Related ArticlesDifferent surgical outcomes in a patient with bilateral atypical femoral fracture related to bisphosphonate use with or without teriparatide treatment. Osteoporos Int. 2019 Aug 19;: Authors: Zhang HY, Weng HL, Li M, Zhang J Abstract Bisphosphonates (BPs) are first-line drugs for the treatment of osteoporotic fractures, but long-term use of BP reduces bone turnover and is associated with atypical femur fractures (AFFs). Additionally,...
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Related ArticlesEffects of anti-osteoporosis medications on radiological and clinical results after acute osteoporotic spinal fractures: a retrospective analysis of prospectively designed study. Osteoporos Int. 2019 Aug 17;: Authors: Min HK, Ahn JH, Ha KY, Kim YH, Kim SI, Park HY, Rhyu KW, Kim YY, Oh IS, Seo JY, Chang DG, Cho JH Abstract Effects of anti-osteoporosis medications such as anti-resorptive and anabolic agents on healing of osteoporotic spinal...
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Related ArticlesSecular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010. Osteoporos Int. 2019 Aug 15;: Authors: Abtahi S, Driessen JHM, Vestergaard P, van den Bergh J, Boonen A, de Vries F, Burden AM Abstract We investigated the incidence trend in all major osteoporotic fractures for the whole country of Denmark between 1995 and 2010. Hip and other osteoporotic fractures declined for the general population and...
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Related ArticlesLaboratory evaluation of secondary causes of bone loss in Veterans with spinal cord injury and disorders. Osteoporos Int. 2019 Aug 13;: Authors: Le B, Ray C, Gonzalez B, Miskevics S, Weaver FM, Priebe M, Carbone LD Abstract An electronic health record (eHR) review of Veterans with a spinal cord injury and disorder (SCI/D) was conducted to understand the extent to which Veterans Affairs (VA) providers pursue workups for secondary causes...
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Related ArticlesFGF 23 and trabecular microarchitecture. Osteoporos Int. 2019 Aug 12;: Authors: Minisola S, Colangelo L, Cipriani C, Pepe J PMID: 31407024 [PubMed - as supplied by publisher]
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Related ArticlesFGF23 and bone microarchitecture. Osteoporos Int. 2019 Aug 12;: Authors: Rupp T, Amling M, Rolvien T PMID: 31407023 [PubMed - as supplied by publisher]
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Related ArticlesVitamin D and cardiovascular disorders. Osteoporos Int. 2019 Aug 11;: Authors: Bouillon R Abstract Vitamin D is necessary for bone health but may also have many extra-skeletal effects. The vitamin D endocrine system has major effects on gene and protein expression in many cells and tissues related to the cardiovascular system. In addition, many preclinical studies in animals with vitamin D deficiency or genetically silenced expression...
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Related ArticlesPrediction of lumbar vertebral strength of elderly men based on quantitative computed tomography images using machine learning. Osteoporos Int. 2019 Aug 10;: Authors: Zhang M, Gong H, Zhang K, Zhang M Abstract The parameters extracted from quantitative computed tomography (QCT) images were used to predict vertebral strength through machine learning models, and the highly accurate prediction indicated that it may be a promising approach...
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Related ArticlesA rare case of sinonasal glomangiopericytoma post operative accidental diagnosis and managment-A case report. Int J Surg Case Rep. 2019 Aug 09;62:54-57 Authors: Sharma N, Mandlik D, Patel P, Patel P, Joshipura A, Patel M, Mankiwala S, Vatsyayan A, Dubey T, Sanghvi K, Shah D, Kanhere S, Talati S, Patel K Abstract INTRODUCTION: Glomangiopericytoma is a rare neoplasm of low malignant potential. It is a rare type of haemangiopericytoma located...
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Related ArticlesTorsion of wandering spleen treated by laparoscopic splenopexy: A case report. Int J Surg Case Rep. 2019 Jun 26;62:58-61 Authors: Awan M, Gallego JL, Al Hamadi A, Vinod VC Abstract INTRODUCTION: A wandering spleen is a mobile spleen as a result of deficient splenic peritoneal ligaments and elongation of its vascular pedicle. It is a rare entity affecting mainly young adults commonly females and children, presenting as an asymptomatic...
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Related ArticlesChronic Serratia marcescens sternal infection presenting 13 years after coronary artery surgery. Int J Surg Case Rep. 2019 Aug 17;62:50-53 Authors: Chinn A, Knabel M, Sanger JR, Pagel PS, Almassi GH Abstract INTRODUCTION: Serratia marcescens is a facultative anaerobic bacillus that very rarely causes sternal infections. We describe a sternal abscess resulting from chronic S. marcescens infection that presented 13 years after coronary...
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Related ArticlesBilateral skull fracture with massive epidural hematoma secondary to pin-type head fixation in a pediatric patient: Case report and review of the literature. Int J Surg Case Rep. 2019 Aug 13;62:43-49 Authors: Parenrengi MA, Adhiatmadja F, Arifianto MR, Apriawan T, Fauzi AA, Servadei F Abstract INTRODUCTION: A head fixation device containing pins is common equipment used in neurosurgical procedures. Previous reports analysed some of the...
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Related ArticlesErratum to "An anatomic aberration and a surgical challenge: Mediastinal parathyroid adenoma anterior the pericardium. A case report" [Int. J. Surg. Case Rep. 57C (2019) 106-109]. Int J Surg Case Rep. 2019;61:327 Authors: Patrinos A, Zarokosta M, Piperos T, Chrysikos D, Kakaviatos D, Theodoropoulos P, Kalles V, Tsiaoussis J, Noussios G, Mariolis-Sapsako T PMID: 31443949 [PubMed - in process]
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Publication date: Available online 26 August 2019Source: Neurobiology of AgingAuthor(s): Samuel A. Jones, Ulrik Beierholm, David Meijer, Uta NoppeneyAbstractAgeing has been shown to impact multisensory perception, but the underlying computational mechanisms are unclear. For effective interactions with the environment, observers should integrate signals that share a common source, weighted by their reliabilities, and segregate those from separate sources. Observers are thought to accumulate evidence...
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Publication date: Available online 26 August 2019Source: Neurobiology of AgingAuthor(s): Marianne Nygaard, Martin J. Larsen, Mads Thomassen, Matt McGue, Kaare Christensen, Qihua Tan, Lene ChristiansenAbstractOnly few studies have investigated the genome-wide transcriptome of normative cognitive aging. We therefore aimed at investigating blood gene expression patterns associated with cognitive aging using a population-based sample of 235 middle-aged monozygotic twin pairs with longitudinal data on...
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Publication date: Available online 25 August 2019Source: Free Radical Biology and MedicineAuthor(s): Olga Jovanović, Sanja Škulj, Elena E. Pohl, Mario VazdarAbstractReactive aldehydes (RAs), such as 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE), produced by cells under conditions of oxidative stress, were shown to react with phosphatidylethanolamine (PE) in biological and artificial membranes. They form RA-PE adducts, which affect the function of membrane proteins by modifying various biophysical...
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Publication date: Available online 22 August 2019Source: Free Radical Biology and MedicineAuthor(s): Somaiah Chinnapaka, Guoxing Zheng, Aoshuang Chen, Gnanasekar MunirathinamAbstractNon-steroidal anti-inflammatory drugs (NSAID) have shown promise as anticancer agents by inducing cell death apart from their antipyretic, anti-inflammatory and anti-thrombogenic effects. In our current study, we investigated the oxidative stress mediated cell death mechanism of a NSAID derivative NCX4040 (a nitric oxide...
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Publication date: Available online 22 August 2019Source: Free Radical Biology and MedicineAuthor(s): Eduardo Fuentes-Lemus, Michele Mariotti, Per Hägglund, Fabian Leinisch, Angélica Fierro, Eduardo Silva, Camilo López-Alarcón, Michael J. DaviesAbstractThis work examined the hypothesis that interactions of Rose Bengal (RB2−) with lysozyme (Lyso) might mediate type 1 photoreactions resulting in protein cross-linking even under conditions favoring 1O2 formation. UV–visible spectrophotometry, isothermal...
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Publication date: Available online 22 August 2019Source: Free Radical Biology and MedicineAuthor(s): Xiang-zhong Xu, Yu Tang, Li-bo Cheng, Jin Yao, Qin Jiang, Ke-ran Li, Yun-fang ZhenAbstractActivation of the NF-E2-related factor 2 (Nrf2) cascade can offer significant protection against oxidative stress in retinal pigment epithelium (RPE) cells. Here, we indentified a novel kelch-like ECH-associated protein 1 (Keap1)-targeting microRNA, microRNA-626 (miR-626) that activates Nrf2 signaling. In ARPE-19 cells...
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Publication date: Available online 22 August 2019Source: Free Radical Biology and MedicineAuthor(s): N. Rocco-Machado, D. Cosentino-Gomes, M.T. Nascimento, L. Paes-Vieira, Y.A. Khan, B. Mittra, N.W. Andrews, J.R. Meyer-FernandesAbstractLeishmania amazonensis is one of leishmaniasis’ causative agents, a disease that has no cure and leads to the appearance of cutaneous lesions. Recently, our group showed that heme activates a Na+/K+ ATPase in these parasites through a signaling cascade involving hydrogen...
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Publication date: Available online 22 August 2019Source: Free Radical Biology and MedicineAuthor(s): Mizuki Nakamura, Toshihide Yamasaki, Megumi Ueno, Sayaka Shibata, Yoshikazu Ozawa, Tadashi Kamada, Ikuo Nakanishi, Ken-ichi Yamada, Ichio Aoki, Ken-ichiro MatsumotoAbstractTime courses of the redox status in the brains of mice after X-ray or carbon-ion beam irradiation were observed by magnetic resonance redox imaging (MRRI). The relationship between radiation-induced oxidative stress on the cerebral...
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Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation associated with a Th1/17-biased cytokine environment. Acute exacerbations of COPD (AECOPD) are most often triggered by respiratory infections, which elicit an exaggerated inflammatory response in these patients, via poorly defined mechanisms. We investigated the responses of airway epithelial cells (AECs) to infective stimuli in COPD and the effects of the Th1/17-biased environment on these responses. Cytokine expression...
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Changes in the in utero environment result in generational transfer of maladapted physiology in the context of conditions such as stress, obesity, and anxiety. Given the significant contribution of noncommunicable diseases—which are characterised by chronic inflammation—to population mortality, the potential for chronic maternal inflammation mediating foetal programming is a growing concern. The extent of generational transfer in terms of immune functionality and leukocyte glucocorticoid sensitivity...
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Related ArticlesTo eat is to practice-managing eating problems after head and neck cancer. J Cancer Surviv. 2019 Aug 24;: Authors: Kristensen MB, Mikkelsen TB, Beck AM, Zwisler AD, Wessel I, Dieperink KB Abstract PURPOSE: The purpose of this qualitative study was twofold: (1) to explore head and neck cancer (HNC) survivors' experiences of everyday life with eating problems after cancer treatment and (2) to explore their experiences of participating in...
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Related ArticlesCardiovascular Effects of Androgen Deprivation Therapy in Prostate Cancer. Curr Oncol Rep. 2019 Aug 24;21(10):91 Authors: Agarwal M, Canan T, Glover G, Thareja N, Akhondi A, Rosenberg J Abstract PURPOSE OF THE REVIEW: This review paper is a comprehensive look at the cardiovascular disease (CVD) risk that is associated with the use of androgen deprivation therapy in prostate cancer. It summarizes when certain cancer therapies are indicated...
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Related ArticlesPilot Study of Bortezomib and Dexamethasone Pre- and Post-Risk-Adapted Autologous Stem Cell Transplantation in AL Amyloidosis. Biol Blood Marrow Transplant. 2019 Aug 22;: Authors: Landau H, Lahoud O, Devlin S, Lendvai N, Chung DJ, Dogan A, Landgren CO, Giralt S, Hassoun H Abstract Treatment for AL amyloidosis aims to eradicate clonal plasma cells, thereby disrupting the amyloid deposition causing organ damage. Risk-adapted high-dose melphalan...
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Related ArticlesCommercial Insurance Coverage of Advanced Radiotherapy Techniques Compared to American Society for Radiation Oncology Model Policies. Pract Radiat Oncol. 2019 Aug 22;: Authors: Verma V, Ludmir EB, Mesko SM, Brooks ED, Augustyn A, Milano MT, Lin SH, Chang JY, Welsh JW Abstract BACKGROUND: To compare and contrast the American Society for Radiation Oncology (ASTRO) Model Policies (MPs) for intensity-modulated radiation therapy (IMRT), stereotactic...
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Related ArticlesDesign of an immunohistochemistry biomarker panel for diagnosis of pancreatic adenocarcinoma. Pancreatology. 2019 Aug 13;: Authors: Burnett AS, Quinn PL, Ajibade DV, Peters SR, Ahlawat SK, Mahmoud OM, Chokshi RJ Abstract BACKGROUND: Challenges still exist in differentiating pancreatic adenocarcinoma from benign disease. The use of adjuvant testing of tissue biopsies has demonstrated potential diagnostic value. We designed a proof of concept...
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Related ArticlesCurrent Methods of Maxillofacial Tissue Engineering. Oral Maxillofac Surg Clin North Am. 2019 Aug 21;: Authors: Melville JC, Mañón VA, Blackburn C, Young S Abstract For several decades, the multidisciplinary field of tissue engineering has striven to improve conventional methods of dental, oral, and craniofacial rehabilitation for millions of people annually. Several bone tissue engineering strategies are now readily available in the...
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Related ArticlesGastric cancer: Translating novels concepts into clinical practice. Cancer Treat Rev. 2019 Aug 14;79:101889 Authors: Salati M, Orsi G, Smyth E, Beretta G, De Vita F, Di Bartolomeo M, Fanotto V, Lonardi S, Morano F, Pietrantonio F, Pinto C, Rimassa L, Vasile E, Vivaldi C, Zaniboni A, Ziranu P, Cascinu S Abstract The overall 5-year survival of gastric cancer (GC) has change only little in the last decades and it remains the fifth leading...
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Related ArticlesThe adjuvant treatment revolution for high-risk melanoma patients. Semin Cancer Biol. 2019 Aug 21;: Authors: Spagnolo F, Boutros A, Tanda E, Queirolo P Abstract The past 5 years have witnessed the results of many practice-changing studies that have dramatically improved the landscape of adjuvant therapy in patients with resected, high-risk melanoma. After a 20-year era of adjuvant interferon, the anti-CTLA-4 and anti-PD-1 immune-checkpoint...
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Related ArticlesThe Dichotomous Role of the Glycolytic Metabolism Pathway in Cancer Metastasis: Interplay with the Complex Tumor Microenvironment and Novel Therapeutic Strategies. Semin Cancer Biol. 2019 Aug 21;: Authors: El Hassouni B, Granchi C, Vallés-Martí A, Supadmanaba IGP, Bononi G, Tuccinardi T, Funel N, Jimenez CR, Peters GJ, Giovannetti E, Minutolo F Abstract Cancer metastasis to distant organs is initiated by tumor cells that disseminate from...
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Related ArticlesUmbrella and basket trials in oncology: ethical challenges. BMC Med Ethics. 2019 Aug 23;20(1):58 Authors: Strzebonska K, Waligora M Abstract BACKGROUND: Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. However, they present some ethical concerns referred to scientific validity, risk-benefit balance and informed consent. Our aim...
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Related ArticlesNeoantigen vaccine: an emerging tumor immunotherapy. Mol Cancer. 2019 Aug 23;18(1):128 Authors: Peng M, Mo Y, Wang Y, Wu P, Zhang Y, Xiong F, Guo C, Wu X, Li Y, Li X, Li G, Xiong W, Zeng Z Abstract Genetic instability of tumor cells often leads to the occurrence of a large number of mutations, and expression of non-synonymous mutations can produce tumor-specific antigens called neoantigens. Neoantigens are highly immunogenic as they are...
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Related ArticlesThe utility of intraoperative MRI during pediatric brain tumor surgery: a single-surgeon case series. J Neurosurg Pediatr. 2019 Aug 23;:1-7 Authors: Day EL, Scott RM Abstract OBJECTIVE: The authors sought to evaluate the utility of intraoperative MRI (ioMRI) during brain tumor excision in pediatric patients and to suggest guidelines for its future use. METHODS: All patients who underwent brain tumor surgery by the senior author...
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