Related ArticlesRadiological assessment of the lateral osteotomy line-lacrimal system distance on three-dimensional models. J Craniomaxillofac Surg. 2019 Jul 25;: Authors: Sarıaltın Y, Ortak T, Öz C, Kuş E, Yunusoğlu GU, Doğan Ş, Çetin M Abstract AIMS: One of the most commonly performed operations in aesthetic, plastic, and reconstructive surgery is rhinoplasty, the aim of which is to construct an altered nasal shape, either for aesthetic or functional...
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Related ArticlesInfluence of different surgical concepts for moderate skeletal class II and III treatment on the nasopharyngeal airway space. J Craniomaxillofac Surg. 2019 Jul 18;: Authors: Moscarino S, Kötter F, Brandt M, Modabber A, Kniha K, Hölzle F, Wolf M, Möhlhenrich SC Abstract PURPOSE: This study aimed to compare the effects of different orthognathic and camouflage treatments for correcting moderate skeletal class II and III malocclusions on...
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Abstract Introduction Primary and post‐ET/PV myelofibrosis are myeloproliferative neoplasms harboring in most cases driving mutations in JAK2, CALR or MPL, and a variable number of additional mutations in other genes. Molecular analysis represents a powerful tool to guide prognosis and clinical management. Only about 10% of patients with myelofibrosis harbor alterations in MPL gene. No data are available about the transplantation outcome in the specific MPL‐mutated group. Patients We collected...
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Abstract Objectives Thresholds for the minimally important difference (MID) or responder definition (RD) in health‐related quality of life (HRQoL) scores are required to interpret the impact of an intervention or change in the trajectory of the condition which is meaningful to patients. This study aimed to establish MID and RD for the European Organisation for Research and Treatment of Cancer Quality of Life Multiple Myeloma questionnaire (EORTC QLQ‐MY20). Methods A novel mixed methods...
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Abstract Purpose To investigate the activity and safety of daratumumab added to standard of care, and evaluate the relative efficacy of DRd versus DVMP and other regimens on survival endpoints for untreated myeloma, we undertook this meta‐analysis. Methods We searched published reports that described the activity and safety of daratumumab added to standard of care for untreated myeloma. Results Six daratumumab trials were identified, covering 5106 subjects. Daratumumab containing...
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Abstract Purpose of the study To discuss the ethical challenges for the therapeutic team when dealing with a young savior sibling as a potential tissue donor. Basic procedures Savior siblings are children that are created to serve a sibling as a donor of umbilical cord blood, bone marrow, or peripheral blood from which hematopoietic stem cells are derived. These cells are used for hematopoietic stem cell therapy which is the only curative treatment for certain hemoglobinopathies. We used...
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Abstract Objective The primary objective was to assess the effect of central nervous system involvement in acute myeloid leukemia (CNS‐AML) on outcomes after allogeneic hematopoietic stem cell transplant (allo‐HCT). The secondary objective was to assess the utility of pre‐transplant cerebro‐spinal fluid (CSF) assessment in AML. Methods We retrospectively analyzed survival outcomes in 338 adult AML patients (with and without CNS‐AML) after allo‐HCT. CNS involvement was defined as clinical,...
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Abstract Objective Relapse of AML after allogeneic hematopoietic stem cell transplantation (HSCT) has a poor prognosis and standard of care therapy is lacking. Early (<6 months) relapse is associated with dismal outcome, while the majority of relapses occur early after transplantation. A more precise indication which patients could benefit from reinduction therapy is warranted. Methods We retrospectively analyzed outcomes of 83 patients with post‐allogeneic HSCT relapse. Patients were...
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Abstract In their recent paper, Santaliestra et al measured bone marrow (BM) Wilms' tumor (WT1) mRNA levels in patients with myeloid neoplasms treated with 5‐azacytidine (5‐AZA)1. Patients with initial WT1 levels greater than 100 copies but with a conversion to sustained levels below 100 had better overall survival (OS) compared to patients whose WT1 levels were always less than 100 copies. This article is protected by copyright. All rights reserved.
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Abstract Hereditary spherocytosis (HS) is the most common inherited anemia affecting people of Northern European ancestry, even if it can affect patients in all ethnic groups worldwide. Prevalence of HS is 1 to 5 cases per 10.000 individuals in people of Northern European descent. While here is no exact epidemiological information regarding HS in China. Its prevalence has been estimated to be 1.27 cases per 100.000 people in males and 1.49 cases per 100.000 people in females [1]. HS is a congenital...
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Abstract Providing a better understanding of the risk factors for amputation in this particular region, Hunan province, in China might help patients with diabetic foot ulcers receive timely and appropriate medical care and help prevent amputation. Diabetic foot ulcer patients referred to the Third Xiangya Hospital during the period between December 2014 and September 2018 were enrolled. Participants who underwent amputations and received conservative treatments were compared using univariate and...
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Abstract In forensic medicine, it is vital to verify with the best attainable accuracy once injuries occurred during vital or post‐mortem conditions. An immunohistochemical study was carried out to examine the time‐dependent expression of macrophage‐specific gene CD68 (cluster of differentiation 68), alpha‐smooth muscle actin (α‐SMA), and vascular endothelial growth factor (VEGF) in different skin wound timings (0, 1, 3, 5, 7, and 14 days) in rats. Histopathological studies were performed to assess...
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Abstract Hyperthermic intraperitoneal chemotherapy (HIPEC) has cytotoxic effects on tumour cells but also negative impacts on anastomotic healing. Platelet‐rich‐plasma (PRP) is used for wound care but data about effects on gastrointestinal anastomosis are limited. In this experimental study, we aimed to investigate the effects of PRP application on colon anastomosis in rats those received HIPEC with cisplatin. Five rats were sacrificed to obtain PRP gel. Thirty rats were divided into three groups;...
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Abstract There are many chemicals that can cause burns. Although they are generally acidic and basic in nature, there are more than one million known chemical compounds, of which 300 have been declared highly hazardous chemical substances by the National Fire Protection Society. Chemical burns account for approximately 10.7% of all burn injuries and 30% of deaths because of burns. Chemicals can be classified as acid, alkali, organic, and inorganic compounds. Acids act by denaturing and coagulating...
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Abstract Diabetic foot ulcer is one of the most frightened diabetic complications leading to amputation disability and early mortality. Diabetic wounds exhibit a complex networking of inflammatory cytokines, local proteases, and reactive oxygen and nitrogen species as a pathogenic polymicrobial biofilm, overall contributing to wound chronification and host homeostasis imbalance. Intralesional infiltration of epidermal growth factor (EGF) has emerged as a therapeutic alternative to diabetic wound...
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Abstract The use of split‐thickness skin autografts (STSA) with dermal substitutes is the gold standard treatment for third‐degree burn patients. In this article, we tested whether cryopreserved amniotic membranes could be beneficial to the current treatments for full‐thickness burns. Swines were subjected to standardised full‐thickness burn injuries, and then were randomly assigned to treatments: (a) STSA alone; (b) STSA associated with the dermal substitute, Matriderm; (c) STSA plus human amniotic...
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Abstract Healing rates may not give a complete indication of the effectiveness and management of diabetic foot ulcers because of high recurrence rates. The most important outcome for patients is remaining ulcer‐free; however, this has hardly been investigated. The aim of our study was to prospectively investigate ulcer‐free survival days and ulcer healing in patients with diabetic foot ulcers. This was a prospective cohort study of all referrals to our diabetic foot expertise centre from December...
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Abstract Studies on the frequency of burned limbs according to season and months are limited. The burning of some body limbs, especially in some months, shows that the causes of burns are different, and knowing the reasons is important for providing preventive measures. The aims of this study were to determine the distribution rate of child burns by months and seasons and to contribute to preventive measures by determining the distribution of the burning of body limbs by months. We retrospectively...
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Abstract Patients with ostomy are faced with several physical, psychological, and social challenges and need to be prepared to overcome these challenges. Studies have shown that training plays an important role in helping patients to adapt with ostomy, live with it, and improve their psychological well‐being and quality of life (QOL). Therefore, the present study aimed to determine the effect of structured ostomy care training on QOL and anxiety of the patients with permanent ostomy. In this randomised...
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Abstract Necrotising fasciitis (NF) is mostly a polymicrobial, severe soft tissue infection that progresses rapidly, penetrating through the subcutaneous tissue to the fascial planes and the muscles. The pyoderma gangrenosum (PG), on the other hand, is a rare, rapidly progressive (except for the post‐surgical PG), autoinflammatory ulcerative skin and soft tissue condition. In this study, we tried to emphasise the importance of diagnosing the NF as well as the PG. Although these two clinical presentations...
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Abstract To assess the efficacy and safety of dexmedetomidine (DEX) as an adjuvant to local wound infiltration anaesthesia in abdominal surgery, we conducted this meta‐analysis. First, the systematic search strategy was performed on PubMed, Embase, and Cochrane Library and five randomised controlled trials (RCTs) involving 294 patients were included. Then, the outcome data were extracted from the studies and their effect sizes were calculated using Review Manager 5. As a result, the addition of...
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Abstract The aim of this study was to identify diabetic foot ulcer (DFU) patients at risk for the development of a hard‐to‐heal wound. This is a post‐hoc analysis of a prospective cohort study including a total of 208 patients with a DFU. The primary endpoints were time to healing and the development of a hard‐to‐heal‐wound. Univariable and multivariable logistic and Cox regression analysis were used to study the associations of patient characteristics with the primary endpoints. The number of previous...
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Abstract Schizophyllum commune is an emerging basidiomycetous fungus increasingly reported attributing pulmonary infections. However, the involvement of S. commune in primary cutaneous ulcerative lesions in humans has not yet been reported. The aetiology of S. commune in wound infection may be overlooked or misdiagnosed. This may be due to the atypical colony morphology, lack of sporulation, and familiarity with this fungus as well as the difficulty in accurate identification. We report here the...
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Abstract Brochures are a useful supplement to patient education. There is increasing evidence that they are an effective medium to support patient satisfaction, adherence, and empowerment. This study aims to produce reliable data on how much patients with venous leg ulcer (VLU) may profit from a brochure that focuses on VLU and on measures and aims of the related compression therapy. The evaluation took part from October 2018 until March 2019 and included 136 patients with VLU and related compression...
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Abstract The factors preventing healing in venous leg ulcers are still not fully understood. Iron‐mediated tissue damage has been hypothesised, yet anecdotally anaemia is also thought to have a negative effect on wound healing. This article summarises the current evidence for these theories and their likely effects in the context of venous ulceration. A comprehensive search of the literature was conducted. Studies suggest that a number of forms of iron including haemosiderin and ferritin are implicated...
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Abstract Fistula‐in‐ano and pilonidal disease are not known to occur together. In a retrospective study, all patients having fistula‐pilonidal disease coexisting simultaneously were included. Out of 1284 patients, 933 were operated (fistula‐in‐ano, 849; pilonidal disease, 77; and coexisting fistula‐pilonidal, 7). A total of 351 patients did not undergo any surgery (two patients had coexisting fistula‐pilonidal). Thus, a total of nine patients having coexisting fistula‐pilonidal sinus were included...
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Abstract We demonstrate sodium pyruvate (NaPy) pre‐treatment as a successful approach for pressure ulcer (PU) prevention by averting their aetiological origin—cell‐level damage and death by large, sustained mechanical loads. We evaluated the NaPy pre‐treatment effect on permeability changes in the cell's plasma membrane (PM) following application of in vitro damaging‐level strains. Fibroblasts or myoblasts, respectively, models for superficial or deep‐tissue damage were grown in 0 or 1 mM NaPy,...
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Abstract Closed incision negative pressure wound therapy (CINPWT) has been shown to be clinically effective compared with the traditional gauze dressing, reducing surgical site infections and wound complications. We evaluated the effect of CINPWT compared with gauze dressing on the need for revision surgery and survival after non‐traumatic major lower amputation. We included 309 patients undergoing 403 major lower amputations in a retrospective study from January 1, 2010 to November 23, 2017. A...
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Abstract Necrotising fasciitis, widespread necrosis of the skin, subcutaneous tissue, and superficial fascia, may be caused by many factors, among which underlying malignancy is observed rarely. We report a case with necrotising fasciitis of the lower extremity because of a duodenum to retroperitoneum fistula caused by renal cell carcinoma invasion. A 62‐year‐old male with newly diagnosed renal cell carcinoma was diagnosed with necrotising fasciitis at the end of 2 days in hospital. One day after...
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Abstract Reactive oxygen species (ROS) are crucial in all wound‐healing processes. Raftlin also plays an important role in the induction of the autoimmune response and the vascular inflammatory response. Inflammatory mediators induce continuous synthesis and secretion. To the best of our knowledge, although there are studies in the literature on antioxidant enzyme levels (superoxide dismutase [SOD], catalase [CAT]) and oxidative stress markers, there are no studies on the comparison of these levels...
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Abstract The most commonly used local anaesthetics (LAs) for postoperative analgesia and surgical anaesthesia are lidocaine and bupivacaine. Adrenaline is a vasopressor agent, which is widely used in anaesthesia for many purposes. This study aims to determine the antibacterial efficacy of lidocaine, mupirocin, adrenaline, and lidocaine + adrenaline combination. In our study, the in vitro antimicrobial effect of 1 mL of sterile saline, 20 mg/mL mupirocin, 20 mg/mL lidocaine, 1 mg/mL adrenaline, and...
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Abstract This study aimed to demonstrate the antibacterial effects of bupivacaine and prilocaine on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. In our study, the in vitro antimicrobial effects of 20 mg/mL prilocaine and 5 mg/mL bupivacaine were tested against a S. aureus American‐type culture collection (ATCC) 29213, P. aeruginosa ATCC 27853, and E. coli ATCC 25922, divided into Group P (Prilocaine) and Group B (Bupivacaine), respectively. S. aureus ATCC 29213, P. aeruginosa...
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Related ArticlesClinicopathologic study of deciduoid mesothelioma using SMARCB1/INI1 immunohistochemistry and fluorescence in situ hybridization. Hum Pathol. 2019 Aug 22;: Authors: Kawai T, Ogata S, Nakashima H, Urabe S, Murakami I, Hiroshima K Abstract Deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. Malignant rhabdoid tumors, renal medullary carcinoma, and some synovial sarcomas show a loss of SMARCB1/INI1 protein, a member of...
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Related ArticlesIsolated tumor cells in regional lymph nodes in patients with adenocarcinoma of the esophagogastric junction might represent part of true metastases. Hum Pathol. 2019 Aug 22;: Authors: Fiehn AK, Jepsen DNM, Achiam MP, Bmls HU, Federspiel B Abstract Regional lymph node metastases in patients with carcinoma of the esophagogastric junction (EGJ) is an important prognostic factor. According to the TNM classification isolated tumor cells (ITCs)...
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Related ArticlesMucoepidermoid carcinoma of the oropharynx: a tumor type with a propensity for regional metastasis unrelated to histologic grade. Hum Pathol. 2019 Aug 20;: Authors: Navale P, Rooper LM, Bishop JA, Westra WH Abstract The designation "mucoepidermoid tumor" is a historic one used in reference to a form of mucoepidermoid carcinoma (MEC) that was believed to be benign. This bygone notion was based on the observation that the vast majority...
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