A new Baylor College of Medicine study in mice found that overfed infant animals have more DNA methylation, a kind of chemical tagging linked to faster aging and higher type 2 diabetes risks. (Source: the Mail online | Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(CNN) — There are currently 93,000 people in the United States on a waiting list for a donated kidney, yet at least 3,500 donated kidneys are discarded every year, according to a study published Monday in the journal JAMA Internal Medicine. The lack of organs for kidney failure patients is a major public health problem and one that President Donald Trump addressed in July when he signed an executive order promising to transform kidney care in this country. More than 37 million Americans have chronic...
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TYPE 2 diabetes is a life-long condition and can pose grave health risks if left untreated. It is widely understood that the chronic condition can cause life-threatening complications but it can also have a debilitating impact on another part of the body too. (Source: Daily Express - Health)
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(Natural News) Black cumin seed (Nigella sativa) is a traditional medicine that “remedies all but death.” Today, various studies have been conducted on black cumin to prove its health benefits. Studies revealed that black cumin seed oil speeds up wound healing and protects against pancreatic damage that can lead to diabetes. A study published in... (Source: NaturalNews.com)
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Alternative splicing (AS) has a critical role in tumor progression and prognosis. Our study aimed to investigate pancreatic cancer-specific AS events using RNA-seq data, gaining systematic insights into potential prognostic predictors. We downloaded 10623 genes with 45313 pancreatic cancer-specific AS events from the Cancer Genome Atlas (TCGA) and SpliceSeq database. Cox univariate analyses of overall survival suggested there was a remarkable association between 6711 AS events and overall survival...
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Repair of DNA damage protects genomic integrity, which is key to tissue functional integrity. In cancer, the type and fidelity of DNA damage response is the fundamental basis for clinical response to cytotoxic therapy. Here we consider the contribution of transforming growth factor-beta (TGFβ), a ubiquitous, pleotropic cytokine that is abundant in the tumor microenvironment, to therapeutic response. The action of TGFβ is best illustrated in head and neck squamous cell carcinoma (HNSCC). Survival...
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Advances in the understanding of growth hormone-producing adenomas (GHomas) are ongoing, but current therapy is limited by moderate and variable efficacy and in need of life-long treatment. In this study, the molecular signaling pathway related to GHoma was investigated by proteomics and transcriptomics. The differentially expressed proteins and genes were significantly enriched in Extracellular Matrix-Receptor Interactions, Notch Signaling, Basal Cell Carcinoma Signaling, JAK-STAT3, Wnt Signaling...
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Recent studies have highlighted the potential of photodynamic therapy (PDT) to induce immunogenic cell death (ICD). The clinical use of photosensitizers (PS) to stimulate an anticancer immune response, and not to sterilize tumor cells, may however require some optimizations. Here, we examined how the dose of PS and the scheduling of PDT influence the generation of danger-associated molecular patterns proteins (DAMPs) and favor T cell antitumor activity. We found that upon photoactivation, a low dose...
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Introduction: Glioblastoma (GBM) is the most common and the most malignant variant in the intrinsic glial brain tumors. The poor prognosis of GBM has not significantly improved despite the development of innovative diagnostic methods and new therapies. Therefore, understanding the molecular mechanism of aggressive behavior of GBM and finding appropriate prognostic markers and therapeutic targets may lead to early diagnosis, appropriate therapies, and reliable prognosis Methods: We used weighted...
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Treating head and neck cancer patients with systemic therapy is challenging because of tumor related, patient related and treatment related factors. In this review, we aim to summarize the current standard of care in the curative and palliative setting, and to describe best practice with regard to structural requirements, procedures and monitoring outcome. Treatment advice for individual head and neck cancer patients should be discussed within a multidisciplinary team. Cisplatin is the drug...
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Cancer cell plasticity plays critical roles in both tumorigenesis and tumor progression. Metastasis-associated protein 3 (MTA3), a component of the nucleosome remodeling and histone deacetylase (NuRD) complex and multi-effect coregulator, can serve as a tumor suppressor in many cancer types. However, the role of MTA3 in tongue squamous cell cancer (TSCC) remains unclear although it is the most prevalent head and neck cancer and often with poor prognosis. By analyzing both published datasets and clinical...
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Meta-analysis is important in oncological research to provide a more reliable answer to a clinical research question that was assessed in multiple studies but with inconsistent results. Pair-wise meta-analysis can be applied when comparing two treatments at once, whereas it is possible to compare multiple treatments at once with network meta-analysis (NMA). After careful systematic review of the literature and quality assessment of the identified studies, the added value of meta-analysis should...
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Growth factor independence 1 (GFI1) is known as a DNA binding zinc finger protein which can mediate transcriptional repression mainly by recruiting histone-modifying enzymes to its target genes. GFI1 plays important roles in hematopoiesis, in particular in regulating the function of hematopoietic stem- and precursor cells and the differentiation along myeloid and lymphoid lineages. In recent years, a number of publications provided evidence that GFI1 is involved in the pathogenesis of both acute...
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Competitive endogenous RNA (ceRNA) networks have emerged as critical regulators of carcinogenesis. Their activity is mediated by various non-coding RNAs (ncRNAs), including long non-coding RNAs and microRNAs, which competitively bind to targets, thereby modulating gene expression and activity of proteins. Of particular interest, ncRNAs encoded by the 8q24 chromosomal region are associated with the development and progression of several human cancers, most prominently lncPVT1. Chemoresistance presents...
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by Nicolas Giguère, Benoît Delignat-Lavaud, Freja Herborg, Aurore Voisin, Yuan Li, Vincent Jacquemet, Madhu Anand-Srivastava, Ulrik Gether, Bruno Giros, Louis-Éric Trudeau Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic mutations in genes such as Parkin, Pink1, DJ-1, α-synuclein, LRRK2 and GBA are found to be responsible for the disease in about 15% of the cases. A key unanswered...
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by Richard J. Wang, Beth L. Dumont, Peicheng Jing, Bret A. Payseur The synaptonemal complex (SC) is a proteinaceous scaffold required for synapsis and recombination between homologous chromosomes during meiosis. Although the SC has been linked to differences in genome-wide crossover rates, the genetic basis of standing variation in SC structure remains unknown. To investigate the possibility that recombination evolves through changes to the SC, we characterized the genetic architecture of SC...
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by Silvie Neradilová, Laurie Connell, Pavel Hulva, Barbora Černá Bolfíková Cesky Fousek is considered to be one of the oldest pointing dog breeds in Europe and has been appreciated for its versatile working skills. Because it faced extinction in the past, the Cesky Fousek was restored from German Wirehaired and Shorthaired Pointers. Additionally, the breed was recently used in the USA with the initial intent of improvement of the Wirehaired Pointing Griffon (synonymous with Korthals Griffon)...
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by Maria Angeles Garcia-Leon, Maria Isabel Peralta-Ramirez, Laura Arco-Garcia, Borja Romero-Gonzalez, Rafael A. Caparros-Gonzalez, Noelia Saez-Sanz, Ana Maria Santos-Ruiz, Eva Montero-Lopez, Andres Gonzalez, Raquel Gonzalez-Perez
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by Lars J. Kjerpeseth, Randi Selmer, Inger Ariansen, Øystein Karlstad, Hanne Ellekjær, Eva Skovlund Objective To compare effectiveness and safety of warfarin and the direct oral anticoagulants (DOAC) dabigatran, rivaroxaban and apixaban in non-valvular atrial fibrillation in routine care. Methods From nationwide registries, we identified treatment-naïve patients initiating warfarin, dabigatran, rivaroxaban or apixaban for non-valvular atrial fibrillation from July 2013 to December 2015 in Norway....
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by Emil Israel, Nir Cohen, Daniel Czamanski
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by Meli’sa S. Crawford, Eric Gumpricht, Karen L. Sweazea The prevalence of metabolic syndrome (MetSyn) has risen 35% since 2012 and over two-thirds of Americans exhibit features characterizing this condition (obesity, dyslipidemia, hyperglycemia, insulin resistance and/or endothelial dysfunction). The aim of this study was to evaluate the effects of a novel dietary supplemental organic mineral complex (OMC) on these risk factors in a rodent model of MetSyn. Six-week old male Sprague-Dawley rats...
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by Qamar Schuyler, Britta Denise Hardesty, Chris Wilcox, Kathy Townsend
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by Sarah J. Girdwood, Brooke E. Nichols, Crispin Moyo, Thomas Crompton, Dorman Chimhamhiwa, Sydney Rosen Introduction Viral load (VL) monitoring programs have been scaled up rapidly, but are now facing the challenge of providing access to the most remote facilities (the “last mile”). For the hardest-to-reach facilities in Zambia, we compared the cost of placing point of care (POC) viral load instruments at or near facilities to the cost of an expanded sample transportation network (STN) to deliver...
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by Tracie A. Seimon, Sarah H. Olson, Kerry Jo Lee, Gail Rosen, Alain Ondzie, Kenneth Cameron, Patricia Reed, Simon J. Anthony, Damien O. Joly, William B. Karesh, Denise McAloose, W. Ian Lipkin
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by Pieter Severijns, Thomas Overbergh, Lennart Scheys, Lieven Moke, Kaat Desloovere Objective To test the reliability of the Balance Evaluation Systems Test (BESTest) and Trunk Control Measurement Scale (TCMS) between sessions and raters in the adult spinal deformity (ASD) population. Summary of background data Up to now evaluation in ASD was mainly based on static radiographic parameters. Recently literature showed that dynamic balance was a better predictor of health-related quality of life than...
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by Katayoun Maleki, Randah R. Hamadeh, Jaleh Gholami, Ahmed Mandil, Saima Hamid, Zahid Ahmad Butt, Abdulaziz Bin Saeed, Dalia Y. M. El Kheir, Mohammed Saleem, Sahar Maqsoud, Najibullah Safi, Ban A. Abdul-Majeed, Reza Majdzadeh
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by Bianca J. Tumino, Thomas J. Duff, Jason Q. D. Goodger, Jane G. Cawson Vegetation is a key determinant of wildfire behaviour at field scales as it functions as fuel. Past studies in the laboratory show that plant flammability, the ability of plants to ignite and maintain combustion, is a function of their traits. However, the way the traits of individual plants combine in a vegetation community to affect field flammability has received little attention. This study aims to bridge the gap between...
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by Yukihiro Maeda, Rie Ichikawa, Jimpei Misawa, Akiko Shibuya, Teruyoshi Hishiki, Takeshi Maeda, Atsuo Yoshino, Yoshiaki Kondo In Japan, a range of patients with traumatic brain injury (TBI) has been recorded in a nationwide database (Japan Neurotrauma Data Bank; JNTDB). This study aimed to externally validate three international prediction models using JNTDB data: Trauma and Injury Severity Score (TRISS), Corticosteroid Randomization After Significant Head Injury (CRASH), and International Mission...
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by Shalini Suresh, Anne Paxton, Bhim Kumari Pun, Min Raj Gyawali, Indra Dhoj Kshetri, Pooja Pandey Rana, Kenda Cunningham The prevalence of maternal and child malnutrition in Nepal is among the highest in the world, despite substantial reductions in the last few decades. One effort to combat this problem is Suaahara II (SII), a multi-sectoral program implemented in 42 of Nepal’s 77 districts to improve dietary diversity (DD) and reduce maternal and child undernutrition. Using cross-sectional data...
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by Katie J. Tastad, Mark R. Schleiss, Sara M. Lammert, Nicole E. Basta Objectives To assess awareness of cytomegalovirus (CMV); attitudes towards screening; and frequency of behaviors that could increase the risk of prenatal infection. Methods We conducted a survey among 726 women at the 2017 Minnesota State Fair. Minnesota residents aged 18–44 were eligible if they had never been pregnant or had been pregnant within the past 10 years. We compared responses between never-pregnant and recently-pregnant...
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by Ki-Woong Nam, Tae Jung Kim, Ji Sung Lee, Soo-Hyun Park, Hae-Bong Jeong, Byung-Woo Yoon, Sang-Bae Ko Background Inflammation plays an important role in atherosclerosis and its complications. Since a dysregulated inflammatory response is associated with early neurological deterioration (END), serum neutrophil-to-lymphocyte ratio (NLR) could be a marker of END as well. Aim In this study, we evaluated the relationship between the serum NLR and END in patients with ischemic stroke due to large-artery...
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by Chang Ik Yoon, Sung Gwe Ahn, Soong June Bae, Yun Jin Shin, Chihwan Cha, So Eun Park, Ji-Hyung Lee, Akira Ooshima, Hye Sun Lee, Kyung-Min Yang, Seong-Jin Kim, Seok Hee Park, Joon Jeong Background A20 protein has ubiquitin-editing activities and acts as a key regulator of inflammation and immunity. Previously, our group showed that A20 promotes tumor metastasis through multi-monoubiquitylation of SNAIL1 in basal-like breast cancer. Here, we investigated survival outcomes in patients with breast...
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by Yueh-Lung Peng, Chien-Te Lee, You-Lin Tain, Yaw-Bin Huang, Hung-Yi Chuang, Yen-Hsia Wen, Shiou-Huei Huang, Chun-Yu Tsai, Chien-Ning Hsu Objectives Changes in treatment choice of therapy and size of treated population that can lead to under- or overestimate of payer’s budget are less likely to be reassured after reimbursement adoption of a new drug. The aim of this study was to evaluate the effects of febuxostat introduction and the modifications in its insurance coverage on the utilization and...
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Muscle activity of Bulgarian squat. Effects of additional vibration, suspension and unstable surface
by Joan Aguilera-Castells, Bernat Buscà, Jose Morales, Mònica Solana-Tramunt, Azahara Fort-Vanmeerhaeghe, Fernando Rey-Abella, Jaume Bantulà, Javier Peña Practitioners of strength and conditioning are increasingly using vibration and unstable environments to enhance training effects. However, little evidence has been found comparing the use of suspension devices and vibratory platforms used in the Bulgarian squat. The purpose of this cross-sectional study was to examine the effect of suspension...
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by Rafal Pankowski, Marek Roclawski, Marcin Ceynowa, Tomasz Mazurek, Lechoslaw Ciupik, Agnieszka Kierzkowska It remains unclear what is the real safe limit of torque magnitude during Bilateral Apical Vertebral Derotation (BAVD) in thoracic curve correction. Up to author’s knowledge there is no study except this one, to reproduce in–vivo real measurements and intraoperative conditions during BAVD maneuver. The objective of this study was to evaluate the torsional strength of the instrumented...
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by Zulfiya Charyeva, Siân Curtis, Stephanie Mullen, Tatyana Senik, Olga Zaliznyak Background Worldwide, TB is one of the top 10 causes of death and the leading cause from a single infectious agent. Ukraine is one of 30 countries with the highest burden of multidrug-resistant tuberculosis. Global literature shows that social support (SS) is important in improving TB treatment adherence, reducing lost to follow up rates and improving treatment outcomes. There are several models of SS available, and...
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by Tamar E. Crum, Robert D. Schnabel, Jared E. Decker, Luciana C. A. Regitano, Jeremy F. Taylor In many beef and some dairy production systems, crossbreeding is used to take advantage of breed complementarity and heterosis. Admixed animals are frequently identified by their coat color and body conformation phenotypes, however, without pedigree information it is not possible to identify the expected breed composition of an admixed animal and in the presence of selection, the actual composition...
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by Yu Liu, Liping Li, Ting Huang, Rui Wang, Wanwen Liang, Qiong Yang, Aiying Lei, Ming Chen Streptococcus agalactiae(GBS) is a seriously threat to the farmed tilapia, and oral vaccination was considered to be the most desirable means which requires deep understanding of virulence mechanism of the fish-derived GBS. Our previous genome study of the fish-derived attenuated strain YM001 showed that there were two large deletions in YM001 compared to its parental virulent strain HN016. In this study,...
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by Jong-Geol Kim, Joo-Han Gwak, Man-Young Jung, Sung-Uk An, Jung-Ho Hyun, Sanghoon Kang, Sung-Keun Rhee The Yellow Sea features unique characteristics due to strong tides and nutrient-enriched freshwater outflows from China and Korea. The coupling of archaeal and bacterial assemblages associated with environmental factors at two bay areas in the Yellow Sea was investigated. Temporal variations of the archaeal and bacterial assemblages were shown to be greater than the spatial variations based...
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by Maria Soroko, Daniel Zaborski, Krzysztof Dudek, Kelly Yarnell, Wanda Górniak, Ricardo Vardasca The impact of a rider’s and saddle’s mass on saddle thermal pattern distribution was evaluated using infrared thermography (IRT). Eighteen racehorses were ridden by four riders with their own saddle. Images of the saddle panels were captured at each of six thermographic examinations. On each image, six regions of interest (ROIs) were marked on the saddle panels. The mean temperature for each ROI...
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by Seung Mi Lee, Byoung Jae Kim, Ja Nam Koo, Errol R. Norwitz, Ig Hwan Oh, Sun Min Kim, Sang Youn Kim, Gyoung Min Kim, Soo Heon Kwak, Won Kim, Sae Kyung Joo, Sue Shin, Chanthalakeo Vixa, Chan-Wook Park, Jong Kwan Jun, Joong Shin Park Objective Nonalcoholic fatty liver disease (NAFLD) is a well-recognized hepatic manifestation of metabolic disease in adults and has been associated with the development of gestational diabetes (GDM). Hepatic insulin resistance can result in increased release of glucose...
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by Jennifer Uyei, Tamar H. Taddei, David E. Kaplan, Michael Chapko, Elizabeth R. Stevens, R. Scott Braithwaite Background Hepatocelluar cancer (HCC) is the leading cause of death among people with hepatitis C virus (HCV)-related cirrhosis. Our aim was to determine the optimal surveillance frequency for patients with HCV-related compensated cirrhosis. Methods We developed a decision analytic Markov model and validated it against data from the Veterans Outcomes and Costs Associated with Liver Disease...
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by Tetsuya Tani, Takahiro Eitsuka, Masafumi Katayama, Takashi Nagamine, Yumiko Nakaya, Hajime Suzuki, Tohru Kiyono, Kiyotaka Nakagawa, Miho Inoue-Murayama, Manabu Onuma, Tomokazu Fukuda The Bonin flying fox (Pteropus pselaphon) is one of the most critically endangered species of animals. The number of this species is estimated to be around 150; being classified at the top rank in the list by International Union of Animal Conservation. Our group previously showed that expression of CDK4, CYCLIN...
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by Belén Alejos, Inés Suárez-García, Otilia Bisbal, José Antonio Iribarren, Víctor Asensi, Miguel Górgolas, Roberto Muga, Santiago Moreno, Inma Jarrín, CoRIS cohort Background We aimed to describe the most frequently prescribed initial antiretroviral therapy (ART) regimens in recent years in HIV-positive persons in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) and to investigate factors associated with the choice of each regimen. Methods We analyzed initial ART regimens prescribed...
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by Deborah Fleck, Chistopher Curry, Kate Donnan, Orla Logue, Kathryn Graham, Kate Jackson, Karen Keown, John Winder, Michael D. Shields, Ciara M. Hughes Background Children and young people with neuromuscular disorders (NMD), such as Duchenne Muscular Dystrophy (DMD), develop progressive respiratory muscles weakness and pulmonary restriction. Pulmonary function monitoring of the decline in lung function allows for timely intervention with cough assist techniques and nocturnal non-invasive ventilation...
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