogram and risk classification system integrating clinicopathological, dosimetric and biological parameters were built to provide individualized risk assessment and accurate prediction of SARP in patients with esophageal cancer (EC) who received radiotherapy (RT). (Source: International Journal of Radiation Oncology * Biology * Physics)
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Synchrotron Microbeam radiation-therapy (MRT) is a unique treatment that spatially distributes the X-ray beam into several microbeams of very high dose. MRT significantly delays the tumor regrowth compared to uniform radiotherapy. The underling mechanisms include tumor vascular disruption, senescence, inflammatory and anti-tumor immune responses. MRT could be considered as a new and promising therapeutic approach in the treatment of radioresistant melanoma. (Source: International Journal of Radiation...
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Malignant transformation (MT) of adult grade II glioma (low-grade glioma [LGG]) is associated with adverse survival. We sought to describe the incidence, outcomes, and risk-factors for MT of molecularly-classified LGG. (Source: International Journal of Radiation Oncology * Biology * Physics)
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Publication date: Available online 24 August 2019Source: Pathology - Research and PracticeAuthor(s): Radhika Sekhri, Shweta Agarwal (Source: Pathology Research and Practice)
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ConclusionOur results indicated that FAM83H-AS1 may function as an oncogene in gastric cancer and could be used as a prognosis predictor or diagnostic biomarker in gastric cancer. (Source: Pathology Research and Practice)
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ConclusionsAPOE is a useful marker for assessing NSCLC patients with lymph node metastasis. (Source: Pathology Research and Practice)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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ConclusionsExercise training reduces pro-inflammatory markers in cancer survivors, with the strongest evidence for combined training and for prostate and breast cancer survivors. Further research is warranted to determine if these changes are clinically relevant or are associated with improvements in symptoms. To strengthen future research, focusing on novel immune populations that include functional parameters and standardized reporting of key immune outcomes is recommended. (Source: Brain, Behavior,...
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In conclusion, although human studies are needed, NPs obtained from food-derived flavonoids have promising anticancer effects in vivo. (Source: Seminars in Cancer Biology)
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Publication date: Available online 24 August 2019Source: Seminars in Cancer BiologyAuthor(s): Ahmad Khurshid, Ju Lee Eun, Shaikh Sibhghatulla, Kumar Anuj, Madhusudana Rao Kummara, Park So-Yong, O Jin Jun, Soo Han Sung, Choi InhoAbstractIntegrins are the main cell surface receptors and execute multifaceted functions such as the bidirectional transmission of signals (i.e., inside-out and outside-in) and provide communication between cells and their microenvironments. Integrins are the key regulators...
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Publication date: Available online 24 August 2019Source: Seminars in Cancer BiologyAuthor(s): Sébastien Marx, Thomas Dal Maso, Jia-Wei Chen, Marina Bury, Johan Wouters, Carine Michiels, Benjamin Le CalvéAbstractThe majority of cancer-associated deaths are related to secondary tumor formation. This multistep process involves the migration of cancer cells to anatomically distant organs. Metastasis formation relies on cancer cell dissemination and survival in the circulatory system, as well as adaptation...
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Publication date: Available online 24 August 2019Source: Seminars in Cancer BiologyAuthor(s): Crescenzo D’Alterio, Stefania Scala, Gabriella Sozzi, Luca Roz, Giulia BertoliniAbstractSeveral lines of compelling pre-clinical evidence identify chemotherapy as a potentially double-edged sword: therapeutic efficacy on the primary tumor may in fact be counterbalanced by the induction of tumor/host reactive responses supportive for survival and dissemination of cancer cell subpopulations. This paradoxical...
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