The goal of the protocol is to enable visualization of the detailed flow fields and determination of the near-boundary shear and normal stresses within an equilibrium scour hole induced by a vibrating pipeline.
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Here we present a protocol, designed to use chemogenetic tools to manipulate the activity of cortical interneuron progenitors transplanted into the cortex of early postnatal mice.
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Drawbridge Health, out of Menlo Park, California, won FDA clearance for its OneDraw A1C Test System, which consists of the OneDraw Blood Collection Device and the OneDraw A1C Test. Designed for use by clinicians, the disposable product is used to draw, collect, and stabilize blood to measure hemoglobin A1c (HbA1c) levels to help manage glucose in patients with diabetes. Blood is drawn from the capillaries in the upper arm, which avoids the need to use hypodermic needles to access...
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Wearable health monitors, ubiquitous sensors, and the ability to collect and store huge amounts of data are creating challenges for researchers hoping to use artificial intelligence to identify diseases. While the gathered data can hold important clinical answers, finding those answers means that the data must be categorized and labeled. Now, researchers at MIT have developed a system that can autonomously identify signs of a disease from data gathered from a relatively small group...
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Lumendi, an English firm, won FDA clearance to introduce its DiLumen Ik endolumenal interventional knife. The single-use monopolar device is used for surgical dissections, performing cuts, and cauterizing of tissues of the gastrointestinal tract. To help perform many procedures that require a section to be elevated from the surrounding tissue, the same device can be used to administer submucosal fluid injections. The knife is designed to be compatible with the company’s latest...
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CT-guided pulsed radiofrequency, a relatively new technique that delivers bursts...Read more on AuntMinnie.comRelated Reading: SIR: UFE bests myomectomy for fibroid treatment CT-guided pulsed radiofrequency provides back pain relief SIR studies show breadth of interventional radiology Image-guided IR treatment relieves back pain (Source: AuntMinnie.com Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100%...
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The increasing utilization of 7-tesla MRI in the clinical setting has prompted...Read more on AuntMinnie.comRelated Reading: 7T MRI and 3D printing uncover signs of severe MS 7T MRI shows path to MS progression 7T finds epilepsy abnormalities missed at lower field strengths Is 7-tesla MRI ready yet to go clinical? Can 7-tesla MRI make the transition to clinical prime time? (Source: AuntMinnie.com Headlines)
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Artificial intelligence (AI) may create new opportunities to improve outcomes...Read more on AuntMinnie.comRelated Reading: Data biases for AI could worsen healthcare disparities Preparing healthcare IT architecture for AI: Part 2 Preparing healthcare IT architecture for AI: Part 1 AI can improve reproducibility of radiomics in CT AI, radiomics can help predict chemotherapy response (Source: AuntMinnie.com Headlines)MedWorm Message: If you are looking to buy something in the January Sales please...
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The Society for Imaging Informatics in Medicine (SIIM) is looking for a new...Read more on AuntMinnie.comRelated Reading: SIIM announces new board members for 2019-2020 term ACR, SIIM, STR announce AI challenge for pneumothorax SIIM announces awards at annual meeting NYMIIS pairs with SIIM to revive informatics symposium Mason to retire as SIIM executive director (Source: AuntMinnie.com Headlines)
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Virtual 3D models of the knee based on MRI scans of anterior cruciate ligament...Read more on AuntMinnie.comRelated Reading: 3D models advance therapy for heart rhythm disorders 3D MRI captures changes to fetal head during birth 3D-printed device aids knee replacement surgery New 3D CT technique tops x-ray for diagnosing arthritis 3D MRI technique depicts postablation prostate changes (Source: AuntMinnie.com Headlines)
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Philips Healthcare was warned of "suspicious sales" of its medical equipment...Read more on AuntMinnie.comRelated Reading: Philips asserts it has no intention of buying Corindus Philips, Carestream healthcare IT deal nears completion Philips reports continued sales growth in Q2 Philips highlights ambient room for FDG uptake Philips integrates AI into latest Epiq CVx upgrade Report: SEC looking into charges of bribery in China (Source: AuntMinnie.com Headlines)
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Abstract Research that makes secondary use of administrative and clinical healthcare databases is increasingly influential for regulatory, reimbursement, and other healthcare decision-making. Consequently, there are numerous guidance documents on reporting for studies that use ‘real-world’ data captured in administrative claims and electronic health record (EHR) databases. These guidance documents are intended to improve transparency, reproducibility, and the ability to evaluate...
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Nature Neuroscience, Published online: 26 August 2019; doi:10.1038/s41593-019-0468-2Zhou et al. report a novel 5-HT circuit from the dorsal raphe nucleus to somatostatin-expressing neurons in the central nucleus of the amygdala that partially mediates depressive-like behavior in a mouse model of chronic pain.
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Nature Neuroscience, Published online: 26 August 2019; doi:10.1038/s41593-019-0461-9The authors leverage extensive RNA sequencing data from postmortem brains of controls and individuals with autism spectrum disorder (ASD) to identify altered patterns of allele specific gene expression.
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Nature Neuroscience, Published online: 26 August 2019; doi:10.1038/s41593-019-0467-3While we sleep, the brain replays memories of our experiences during the day. In this review, Klinzing et al. provide a concise overview of how the sleeping brain transforms and builds persisting memories through this process.
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Nature Neuroscience, Published online: 26 August 2019; doi:10.1038/s41593-019-0465-5Furlanis, Traunmüller et al. uncover hundreds of alternative splicing events that distinguish neuronal cell classes. Splice isoforms primarily encode synaptic and intrinsic neuronal properties. Data are available online in the SpliceCode database.
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Abstract Purpose In this study we evaluated the utility of in-vitro screening tools for predicting the in-vivo behavior of six cyclic peptides with different solubility and permeability properties (BCS class II and III), intended for oral delivery in presence of permeation enhancer Labrasol. Methods An in vitro flux assay was used to assess...
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Nature Immunology, Published online: 26 August 2019; doi:10.1038/s41590-019-0471-5Protein transcription factor paralogs are not equivalent and serve distinct roles in immune cells. Merkenschlager and colleagues show that RUNX1 and RUNX3 differ in binding strength to motif sequences and how this leads to differential functional activities.
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Nature Immunology, Published online: 26 August 2019; doi:10.1038/s41590-019-0469-zLove and colleagues show that β-selection-associated proliferation requires the combined activity of SCF ubiquitin ligases that contain the F-box proteins Fbxl1 and Fbxl12, which are induced by Notch and pre-TCR signals, respectively.
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Conditions: Hearing Loss, Sensorineural; Bilateral Vestibular Deficiency; DFNA9; Radiology Intervention: Diagnostic Test: video nystagmografy Sponsor: Jessa Hospital Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Abstract Background Mechanical thrombectomy (MT) has become first-line treatment for patients with acute ischemic stroke caused by large vessel occlusion (AIS-LVO). Delay in the interhospital transfer (IHT) of patients from referral hospitals to a comprehensive stroke center is associated with worse outcomes. At our academic tertiary care facility in an urban setting, a neurocritical care and emergency neurology unit (NCCU) receives patients...
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by William J. Pandori, Tatiane S. Lima, Sharmila Mallya, Tiffany H. Kao, Lanny Gov, Melissa B. Lodoen IL-1β is a potent pro-inflammatory cytokine that promotes immunity and host defense, and its dysregulation is associated with immune pathology. Toxoplasma gondii infection of myeloid cells triggers the production and release of IL-1β; however, the mechanisms regulating this pathway, particularly in human immune cells, are incompletely understood. We have identified a novel pathway of T. gondii...
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by Jay Vornhagen, Yuang Sun, Paul Breen, Valerie Forsyth, Lili Zhao, Harry L. T. Mobley, Michael A. Bachman Klebsiella pneumoniae (Kp), one of the most common causes of healthcare-associated infections, increases patient morbidity, mortality, and hospitalization costs. Kp must acquire nutrients from the host for successful infection; however, the host is able to prevent bacterial nutrient acquisition through multiple systems. This includes the innate immune protein lipocalin 2 (Lcn2), which...
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by Daniel T. Claiborne, Eileen P. Scully, Christine D. Palmer, Jessica L. Prince, Gladys N. Macharia, Jakub Kopycinski, Clive M. Michelo, Howard W. Wiener, Rachel Parker, Krystelle Nganou-Makamdop, Daniel Douek, Marcus Altfeld, Jill Gilmour, Matt A. Price, Jianming Tang, William Kilembe, Susan A. Allen, Eric Hunter Despite extensive research on the mechanisms of HLA-mediated immune control of HIV-1 pathogenesis, it is clear that much remains to be discovered, as exemplified by protective HLA...
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Abstract Background Rhinoplasty is associated with intraoperative bleeding which affects the quality of the operation and may increase the time of surgery. The aim of this study was to assess the role of nasal spray of desmopressin on reduction in intraoperative bleeding during elective open rhinoplasty. Methods Conducting an interventional study in our hospital,...
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Abstract Objective To evaluate the efficacy of ReCell® autologous cell regeneration techniques combined with dermabrasion treatment on the therapy of acne scars. Methods We analyzed retrospectively 78 patients with acne scars who presented to the Department of Plastic Surgery at Peking Union Medical College Hospital from May 2015 to May 2017; 30 patients...
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Abstract Introduction Whereas body-contouring surgery after massive weight loss in women receives much attention, little attention has been devoted to accentuating the male physique. Male patients after massive weight loss often suffer from redundant skin and soft tissue in the anterior and lateral chest region, causing various deformities of pseudogynecomastia. The authors present their approach to high-grade pseudogynecomastia correction...
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Abstract Introduction This systematic review aims to examine surgical and non-surgical treatments and identify those procedures that are most effective in terms of patient satisfaction. Materials and Methods A systematic review protocol was developed a priori in accordance with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols...
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Abstract Background Chest reconstruction (‘top surgery’) is an important component of transition in the transmasculine population that can substantially improve gender incongruence. The aim of this study was to evaluate the demographic characteristics, surgical technique, and postoperative outcomes following transmasculine chest surgery. Methods Using ICD...
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