Publication date: Available online 21 August 2019Source: Allergology InternationalAuthor(s): He Li, Yunzhe Tian, Lihui Xie, Xiuxing Liu, Zhaohao Huang, Wenru SuAbstractAllergic diseases, which include asthma, allergic skin diseases, allergic rhinitis and allergic conjunctivitis, have already garnered worldwide public health attention over recent decades. Mesenchymal stem cells (MSCs) have gradually emerged as a potential method for treating allergic diseases due to their immunosuppressive characteristics,...
15h
Publication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Carole Le Coz, Bertram Bengsch, Caroline Khanna, Melissa Trofa, Takuya Ohtani, Brian E. Nolan, Sarah E. Henrickson, Michele P. Lambert, Taylor Olmsted Kim, Jenny M. Despotovic, Scott Feldman, Olajumoke O. Fadugba, Patricia Takach, Melanie Ruffner, Soma Jyonouchi, Jennifer Heimall, Kathleen E. Sullivan, E.John Wherry, Neil RombergAbstract:BackgroundAlthough chiefly a B-lymphocyte disorder,...
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Publication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jian Luo, Yanqiu Wu, Rahul Shrimanker, Simei Go, Yuan Ye, Clare Hardman, Janina Nahler, Yi-Ling Chen, Linda Stöger, Ni Zeng, Wei Liu, Lara Reed, Aviva M. Tolkovsky, Paul Klenerman, Graham Ogg, Ian D. Pavord, Luzheng Xue
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Publication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): William J. Branchett, Helen Stölting, Robert A. Oliver, Simone A. Walker, Franz Puttur, Lisa G. Gregory, Leona Gabryšová, Mark S. Wilson, Anne O’Garra, Clare M. LloydBackgroundAlthough originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly severe disease. IL-10 regulates T helper...
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Publication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Joost Westerhout, Joseph L. Baumert, W. Marty Blom, Katrina J. Allen, Barbara Ballmer-Weber, René W.R. Crevel, Anthony E.J. Dubois, Montserrat Fernández-Rivas, Matthew J. Greenhawt, Jonathan O’B Hourihane, Jennifer J. Koplin, Astrid G. Kruizinga, Thuy-My Le, Hugh A. Sampson, Wayne G. Shreffler, Paul J. Turner, Steve L. Taylor, Geert F. Houben, Benjamin C. RemingtonAbstractBackgroundFood allergies...
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Publication date: Available online 21 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jean Bousquet, Ignacio J. Ansotegui, Josep M. Anto, Sylvie Arnavielhe, Claus Bachert, Xavier Basagaña, Annabelle Bédard, Anna Bedbrook, Matteo Bonini, Sinthia Bosnic-Anticevich, Fulvio Braido, Vicky Cardona, Wienczyslawa Czarlewski, Alvaro A. Cruz, Pascal Demoly, Govert De Vries, Stephanie Dramburg, Eve Mathieu-Dupas, Marina Erhola, Wytske J. FokkensAbstractSmart devices...
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Aspirin is first-line treatment in coronary artery disease (CAD) patients, but in patients with acute coronary syndrome (ACS) or who require dual antiplatelet therapy after myocardial revascularization, aspirin therapy becomes critical and time-sensitive1. Approximately 1.5% of CAD patients report aspirin allergy2. Most reactions are considered non-immunologic, related to aspirin’s inhibition of cyclo-oxygenase causing allergic-like symptoms3. A subset of patients has aspirin exacerbated respiratory...
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In 1966, Dr. Bernie Berman, a Boston allergist, described 6 children with a chronic cough that could be stopped by “the art of suggestion.” Dr. Berman called this a Habit Cough. This disorder has been repeatedly described, sometimes with different terminology, but with the same description of the characteristic sound of the cough, barking or honking, and the absence of the cough once asleep.2,3,4,5,6,7,8 The frequency of Habit Cough diagnoses were reported at the rates of 7 per year at the University...
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Current guidelines state that there is insufficient evidence to recommend testing siblings of food allergic children before introduction of potential allergic foods, but the topic continues to remain controversial. Although the proportion of siblings who are sensitized to a food without clinical reactivity is high in comparison to those with a true food allergy, there is still a known increased risk amongst siblings of children with food allergies that has led to much apprehension about management....
41m
A landmark study showed that early peanut introduction in high-risk infants, defined as infants with moderate to severe atopic dermatitis or egg allergy, reduced the risk of developing peanut allergy. Since this trial, many international societies have updated feeding guidelines to promote early introduction of peanut, usually around 6 months of age. Implementing these guidelines on a national and international level has been challenging. Furthermore, there is confusion if allergy testing is needed...
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Thus far, the most effective strategy for the prevention of food allergy is early introduction of allergenic solids to at-risk infants. Early skin moisturization may have a role in food allergy prevention. There is insufficient evidence for hydrolyzed formula as a means of allergy prevention. Studies on vitamin D, omega 3, and probiotic supplementation; breastfeeding; early infant dietary diversity; and maternal peanut ingestion during pregnancy and breastfeeding are inconsistent. (Source: Immunology...
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We read with great interest the article titled “Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model” by Ottman et al.1 The study investigated the effect and mechanism of soil exposure–induced immune tolerance. However, soil exposure to adults might not be practical in asthma treatment and prevention. (Source: Journal of Allergy and Clinical Immunology)
8h
We appreciate the interest from Jiang et al1 regarding our article titled “Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model.”2 The readers' first question addresses the induction of a possible pathology in the intestines of the mice by the soil exposure. This is an important question, and one t hat we did not fully consider in the article. (Source: Journal of Allergy and Clinical Immunology)
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Mast cells (MCs) are capable of executing powerful inflammatory response programs triggered by surface IgE cross-linking or through pattern recognition receptors. The question of how MCs contribute to human disease has been intensely investigated and stimulated much controversy. Correlative evidence comes from human studies, pointing to pathogenetic or protective MC functions in patients with atopic conditions, autoimmune disorders, type 2 diabetes, chronic urticaria, mastocytosis, and cancer. Experiments...
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Capsule Summary: Endotoxin and plasma from IgA-deficient common variable immunodeficiency subjects with autoimmune cytopenias promote enlarged and altered T follicular helper cell populations.
8h
Food allergies are a significant public health issue and the only effective management option currently available is strict avoidance of all foods containing the allergen. In view of the practical impossibility to limit risks to zero, quantitative allergen risk assessment and management strategies are needed.
8h
Effector CD4 T cells signal to myeloid cells via IL-10 to restrict pathogenic IFN-γ-dependent immunity in the context of type 2-low allergic airway disease in mice
8h
We appreciate the interest from Jiang et al1 regarding our article titled “Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model.”2 The readers' first question addresses the induction of a possible pathology in the intestines of the mice by the soil exposure. This is an important question, and one that we did not fully consider in the article.
9h
We read with great interest the article titled “Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model” by Ottman et al.1 The study investigated the effect and mechanism of soil exposure–induced immune tolerance. However, soil exposure to adults might not be practical in asthma treatment and prevention.
9h
Abstract Background The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency (SCID) patients. However, definitive diagnosis between GVHD and Omenn’s syndrome is often difficult based on clinical and immunological phenotypes particularly in the patients with hypomorphic mutations....
17h
Abstract Background Dermatological illness can affect the quality of life and may coexist with psychiatric disorders. Objective The aim of this review was to systematically evaluate the published evidence of any psychiatric disorders that may coexist with chronic urticaria (CU) and any effect psychiatric interventions may have on CU. ...
5h
Abstract Diffuse alveolar hemorrhage (DAH) is a rare but potentially deadly manifestation of systemic lupus erythematosus (SLE). The aim of this study was to investigate the clinical characteristics and risk factors of DAH in SLE. A systematic review and meta-analysis of previous observational studies compared the clinical characteristics and risk factors between DAH-SLE and SLE patients without DAH. A total of 5 observational studies were included in this meta-analysis. Compared...
20h
A combination of AstraZeneca's lung cancer drug Imfinzi and an experimental treatment failed to extend the lives of patients with advanced non-small cell lung cancer (NSCLC) and high levels of gene mutations, the drugmaker said on Wednesday.Reuters Health Information (Source: Medscape Allergy Headlines)
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Publication date: Available online 21 August 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): George N. Konstantinou, Elisavet Kaitalidou, Nikos Skoulikaris
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