Cancers, Vol. 11, Pages 1236: Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players Cancers doi: 10.3390/cancers11091236 Authors: Carmel Mothersill Andrej Rusin Colin Seymour Non-targeted effects (NTE) such as bystander effects or genomic instability have been known for many years but their significance for radiotherapy or medical diagnostic radiology are far from clear. Central to the issue are reported...
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Cancers, Vol. 11, Pages 1231: Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance Cancers doi: 10.3390/cancers11091231 Authors: Weihua Zhou Daniel R. Wahl Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly universally fatal. Targeted therapy and immunotherapy have had limited success in GBM, leaving surgery, alkylating chemotherapy and ionizing radiation as the standards of care. Like most cancers, GBMs...
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Cancers, Vol. 11, Pages 1233: The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing Cancers doi: 10.3390/cancers11091233 Authors: Hayley J. Luxton Benjamin S. Simpson Ian G. Mills Nicola R. Brindle Zeba Ahmed Vasilis Stavrinides Susan Heavey Stefan Stamm Hayley C. Whitaker Oncogenic metadherin is a key contributor to tumourigenesis with metadherin expression and cytoplasmic...
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Related ArticlesComparable radiation response of ex vivo and in vivo irradiated tumor samples determined by residual γH2AX. Radiother Oncol. 2019 Aug 21;: Authors: Rassamegevanon T, Löck S, Baumann M, Krause M, von Neubeck C Abstract PURPOSE: a) To investigate if an ex vivo cultured and irradiated tumor biopsy reflects and predicts the radiation response of the corresponding in vivo irradiated tumor measured with the DNA double strand break marker γH2AX...
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Related ArticlesA single-blind, randomised controlled trial of StrataXRT® - A silicone-based film-forming gel dressing for prophylaxis and management of radiation dermatitis in patients with head and neck cancer. Radiother Oncol. 2019 Aug 21;: Authors: Chan RJ, Blades R, Jones L, Downer TR, Peet SC, Button E, Wyld D, McPhail S, Doolan M, Yates P Abstract AIM: Investigate the effects of StrataXRT® versus 10% Glycerine (Sorbolene cream) for preventing...
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Related ArticlesSingle vs multiple fraction palliative radiation therapy for bone metastases: Cumulative meta-analysis. Radiother Oncol. 2019 Aug 21;: Authors: Chow R, Hoskin P, Schild SE, Raman S, Im J, Zhang D, Chan S, Chiu N, Chiu L, Lam H, Chow E, Lock M Abstract INTRODUCTION: There has been a long-standing debate regarding the efficacy of single fraction radiotherapy (SFRT) compared to multiple fraction radiotherapy (MFRT); many systematic reviews...
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Related ArticlesFLASH radiotherapy International Workshop. Radiother Oncol. 2019 Aug 21;: Authors: Vozenin MC, Baumann M, Coppes RP, Bourhis J PMID: 31445836 [PubMed - as supplied by publisher]
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Related ArticlesDNA damage enhancement by radiotherapy-activated hafnium oxide nanoparticles improves cGAS-STING pathway activation in human colorectal cancer cells. Radiother Oncol. 2019 Aug 19;: Authors: Marill J, Mohamed Anesary N, Paris S Abstract The cGAS-STING pathway can be activated by radiation induced DNA damage and because of its important role in anti-cancer immunity activation, methods to increase its activation in cancer cells could provide...
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Related ArticlesDosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma. Radiother Oncol. 2019 Aug 19;: Authors: Kubo N, Kubota Y, Kawamura H, Oike T, Sakai M, Kumazawa T, Miyasaka Y, Okazaki S, Kobayashi D, Sato H, Mizukami T, Musha A, Shirai K, Saitoh JI, Yokoo S, Chikamatsu K, Ohno T, Nakano T Abstract BACKGROUND AND PURPOSE: Little information is available on the risk factors for...
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Related ArticlesChemoradiotherapy of locally-advanced non-small cell lung cancer: Analysis of radiation dose-response, chemotherapy and survival-limiting toxicity effects indicates a low α/β ratio. Radiother Oncol. 2019 Aug 19;: Authors: Nix MG, Rowbottom CG, Vivekanandan S, Hawkins MA, Fenwick JD Abstract PURPOSE: To analyse changes in 2-year overall survival (OS2yr) with radiotherapy (RT) dose, dose-per-fraction, treatment duration and chemotherapy...
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Related Articles18F-FDG-PET/CT-based treatment planning for definitive (chemo)radiotherapy in patients with head and neck squamous cell carcinoma improves regional control and survival. Radiother Oncol. 2019 Aug 19;: Authors: van den Bosch S, Doornaert PAH, Dijkema T, Zwijnenburg EM, Verhoef LCG, Hoeben BAW, Kasperts N, Smid EJ, Terhaard CHJ, Kaanders JHAM Abstract BACKGROUND AND PURPOSE: Multimodality imaging including 18F-FDG-PET has improved the detection...
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25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Radiother Oncol These pubmed results were generated on 2019/08/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related ArticlesAn open-label phase IB study to evaluate GSK3052230 in combination with paclitaxel and carboplatin, or docetaxel, in FGFR1-amplified non-small cell lung cancer. Lung Cancer. 2019 Aug 14;136:74-79 Authors: Morgensztern D, Karaseva N, Felip E, Delgado I, Burdaeva O, Dómine M, Lara P, Paik PK, Lassen U, Orlov S, Trigo J, Shomova M, Baker-Neblett K, Vasquez J, Wang X, Yan L, Mitrica I, DeYoung MP, Garrido P Abstract OBJECTIVES: GSK3052230...
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Related ArticlesYBX-1 mediated sorting of miR-133 into hypoxia/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT. Stem Cell Res Ther. 2019 Aug 23;10(1):263 Authors: Lin F, Zeng Z, Song Y, Li L, Wu Z, Zhang X, Li Z, Ke X, Hu X Abstract BACKGROUND: Myocardial fibrosis is a common pathophysiological change in cardiovascular disease, which can cause cardiac dysfunction and even sudden death. Excessively activated fibroblasts...
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Related ArticlesInhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells. Sci Rep. 2019 Aug 22;9(1):12277 Authors: Lee HE, Lee JY, Yang G, Kang HC, Cho YY, Lee HS, Lee JY Abstract Tumor microenvironment favors tumor cells to promote their growth and metastasis such as migration, invasion, and angiogenesis. IL-1β, one of the inflammatory cytokines released from myeloid cells in tumor microenvironment,...
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Related ArticlesIntegrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment. Cancers (Basel). 2019 Aug 21;11(9): Authors: Brown NF, Marshall JF Abstract TGFβ (transforming growth factor-beta) is a pleotropic cytokine with contrasting effects in cancer. In normal tissue and early tumours, TGFβ acts as a tumour suppressor, limiting proliferation and inducing apoptosis. However, these effects are eventually abrogated by the loss or inactivation...
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Related Articles[XELIRI plus Bmab Therapy as a Secondary Treatment for Recurrent Colorectal Cancer with Long-Term Survival]. Gan To Kagaku Ryoho. 2019 Feb;46(2):369-371 Authors: Yukimoto R, Fukunaga M, Konishi K, Matsuno Y, Nakai S, Takiguchi N, Honda S, Saito A, Takeoka T, Okada K, Ota H, Yokoyama S, Kobayashi K Abstract A 71-year-old woman complained of melena, and laparoscopic right hemicolectomy was performed for advanced colorec- tal cancer. Pathological...
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Related Articles[Proteinuria in Patients with Gastric Cancer Treated with Ramucirumab]. Gan To Kagaku Ryoho. 2019 Feb;46(2):245-249 Authors: Kimura Y, Mikami J, Makari Y, Fujii C, Hiraki Y, Imano M, Fujita J, Yasuda T Abstract BACKGROUND: Ramucirumab, an antiangiogenic agent, often causes proteinuria as a characteristic adverse effect. We retro- spectively evaluated proteinuria and clarified the significance of the protein/creatinine ratio by using...
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Related ArticlesReduced Vessel Density of the Choriocapillaris during Anti-Vascular Endothelial Growth Factor Therapy for Neovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2019 03 01;60(4):1088-1095 Authors: Hikichi T, Agarie M Abstract Purpose: To investigate macular vascular alterations by using optical coherence tomography angiography (OCTA) in patients with a history of long-term anti-vascular endothelial growth factor (VEGF)...
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Related ArticlesApremilast induced chronic diarrhea and malnutrition. Drug Discov Ther. 2018;12(6):379-380 Authors: Mallick B, Praharaj DL, Nath P, Panigrahi SC Abstract Apremilast is used as a systemic therapy for the treatment of psoriasis and psoriatic arthritis. This drug is considered relatively safe with a very low incidence of serious side effects. Common side effects are diarrhea, nausea, headache, nasopharyngitis, upper respiratory tract infections...
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Related ArticlesDelta tocotrienol in recurrent ovarian cancer. A phase II trial. Pharmacol Res. 2019 03;141:392-396 Authors: Thomsen CB, Andersen RF, Steffensen KD, Adimi P, Jakobsen A Abstract Delta tocotrienol has anti-neoplastic activity as demonstrated in several in-vitro and in-vivo investigations. The effect relies on inhibition of different pathways. It also has antiangiogenic activity, and an additive effect to bevacizumab may be expected....
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Related ArticlesRecombined humanized endostatin-induced suppression of HMGB1 expression inhibits proliferation of NSCLC cancer cells. Thorac Cancer. 2019 01;10(1):90-95 Authors: Meng FJ, Wang S, Yan YJ, Wang CY, Guan ZY, Zhang J Abstract BACKGROUND: Recombined humanized endostatin (Rh-endostatin) exhibits a potent anti-cancer effect involving multiple molecular targets and signaling pathways. HMGB1 is a highly conserved DNA-binding protein involved...
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Related ArticlesEfficacy and toxicities of gemcitabine and cisplatin combined with endostar in advanced thymoma and thymic carcinoma. Thorac Cancer. 2019 01;10(1):17-23 Authors: Wang Y, Nie J, Dai L, Hu W, Chen X, Han J, Ma X, Tian G, Han S, Long J, Zhang Z, Fang J Abstract BACKGROUND: Thymoma and thymic carcinoma are rare thymic epithelial tumors. We investigated the efficacy of first-line gemcitabine and cisplatin (GP) chemotherapy versus gemcitabine...
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Related ArticlesNogo-B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma. Mol Oncol. 2018 12;12(12):2042-2054 Authors: Cai H, Saiyin H, Liu X, Han D, Ji G, Qin B, Zuo J, Shen S, Yu W, Wu J, Wu Y, Yu L Abstract Tumor angiogenesis is one of the hallmarks of cancer as well as an attractive target for cancer therapy. Characterization of novel pathways that act in parallel with the VEGF/VEGFR axis to promote...
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Related ArticlesWhat Is the Nature of the Reach and Grasp Deficit in Wet Age-related Macular Degeneration? Optom Vis Sci. 2018 03;95(3):171-182 Authors: Corveleyn X, Lenoble Q, Szaffarczyk S, Tran THC, Boucart M Abstract SIGNIFICANCE: Vision is paramount for motor actions directed toward objects. Vision allows not only the identification of objects and their shape and spatial location, but also the adaptation of our movement when it arrives on the object....
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Related ArticlesNovel repair mechanisms in a renal ischaemia/reperfusion model: Subsequent saxagliptin treatment modulates the pro-angiogenic GLP-1/cAMP/VEGF, ANP/eNOS/NO, SDF-1α/CXCR4, and Kim-1/STAT3/HIF-1α/VEGF/eNOS pathways. Eur J Pharmacol. 2019 Aug 19;:172620 Authors: Kamel NM, Abd El Fattah MA, El-Abhar HS, Abdallah DM Abstract The reno-protective effects of antidiabetic dipeptidyl peptidase (DPP)-4 inhibitors have been studied regarding their...
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Related ArticlesSCF (Stem Cell Factor) and cKIT Modulate Pathological Ocular Neovascularization. Arterioscler Thromb Vasc Biol. 2019 Aug 22;:ATVBAHA119313179 Authors: Kim KL, Seo S, Taek Kim J, Kim J, Kim W, Yeo Y, Sung JH, Gyu Park S, Suh W Abstract OBJECTIVE: Aberrant neovascularization is a leading cause of blindness in several eye diseases, including age-related macular degeneration and proliferative diabetic retinopathy. The identification of key...
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John Tyndall is credited with the link between carbon dioxide and climate—but Eunice Newton Foote got there first -- Read more on ScientificAmerican.com
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The volcanoes on other worlds make our wildest fire mountains look positively tame. -- Read more on ScientificAmerican.com
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But here’s the good news: new research finds it was actually six different species, and five still exist—for now -- Read more on ScientificAmerican.com
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A fable for our time -- Read more on ScientificAmerican.com
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Bones found in Morocco underscore that many more dinosaurs await discovery. -- Read more on ScientificAmerican.com
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The science community must join forces to provide the most accurate long-term predictions and make their results publicly accessible -- Read more on ScientificAmerican.com
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A reminder that there is more going on in the universe than we ordinarily perceive -- Read more on ScientificAmerican.com
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The House of Representatives has taken the first step toward honoring a pioneering woman in astronomy -- Read more on ScientificAmerican.com
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Abstract The purpose of this study is to define departmental action limits for energy percentage variation measured by means of step-wedge helical Tomotherapy quality assurance module. Individual charts using the Statistical Process Control techniques have been used to identify retrospectively out-of-control situations ascribable to documented actions performed on the Tomotherapy system. Using the in-control data of our analysis process capability indices (cp, cpk, cpm and cpmk)...
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Abstract Cognitive dysfunction in multiple sclerosis (MS) seems to be the result of neural disconnections, leading to a wide range of brain functional network alterations. It is assumed that the analysis of the topological structure of brain connectivity network can be used to assess cognitive impairments in MS disease. We aimed to identify these brain connectivity pattern alterations and detect the significant features for the distinction of MS patients from healthy controls (HC)....
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