Publication date: Available online 25 August 2019Source: Clinical TherapeuticsAuthor(s): Laura K. GrubbAbstractOpioid use disorder (OUD) is a pediatric and adolescent problem as most young adults (aged <25 years) in treatment programs report initiating use before 25 years of age, and there are lifelong impacts from early substance use necessitating early screening for opioid use and subsequent treatment. Medication-assisted treatment (MAT) is a highly effective intervention for OUD, and there...
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Publication date: Available online 22 August 2019Source: Clinical TherapeuticsAuthor(s): Stephen E. Daniels, Rebecca Playne, Ioana Stanescu, Jennifer Zhang, Ira J. Gottlieb, Hartley C. AtkinsonAbstractPurposeMultimodal analgesia with acetaminophen and/or nonsteroidal anti-inflammatory drugs is recommended for the treatment of postoperative pain. Although oral fixed-dose combinations (FDCs) are available, parenteral administration may be clinically justified. The goal of this study was to investigate...
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Publication date: Available online 22 August 2019Source: Clinical TherapeuticsAuthor(s): Richard Haynes, Elsa Valdes-Marquez, Jemma C. Hopewell, Fang Chen, Jing Li, Sarah Parish, Martin J. Landray, Jane Armitage, for the HPS2-THRIVE Collaborative Group, Richard Haynes, Elsa Valdes-Marquez, Jemma C. Hopewell, Fang Chen, Jing Li, Sarah Parish, Martin J. Landray, Jane Armitage, R. Collins, J. Armitage, C. Baigent, Z. ChenAbstractPurposeThe Heart Protection Study 2–Treatment of HDL to Reduce the Incidence...
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Publication date: Available online 22 August 2019Source: Clinical TherapeuticsAuthor(s): Ravi JhaveriAbstractHost factors are critically important in governing the susceptibility and severity of most viral infections. The importance of these host factors is governed by the prevalence of the virus and the availability of effective therapeutic and/or preventive measures. This review highlights 2 such host factors that were initially judged to be important but over time have moved in opposite directions:...
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Publication date: Available online 22 August 2019Source: Clinical TherapeuticsAuthor(s): Sandhya Khurana, Guy G. Brusselle, Elisabeth H. Bel, J. Mark FitzGerald, Matthew Masoli, Stephanie Korn, Motokazu Kato, Frank C. Albers, Eric S. Bradford, Martyn J. Gilson, Robert G. Price, Marc HumbertAbstractPurposeThe goal of this study was to assess the long-term safety and efficacy of mepolizumab in patients with the most severe eosinophilic asthma.MethodsThis multicenter, open-label, long-term, Phase IIIb...
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Related ArticlesIntracranial synovial sarcoma: A clinical, radiological and pathological study of 16 cases. Eur J Surg Oncol. 2019 Aug 16;: Authors: Zhang G, Xiao B, Huang H, Zhang Y, Zhang X, Zhang J, Wang Y Abstract INTRODUCTION: Synovial sarcoma (SS) is a tumor of unknown origin and is extremely rare in the central nervous system. Most studies on intracranial SS included only one or two cases. To better understand the disease, we review a series of...
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Related ArticlesManagement of the axilla in patients with breast cancer and positive sentinel lymph node biopsy: An evidence-based update in a European breast center. Eur J Surg Oncol. 2019 Aug 13;: Authors: Garcia-Etienne CA, Ferrari A, Della Valle A, Lucioni M, Ferraris E, Di Giulio G, Squillace L, Bonzano E, Lasagna A, Rizzo G, Tancredi R, Scotti Foglieni A, Dionigi F, Grasso M, Arbustini E, Cavenaghi G, Pedrazzoli P, Filippi AR, Dionigi P, Sgarella A Abstract...
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Related ArticlesThe pre- and postoperative course of functional status in patients undergoing esophageal cancer surgery. Eur J Surg Oncol. 2019 Aug 06;: Authors: van Egmond MA, van der Schaaf M, Klinkenbijl JHG, Twisk JWR, Engelbert RHH, van Berge Henegouwen MI Abstract INTRODUCTION: To optimally target physiotherapy treatment, knowledge of the pre- and postoperative course of functional status in patients undergoing esophagectomy is required. The aim...
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Related ArticlesIntraoperative packed red blood cell transfusion (iPRBT) and PCI-normalised iPRBT rates (iPRBT/PCI ratio) negatively affect short- and long-term outcomes of patients undergoing cytoreductive surgery and intraperitoneal chemotherapy - An analysis of 880 patients. Eur J Surg Oncol. 2019 Jul 30;: Authors: Fisher OM, Alzahrani NA, Kozman MA, Valle SJ, Liauw W, Morris DL Abstract BACKGROUND: Most studies on the effects of intraoperative packed...
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Related ArticlesOncologic outcome of mixed adenoneuroendocrine carcinoma (MANEC): A single center case series. Eur J Surg Oncol. 2019 Aug 02;: Authors: Dulskas A, Pilvelis A Abstract INTRODUCTION: Mixed adeno-neuroendocrine carcinomas (MANEC) are rare tumors of gastrointestinal tract mostly found in stomach. There are very few case reports and case series with location of colon and rectum. We aimed to report our results in the treatment of colorectal...
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Related ArticlesImplementation of enhanced recovery after surgery in patients undergoing radical cystectomy: A retrospective cohort study. Eur J Surg Oncol. 2019 Jul 17;: Authors: Zhang H, Wang H, Zhu M, Xu Z, Shen Y, Zhu Y, Xu Y, Chen W, Miao C Abstract BACKGROUND: To evaluate the feasibility and effect of implementing enhanced recovery after surgery (ERAS) in patients undergoing radical cystectomy (RC) and urinary diversion. MATERIALS AND...
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Related ArticlesAddressing frailty in patients with breast cancer: A review of the literature. Eur J Surg Oncol. 2019 Aug 12;: Authors: Jauhari Y, Gannon MR, Dodwell D, Horgan K, Tsang C, Clements K, Medina J, Tang S, Pettengell R, Cromwell DA Abstract Various studies have documented variation in the management of older patients with breast cancer, and some of this variation stems from different approaches to balancing the expected benefit of different...
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Related ArticlesPatterns of axillary staging and management in clinically node positive breast cancer patients treated with neoadjuvant systemic therapy: Results of a survey amongst breast cancer specialists. Eur J Surg Oncol. 2019 Aug 13;: Authors: Simons JM, Maaskant-Braat AJG, Luiten EJT, Leidenius MHK, van Nijnatten TJA, Boelens PG, Koppert LB, van der Pol CC, van de Velde CJH, Audisio RA, Smidt ML Abstract INTRODUCTION: Various options for axillary...
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Related ArticlesA rare case of sinonasal glomangiopericytoma post operative accidental diagnosis and managment-A case report. Int J Surg Case Rep. 2019 Aug 09;62:54-57 Authors: Sharma N, Mandlik D, Patel P, Patel P, Joshipura A, Patel M, Mankiwala S, Vatsyayan A, Dubey T, Sanghvi K, Shah D, Kanhere S, Talati S, Patel K Abstract INTRODUCTION: Glomangiopericytoma is a rare neoplasm of low malignant potential. It is a rare type of haemangiopericytoma located...
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Related ArticlesA new application of modified Nishida muscle transposition procedure for medial rectus muscle transection following endoscopic sinus surgery without tenotomy or splitting muscles. J AAPOS. 2019 Aug 21;: Authors: Kong M, Zhang LJ, Dai S, Li JH PMID: 31445084 [PubMed - as supplied by publisher]
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Related ArticlesDoes Middle Meatal Antrostomy Prevent the Onset of Maxillary Sinusitis After Zygomatic Implant Placement? J Oral Maxillofac Surg. 2019 Jul 05;: Authors: D'Agostino A, Favero V, Nocini R, Venco J, Nocini PF, Trevisiol L Abstract PURPOSE: To evaluate the role of middle meatal antrostomy in preventing the onset of maxillary sinusitis after placement of zygomatic implants. We hypothesized that middle meatal antrostomy might reduce the incidence...
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17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Endoscopic sinus surgery These pubmed results were generated on 2019/08/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Abstract Purpose Experimental studies suggested that green tea may have an anticancer effect on hematologic neoplasms. However, few prospective studies have been conducted. Methods A total of 65,042 individuals aged 40–79 years participated in this study and completed a self-administered questionnaire about their lifestyle and medical history at baseline...
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Abstract Background Skin-sparing (SSME) and nipple-sparing mastectomy (NSME) were developed to improve the cosmetic results for breast cancer (BC) patients, both allowing for immediate breast reconstruction. Recommendations for post-mastectomy radiotherapy (PMRT) are primarily derived from trials where patients were treated by standard mastectomies. Due to their more conservative character, SSME and especially NSME potentially leave more...
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Series Type : Methylation profiling by genome tiling array ; Expression profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
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Contributors : Sven Beyes ; Geoffroy Andrieux ; Monika Schrempp ; David Aicher ; Janna Wenzel ; Melanie Boerries ; Andreas HechtSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAt the molecular level, epithelial-to-mesenchymal transition (EMT) necessitates extensive transcriptional reprogramming which is orchestrated by a small group of gene regulatory proteins. The transcription factor SNAIL1 is a zinc-finger DNA-binding protein and well-known...
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Contributors : Guillermo Martín-Serrano ; Osvaldo Graña-Castro ; Cristina Montero-Conde ; Mercedes RobledoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe explored alternative splicing events upon hsa-miR-139-5p/HNRNPF axis regulation in our cell system using the Multivariate Analysis of Transcript Splicing (rMATS) computational tool (https://doi.org/10.1073/pnas.1419161111). Differential analysis of major splicing outcomes (skipped exon, alternative 5’/3’...
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Contributors : Guillermo Martín-Serrano ; Osvaldo Graña-Castro ; Cristina Montero-Conde ; Mercedes RobledoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensSmall RNAs of 49 thyroid tissues were extracted and isolated to investigate the correlation of miRNome profiles with specific clinic-pathological and molecular features of the tumors.
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Contributors : Justine M Abais-Battad ; David L MattsonSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBackground. The Dahl salt-sensitive (SS) rat is an established model of salt-sensitive hypertension and renal damage. Recently, sodium-independent dietary effects were shown to be important in the development of the SS hypertensive phenotype. Compared to Dahl SS/JrHsdMcwi (SS/MCW) rats fed a purified diet (AIN-76A), grain-fed Dahl SS/JrHsdMcwiCrl rats...
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Contributors : Won Yoo ; Tae Kim ; Sung-Jong HongSeries Type : Expression profiling by arrayOrganism : Clonorchis sinensisDevelopmental gene expression patterns (9812 genes) of juvenile and adult C. sinensis were analyzed using a 12K oligonucleotide microarray (a total of 11617 genes). A number of significantly differentially expressed genes having more than 2-fold difference were observed in adult stage compared to juvenile stage. This finding suggests that the expression levels of different...
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Contributors : Michael Simons ; Pei-Yu ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEndothelial TGFβ signaling is one of the primary drivers of atherosclerosis-associated vascular inflammation. Inhibition of endothelial TGFβ signaling in hyperlipidemic mice reduces vessel wall inflammation and vascular permeability and leads to arrest of disease progression and regression of established lesions. We performed scRNAseq method to examine...
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Contributors : Charles M Perou ; Daniel P HollernSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study identifies mechanisms of response to immune checkpoint inhibition in mouse models of triple negative breast cancer.
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Contributors : Alison Hirukawa ; Willliam Muller ; Jarey WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMonoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proportion of patients exhibits de novo resistance. Here, by comparing matched Trastuzumab-naïve and post-treatment patient...
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Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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GSE134555 Endothelial TGFb signaling drives vascular inflammation and atherosclerosis [bulk RNA-Seq]
Contributors : Michael Simons ; Pei-Yu ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndothelial TGFβ signaling is one of the primary drivers of atherosclerosis-associated vascular inflammation. Inhibition of endothelial TGFβ signaling in hyperlipidemic mice reduces vessel wall inflammation and vascular permeability and leads to arrest of disease progression and regression of established lesions. We performed scRNAseq method to examine endothelial cell...
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Contributors : Michael Simons ; Pei-Yu ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndothelial TGFβ signaling is one of the primary drivers of atherosclerosis-associated vascular inflammation. Inhibition of endothelial TGFβ signaling in hyperlipidemic mice reduces vessel wall inflammation and vascular permeability and leads to arrest of disease progression and regression of established lesions. We performed scRNAseq method to examine endothelial cell...
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Contributors : Sornkom Jirawas ; Poortinga GretchenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur results confirmed that CX-5461, a Pol I inhibitor, does not significantly impact mRNA expression at 6 hrs, while I-BET151 alone, known to inhibit MYC and expression of other oncognes, resulted in widespread changes in select gene expression programs as previously demonstrated (Dawson et al., 2011). Interestingly, the combination of CX-5461 and I-BET151 demonstrated...
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Contributors : Xiaqing Yu ; Zaobing Zhu ; Tinglin Zhang ; Ji Li ; Chunyan Cheng ; Qunfeng Lou ; Carl-Otto Ottosen ; Jinfeng ChenSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Cucumis hystrix ; Cucumis sativus ; Cucumis x hytivusAllopolyploidy is long recognized as an essential driving force in plant evolution. Recent studies have demonstrated that small RNAs, including microRNAs (miRNAs), play important roles in the process of allopolyploidy. However, the question...
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