Related ArticlesDigital whole-slide image analysis for automated diatom test in forensic cases of drowning using a convolutional neural network algorithm. Forensic Sci Int. 2019 Aug 08;302:109922 Authors: Zhou Y, Zhang J, Huang J, Deng K, Zhang J, Qin Z, Wang Z, Zhang X, Tuo Y, Chen L, Chen Y, Huang P Abstract Diatom examinations have been widely used to perform drowning diagnosis in forensic practice. However, current methods for recognizing diatoms,...
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Related ArticlesIntegrated analysis of circular RNA-associated ceRNA network in cervical cancer: Observational Study. Medicine (Baltimore). 2019 Aug;98(34):e16922 Authors: Gong J, Jiang H, Shu C, Hu MQ, Huang Y, Liu Q, Li RF, Wei YZ Abstract BACKGROUND: Circular RNAs (circRNAs) have displayed dysregulated expression in several types of cancer. Nevertheless, their function and underlying mechanisms in cervical cancer remains largely unknown. This study...
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Related ArticlesPersonal Reflections on Gynecologic Oncology and Its Future. Obstet Gynecol. 2019 Sep;134(3):649-650 Authors: Benoit MF, Teoh D, Chandavarkar U, Hong L, Stevens E, Brockmeyer A PMID: 31441814 [PubMed - in process]
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Related ArticlesMeta-Analysis of the Efficacy of Virtual Reality-Based Interventions in Cancer-Related Symptom Management. Integr Cancer Ther. 2019 Jan-Dec;18:1534735419871108 Authors: Zeng Y, Zhang JE, Cheng ASK, Cheng H, Wefel JS Abstract Background. This meta-analysis summarizes the results from recent studies that examined the use of virtual reality (VR)-based interventions on health-related outcomes in patients with cancer, and quantitatively evaluates...
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Related ArticlesThe rise of oncology biosimilars: from process to promise. Future Oncol. 2019 Aug 23;: Authors: Verrill M, Declerck P, Loibl S, Lee J, Cortes J Abstract Biosimilars are biologic products that are highly similar to, and have no clinically meaningful differences from, the approved originator molecule. They are poised to play an increasingly central role in cancer treatment, helping to improve access by driving down costs. Regulatory bodies...
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Related ArticlesCurrent practices in menstrual management in adolescents with cancer: A national survey of pediatric oncology providers. Pediatr Blood Cancer. 2019 Aug 23;:e27961 Authors: Close AG, Jones KA, Landowski A, Switzer GE, Kazmerski TM, Miller E, Friehling E Abstract BACKGROUND: Adolescents and young adult (AYA) women with cancer are at risk of heavy menstrual bleeding (HMB) due to thrombocytopenia, coagulopathy, and/or disruption of the hypothalamic-pituitary-gonadal...
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Related ArticlesQuality of life outcomes after low dose-rate brachytherapy for localized prostate cancer: Current status and future perspectives. Int J Urol. 2019 Aug 22;: Authors: Murakami Y, Satoh T, Tsumura H, Tabata KI, Matsumoto K, Ishiyama H, Iwamura M Abstract The present review summarizes data from studies reporting on health-related quality of life after brachytherapy and competing modalities. There are various therapeutic modalities for localized...
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Related ArticlesModels of Intracellular Transport: Pros and Cons. Front Cell Dev Biol. 2019;7:146 Authors: Mironov AA, Beznoussenko GV Abstract Intracellular transport is one of the most confusing issues in the field of cell biology. Many different models and their combinations have been proposed to explain the experimental data on intracellular transport. Here, we analyse the data related to the mechanisms of endoplasmic reticulum-to-Golgi and intra-Golgi...
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Related ArticlesGroup B Streptococcus colonization induces Prevotella and Megasphaera abundance-featured vaginal microbiome compositional change in non-pregnant women. PeerJ. 2019;7:e7474 Authors: Mu X, Zhao C, Yang J, Wei X, Zhang J, Liang C, Gai Z, Zhang C, Zhu D, Wang Y, Zhang L Abstract Background: Previous studies have indicated that variations in the vaginal microbiome result in symptomatic conditions. Group B Streptococcus (GBS) is a significant...
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Related ArticlesDifferent Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade. Front Immunol. 2019;10:1888 Authors: Niu B, Zhou F, Su Y, Wang L, Xu Y, Yi Z, Wu Y, Du H, Ren G Abstract The impairment of immunity characterized by T cell exhaustion is the main cause of death in patients with sepsis after the acute phase. Although PD-1 blockade is highly touted...
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Related ArticlesTopical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice. Front Neurosci. 2019;13:781 Authors: Yli-Karjanmaa M, Clausen BH, Degn M, Novrup HG, Ellman DG, Toft-Jensen P, Szymkowski DE, Stensballe A, Meyer M, Brambilla R, Lambertsen KL Abstract Background: Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke...
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Related ArticlesPhase II Study of Carfilzomib in Patients With Refractory Renal Cell Carcinoma. Clin Genitourin Cancer. 2019 Jul 23;: Authors: Hasanov E, Tidwell RSS, Fernandez P, Park L, McMichael C, Tannir NM, Jonasch E Abstract BACKGROUND: A von Hippel Lindau (VHL) mutation or functional inactivation occurs in the a large proportion of patients with clear-cell renal cell carcinoma (ccRCC), which results in the dysregulation of a number of key cellular...
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Related ArticlesHow might financial pressures have impacted brachytherapy? A proposed narrative to explain the declines in cervical and prostate brachytherapy utilization. Brachytherapy. 2019 Aug 19;: Authors: Schad M, Kowalchuk R, Beriwal S, Showalter TN Abstract Rates of brachytherapy administration in the United States have declined for both cervical and prostate cancers, and we argue that the available facts suggest financial considerations are a...
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Related ArticlesWnt Signaling Pathways in Keratinocyte Carcinomas. Cancers (Basel). 2019 Aug 21;11(9): Authors: Lang CMR, Chan CK, Veltri A, Lien WH Abstract The skin functions as a barrier between the organism and the surrounding environment. Direct exposure to external stimuli and the accumulation of genetic mutations may lead to abnormal cell growth, irreversible tissue damage and potentially favor skin malignancy. Skin homeostasis is coordinated...
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Related ArticlesPredicting response to BET inhibitors using computational modeling: A BEAT AML project study. Leuk Res. 2019 02;77:42-50 Authors: Drusbosky LM, Vidva R, Gera S, Lakshminarayana AV, Shyamasundar VP, Agrawal AK, Talawdekar A, Abbasi T, Vali S, Tognon CE, Kurtz SE, Tyner JW, McWeeney SK, Druker BJ, Cogle CR Abstract Despite advances in understanding the molecular pathogenesis of acute myeloid leukaemia (AML), overall survival rates remain...
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Related ArticlesPostoperative Radiotherapy for Surgically Resected ypN2 Non-Small Cell Lung Cancer. Ann Thorac Surg. 2018 09;106(3):848-855 Authors: Brandt WS, Yan W, Leeman JE, Tan KS, Park BJ, Adusumilli PS, Bott MJ, Molena D, Isbell J, Chaft J, Rimner A, Jones DR Abstract BACKGROUND: The role of postoperative radiotherapy (PORT) in patients with clinical stage III-N2 (cIII-N2) non-small cell lung cancer (NSCLC) treated with induction chemotherapy...
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Related ArticlesLearning climate and quality of Italian training courses in gynecology and obstetrics. Eur J Obstet Gynecol Reprod Biol. 2019 Jul 23;241:13-18 Authors: Sartori E, Ghezzi F, Cromi A, Laganà AS, Garzon S, Raffaelli R, Scambia G, Franchi M, Italian Society of Gynecology and Obstetrics (SIGO), Candiani M, Casarin J, Ciavattini A, Di Paola R, Greco P, Guaschino S, Marchesoni D, Milani R, Rizzo N, Venturini PL, Valente E, Vizza E, Zanconato G, Zullo F ...
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Related ArticlesJapanese encephalitis virus: Associated immune response and recent progress in vaccine development. Microb Pathog. 2019 Aug 19;:103678 Authors: Kumar A, Sharma P, Shukla KK, Misra S, Nyati KK Abstract Japanese encephalitis (JE) has emerged as one of the most important form of viral encephalitis, which accounts for an estimated 70,000 cases each year with approximately 10,000 fatalities. The clinical presentations and outcome of the infection...
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Related ArticlesCommunication interventions in adult and pediatric oncology: A scoping review and analysis of behavioral targets. PLoS One. 2019;14(8):e0221536 Authors: Sisk BA, Schulz GL, Mack JW, Yaeger L, DuBois J Abstract BACKGROUND: Improving communication requires that clinicians and patients change their behaviors. Interventions might be more successful if they incorporate principles from behavioral change theories. We aimed to determine which...
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Related ArticlesBiology and Significance of Alpha-Fetoprotein in Hepatocellular Carcinoma. Liver Int. 2019 Aug 22;: Authors: Galle PR, Foerster F, Kudo M, Chan SL, Llovet JM, Qin S, Schelman W, Chintharlapalli S, Abada P, Sherman M, Zhu AX Abstract Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths globally due, in part, to the majority of patients being diagnosed with intermediate or advanced stage disease. Our...
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Related ArticlesPhytol and its metabolites phytanic and pristanic acids for risk of cancer: current evidence and future directions. Eur J Cancer Prev. 2019 Aug 20;: Authors: Bobe G, Zhang Z, Kopp R, Garzotto M, Shannon J, Takata Y Abstract This review summarizes the current evidence on the potential role of phytol, a microbial metabolite of chlorophyl A, and its metabolites, phytanic and pristanic acids, in carcinogenesis. Primary food sources in Western...
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Related ArticlesReporting of Resistance Training Dose, Adherence, and Tolerance in Exercise Oncology. Med Sci Sports Exerc. 2019 Aug 19;: Authors: Fairman CM, Nilsen TS, Newton RU, Taaffe DR, Spry N, Joseph D, Chambers SK, Robinson ZP, Hart NH, Zourdos MC, Focht BC, Peddle-McIntyre CJ, Galvão DA Abstract PURPOSE: While general guidelines (such as CONSORT or CERT) exist to enhance the reporting of exercise interventions in the field of exercise science,...
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Related ArticlesDevelopment of a Model to Predict Portal Vein Thrombosis in Liver Transplant Candidates: The Portal Vein Thrombosis Risk Index. Liver Transpl. 2019 Aug 22;: Authors: Gaballa D, Bezinover D, Kadry Z, Eyster E, Wang M, Northup PG, Stine JG Abstract Portal vein thrombosis (PVT) is associated with inferior pre- and post-transplantation outcomes. We aimed to create a predictive model to risk stratify transplant candidates for PVT. Data on...
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Related ArticlesEarly MRI predictors of disease-free survival in locally advanced rectal cancer from the GRECCAR 4 trial. Br J Surg. 2019 Aug 22;: Authors: Nougaret S, Castan F, de Forges H, Vargas HA, Gallix B, Gourgou S, Rouanet P, GRECCAR Study Group Abstract BACKGROUND: Tailored neoadjuvant treatment of locally advanced rectal cancer (LARC) may improve outcomes. The aim of this study was to determine early MRI prognostic parameters with which to...
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Related ArticlesFeasibility of three-dimensional-printed template-guided 125I seed brachytherapy and dosimetric evaluation in patients with malignant tumor. J Cancer Res Ther. 2019;15(4):793-800 Authors: Zhang H, Dev D, Yu H, Di X, Liang Y, Zhang L, Liu X, Zhao J, Liu Z, Sui A, Wang J, Hu M Abstract Objective: The objective of the study is to test whether three-dimensional (3D)-printed template can be used reproducibly for guiding malignant tumors brachytherapy...
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Related ArticlesPembrolizumab for the treatment of nonsmall cell lung cancer: Current status and future directions. J Cancer Res Ther. 2019;15(4):743-750 Authors: Qin Q, Li B Abstract The development of inhibitors of immune checkpoints has revolutionized the treatment for a subset of patients with advanced nonsmall cell lung cancer (NSCLC), resulting in promising clinical outcomes and durable responses. Pembrolizumab, a humanized anti-programmed cell...
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Related ArticlesWhy wait for posterity (or the future) to provide proof to savor the elixir of precision oncology? Read interviews with intellects and dine with the doyens of discovery. Eur J Nucl Med Mol Imaging. 2019 Aug 21;: Authors: Prasad V, Modlin I, Chiti A PMID: 31435715 [PubMed - as supplied by publisher]
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Related ArticlesThe journey of orthopaedic surgery from residency to fellowship: A cross-sectional study in the Gulf Cooperation Council countries. J Taibah Univ Med Sci. 2019 Apr;14(2):131-138 Authors: Shafiq MO, Khaja AF, Alshammari AN, Altayeb MA, Ghabban KM, Khoshhal KI Abstract Objectives: Becoming an Orthopaedic Surgeon is a challenge worldwide. This study attempted to determine the level of training at which orthopaedic surgery is chosen as a...
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Related ArticlesProtocol of a prospective, monocentric phase I/II feasibility study investigating the safety of multimodality treatment with a combination of intraoperative chemotherapy and surgical resection in locally confined or borderline resectable pancreatic cancer: the combiCaRe study. BMJ Open. 2019 Aug 20;9(8):e028696 Authors: Roth S, Springfeld C, Diener MK, Tjaden C, Knebel P, Klaiber U, Michalski CW, Mieth M, Jäger D, Büchler MW, Thilo H Abstract...
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Related ArticlesTargeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discov. 2019 Aug 21;: Authors: Amaravadi RK, Kimmelman AC, Debnath J Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy...
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Related ArticlesIndividualising breast cancer treatment to improve survival and minimise complications in older women: a research programme including the PLACE RCT Book. 2019 8 Authors: Bundred N, Todd C, Morris J, Keeley V, Purushotham A, Bagust A, Foden P, Bramley M, Riches K Abstract BACKGROUND: Over 44,000 women are diagnosed with breast cancer annually in the UK. The research comprised three workstreams (WSs) focused on older women. MAXIMISING SURVIVAL: WS1...
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Background. Danhong injection (DHI) has been mainly used for the treatment of myocardial infarction, atherosclerosis, and coronary heart disease in clinical practice. Our previous studies have shown that DHI improves ventricular remodeling and preserves cardiac function in rats with myocardial infarction (MI). In this study, we focused on the potential mechanism of DHI in protecting cardiac function in MI rats. Methods. Sprague-Dawley rats were subjected to ligation of the left anterior descending...
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Background. Dihydroartemisinin (DHA) is a predominant compound in Artemisia annua L., and it has been shown to inhibit tumorigenesis. Methods. In this study, the antitumor potential of DHA was investigated in the MHCC97-L hepatocellular carcinoma cell line. Cells were treated at various concentrations of DHA, and then the cell cycle, viability, and DNA synthesis were measured to evaluate cell proliferation. Furthermore, the expression of genes and proteins related to proliferation and apoptosis was...
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Comparing Verum and Sham Acupuncture in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis
Objectives. Acupuncture is often used for relieving symptoms of fibromyalgia syndrome (FMS). Our aim is to ascertain whether verum acupuncture is more effective than sham acupuncture in FMS. Methods. We collected RCTs to investigate the effects of verum acupuncture and sham acupuncture on pain, sleep quality, fatigue, and general status in FMS patients. The databases used for data retrieval were PubMed, Central Cochrane, EMBASE, PsycINFO, CNKI, VIP, OASIS, KoreaMed, and RISS. Selection/exclusion...
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Object. To investigate the effect of Kuijieling (KJL) on the balance between T helper 17 (Th17) and regulatory T (Treg) cells in peripheral blood mononuclear cells (PBMC) in vitro and explore the underlying mechanism. Materials and Methods. PBMCs isolated from rats were stimulated with transforming growth factor-β, interleukin (IL)-6, and IL-23 to induce the imbalance of Th17 and Treg cells and were treated with 10, 5, or 2.5% KJL-containing serum. The proportion of Th17 or Treg cells in CD4+ T cells...
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In recent years, an increasing number of natural plant extracts have been determined to be potential drugs for various illnesses. In this study, we investigated the effects of dracorhodin perchlorate (DP) on fibroblast proliferation, which is crucial for wound healing. Cell proliferation assays were performed by different concentrations of DP, and the cell viability was detected by CCK-8 kits. After DP treatment for 24 h, the cell cycle was checked by flow cytometer. EGFR and downstream signaling...
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In humans, the inhalation of warm steam has been reported to decrease the respiratory rate. However, the effects of warm steam inhalation on sleep have not been studied closely. This study aimed to examine the effects of warm steam inhalation before bedtime on subsequent sleep quality. The participants included 17 adult men with mild sleep difficulties and anxiety. All experiments were conducted in the participants’ homes. The participants were instructed to wear a warm steam-generating mask or sham...
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Related ArticlesDecompressive craniectomy in malignant middle cerebral artery infarction: family perception, outcome and prognostic factors. Neurocirugia (Astur). 2019 Aug 21;: Authors: García-Feijoo P, Isla A, Díez-Tejedor E, Mansilla B, Palpan Flores A, Sáez-Alegre M, Vivancos C Abstract OBJECTIVE: The prognosis of one hemisphere malignant infarction creates doubt among neurosurgeons about decompressive hemicraniectomy indication. What results are...
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Abstract Acid-sensing ion channels (ASICs) are voltage-independent and proton-gated channels. In this study, we aimed to test the hypothesis whether ASICs might be involved in modifying the excitability of stellate cells in the cochlear nucleus (CN). We determined gene expressions of ASIC1, ASIC2 and ASIC3 in the CN of BALB/mice. ASIC currents in stellate cells were characterized by using whole-cell patch-clamp technique. In the voltage-clamp experiments, inward currents were recorded...
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