Related ArticlesClinicopathological features of melanotic and non-melanotic oncocytic lesions of the nasopharynx. Pathology. 2019 Aug 21;: Authors: Li JJX, Ng JKM, Chan ABW Abstract Oncocytic metaplastic lesions of the nasopharynx are rare benign entities which are divided into melanotic and non-melanotic forms. Less than 40 non-melanotic and 30 melanotic cases have been reported in the literature. We present the largest known case series to date of...
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Related ArticlesThe adjuvant treatment revolution for high-risk melanoma patients. Semin Cancer Biol. 2019 Aug 21;: Authors: Spagnolo F, Boutros A, Tanda E, Queirolo P Abstract The past 5 years have witnessed the results of many practice-changing studies that have dramatically improved the landscape of adjuvant therapy in patients with resected, high-risk melanoma. After a 20-year era of adjuvant interferon, the anti-CTLA-4 and anti-PD-1 immune-checkpoint...
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Related ArticlesSafety and efficacy of nivolumab in patients with rare melanoma subtypes who progressed on or after ipilimumab treatment: a single-arm, open-label, phase II study (CheckMate 172). Eur J Cancer. 2019 Aug 21;119:168-178 Authors: Nathan P, Ascierto PA, Haanen J, Espinosa E, Demidov L, Garbe C, Guida M, Lorigan P, Chiarion-Sileni V, Gogas H, Maio M, Fierro MT, Hoeller C, Terheyden P, Gutzmer R, Guren TK, Bafaloukos D, Rutkowski P, Plummer R, Waterston A, Kaatz...
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Related ArticlesPhotodynamic therapy enhancing anti-skin cancer chemotherapy effects through autophagy regulation. Photodiagnosis Photodyn Ther. 2019 Aug 21;: Authors: Zhang L, Ji Z, Zhang J, Yang S Abstract Non-melanotic cutaneous cancers and melanoma are the main common type skin cancers worldwide, and squamous cell carcinoma (SCC) and melanoma were most serious and high aggressive. Despite many therapeutic options, but the therapeutic efficacy is...
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Related ArticlesActivation of human vascular endothelium in melanoma metastases induces ICAM-1 and E-selectin expression and results in increased infiltration with effector lymphocytes. Exp Dermatol. 2019 Aug 24;: Authors: Weishaupt C, Steinert M, Brunner G, Schulze HJ, Fuhlbrigge RC, Goerge T, Loser K Abstract Lymphocytic infiltration into melanoma tissue is an important prerequisite for effective anti-tumoral immunity. However, analysis of human metastatic...
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Related ArticlesTREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for a European safety study of dupilumab and other systemic therapies in patients with atopic eczema. Br J Dermatol. 2019 Aug 24;: Authors: Bosma AL, Spuls PI, Garcia-Doval I, Naldi L, Prieto-Merino D, Tesch F, Apfelbacher CJ, Arents BWM, Barbarot S, Baselga E, Deleuran M, Eichenfield LF, Gerbens LAA, Irvine AD, Manca A, Mendes-Bastos P, Middelkamp-Hup MA, Roberts A, Seneschal J, Svensson...
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Related ArticlesExploring new applications of tulip tree (Liriodendron tulipifera L.): leaf essential oil as apoptotic agent for human glioblastoma. Environ Sci Pollut Res Int. 2019 Aug 23;: Authors: Quassinti L, Maggi F, Ortolani F, Lupidi G, Petrelli D, Vitali LA, Miano A, Bramucci M Abstract Liriodendron tulipifera L. (Magnoliaceae), also known as "tulip tree," is a hardwood plant native to North America, cultivated all over the world and used on...
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Related ArticlesMelanoma-conditioned medium promotes cytotoxic immune responses by murine bone marrow-derived monocytes despite their expression of 'M2' markers. Cancer Immunol Immunother. 2019 Aug 23;: Authors: Tremble LF, Moore AC, Forde PF Abstract Macrophages have been shown to infiltrate a wide range of malignancies and are often considered to promote tumour survival, growth and spread. However, the source and behaviour of discrete tumour-associated...
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Related ArticlesSequential adjustment of cytotoxic T lymphocyte densities improves efficacy in controlling tumor growth. Sci Rep. 2019 Aug 23;9(1):12308 Authors: Khazen R, Müller S, Lafouresse F, Valitutti S, Cussat-Blanc S Abstract Understanding the human cytotoxic T lymphocyte (CTL) biology is crucial to develop novel strategies aiming at maximizing their lytic capacity against cancer cells. Here we introduce an agent-based model, calibrated on population-scale...
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Related ArticlesLow-level inhibition of Hsp90 forces cells to tip their (antigenic) hand. Clin Cancer Res. 2019 Aug 23;: Authors: Srivastava PK, Callahan MK Abstract Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity is only partially clear. Regardless, these observations have profound implications in protein trafficking and antigen...
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Related ArticlesExperimental validation of a new COMS-like 24 mm eye plaque for the treatment of large ocular melanoma tumors. Brachytherapy. 2019 Aug 20;: Authors: McCauley Cutsinger S, Forsman R, Corner S, Deufel CL Abstract PURPOSE: A new Collaborative Ocular Melanoma Study (COMS)-like 24 mm eye plaque was experimentally characterized using physical and dosimetric measurements in preparation for clinical usage. The new eye plaque will enable surgeons...
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Related ArticlesHigh lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced β-catenin-mediated activity. Med Hypotheses. 2019 Oct;131:109302 Authors: Guttuso T Abstract Parkinson's disease (PD) patients have higher rates of melanoma and vice versa, observations suggesting that the two conditions may share common pathogenic pathways. β-Catenin is a transcriptional cofactor that,...
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Related ArticlesInclusion Complexes of Melphalan with Gemini-Conjugated β-Cyclodextrin: Physicochemical Properties and Chemotherapeutic Efficacy in In-Vitro Tumor Models. Pharmaceutics. 2019 Aug 22;11(9): Authors: Mohammed-Saeid W, Karoyo AH, Verrall RE, Wilson LD, Badea I Abstract β-cyclodextrin (βCD) has been widely explored as an excipient for pharmaceuticals and nutraceuticals as it forms stable host-guest inclusion complexes and enhances the solubility...
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Related ArticlesDietary cadmium intake and risk of cutaneous melanoma: An Italian population-based case-control study. J Trace Elem Med Biol. 2019 Aug 02;56:100-106 Authors: Filippini T, Malagoli C, Wise LA, Malavolti M, Pellacani G, Vinceti M Abstract INTRODUCTION: Exposure to the heavy metal cadmium has been associated with many adverse health effects, such as atherosclerosis, diabetes, and cancer, possibly melanoma. In non-occupationally exposed individuals,...
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Related ArticlesAge favoured overall survival in a large population-based Danish patient cohort treated with anti-PD1 immune checkpoint inhibitor for metastatic melanoma. Eur J Cancer. 2019 Aug 20;119:122-131 Authors: Bastholt L, Schmidt H, Bjerregaard JK, Herrstedt J, Svane IM Abstract BACKGROUND AND PATIENTS: Age-related immune dysfunction (ARID) describes age-associated changes in immunity that may affect the efficacy of immunotherapy with checkpoint...
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Related ArticlesCancer Panel Assay for Precision Oncology Clinic: Results from a 1-Year Study. Transl Oncol. 2019 Aug 20;12(11):1488-1495 Authors: Kwon D, Kim B, Shin HC, Kim EJ, Ha SY, Jang KT, Kim ST, Lee J, Kang WK, Park JO, Kim KM Abstract Next-generation sequencing (NGS)-based cancer panel tests are actively being applied in the clinic for precision oncology. Given the importance of NGS panel tests in the palliative clinical setting, it is critical...
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Related ArticlesKalantuboside B induced apoptosis and cytoprotective autophagy in human melanoma A2058 cells: An in vitro and in vivo study. Free Radic Biol Med. 2019 Aug 20;: Authors: Hseu YC, Cho HJ, Gowrisankar YV, Thiyagarajan V, Chen XZ, Lin KY, Huang HC, Yang HL Abstract Kalantuboside B (KB), a natural bufadienolide derivative extracted from the succulent plant Kalanchoe tubiflora, is well-known for its cardiotonic, immunomodulatory, and anti-inflammatory...
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Related ArticlesWithaferin A modulates AIM2 inflammasome and caspase-1 expression in THP-1 polarized macrophages. Exp Cell Res. 2019 Aug 20;:111564 Authors: Ngoungoure FP, Owona BA Abstract Inflammasomes are cytoplasmic protein complexes that regulate the secretion of pro-inflammatory cytokines including IL-1β and IL18, thereby playing a crucial role in inflammatory and chronic diseases. Plant compound Withaferin A (WFA) has been demonstrated to possess...
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Related ArticlesNeoadjuvant PD-1 Blockade in Resectable Lung Cancer; Nivolumab and Ipilimumab in Advanced Melanoma; Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma; Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy; Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma; Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma; Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma; Rapid Eradication of a...
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Related ArticlesSun-protection and sun-exposure habits among sailors: Results of the 2018 world's largest sailing race "Barcolana" skin cancer prevention campaign. J Eur Acad Dermatol Venereol. 2019 Aug 23;: Authors: Zalaudek I, Conforti C, Corneli P, Jurakic Toncic R, di Meo N, Antonietta Pizzichetta M, Fadel M, Mitija G, Curiel-Lewandrowski C Abstract BACKGROUND: Epidemiologic data suggest an increased risk of melanoma (MM) and non-melanoma skin cancer...
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Related ArticlesDermoscopic features in BRAF and NRAS primary cutaneous melanoma: association with peppering and blue-white veil. J Eur Acad Dermatol Venereol. 2019 Aug 23;: Authors: Gouillon L, Perier-Muzet M, Amini-Adle M, Poulalhon N, Debarbieux S, Boespflug A, Balme B, Depaepe L, Harou O, Lopez J, Bringuier PP, Ferraro-Peyret C, Maucort-Boulch D, Robinson P, Thomas L, Dalle S Abstract Most somatic mutations in BRAF and NRAS oncogenes result in the...
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Related ArticlesEnhancing Case Capture, Quality, and Completeness of Primary Melanoma Pathology Records via Natural Language Processing. JCO Clin Cancer Inform. 2019 Aug;3:1-11 Authors: Malke JC, Jin S, Camp SP, Lari B, Kell T, Simon JM, Prieto VG, Gershenwald JE, Haydu LE Abstract PURPOSE: Medical records contain a wealth of useful, informative data points valuable for clinical research. Most data points are stored in semistructured or unstructured...
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Related ArticlesCranial nerve outcomes in regionally recurrent head & neck melanoma after sentinel lymph node biopsy. Laryngoscope. 2019 Aug 23;: Authors: Hanks JE, Yalamanchi P, Kovatch KJ, Ali SA, Smith JD, Durham AB, Bradford CR, Malloy KM, McLean SA Abstract OBJECTIVE: Characterize long-term cranial nerve (CN) outcomes following sentinel lymph node biopsy (SLNB) based management for head and neck cutaneous melanoma (HNCM). METHODS: Longitudinal...
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Related ArticlesA meta-analysis on the influence of partial biopsy of primary melanoma on disease recurrence and patient survival. J Eur Acad Dermatol Venereol. 2019 Aug 23;: Authors: Moscarella E, Pampena R, Palmiotti G, Bonamonte D, Brancaccio G, Piccolo V, Longo C, Argenziano G Abstract BACKGROUND: Conplete surgical excision is the preferred biopsy type for suspicious melanocytic lesions. However, partial biopsy is sometimes used in special situations....
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Related ArticlesResponse to Stahlie et al regarding "A systematic review and meta-analysis of locoregional treatments for in-transit melanoma". J Surg Oncol. 2019 Aug 22;: Authors: Read T, Lonne M, Sparks DS, David M, Wagels M, Schaider H, Soyer PH, Smithers MB PMID: 31441059 [PubMed - as supplied by publisher]
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Related ArticlesA systematic review and meta-analysis of locoregional treatments for in-transit melanoma. J Surg Oncol. 2019 Aug 22;: Authors: Stahlie EHA, Blankenstein SA, van Houdt WJ, Wouters MWJM, van Akkooi ACJ PMID: 31441058 [PubMed - as supplied by publisher]
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Related ArticlesIndirect Treatment Comparison of Nivolumab Versus Observation or Ipilimumab as Adjuvant Therapy in Resected Melanoma Using Pooled Clinical Trial Data. Adv Ther. 2019 Aug 22;: Authors: Freeman M, Betts KA, Jiang S, Du EX, Gupte-Singh K, Lu Y, Rao S, Shoushtari AN Abstract INTRODUCTION: Nivolumab has been approved in patients with melanoma with lymph node involvement or metastatic disease who have undergone complete resection, in the adjuvant...
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Related ArticlesMelanoma Differentiation-Associated Gene 5 Positively Modulates TNF-α-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells. Inflammation. 2019 Aug 22;: Authors: Kawaguchi S, Sakuraba H, Haga T, Matsumiya T, Seya K, Endo T, Sawada N, Iino C, Kikuchi H, Hiraga H, Fukuda S, Imaizumi T Abstract The molecular mechanisms of innate immunity are closely associated with the development of non-alcoholic fatty liver disease (NAFLD). TNF-α is...
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Related ArticlesTreatment with flaxseed oil induces apoptosis in cultured malignant cells. Heliyon. 2019 Aug;5(8):e02251 Authors: Buckner AL, Buckner CA, Montaut S, Lafrenie RM Abstract Flaxseed oil is widely recognized for its exceptional nutritional value, high concentration of fiber-based lignans and large amounts of ω-fatty acids. It is one of a generic group of functional foods that is often taken by cancer patients as a potential treatment. We...
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Related ArticlesGlioma-associated radiation retinopathy treated successfully with aflibercept. Ther Clin Risk Manag. 2019;15:937-941 Authors: Karagiannis D, Kontomichos L, Georgalas I, Peponis V, Antoniou E, Parikakis E Abstract Radiation retinopathy is a chronic, progressive retinal microangiopathy which can occur with variable latency after retina exposure to ionizing radiation used for cancer treatment. It can occur secondary to treatment of nasopharyngeal...
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Related ArticlesSentinel lymph node biopsy in the management of conjunctival melanoma: current insights. Clin Ophthalmol. 2019;13:1297-1302 Authors: Mor JM, Rokohl AC, Koch KR, Heindl LM Abstract Purpose: To evaluate the role of sentinel lymph node biopsy (SLNB) in conjunctival melanoma (CM). Methods: This article provides a review of the literature from PUBMED. Results: Data on SLNB in the management of CM are scarce and only two relatively large cohorts...
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Related ArticlesInhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells. Sci Rep. 2019 Aug 22;9(1):12277 Authors: Lee HE, Lee JY, Yang G, Kang HC, Cho YY, Lee HS, Lee JY Abstract Tumor microenvironment favors tumor cells to promote their growth and metastasis such as migration, invasion, and angiogenesis. IL-1β, one of the inflammatory cytokines released from myeloid cells in tumor microenvironment,...
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Related ArticlesRegulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma. Proc Natl Acad Sci U S A. 2019 Aug 22;: Authors: AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, Vergara IA, Papenfuss AT, Lau P, Ghosh P, Haupt S, Haupt Y, Sanij E, Poortinga G, Pearson RB, Falk H, Curtis DJ, Stupple P, Devlin M, Street I, Davies MA,...
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Related ArticlesA novel mitochondrial inhibitor blocks MAPK pathway and overcomes MAPK inhibitor-resistance in melanoma. Clin Cancer Res. 2019 Aug 22;: Authors: Vashisht Gopal YN, Gammon ST, Prasad R, Knighton B, Pisaneschi F, Roszik J, Feng N, Johnson S, Pramanik S, Sudderth J, Sui D, Hudgens CW, Fischer GM, Deng W, Reuben A, Peng W, Wang J, Di Francesco ME, Marszalek JR, McQuade JL, Tetzlaff MT, Piwnica-Worms D, DeBerardinis RJ, Davies MA Abstract ...
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Related ArticlesAnti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies. J Immunother Cancer. 2019 Aug 22;7(1):225 Authors: Naing A, Infante J, Goel S, Burris H, Black C, Marshall S, Achour I, Barbee S, May R, Morehouse C, Pollizzi K, Song X, Steele K, Elgeioushi N, Walcott F, Karakunnel J, LoRusso P, Weise A, Eder J, Curti B, Oberst M Abstract BACKGROUND: The safety, efficacy, pharmacokinetics, and pharmacodynamics...
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Related ArticlesSmall molecule immunomodulation: the tumor microenvironment and overcoming immune escape. J Immunother Cancer. 2019 Aug 22;7(1):224 Authors: Osipov A, Saung MT, Zheng L, Murphy AG Abstract Immunotherapy has led to a paradigm shift in the treatment of many advanced malignancies. Despite the success in treatment of tumors like non-small cell lung cancer (NSCLC) and melanoma, checkpoint inhibition-based immunotherapy has limitations. Many...
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Related ArticlesA novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells. J Exp Clin Cancer Res. 2019 Aug 22;38(1):373 Authors: Orienti I, Salvati V, Sette G, Zucchetti M, Bongiorno-Borbone L, Peschiaroli A, Zolla L, Francescangeli F, Ferrari M, Matteo C, Bello E, Di Virgilio A, Falchi M, De Angelis ML, Baiocchi M, Melino G, De Maria R, Zeuner A, Eramo A Abstract ...
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Related ArticlesWnt Signaling Pathways in Keratinocyte Carcinomas. Cancers (Basel). 2019 Aug 21;11(9): Authors: Lang CMR, Chan CK, Veltri A, Lien WH Abstract The skin functions as a barrier between the organism and the surrounding environment. Direct exposure to external stimuli and the accumulation of genetic mutations may lead to abnormal cell growth, irreversible tissue damage and potentially favor skin malignancy. Skin homeostasis is coordinated...
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Related ArticlesThe Value of Teledermoscopy to the Expertise of General Practitioners Diagnosing Skin Disorders Based on ICD-10 Coding. Stud Health Technol Inform. 2019 Aug 21;264:834-838 Authors: Tensen E, van Sinderen F, Witkamp L, Jaspers MWM, Peute LWP Abstract Early recognition of skin cancer is vital to enhance patient outcomes. Teledermoscopy (TDsc), a telemedicine service, supports general practitioners (GPs) in gaining fast access to dermatologists'...
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