Related ArticlesPsychosocial and Cultural Determinants of Interest and Uptake of Skin Cancer Genetic Testing in Diverse Primary Care. Public Health Genomics. 2019 Aug 22;:1-11 Authors: Hay JL, Meyer White K, Sussman A, Kaphingst K, Guest D, Schofield E, Dailey YT, Robers E, Schwartz MR, Zielaskowski K, Li Y, Buller D, Hunley K, Berwick M Abstract BACKGROUND: Translational research in genomics has limited reach and requires efforts to broaden access and...
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Related ArticlesRole of 18F-Fluorodeoxyglucose Positron Emission Tomography or Positron Emission Tomography/Computed Tomography for the Detection of Recurrent Disease after Treatment of Malignant Melanoma. Oncology. 2019 Aug 22;:1-8 Authors: Lee JW, Nam SB, Kim SJ Abstract BACKGROUND: The purpose of the current study was to investigate the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/computed tomography...
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Related ArticlesAdverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management. Eur J Cancer. 2019 Aug 19;119:97-106 Authors: Gogas HJ, Flaherty KT, Dummer R, Ascierto PA, Arance A, Mandala M, Liszkay G, Garbe C, Schadendorf D, Krajsova I, Gutzmer R, Sileni VC, Dutriaux C, de Groot JWB, Yamazaki N, Loquai C, Gollerkeri A, Pickard MD, Robert C Abstract BACKGROUND: Dual inhibition of the mitogen-activated...
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Related ArticlesKernel sparse representation based model for skin lesions segmentation and classification. Comput Methods Programs Biomed. 2019 Aug 16;182:105038 Authors: Moradi N, Mahdavi-Amiri N Abstract BACKGROUND AND OBJECTIVES: Melanoma is a dangerous kind of skin disease with a high death rate, and its prevalence has increased rapidly in recent years. Diagnosis of melanoma in a primary phase can be helpful for its cure. Due to costs for dermatology,...
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Related ArticlesCardiotoxicity associated with immune checkpoint inhibitors in cutaneous oncology. J Am Acad Dermatol. 2019 Aug 19;: Authors: Tabata MM, Choi S, Hirotsu K, Kwong B, Soleymani T PMID: 31437546 [PubMed - as supplied by publisher]
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Related ArticlesImmunohistochemical analysis of Bcl-2, nuclear S100A4, MITF and Ki67 for risk stratification of early-stage melanoma - A combined IHC score for melanoma risk stratification. J Dtsch Dermatol Ges. 2019 Aug;17(8):800-808 Authors: Jurmeister P, Bockmayr M, Treese C, Stein U, Lenze D, Jöhrens K, Friedling F, Dietel M, Klauschen F, Marsch W, Fiedler E, von Laffert M Abstract BACKGROUND AND OBJECTIVES: Overall survival (OS) in patients with...
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Related ArticlesGranulomatous/sarcoid-like reactions in the setting of PD-1 inhibition: a potential mimic of disease recurrence. J Cutan Pathol. 2019 Aug 22;: Authors: Hiraki T, Hatanaka M, Arimura A, Kawahira H, Kirishima M, Kitazono I, Horinouchi M, Higashi M, Kanekura T, Tanimoto A Abstract Nivolumab and pembrolizumab are humanized IgG4 monoclonal antibodies against programmed cell death 1 (PD-1). Although these agents are effective in treating advanced...
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Related ArticlesA pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion. J Cutan Pathol. 2019 Aug 22;: Authors: Friedman BJ, Hernandez S, Fidai C, Jiang A, Shwayder TA, Carskadon S, Andea AA, Harms PW, Chitale D, Palanisamy N Abstract Pigmented epithelioid melanocytoma (PEM) represents a group of rare, heavily pigmented melanocytic tumors encompassing lesions...
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Related ArticlesImaging challenges of immunotherapy and targeted therapy in patients with brain metastases: Response, Progression, and Pseudoprogression. Neuro Oncol. 2019 Aug 22;: Authors: Galldiks N, Kocher M, Ceccon G, Werner JM, Brunn A, Deckert M, Pope WB, Soffietti R, Le Rhun E, Weller M, Tonn JC, Fink GR, Langen KJ Abstract The advent of immunotherapy using immune checkpoint inhibitors (ICI) and targeted therapy (TT) has dramatically improved...
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Related ArticlesBinimetinib in heavily pretreated NRAS-mutant Melanoma Patients with Brain Metastases. Br J Dermatol. 2019 Aug 22;: Authors: Goldinger SM, Valeska Matter A, Urner-Bloch U, Narainsing J, Micaletto S, Blume I, Mangana J, Dummer R Abstract Brain metastases are frequent in metastatic melanoma patients and indicate poor prognosis. Approximately 20% of all melanomas harbor an NRAS mutation (1). Although direct targeting RAS GTPase is difficult,...
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Related ArticlesOnychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases). Am J Dermatopathol. 2019 Aug 13;: Authors: Perrin C Abstract This is a report of a previously undescribed type of onychomatricoma (OM) with an unusual clinical presentation as a thickened free edge of the nail plate without discernible cavities and distinguished histologically from the ordinary...
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Related ArticlesAdvances in encapsulated dermal formulations in chemoprevention of melanoma: An overview. J Cosmet Dermatol. 2019 Aug 22;: Authors: Ravikumar P, Tatke P Abstract BACKGROUND: The three forms of skin cancer are cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Melanoma skin cancer is an aggressive type and one of the most chemotherapy-resistant malignancies. Conventional topical products are beset with limitations,...
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Related ArticlesInhibition of melanin synthesis and melanosome transfer by chitosan biomaterials. J Biomed Mater Res B Appl Biomater. 2019 Aug 22;: Authors: Chen HW, Chou YS, Young TH, Cheng NC Abstract Decreasing skin pigmentation is desirable for various medical or cosmetic conditions. Although numerous pharmaceutical agents are currently available, their depigmentation effects are still not satisfactory. In this study, we investigated the effects...
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Related ArticlesCase of acute-onset type 1 diabetes induced by long-term immunotherapy with nivolumab in a patient with mucosal melanoma. J Dermatol. 2019 Aug 22;: Authors: Maekawa T, Okada K, Okada H, Kado S, Kamiya K, Komine M, Murata S, Oka K, Ishibashi S, Ohtsuki M PMID: 31436330 [PubMed - as supplied by publisher]
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Related ArticlesGenetic variants in glutamine metabolic pathway genes predict cutaneous melanoma-specific survival. Mol Carcinog. 2019 Aug 22;: Authors: Chen K, Liu H, Liu Z, Bloomer W, Amos CI, Lee JE, Li X, Nan H, Wei Q Abstract Glutamine dependence is a unique metabolic defect seen in cutaneous melanoma (CM), directly influencing the treatment and prognosis. Here, we investigated the associations between 6025 common single-nucleotide polymorphisms...
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Related ArticlesA retrospective chart review study describing metastatic melanoma patients profile and treatment patterns in Spain. Clin Transl Oncol. 2019 Aug 21;: Authors: Márquez-Rodas I, Arance A, Berrocal A, Larios CL, Curto-García J, Campos-Tapias IX, Blanca AB, Martin-Algarra S Abstract PURPOSE: To describe patient characteristics by disease stage, resectability status and current treatment management after first diagnosis of IIIB to IV1c advanced...
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Related ArticlesDnmt3a is required for the tumor stemness of B16 melanoma cells. Acta Biochim Biophys Sin (Shanghai). 2019 Aug 22;: Authors: Wang H, Kuang Y, Li J, Shen R, Sun R, Huang D, Sheng Z, Shi J, Zhang M, Huang F, Yang H, Fei J Abstract The relationship of carcinogenesis and DNA methyltransferases has attracted extensive attention in tumor research. We reported previously that inhibition of de novo DNA methyltransferase 3a (Dnmt3a) in murine...
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Related ArticlesThe dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression. Oncogene. 2019 Aug 21;: Authors: Hwang BJ, Zhang Y, Brozowski JM, Liu Z, Burette S, Lough K, Smith CC, Shan Y, Chen J, Li N, Williams S, Su M, Googe P, Thomas NE, Liu Z Abstract BP180, also termed collagen XVII, is a hemidesmosomal transmembrane glycoprotein expressed in basal keratinocytes, and functions as a cell-matrix adhesion molecule in the dermal-epidermal...
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Related ArticlesExhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma. Sci Rep. 2019 Aug 21;9(1):12150 Authors: Rad Pour S, Morikawa H, Kiani NA, Yang M, Azimi A, Shafi G, Shang M, Baumgartner R, Ketelhuth DFJ, Kamleh MA, Wheelock CE, Lundqvist A, Hansson J, Tegnér J Abstract Kynurenine pathway (KP) activation by the enzymatic activity of indoleamine 2,3-dioxygenase1 (IDO1) and kynurenine (KYN) production represents an attractive...
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Related ArticlesMetabolic landscape of the tumor microenvironment at single cell resolution. Nat Commun. 2019 Aug 21;10(1):3763 Authors: Xiao Z, Dai Z, Locasale JW Abstract The tumor milieu consists of numerous cell types each existing in a different environment. However, a characterization of metabolic heterogeneity at single-cell resolution is not established. Here, we develop a computational pipeline to study metabolic programs in single cells. In...
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Related ArticlesDermoscopy for melanoma detection and triage in primary care: a systematic review. BMJ Open. 2019 Aug 20;9(8):e027529 Authors: Jones OT, Jurascheck LC, van Melle MA, Hickman S, Burrows NP, Hall PN, Emery J, Walter FM Abstract OBJECTIVE: Most skin lesions first present in primary care, where distinguishing rare melanomas from benign lesions can be challenging. Dermoscopy improves diagnostic accuracy among specialists and is promoted for...
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Related ArticlesAcquired Generalized Lipodystrophy: A New Cause of Anti-PD-1 Immune-Related Diabetes. Diabetes Care. 2019 Aug 21;: Authors: Jehl A, Cugnet-Anceau C, Vigouroux C, Legeay AL, Dalle S, Harou O, Marchand L, Lascols O, Caussy C, Thivolet C, Laville M, Disse E Abstract OBJECTIVE: Anti-programmed cell death-1 (anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD-1 therapy is responsible for immune-related adverse events,...
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Related Articles[Radical vulvectomy and inguinal lymphadenectomy using a single incision for the treatment of vulvar malignancy]. Zhonghua Yi Xue Za Zhi. 2019 Aug 20;99(31):2450-2454 Authors: Wang YF, Chen GW, Ma Y, Zheng YH, He LQ, He WQ, Dai GY, Zhou YF, Chen YY, Liu MJ, Feng WQ Abstract Objective: To describe a novel procedure of radical vulvectomy and inguinal lymphadenectomy using a single incision (RVIL-SI) for the treatment of vulvar malignancy....
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Related ArticlesDROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis. Cells. 2019 Aug 20;8(8): Authors: Cho SJ, Hong KS, Jeong JH, Lee M, Choi AMK, Stout-Delgado HW, Moon JS Abstract Idiopathic pulmonary fibrosis (IPF) has been linked to chronic lung inflammation. Drosha ribonuclease III (DROSHA), a class 2 ribonuclease III enzyme, plays a key role in microRNA (miRNA) biogenesis. However,...
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Related ArticlesMiddle East Respiratory Syndrome Coronavirus-Encoded Accessory Proteins Impair MDA5-and TBK1-Mediated Activation of NF-κB. J Microbiol Biotechnol. 2019 Aug 14;: Authors: Lee JY, Bae S, Myoung J Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging coronavirus which is zoonotic from bats and camels. Its infection in humans can be fatal especially in patients with preexisting conditions due to smoking and...
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Related ArticlesscFTD-seq: freeze-thaw lysis based, portable approach toward highly distributed single-cell 3' mRNA profiling. Nucleic Acids Res. 2019 02 20;47(3):e16 Authors: Dura B, Choi JY, Zhang K, Damsky W, Thakral D, Bosenberg M, Craft J, Fan R Abstract Cellular barcoding of 3' mRNAs enabled massively parallel profiling of single-cell gene expression and has been implemented in droplet and microwell based platforms. The latter further adds the...
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Related ArticlesStability of bioresorbable plates following reduction of mandibular body fracture: Three-dimensional analysis. J Craniomaxillofac Surg. 2019 Aug 07;: Authors: Song IS, Choi J, Kim SR, Lee JH Abstract PURPOSE: The recent development of bioresorbable bone plates and screws allows plates to be applied to the load-bearing regions of the mandible and to remain in place over time without the need for removal. We hypothesized that the stability...
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Related ArticlesDifferential regulation of blood vessel formation between traumatic temporomandibular joint fibrous ankylosis and bony ankylosis in a sheep model. J Craniomaxillofac Surg. 2019 Aug 01;: Authors: Liang SX, Wang HL, Zhang PP, Shen J, Yang K, Meng L, Liu H, Yan YB Abstract OBJECTIVES: Clinical and experimental studies show that the etiology of traumatic temporomandibular joint (TMJ) fibrous ankylosis and bony ankylosis are associated with...
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Related ArticlesComparison of MRI with dedicated head and neck signal amplification coil and cone beam computed tomography: MRI is a useful tool in diagnostics of cranio-facial growth disorders. J Craniomaxillofac Surg. 2019 Jul 25;: Authors: Grandoch A, Nestmann F, Kreppel M, Buller J, Borggrefe J, Zirk M, Zöller JE Abstract OBJECTIVE: Magnetic resonance imaging (MRI) shows excellent image quality for the depiction of soft tissues and is therefore an...
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Related ArticlesPostgraduate training in Oral- and Maxillofacial Surgery: Results of a survey among 74 German interns. J Craniomaxillofac Surg. 2019 Jul 29;: Authors: Pabst A, Zeller AN, Rashad A, Wagner MEH, Eckelt U, Ehrenfeld M, Schiegnitz E Abstract The aim of this study was to asses a survey of residents to obtain relevant information about their current situation in training in Oral and Maxillofacial Surgery in Germany. Special focus was given...
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Related ArticlesThe arrhinias: Proboscis lateralis literature review and surgical update. J Craniomaxillofac Surg. 2018 Dec 27;: Authors: Galiè M, Clauser LC, Tieghi R, Kawamoto HK, Wolfe SA, Bianchi AE Abstract Proboscis lateralis (PL) is a rare malformation, reported for the first time in 1861 by Forster in his monograph on congenital malformations of the human body. The abnormal side of the nose is represented by a tube-like rudimentary nasal structure,...
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Related ArticlesBiomaterial-based bone regeneration and soft tissue management of the individualized 3D-titanium mesh: An alternative concept to autologous transplantation and flap mobilization. J Craniomaxillofac Surg. 2019 Jul 19;: Authors: Ghanaati S, Al-Maawi S, Conrad T, Lorenz J, Rössler R, Sader R Abstract Three-dimensional augmentation in severely atrophic bone and after cancer resection is a challenging clinical indication that is mostly solved...
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Related ArticlesDistraction osteogenesis in the management of mandibular hypoplasia secondary to temporomandibular joint ankylosis. Long term follow up. J Craniomaxillofac Surg. 2019 Jul 29;: Authors: Hassan SAE, Mohamed FI Abstract PURPOSE: The aim of this retrospective study was to evaluate the short-term and long-term skeletal and soft-tissue stability after MDO with or without genioplasty, as well as the stability of the achieved maximum inter-incisal...
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Related ArticlesEfficacy of morpho-functional repair in management of different morphological variants of unilateral complete cleft lip. J Craniomaxillofac Surg. 2019 Jul 25;: Authors: Gosla Reddy S, Shah R, Ansari S, Reddy RR, Fanan A Abstract BACKGROUND: To study the surgical outcome in various morphological variants of unilateral complete cleft lip in our high volume centre over a period of 4 years, using Morpho-Functional technique in all cases...
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Related ArticlesThe relationship between external bony defects and widened lateral interorbital distance in frontoethmoidal encephalomeningocele. J Craniomaxillofac Surg. 2019 Jul 19;: Authors: Sirimaharaj W, Kanpuan W, Angkurawaranon S Abstract PURPOSE: The aim of this study was to identify the prevalence of the abnormal lateral interorbital distance (LIOD), micropthalmia or anopthalmia and incidence of hydrocephalus in frontoethmoidal encephalomeningocele...
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Related ArticlesObjective evaluation of vertical Z-plasty with double transposition vermillion flaps for secondary whistling deformity correction: A method for uni- and bilateral correction. J Craniomaxillofac Surg. 2019 Jul 19;: Authors: Scheller K, Bolz J, Scheller C, Haase R Abstract OBJECTIVES: This study describes a modified method for secondary correction of whistling deformities in patients with unilateral and bilateral cleft lip/palate (CL/P),...
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Related ArticlesStability of the chin after advancement genioplasty using absorbable plate and screws with template devices. J Craniomaxillofac Surg. 2019 Jul 29;: Authors: Ueki K, Moroi A, Yoshizawa K Abstract PURPOSE: The purpose of this study was to compare the stability of the chin between absorbable plate and screws with a template device and titanium plate after advancement genioplasty in class II patients. PATIENTS AND METHODS: The subjects...
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Related ArticlesOncological and aesthetic outcome following surgical management of orbito-palpebral skin cancers: A retrospective study of 132 patients. J Craniomaxillofac Surg. 2019 Jul 16;: Authors: Rougier G, Meningaud JP, Ganry L, Hermeziu O, Bosc R, Sidahmed-Mezi M, Hersant B Abstract BACKGROUND: The incidence of facial skin cancers continues to rise, with major studies on their impacts still lacking in the literature. This study reports on the...
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Related ArticlesPredictability of pharyngeal airway space dimension changes after orthognathic surgery in class II patients: A mathematical approach. J Craniomaxillofac Surg. 2019 Jul 25;: Authors: Wiedemeyer V, Berger M, Martini M, Kramer FJ, Heim N Abstract INTRODUCTION: Angle Class II malocclusion due to mandibular retrognathia is a common dentofacial deformity. It is well known that mandibular advancement increases pharyngeal airway dimensions....
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