Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. Hepatectomy and liver transplantation (LT) are regarded as the radical treatment, but great majority of patients are already in advanced stage on the first diagnosis and lose the surgery opportunity. Multifarious image-guided interventional therapies, termed as locoregional ablations, are recommended by various HCC guidelines for the clinical practice. Transarterial chemoembolization (TACE) is firstly recommended for intermediate-stage...
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Objective. IL-35 was reported as a crucial anti-inflammatory cytokine and could efficiently regulate bone metabolism in murine collagen-induced arthritis model. However, the relationship between IL-35 and bone health in human rheumatoid arthritis (RA) has not been clarified. In this study, the aim was to explore the correlations between IL-35 and bone loss in postmenopausal women with RA. Methods. The study included 76 postmenopausal women with RA and 53 healthy postmenopausal women as healthy controls...
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Abstract The agricultural pest, Homalodisca vitripennis, relies on vibrational communication through plants for species identification, location, and courtship. Their vibrational signal exhibits a dominant frequency between 80 and 120 Hz, with higher frequency, lower intensity harmonics occurring approximately every 100 Hz. However, previous research revealed that not all harmonics are recorded in every signal. Therefore, how the female H. vitripennis vibrational signal changes...
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Related ArticlesPharyngeal Area Changes in Parkinson's Disease and Its Effect on Swallowing Safety, Efficiency, and Kinematics. Dysphagia. 2019 Aug 24;: Authors: Curtis JA, Molfenter SM, Troche MS Abstract Pharyngeal area can increase as a function of normal healthy aging and muscle atrophy. These increases in pharyngeal area can negatively affect swallowing function in healthy older adults (HOA). However, the presence of pharyngeal area changes and...
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Related ArticlesOutcomes of tracheoesophageal puncture in twice-radiated patients. Am J Otolaryngol. 2019 Aug 02;:102272 Authors: Clancy K, Sozansky Lujan J, Xia T, Zender C, Maronian N Abstract OBJECTIVE: Previous research has demonstrated the safety of tracheoesophageal puncture voice prosthesis (TEP) placement in radiated patients; however, there is a growing population of twice-radiated patients with limited research on the outcomes of TEP-placement...
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Related ArticlesDysphagia prevalence and predictors in cancers outside the head, neck, and upper gastrointestinal tract. J Pain Symptom Manage. 2019 Aug 21;: Authors: Kenny C, Regan J, Balding L, Higgins S, O'Leary N, Kelleher F, McDermott R, Armstrong J, Mihai A, Tiernan E, Westrup J, Thirion P, Walsh D Abstract CONTEXT: Dysphagia is usually associated with malignancies of the head, neck, and upper gastrointestinal tract, but also occurs in those with...
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Related ArticlesThe Development of a Digital Dysphagia Guide with Care Homes: Co-Production and Evaluation of a Nutrition Support Tool. Geriatrics (Basel). 2019 Aug 15;4(3): Authors: Pownall S, Barnett E, Skilbeck J, Jimenez-Aranda A, Fowler-Davis S Abstract Good nutrition is a recognised outcome in the health and well-being of older care home residents and dysphagia is a known risk factor associated with under nutrition and poor outcomes. The study...
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Related ArticlesPerioperative Complications of Inpatient and Outpatient Single-Level Posterior Cervical Foraminotomy: A Comparative Retrospective Study. Spine J. 2019 Aug 20;: Authors: Mesregah MK, Chantarasirirat K, Formanek B, Buser Z, Wang JC Abstract BACKGROUND CONTEXT: Posterior cervical foraminotomy (PCF) is a relatively safe procedure for the treatment of cervical radiculopathy. Though most often performed as an inpatient procedure, there is an...
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Related ArticlesEffects of stage II transport and food bolus sampling methods on the properties of food particles. J Oral Rehabil. 2019 Aug 23;: Authors: Tanaka Y, Sugimoto H, Kodama N, Minagi S Abstract BACKGROUND: During mastication, some portion of the food bolus is gradually transported to the oropharynx before deglutition, which is known as stage II transport (STII). Although the importance of STII in mastication and deglutition has been widely...
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Related ArticlesSwallowing-related outcomes associated with late lower cranial neuropathy in long-term oropharyngeal cancer survivors: cross-sectional survey analysis. Head Neck. 2019 Aug 23;: Authors: Aggarwal P, Zaveri JS, Goepfert RP, Shi Q, Du XL, Swartz M, Lai SY, Fuller CD, Lewin JS, Piller LB, Hutcheson KA Abstract BACKGROUND: The purpose of this study was to quantify the association of late lower cranial neuropathy (late LCNP) with swallowing-related...
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Related ArticlesEffects of Verbal Cueing on Respiratory-Swallow Patterning, Lung Volume Initiation, and Swallow Apnea Duration in Parkinson's Disease. Dysphagia. 2019 Aug 22;: Authors: Curtis JA, Troche MS Abstract Respiratory-swallow coordination (RSC) is important for swallowing safety. Atypical RSC is common in Parkinson's disease (PD) and is associated with the presence of dysphagia and aspiration. Verbal cueing is known to affect RSC in healthy...
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Related ArticlesDysphagia after C2-7 in situ Posterior Fusion in a Patient with Diffuse Idiopathic Skeletal Hyperostosis: Case Report of a Rare Presentation. Spine Surg Relat Res. 2019;3(3):270-273 Authors: Ito K, Kadono I, Okada T, Hishida A, Ando K, Kobayashi K, Tsushima M, Machino M, Ota K, Morozumi M, Tanaka S, Nishida Y, Ishiguro N, Imagama S PMID: 31440688 [PubMed]
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Related ArticlesIngested sharp foreign body presented as chronic esophageal stricture and inflammatory mediastinal mass for 113 weeks: Case report. Ann Med Surg (Lond). 2019 Sep;45:91-94 Authors: Tashtush NA, Bataineh ZA, Yusef DH, Al Quran TM, Rousan LA, Khasawneh R, Aleshawi AJ, Altamimi EM Abstract Introduction: Impacted foreign bodies in the esophagus have the potential to cause serious complications. Ingested sharp objects carry the risk of acute...
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Related ArticlesNovel mutations of the POLR3A gene caused POLR3-related leukodystrophy in a Chinese family: a case report. BMC Pediatr. 2019 Aug 22;19(1):289 Authors: Wu S, Bai Z, Dong X, Yang D, Chen H, Hua J, Zhou L, Lv H Abstract BACKGROUND: POLR3-related leukodystrophy is an autosomal recessive neurodegenerative disorder characterized by onset time ranging from the neonatal period to late childhood, progressive motor decline that manifests as spasticity,...
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Related Articles[CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF THE GASTRODUODENAL MUCOSAL LESIONS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION WITH DIFFERENT BODY MASS STATUS]. Georgian Med News. 2019 Mar;(288):73-77 Authors: Derbak M, Boldizhar О, Koval G, Dankanych Е, Lazur Y Abstract The high prevalence and incidence of the chronic hepatitis C infection (CHC) is associated with the considerable medical and social problems, development of variety of...
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Related ArticlesCould Aspiration Pepsin Be Used as a Marker of Gastric Reflux? Chest. 2018 04;153(4):1077 Authors: Ren JJ, Wang J, Zhao Y, He ZP PMID: 29626957 [PubMed - indexed for MEDLINE]
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Related ArticlesIs integrated relaxation pressure a promising predictor of effectiveness of peroral endoscopic myotomy for achalasia? Z Gastroenterol. 2018 02;56(2):111-116 Authors: Jin H, Zhao W, Zhang L, Zheng Z, Wang T, Wu L, Wang B Abstract BACKGROUND: Peroral endoscopic myotomy (POEM), first introduced in 2010, appears to be an effective therapy with few complications. This study aimed to find an optimal predictor of POEM outcome in achalasia....
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Related ArticlesUpper airway tract complications of endotracheal intubation. Br J Hosp Med (Lond). 2019 Aug 02;80(8):441-447 Authors: Tikka T, Hilmi OJ Abstract The gold standard in airway maintenance is translaryngeal endotracheal intubation, but this is not without its complications. Trauma to the upper airway as a result of the act of endotracheal intubation is a common event in adults undergoing procedures under general anaesthesia. Sites requiring...
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Related ArticlesShort Term Effects of Mitomycin C Infiltration for Caustic Oesophageal Strictures in Children. J Pediatr Gastroenterol Nutr. 2019 Aug 16;: Authors: Wishahy AMK, Seleim H, Qinawy M, Mohamed W, Mansour O, Abdullateef KS, Elkadi R, Raslan H, Arafa A, Yassin T Abstract OBJECTIVES: The aim of this study was to investigate the efficacy and safety of endoscopic local infiltration of mitomycin C (MMC) after oesophageal dilation for children suffering...
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Related ArticlesTotal esophagogastric dissociation (TEGD): Lessons from two decades of experience. J Pediatr Surg. 2019 Jun;54(6):1214-1219 Authors: Coletta R, Aldeiri B, Jackson R, Morabito A Abstract BACKGROUND: Total esophagogastric dissociation (TEGD) has been performed in our institution since 1994, predating its published description by Bianchi in 1997. Originally it was considered a rescue procedure when conventional antireflux surgery failed....
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Related ArticlesSHR-A1403, a novel c-Met antibody-drug conjugate, overcomes AZD9291 resistance in NSCLC cells overexpressing c-Met. Cancer Sci. 2019 Aug 25;: Authors: Tong M, Gao M, Xu Y, Fu L, Li Y, Bao X, Fu H, Quan H, Lou L Abstract EGFR tyrosine kinase inhibitors (TKIs) have been used as the first-line treatment of non-small cell lung cancers (NSCLCs) harboring EGFR-activating mutations, while acquired resistance is ubiquitous and needs to be solved...
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Related ArticlesGlutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma. Cancer Sci. 2019 Aug 24;: Authors: Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O Abstract Targeting the function of membrane transporters in cancer stemlike cells is a potential new therapeutic approach. Cystine-glutamate antiporter...
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Related ArticlesSerum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma. Cancer Sci. 2019 Aug 23;: Authors: Maekawa K, Ri M, Nakajima M, Sekine A, Ueda R, Tohkin M, Miyata N, Saito Y, Iida S Abstract Although the proteasome inhibitor bortezomib (BTZ) shows excellent efficacy in multiple myeloma (MM), a fraction of patients has a suboptimal or no response to this agent. In addition, BTZ-induced peripheral neuropathy...
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Related ArticlesMolecular and clinical analysis of Chinese patients with ALK-rearranged non-small cell lung cancer. Cancer Sci. 2019 Aug 23;: Authors: Zhou X, Shou J, Sheng J, Xu C, Ren S, Cai X, Chu Q, Wang W, Zhen Q, Zhou Y, Li W, Pan H, Li H, Sun T, Cheng H, Wang H, Lou F, Rao C, Cao S, Pan H, Fang Y Abstract Anaplastic lymphoma kinase (ALK) fusions have been recognized as a therapeutic target in non-small cell lung cancer (NSCLC). However, molecular...
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Related ArticlesIdo2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma. Cancer Sci. 2019 Aug 23;: Authors: Yamasuge W, Yamamoto Y, Fujigaki H, Hoshi M, Nakamoto K, Kunisawa K, Mouri A, Nabeshima T, Saito K Abstract Tryptophan metabolism is important to induce immune tolerance in tumors. Till date, three types of tryptophan-metabolizing enzymes have been identified: indoleamine 2,3-dioxygenase 1 and 2 (IDO1 and IDO2) and tryptophan...
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Related ArticlesMutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis. Cancer Sci. 2019 Aug 22;: Authors: Suehara Y, Sakata-Yanagimoto M, Hattori K, Kusakabe M, Nanmoku T, Sato T, Noguchi M, Chiba S Abstract Cell-free DNA (cfDNA) analysis to detect circulating tumor DNA has been focused in monitoring of malignant lymphomas. However, clonal hematopoiesis of indeterminate potential (CHIP)-associated...
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Related ArticlesPatient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance. Cancer Sci. 2019 Aug 20;: Authors: Kita K, Fukuda K, Takahashi H, Tanimoto A, Nishiyama A, Arai S, Takeuchi S, Yamashita K, Ohtsubo K, Otani S, Yanagimura N, Suzuki C, Ikeda H, Tamura M, Matsumoto I, Yano S Abstract Patient-derived xenograft (PDX) models are a useful tool in cancer biology research. However, the number...
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Related ArticlesBSP - αvβ3 integrin axis promotes breast cancer metastasis to the bone. Cancer Sci. 2019 Aug 20;: Authors: Wang L, Song L, Li J, Wang Y, Yang C, Kou X, Xiao B, Zhang W, Li L, Liu S, Wang J Abstract The underlying mechanisms of breast cancer cells metastasizing to distant sites are complex and multi-factorial. Bone sialoprotein (BSP) and αvβ3 integrin were reported to promote the metastatic progress of breast cancer cells, particularly...
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Related ArticlesImproved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells. Cancer Sci. 2019 Aug 20;: Authors: Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K Abstract Chimeric antigen receptor-engineered T (CAR-T) cell therapy holds a significant promise for the treatment of hematological malignancies, especially for B-cell leukemia and lymphoma. However, its efficacy against non-hematological malignancies...
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Related ArticlesG9a and HDACs are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Sci. 2019 Aug 20;: Authors: Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B, Zhang H, Cui Y, Kong W, Wu H, Yu X Abstract Functional E-cadherin loss, a hallmark of epithelial-to-mesenchymal transition (EMT), is important for metastasis. However, the mechanism of Snail2 in hepatocellular (HCC) EMT and metastasis remains unclear....
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Related ArticlesInterleukin-17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma. Cancer Sci. 2019 Aug 20;: Authors: Aotsuka A, Matsumoto Y, Arimoto T, Kawata A, Ogishima J, Taguchi A, Tanikawa M, Sone K, Mori-Uchino M, Tsuruga T, Oda K, Kawana K, Osuga Y, Fujii T Abstract The programmed cell death 1/programmed cell death 1 ligand 1 pathway was successfully targeted in cancer immunotherapy. Elevated interleukin-17,...
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Related ArticlesGermline mutation in DNA-repair genes is associated with poor survival in BRCA1/2-negative breast cancer patients. Cancer Sci. 2019 Aug 20;: Authors: Fan Z, Hu L, Ouyang T, Li J, Wang T, Fan Z, Fan T, Lin B, Xu Y, Xie Y Abstract BRCA1/2 genes are the most frequently germline mutated DNA-repair genes and the survival of BRCA1/2 carriers has been extensively explored in breast cancer. However, the prevalence of germline mutations in non-BRCA1/2...
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Related ArticlesCombined administration of medium-chain fatty acids and glucose protects against cancer-associated skeletal muscle atrophy. Cancer Sci. 2019 Aug 20;: Authors: Mori T, Ohmori H, Luo Y, Mori S, Miyagawa Y, Nukaga S, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Kawahara I, Kuniyasu H Abstract Skeletal muscle volume is associated with prognosis of cancer patients. Maintenance of skeletal muscle is an essential issue in cancer treatment....
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Related ArticlesApatinib induces 3-Hydroxybutyric acid production in the liver of mice by PPARα activation to aid its anti-tumor effect. Cancer Sci. 2019 Aug 19;: Authors: Feng S, Wang H, Wang Y, Sun R, Xie Y, Zhou Z, Wang H, A A J, Zhou F, Wang G Abstract Apatinib, an antiangiogenic agent, shows efficient anti-tumor activity on a broad range of malignancies. Considering tumor is a kind of metabolic disease, we investigated the metabolomics changes...
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Related ArticlesTyrosine kinase inhibitor prophylaxis after transplant for Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer Sci. 2019 Aug 11;: Authors: Akahoshi Y, Nishiwaki S, Mizuta S, Ohashi K, Uchida N, Tanaka M, Fukuda T, Ozawa Y, Takahashi S, Onizuka M, Shiratori S, Nakamae H, Kanda Y, Ichinohe T, Atsuta Y, Kako S Abstract Tyrosine kinase inhibitor (TKI) administration after allogeneic hematopoietic stem cell transplantation...
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Related ArticlesCharacterization of myeloid-derived suppressor cells and cytokines GM-CSF, IL-10 and MCP-1 in dogs with malignant melanoma receiving a GD3-based immunotherapy. Vet Immunol Immunopathol. 2019 Jul 31;216:109912 Authors: Hutchison S, Sahay B, de Mello SC, Sayour EJ, Lejeune A, Szivek A, Livaccari AM, Fox-Alvarez S, Salute M, Powers L, Milner RJ Abstract Melanoma in humans and canines is an aggressive and highly metastatic cancer. The mucosal...
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Related ArticlesCommercial Insurance Coverage of Advanced Radiotherapy Techniques Compared to American Society for Radiation Oncology Model Policies. Pract Radiat Oncol. 2019 Aug 22;: Authors: Verma V, Ludmir EB, Mesko SM, Brooks ED, Augustyn A, Milano MT, Lin SH, Chang JY, Welsh JW Abstract BACKGROUND: To compare and contrast the American Society for Radiation Oncology (ASTRO) Model Policies (MPs) for intensity-modulated radiation therapy (IMRT), stereotactic...
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Related ArticlesCombination of cyclodextrin complexation and iontophoresis as a promising strategy for the cutaneous delivery of aluminum-chloride phthalocyanine in photodynamic therapy. Eur J Pharm Sci. 2019 Aug 22;:105056 Authors: Reis TA, Jaculi AE, Ramos KLV, Souza PEN, Veiga-Souza FH, Joanitti GA, Azevedo RB, Gratieri T, Cunha-Filho M, Gelfuso GM Abstract Topical application of aluminum-chloride phthalocyanine (AlClPc) is a challenge because of...
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Related ArticlesDrug resistance of BRAF-mutant melanoma: Review of up-to-date mechanisms of action and promising targeted agents. Eur J Pharmacol. 2019 Aug 22;:172621 Authors: Rossi A, Roberto M, Panebianco M, Botticelli A, Mazzuca F, Marchetti P Abstract Melanoma onset and progression are associated with a high variety of activating mutations in the MAPK-pathway, most frequently involving BRAF (35-45%) and NRAS (15-25%) genes, but also c-KIT and PTEN....
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