Abstract Since the 1960s there has been an escalation in the purposeful utilization of altitude to enhance endurance athletic performance. This has been mirrored by a parallel intensification in research pursuits to elucidate hypoxia-induced adaptive mechanisms and substantiate optimal altitude protocols (e.g., hypoxic dose, duration, timing, and confounding factors such as training load periodization, health status, individual response, and nutritional considerations). The majority...
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Abstract Background At a young age, high-level youth footballers enter structured practice where they engage in regular training and matches. The academy system is considered fundamental to a young footballer’s tactical, technical and physical development. Yet, with regular training and matches, high-level youth footballers may be exposed to the risk of injury. Objective ...
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Related ArticlesExpression patterns of natriuretic peptides in pre-hibernating and hibernating anatolian ground squirrel (Spermophilus xanthoprymnus) lung. Acta Histochem. 2019 Aug 21;: Authors: Öztop M, Özbek M, Liman N, Beyaz F, Ergün E, Ergün L, Kavraal UK, Ergen E Abstract Anatolian ground squirrel (Spermophilus xanthoprymnus) is a true hibernator. This animal transiently reduces pulmonary function during hibernation. Continuance of pulmonary function...
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Abstract Independent verification of transit time and the methodology employed in commercial high dose rate (HDR) afterloaders to compensate its effect is an important part of their commissioning and quality assurance. This study aimed to independently evaluate the Co-60 source transit time of the new BEBIG SagiNova® HDR afterloader unit by employing a dosimetric approach using a well-type ionization chamber. The source was placed at three dwell positions (DPs) to mimic a variety...
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Abstract We propose a simple and efficient method to measure beam attenuation in one or two dimensions using an amorphous silicon electronic portal imaging device (a-Si EPID). The proposed method was validated against ionization chamber measurements. Beam attenuation through treatment couches (Varian Medical Systems) and immobilization devices (CIVCO Radiotherapy, USA) was examined. The dependency of beam attenuation on field size, photon energy, thickness of the couch, and the...
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Publication date: Available online 26 August 2019Source: Experimental Cell ResearchAuthor(s): Neetu Singh, Mohammad Shafiq, Kumaravelu Jagavelu, Kashif HanifAbstractApart from pulmonary vascular resistance and right ventricle (RV) hypertrophy, metabolic dysfunction also plays a major role in pathophysiology of pulmonary hypertension (PH). Recently, we have shown that fatty acid synthase (FAS), an enzyme involved in de novo fatty acid synthesis, plays a pivotal role in PH as its inhibition was protective...
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Publication date: Available online 24 August 2019Source: Experimental Cell ResearchAuthor(s): Jesús Roberto Villalobos-Arellano, Diego Montesinos Valencia, Rosario Ortiz-Hernández, Nayeli Torres-Ramírez, Olga Margarita Echeverría-Martínez, Abrahan Hernández-Hernández, Gerardo Hebert Vázquez-NinAbstractA typical nucleolus structure is shaped by three components. A meshwork of fine fibers forming the fibrillar center (FC) is surrounded by densely packed fibers forming the dense fibrillar component...
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Publication date: Available online 22 August 2019Source: Experimental Cell ResearchAuthor(s): Junichi Tanaka, Kenji Mishima
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Publication date: Available online 22 August 2019Source: Experimental Cell ResearchAuthor(s): Shuangshuang Han, Xia Jiang, Xiao-Feng Sun, Hong Zhang, Chao Li, Zengren Zhao, Weifang YuAbstractChemotherapy and radiotherapy are main adjuvant therapies for the treatment of gastric cancer, the treatment effects are individual difference, but the specific mechanism is unknown. CyTOF 2 mass cytometer (CyTOF) enables the detecting up to 135 parameters on single cell, the emergence of which is an opportunity...
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Related ArticlesDevelopments in understanding and applying prebiotics in research and practice - an ISAPP conference paper. J Appl Microbiol. 2019 Aug 25;: Authors: Scott KP, Grimaldi R, Cunningham M, Sarbini SR, Wijeyesekera A, Tang ML, Lee JC, Yau YF, Ansell J, Theis S, Yang K, Menon R, Arfsten J, Manurung S, Gourineni V, Gibson GR Abstract AIMS: The concept of using specific dietary components to selectively modulate the gut microbiota to confer a...
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Related ArticlesProbiotics supplement for the prevention of eczema in children: Study protocol for a meta-analysis and systematic review. Medicine (Baltimore). 2019 Aug;98(34):e16957 Authors: Yang W, Tu R, Hu Y, He T, Zhang W, Gu L, Liu H Abstract BACKGROUND: Atopic dermatitis (AD), also called eczema, is one of the most familiar chronic diseases in childhood. A possible pathological mechanism is immune dysfunction resulting in IgE sensitization to allergens....
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Related ArticlesAn overview on marine anti-allergic active substances for alleviating food-induced allergy. Crit Rev Food Sci Nutr. 2019 Aug 23;:1-15 Authors: Wang K, Pramod SN, Pavase TR, Ahmed I, Lin H, Liu L, Tian S, Lin H, Li Z Abstract Food provides energy and various nutrients and is the most important substance for the survival of living beings. However, for allergic people, certain foods cause strong reactions, and sometimes even cause shock...
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Vaccines, Vol. 7, Pages 99: Anti-Tat Immunity in HIV-1 Infection: Effects of Naturally Occurring and Vaccine-Induced Antibodies Against Tat on the Course of the Disease Vaccines doi: 10.3390/vaccines7030099 Authors: Aurelio Cafaro Antonella Tripiciano Orietta Picconi Cecilia Sgadari Sonia Moretti Stefano Buttò Paolo Monini Barbara Ensoli HIV-1 Tat is an essential protein in the virus life cycle, which is required for virus gene expression and replication. Most Tat...
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Vaccines, Vol. 7, Pages 98: Dog Ecology, Bite Incidence, and Disease Awareness: A Cross-Sectional Survey among a Rabies-Affected Community in the Democratic Republic of the Congo Vaccines doi: 10.3390/vaccines7030098 Authors: Céline Mbilo Jean-Baptiste Kabongo Pati Patient Pyana Léon Nlonda Raymond Williams Nzita Bobo Luntadila Badivé Badibanga Jan Hattendorf Jakob Zinsstag Despite the existence of safe and efficacious human and animal rabies vaccines, millions...
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Vaccines, Vol. 7, Pages 97: Procurement of Category 2 Vaccines in China Vaccines doi: 10.3390/vaccines7030097 Authors: Zhuang Wagner Laffoon Lu Jiang Internationally, vaccine pricing is relatively opaque, although many low- or lower-middle-income countries belong to international consortiums that jointly procure vaccines. China procures vaccines domestically, and vaccines that require payment from the public (“category 2 vaccines”), have undergone...
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Vaccines, Vol. 7, Pages 96: Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine Vaccines doi: 10.3390/vaccines7030096 Authors: Zifu Zhong João Paulo Portela Catani Séan Mc Cafferty Liesbeth Couck Wim Van Den Broeck Nina Gorlé Roosmarijn E. Vandenbroucke Bert Devriendt Sebastian Ulbert Lieselotte Cnops Johan Michels Kevin K. Ariën Niek N. Sanders To combat emerging infectious diseases like Zika virus (ZIKV),...
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Related ArticlesCord blood zinc status effects on pregnancy outcomes and its relation with maternal serum zinc levels: a systematic review and meta-analysis. World J Pediatr. 2019 Aug 24;: Authors: Akdas S, Yazihan N Abstract BACKGROUND: The association between maternal and cord blood zinc level and pregnancy outcomes remains uncertain. The present study aims to assess whether maternal blood zinc level represents cord blood zinc level correctly. ...
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Related ArticlesAssociation of famine exposure with the risk of type 2 diabetes: A meta-analysis. Clin Nutr. 2019 Aug 10;: Authors: Liu H, Chen X, Shi T, Qu G, Zhao T, Xuan K, Sun Y Abstract PURPOSE: The association between famine exposure and type 2 diabetes (T2DM) remains controversial. A meta-analysis was performed to clarify the relation of famine exposure to T2DM risk in detail. METHODS: A systematic literature search was performed in PubMed,...
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Related ArticlesExcessive daytime sleepiness and fatigue in neurological disorders. Sleep Breath. 2019 Aug 23;: Authors: Maestri M, Romigi A, Schirru A, Fabbrini M, Gori S, Bonuccelli U, Bonanni E Abstract Excessive daytime sleepiness (EDS) and fatigue are some of the most frequent symptoms in neurological diseases and could impact on quality of life by increasing the risk of accidents and generally affecting daily life activities. In this review, we...
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Related ArticlesInterplay of dopamine and GABA in substantia nigra for the regulation of rapid eye movement sleep in rats. Behav Brain Res. 2019 Aug 20;:112169 Authors: Yadav RK, Khanday MA, Mallick BN Abstract Substantia nigra (SN) is rich in dopamine (DA)-ergic and GABA-ergic neurons, which project to and receive inputs from locus coeruleus (LC) and pedunculo-pontine tegmentum (PPT) possessing REM-OFF and REM-ON neurons, respectively. Loss of DA-ergic...
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Related ArticlesDo the levels of particulate matters less than 10 μm and seasons affect sleep? Aging Male. 2019 Aug 23;:1-6 Authors: Yıldız Gülhan P, Güleç Balbay E, Elverişli MF, Erçelik M, Arbak P Abstract Background: There are few studies showing that the increase in particulate matters less than 10 μm (PM10) values increases the apnea-hypopnea index (AHI). We aimed to investigate relationship between air quality parameters and the seasons with the...
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Related ArticlesA Stage-Based Approach to Therapy in Parkinson's Disease. Biomolecules. 2019 Aug 20;9(8): Authors: Carrarini C, Russo M, Dono F, Di Pietro M, Rispoli MG, Di Stefano V, Ferri L, Barbone F, Vitale M, Thomas A, Sensi SL, Onofrj M, Bonanni L Abstract Parkinson's disease (PD) is a neurodegenerative disorder that features progressive, disabling motor symptoms, such as bradykinesia, rigidity, and resting tremor. Nevertheless, some non-motor...
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Related ArticlesREM Sleep: What Is It Good For? Curr Biol. 2019 Aug 19;29(16):R806-R807 Authors: Miller KE, Gehrman PR Abstract Rapid eye movement (REM) sleep serves an important function for processing and consolidating emotional memory. A recent study shows that restless REM sleep impedes this overnight process, providing insights into psychological disorders marked by fragmented REM sleep.PMID: 31430480 [PubMed - in process]
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Related ArticlesThe Interaction of REM Fragmentation and Night-Time Arousal Modulates Sleep-Dependent Emotional Memory Consolidation. Front Psychol. 2019;10:1766 Authors: Lipinska G, Thomas KGF Abstract The sleep-to-forget, sleep-to-remember (SFSR) hypothesis states that the neurobiological environment provided by rapid-eye movement (REM)-rich sleep decouples the content of an emotional memory from its attendant emotional arousal. This decoupling allows...
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Related ArticlesEffects of bilateral stimulation of the subthalamic nucleus in Parkinson's disease with and without REM sleep behaviour disorder. J Neurol Neurosurg Psychiatry. 2019 Aug 17;: Authors: Bargiotas P, Debove I, Bargiotas I, Lachenmayer ML, Ntafouli M, Vayatis N, Schüpbach MW, Krack P, Bassetti CL Abstract BACKGROUND: Although rapid eye movement sleep behaviour disorder (RBD) in Parkinson's disease (PD) is associated with increased non-motor...
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Related ArticlesREM sleep muscle activity in idiopathic REM sleep behavior disorder predicts phenoconversion. Neurology. 2019 Aug 16;: Authors: McCarter SJ, Sandness DJ, McCarter AR, Feemster JC, Teigen LN, Timm PC, Boeve BF, Silber MH, St Louis EK Abstract OBJECTIVE: To determine whether REM sleep without atonia (RSWA) during polysomnography (PSG) predicts phenoconversion in patients with idiopathic REM sleep behavior disorder (iRBD), a prodromal feature...
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Related ArticlesMuscarinic inhibition of hypoglossal motoneurons: possible implications for upper airway muscle hypotonia during REM sleep. J Neurosci. 2019 Aug 16;: Authors: Zhu L, Chamberlin NL, Arrigoni E Abstract Proper function of pharyngeal dilator muscles, including the genioglossus muscle of the tongue, is required to maintain upper airway patency. During sleep the activity of these muscles is suppressed, and as a result individual with obstructive...
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Related ArticlesAdaptation to Hypoxia in Sleep Apnea Patients: Multifaceted Mechanisms. Adv Exp Med Biol. 2019;1150:25-34 Authors: Śmietanowski M, Wysocki J, Balcerzak J, Cudnoch-Jędrzejewska A, Śmietanowska M, Niemczyk K Abstract Obstructive sleep apnea syndrome (OSA) is a form of sleep disordered breathing. The key phenomena are multiple repetitive pauses or restriction of airflow in the airway, defined as apnea and hypopnea. This study was based...
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Viruses, Vol. 11, Pages 785: Combinatorial Avidity Selection of Mosaic Landscape Phages Targeted at Breast Cancer Cells—An Alternative Mechanism of Directed Molecular Evolution Viruses doi: 10.3390/v11090785 Authors: Valery A. Petrenko James W. Gillespie Hai Xu Tiffany O’Dell Laura M. De Plano Low performance of actively targeted nanomedicines required revision of the traditional drug targeting paradigm and stimulated the development of novel phage-programmed, self-navigating...
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Viruses, Vol. 11, Pages 783: New Markers in Monitoring the Reactivation of Hepatitis B Virus Infection in Immunocompromised Hosts Viruses doi: 10.3390/v11090783 Authors: Valentina Svicher Romina Salpini Vincenzo Malagnino Lorenzo Piermatteo Mohammad Alkhatib Carlotta Cerva Loredana Sarmati Hepatitis B virus (HBV) persistence is at the basis of HBV reactivation as a consequence of chemotherapy and immunosuppressive treatments. The identification of early viral replication...
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Viruses, Vol. 11, Pages 784: A Recombinant Turkey Herpesvirus Expressing F and HN Genes of Avian Avulavirus-1 (AAvV-1) Genotype VI Confers Cross-Protection against Challenge with Virulent AAvV-1 Genotypes IV and VII in Chickens Viruses doi: 10.3390/v11090784 Authors: Krzysztof Śmietanka Jolanta Tyborowska Monika Olszewska-Tomczyk Katarzyna Domańska-Blicharz Zenon Minta Lukasz Rabalski Anna Czarnota Krzysztof Kucharczyk Boguslaw Szewczyk Newcastle disease (ND)...
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Viruses, Vol. 11, Pages 782: Identification of Key Residues Required for RNA Silencing Suppressor Activity of p23 Protein from a Mild Strain of Citrus Tristeza Virus Viruses doi: 10.3390/v11090782 Authors: Zhuoran Li Yizhong He Tao Luo Xi Zhang Haoliang Wan Atta Ur Rehman Xinru Bao Qian Zhang Jia Chen Rangwei Xu Yingtian Deng Yunliu Zeng Juan Xu Ni Hong Feng Li Yunjiang Cheng The severe strain of citrus tristeza virus (CTV) causes quick decline...
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Viruses, Vol. 11, Pages 780: Pulmonary Involvement during the Ebola Virus Disease Viruses doi: 10.3390/v11090780 Authors: Eleonora Lalle Mirella Biava Emanuele Nicastri Francesca Colavita Antonino Di Caro Francesco Vairo Simone Lanini Concetta Castilletti Martin Langer Alimuddin Zumla Gary Kobinger Maria R. Capobianchi Giuseppe Ippolito Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa...
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Viruses, Vol. 11, Pages 781: The Role of Reference Materials in the Research and Development of Diagnostic Tools and Treatments for Haemorrhagic Fever Viruses Viruses doi: 10.3390/v11090781 Authors: Giada Mattiuzzo Emma M. Bentley Mark Page Following the Ebola outbreak in Western Africa in 2013–16, a global effort has taken place for preparedness for future outbreaks. As part of this response, the development of vaccines, treatments and diagnostic tools has been accelerated,...
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Viruses, Vol. 11, Pages 779: Chikungunya Virus and (Re-) Emerging Alphaviruses Viruses doi: 10.3390/v11090779 Authors: Penghua Wang Rong Zhang Alphaviruses belong to a family of positive sense, single-stranded RNA viruses that are transmitted mainly by mosquitoes through a blood meal and cause arthritis and/or encephalitis in humans and animals [...]
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Viruses, Vol. 11, Pages 778: Immune-Escape Hepatitis B Virus Mutations Associated with Viral Reactivation upon Immunosuppression Viruses doi: 10.3390/v11090778 Authors: Ivana Lazarevic Ana Banko Danijela Miljanovic Maja Cupic Hepatitis B virus (HBV) reactivation occurs as a major complication of immunosuppressive therapy among persons who have recovered from acute hepatitis and those who have controlled chronic infection. Recent literature data emphasize the presence of a high...
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Viruses, Vol. 11, Pages 777: Novel Mammalian orthorubulavirus 5 Discovered as Accidental Cell Culture Contaminant Viruses doi: 10.3390/v11090777 Authors: Brandi J. Feehan Aleksey A. Penin Alexey N. Mukhin Deepak Kumar Anna S. Moskvina Kizkhalum M. Khametova Anton G. Yuzhakov Maria I. Musienko Alexey D. Zaberezhny Taras I. Aliper Douglas Marthaler Konstantin P. Alekseev A distinct Russian Mammalian orthorubulavirus 5 (PIV5) was detected in cell culture...
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Viruses, Vol. 11, Pages 775: Environmental Surveillance of Polioviruses in Armenia, Colombia before Trivalent Oral Polio Vaccine Cessation Viruses doi: 10.3390/v11090775 Authors: María Mercedes González Magile C. Fonseca Carlos Andrés Rodríguez Alejandra María Giraldo José Joaquín Vila Jhon Carlos Castaño Leonardo Padilla Luis Sarmiento Although acute flaccid paralysis (AFP) surveillance is the “gold standard” for detecting cases of polio, environmental...
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Viruses, Vol. 11, Pages 776: Interactions between Autophagy and DNA Viruses Viruses doi: 10.3390/v11090776 Authors: Hai-chang Yin Shu-li Shao Xin-jie Jiang Peng-yu Xie Wan-shu Sun Tian-fei Yu Autophagy is a catabolic biological process in the body. By targeting exogenous microorganisms and aged intracellular proteins and organelles and sending them to the lysosome for phagocytosis and degradation, autophagy contributes to energy recycling. When cells are stimulated by...
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