Objectives: Peripheral nerve sheath tumors (PNSTs) are clinically heterogenous, comprising benign (BPNST) and malignant (MPNST) variants. BPNSTs can be managed with nerve-sparing excision or observation. MPNSTs require radical resection and multidisciplinary oncologic management (1, 15). Image-guided core-needle biopsy (IGCNBx) is the well-established standard to obtain preoperative tissue diagnosis of soft tissue tumors. However, there has been resistance to performing IGCNBx of PNSTs because...
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Objective: We evaluated our experience treating patients with localized extraskeletal myxoid chondrosarcomas (EMCs) to evaluate outcomes and relapse rates in order to better inform treatment decisions for these rare soft tissue sarcomas. Materials and Methods: We reviewed the records of 41 consecutive patients with localized EMC treated at our institution from 1990 to 2016. Most patients (n=33, 80%) received combined modality therapy with surgery and radiation therapy, whereas only 8 (20%)...
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Objectives: The aim of this study was to analyze breast cancer patients who previously had mantle-field or breast radiation (RT) followed by retreatment with external beam partial breast irradiation (EB PBI). Materials and Methods: We retrospectively reviewed all women with newly diagnosed early-stage breast cancer treated with lumpectomy and partial breast irradiation between 2007 and 2017 who had undergone prior chest or breast RT. Results: Of 11 patients recorded, 8 (73%) had Hodgkin...
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Objective: Hepatocellular carcinoma (HCC) is a complication of the common genetic condition hereditary hemochromatosis (HH). It is unknown whether HH as an etiology of liver disease impacts the outcome. We compared the results of liver transplantation (LT), surgical resection and locoregional therapies in a matched cohort study and investigated whether HH as an etiology has an impact on survival. Materials and Methods: Consecutive patients with HH and HCC (2000 to 2015) were compared with...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Wei Hu, Xin Huang, Xingyue Huang, Wenwei Chen, Lidan Hao, Zubing ChenAbstractT cells edited by chimeric antigen receptors (CAR) have shown great potential in the treatment of tumors, especially malignant blood tumors. However, there remain many obstacles in the CAR-T therapy against solid tumors, such as the expansion of CAR-T cells ex vivo and the exhaustion of CAR-T cells in vivo. In order to solve these...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Zhongwei Sun, Lei Li, Jialin Qu, Hailong Li, Hailong ChenAbstractSevere acute pancreatitis (SAP) is a common acute clinical abdomen syndrome which is characterized by pancreatic self-digestion. As one of the major complication of SAP, acute lung injury is the main reason of high mortality. The traditional Chinese medicine Qingyi pellet (QYT) has been widely used for SAP in clinic. In our study, we constructed...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Yinsheng Guo, Suli Huang, Yue Ma, Jin Zhang, Ying Wen, Li Zhou, Guanxiang Yuan, Jinquan ChengAbstractAtherosclerosis (AS), a severe disease characterized by an accumulation of lipids and fibers in the large arteries, is the most important contributor to ischemic stroke (IS). Although microRNAs (miRNAs) have been found in circulating blood, the role of miRNAs in the progression of AS remains unknown. In a...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jue Yang, Jianfei Qiu, Yong Hu, Yongqiang Zhang, Li Chen, Qun Long, Juan Chen, Jingrui Song, Qing Rao, Yanmei Li, Wei Gu, Xiaojiang HaoAbstractKaempferol-3-O-rhamnoside (KOR) has multiple potency involved in anti-cancer, anti-inflammatory and antibacterial actions. However, the potential roles of KOR and the analogues isolated from the leaves of Cyclocarya paliurus in anti-erythroleukemia remain unclear....
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Junlin Chi, Tonglei Liu, Chengmin Shi, Huayou Luo, Zhizhong Wu, Binghong Xiong, Shuang Liu, Yujian ZengAbstractPurposeThe aim of this study was to research the function of lncRNA LUCAT1 in gastric cancer.MethodsHuman gastric cancer tissues and paracancer tissues were obtained from 98 patients undergoing surgical resection in our hospital. The human gastric cancer cell lines (HGC27, BGC823, MGC803, SGC7901...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Hengsan Chen, Qiang Li, Jin Liang, Ming Jin, Anqing LuAbstractCarbamoyl-phosphate synthetase 1 intronic transcript 1 (CPS1-IT1) is identified recently as a novel tumor suppressive long non-coding RNA (lncRNA). However, the expression status and clinical significance of CPS1-IT1 expression remained unknown in glioma. In our study, we observed CPS1-IT1 levels were decreased in glioma tissues and cells compared...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Qingxin Cui, Fang Ma, Jin Tao, Min Jiang, Gang Bai, Guoan LuoAbstractQingyan formulation (QF) is a common preparation that is often used to control inflammation in the haze environment. However, the efficacy and effective constituents of QF are still uncertain and difficult to identify. This paper aims to evaluate the efficacy by simulating a haze environment and determine its anti-inflammatory compounds...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xinyi Li, Muhammad Jamal, Peipei Guo, Zhao Jin, Feng Zheng, Xuemin Song, Jia Zhan, Huisheng WuAbstractObjectiveAlveolar epithelial barrier dysfunction in response to inflammatory reaction contributes to pulmonary edema in acute lung injury(ALI).Irisin,a newly-found myokine,exerts the anti-inflammatory effects. This study aims to investigate the protective effects of irisin on lipopolysaccharide (LPS)-induced...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Huafeng Wang, Huan Zhang, Yanxia Wang, Luhong Yang, Dong WangAbstractBackground/aimsEmbelin is an active component isolated from Embelia ribes Burm. In this study, we explored the protective effects of embelin on acute liver injury.MethodsAn animal model of acute liver injury was established via administration of a single injection of thioacetamide (TAA) (300 μg/g body weight) to adult mice. Embelin was...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jianrui Zhang, Yichun Guan, Chunyan Shen, Luwen Zhang, Xingling WangAbstractMicroRNAs (miRNAs) have attracted increasing attention for their function in oocyte in vitro maturation (IVM). In this study, we aimed to explore the functional role and underlying mechanism of miR-375 in oocyte IVM. Cumulus-oocyte complexes (COCs) were cultured in standard cell culture conditions until they reach metaphase II (MII)...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Li lei, Yin zongshengAbstractOsteoarthritis (OA) is involved in these pathophysiological changes of articular cartilage, subchondral bone and synovium. As a selective HDAC6 inhibitor, Ricolinostat (ACY-1215) has demonstrated chondroprotective effects in OA. However, its efficacy remains unclear in subchondral bone. In this study, we found that the mRNA and protein levels of HDAC6 were elevated in human OA...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): João Rocha, Rosa Direito, Ana Lima, Joana Mota, Margarida Gonçalves, Maria Paula Duarte, João Solas, Bruno Felício Peniche, Adelaide Fernandes, Rui Pinto, Ricardo Boavida Ferreira, Bruno Sepodes, Maria-Eduardo FigueiraAbstractPurposeLittle is known about the pharmacological effects of the phenolic compounds of Pennyroyal (Mentha pulegium). This Mediterranean aromatic plant, used as a gastronomic spice and...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Qing Zhang, Wei Peng, Shujun Wei, Daneng Wei, Ruolan Li, Jia Liu, Lanyu Peng, Shuang Yang, Yongxiang Gao, Chunjie Wu, Xufeng PuAbstractBackgroundRheumatoid arthritis (RA) is a known intractable chronic inflammatory disease of synovial joints characterized by hyperplasia and consecutive inflammation with a high prevalence.Guizhi-Shaoyao-Zhimu (GSZD) is the first choice for clinical treatment of RA in Chinese...
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RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Zeyu Zhang, Xiaoting Li, Yingyan Han, Teng Ji, Xiaoyuan Huang, Qinglei Gao, Ding MaAbstractRAD54B, a human paralog of RAD54 L, belongs to the SW12/SNF2 superfamily of helicases. Up to now, few studies have reported the role of RAD54B in breast cancer (BC). In this study, we reported that RAD54B was amplified and the expression of RAD54B was elevated in BC, as identified through a bioinformatics analysis...
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Publication date: November 2019Source: Brain and Language, Volume 198Author(s): Vanessa R. Cerda, Amandine E. Grenier, Nicole Y.Y. WichaAbstractTypically, bilinguals learn multiplication facts in only one instruction language. Consequently, these facts may be represented and/or accessed as language-specific memories, requiring a qualitatively different retrieval process in their other language. Indeed, behavioral studies reveal that bilinguals verify arithmetic facts faster and better in the language...
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Parathyroid carcinoma is uncommon, and its coexistence with parathyroid adenoma is extremely rare. A 28-year-old woman with hyperparathyroidism underwent dual-phase 99mTc-sestamibi SPECT/CT scan for presurgical evaluation. The images showed intense activity inside the left side thyroid and mild activity inside the right side of the thyroid. The histopathologic findings showed intrathyroidal parathyroid carcinoma on the left side and intrathyroid parathyroid adenoma on the right side. Received for...
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Small bowel biopsy (SBB) is not always helpful to establish celiac disease diagnosis. Hence we have conducted a retrospective study to know the amount of SBB in our center that was not optimal for this purpose. Histological findings were not appropriate for diagnosis in 3.56% (34 out of 955). The main problem encountered was inadequate sample cutting, although this could be solved by a new recut in almost 30% of cases.
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Gastrointestinal polyps are mucosal overgrowths that, if unchecked, can undergo malignant transformation. Although relatively uncommon in the pediatric age group, they can be the harbingers of multiorgan cancer risk and require close management and follow-up. Additionally, as many polyposis syndromes are inherited, appropriate genetic testing and management of relatives is vital for the health of the entire family. In this review, we discuss both common and uncommon childhood gastrointestinal polyposis...
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Objectives: Behavioral intervention is the only treatment for pediatric feeding problems with well documented empirical support. However, parents may be hesitant to pursue behavioral intervention because of concerns about possible negative side effects on child behavioral health and the parent-child relationship. This study investigated associations between behavioral feeding treatment and parenting stress, internalizing and externalizing behavior problems in young children, and parent-child attachment...
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Objectives: We aimed to evaluate the effect of a single dose of preoperative dexamethasone on postoperative nausea and vomiting (PONV), a frequent complication and a major cause of delayed recovery in pediatric upper gastrointestinal endoscopy (UGIE) under sedation. Methods: In this double-blind randomized controlled study, 98 children aged 2 to 14, with American Society of Anesthesiologists status I to II, and undergoing elective UGIE with deep sedation were included and randomly assigned...
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Guidelines recommend breastfeeding in cystic fibrosis (CF) but breastfeeding rates decline rapidly in CF. We initiated a quality improvement project to improve breastfeeding in CF by incorporating International Board-Certified Lactation Consultants (IBCLC) into the initial CF-diagnosis visit to support mothers who were breastfeeding at diagnosis. In the preintervention group, only 8/14 (57%) continued to provide breast milk after the first visit, whereas postintervention, 16/17 (94%) mothers continued...
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Objectives: Esophagogastroduodenoscopy (EGD) is often performed to evaluate for mucosal and anatomical abnormalities before vertical sleeve gastrectomy (SG). Little is known, however, about how prebariatric EGD in adolescents influences clinical management or outcome. Our aim was to assess if an abnormal prebariatric EGD resulted in interventions or modification of bariatric surgery. Methods: We performed a retrospective cohort study of adolescents undergoing evaluation for bariatric surgery....
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No abstract available
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Objectives: Cecostomy tubes are commonly used for antegrade enema delivery in children with spinal defects and anorectal malformations to help address chronic constipation and fecal incontinence. Once surgically or radiologically placed, cecostomy tubes require changes by a percutaneous approach, which may be unsuccessful requiring repeat laparoscopy or open surgery to re-establish the cecostomy tract. The role of colonoscopy assistance to salvage lost cecostomy access in children who fail percutaneous...
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Introduction: : Biliary atresia (BA) is characterized by rapidly progressive inflammation and fibrosis of the biliary tract, which usually progresses despite surgical intervention (Kasai hepatoportoenterostomy). Lysyl oxidase-like (LOXL2) is an extracellular matrix enzyme that catalyzes the cross-linking of fibrillar collagen and elastin and is thought to play a crucial role in tissue fibrosis; anti-LOXL2 drugs have been shown to be antifibrotic in animals. Objective: The aim of the study...
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Objective: Children with severe acute malnutrition (SAM) may have impaired intestinal function, which can result in malabsorption, diarrhoea, and poor growth. This study evaluated the gut function of children with SAM using fecal and blood biomarkers and assessed their correlates. Methods: A cross-sectional study, nested in a randomized trial (www.isrctn.com, ISRCTN 16454889), was conducted at Mulago hospital, Uganda among subgroups of 400 children with complicated SAM and 30 community controls....
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Objective: The aim of the study was to assess the total protein, lysozyme, and immunoglobulin A (IgA) content of unfortified and fortified Holder-pasteurized donor human milk (HPDHM) during 96 hours of refrigerated storage. Study Design: HPDHM was prepared in a hospital feeding room and subjected to treatment with 3 different fortifiers: an acidic, bovine-based (F-ACID), a neutral, bovine-based, and a human milk–derived (F-HUM) fortifier. Unfortified HPDHM served as the control (CONTROL)....
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Objectives: A questionnaire study demonstrated that some adult patients who were diagnosed with irritable bowel syndrome (IBS) were in fact having an abdominal wall pain syndrome, such as anterior cutaneous nerve entrapment syndrome (ACNES). The aim of the present study was to investigate whether a pediatric version of this questionnaire was useful in diagnosing abdominal wall pain syndromes in children with chronic abdominal pain (CAP). Methods: An 18-item questionnaire was tested in 3 groups...
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Maternal supplementation with 1000 mg/day docosahexaenoic acid (DHA) provides third trimester DHA accretion levels in breast milk for the preterm infant. We hypothesized that DHA supplementation to mothers providing breastmilk for extremely preterm infants would result in decreased inflammatory markers, in the infant. Mother/infant dyads (n = 27) were enrolled at birth and mothers were assigned to receive 200 or 1000 mg/day of DHA. Milk and plasma samples were analyzed for fatty acids and inflammatory...
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Introduction: Approximately 5% of children in the United States have chronic fecal incontinence. Unfortunately, standard medical management of fecal incontinence fails in 20% to 60% of cases. A combined medical-behavioral model is often recommended in these cases. The purpose of this pilot study was to describe an interdisciplinary group-based treatment for fecal incontinence in school-aged children, and to present a description of changes in treatment adherence rates that affect clinical effectiveness. ...
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Objectives: Families affected by Hirschsprung disease (HSCR) have opportunities to learn recurrence risks to their children from statistical genetic and empiric studies and, in some cases, prenatal genetic testing or preimplantation genetic diagnosis (PGD). This study aimed to assess interest in reproductive genetic information for HSCR and factors that predict this interest in 2 groups with elevated risk of having a child with HSCR. Methods: Adult patients with HSCR and parents of children...
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Objectives: The aim of the study was to determine whether pediatric patients with nonalcoholic fatty liver disease (NAFLD) exposed to psychotropic medications have more severe liver disease compared to their counterparts who are not on these medications. We hypothesize that use of psychotropic agents is associated with liver disease severity. Methods: Children and adolescents with biopsy-confirmed NAFLD were included in this study. Histology data, detailed clinical information, and results...
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Hirschsprung disease, like most surgically correctable congenital anomalies, is now survivable well into adulthood. Patients are, therefore, presenting later in life with problems that were previously infrequently encountered by colorectal surgeons or gastroenterologists. The goals of our review are to describe the current state of care transition for this patient population, identify the specific needs for these patients, and propose guidelines which could inform a future model of transition from...
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Objectives: Early identification of children with cystic fibrosis (CF) at risk for severe liver disease (CFLD) would enable targeted study of preventative therapies. There is no gold standard test for CFLD. Ultrasonography (US) is used to identify CFLD, but with concerns for its diagnostic accuracy. We aim to determine if differences in standard blood tests, imaging variables and noninvasive liver fibrosis indices correlate with liver US patterns, and thus provide supportive evidence that a heterogeneous...
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This study retrospectively evaluated the safety, impact on growth, and clinical outcomes of gastrojejunostomy tubes (GJTs) converted from surgically placed gastrostomy tubes (GTs) in 44 developmentally disabled children (median age: 28 months). The total duration of GJT follow-up was 31,378 device-days (median: 643 device-days). Three major complications (aspiration pneumonia) were identified in 3 patients (6.8%), 63 minor complications in 31 patients (70.5%), and 202 tube maintenance issues (TMIs)...
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Objectives: Gut bacteria play an essential role during infancy and are strongly influenced by the mode of birth and feeding. A primate model was used to investigate the benefits of exposure to the mother or conversely the negative impact of early nursery rearing on microbial colonization. Method: Rectal swabs were obtained from rhesus macaques born vaginally and mother-reared (MR, N = 35) or delivered primarily via cesarean-section and human-reared (HR, N = 19). Microbiome composition was...
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Objective: Paediatric-onset inflammatory bowel disease (IBD) is different from adult-onset IBD with respect to disease severity and its effect on growth and development. Care of paediatric IBD patients in some countries is dispersed among paediatricians and adult care providers, which may result in different outcomes. This study aims to assess the effect of care setting (paediatric vs adult-oriented) on health care utilization in adolescent IBD patients. Methods: This is a Dutch population-based...
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Objectives: In this study, we hypothesized that replacing conventional milk, which contains A1 and A2 β-casein proteins, with milk that contains only A2 β-casein in the diet of dairy or milk-intolerant preschoolers (age 5 to 6 years) would result in reduced gastrointestinal symptoms associated with milk intolerance, and that this would correspond with cognitive improvements. Methods: This randomized, double-blind, crossover study aimed to compare the effects of 5 days’ consumption of conventional...
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Introduction: Including individuals with lived experience in pediatric inflammatory bowel disease (IBD) is essential to establishing a research agenda that is mutually impactful to both those treating and those experiencing the disease. Methods: Using the James Lind Alliance approach to research priority setting, a 10-member steering committee composed of current and former pediatric patients with IBD, caregivers, and clinicians was formed. A national survey, disseminated across Canada, elicited...
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Background and Aims: The aim of the study was to aid decisions on prognosis and transplantation; this study describes the outcome of children with intestinal failure managed by the multidisciplinary intestinal rehabilitation program at the Royal Children's Hospital, Melbourne. Methods: Retrospective review of children requiring parenteral nutrition (PN) for >3 months who were assessed for home PN between 1991 and 2011. Results: A total of 51 children were included. Forty-two (82%)...
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Objectives: Adolescents and young adults (AYAs) with chronic illnesses use substances at similar, if not greater, rates compared to healthy peers. The present study aimed to examine rates and patterns of tobacco use, marijuana use, and binge drinking in AYAs with inflammatory bowel diseases. We expected that substance use would be associated with poorer physical health, psychosocial functioning, and disease management. Methods: One hundred thirty-two AYAs completed a single set of surveys...
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No abstract available
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Objectives: Chronic inflammation plays a central role in the etiology of endothelial damage. Endothelial dysfunction (ED) is the inability of the artery to dilate in response to an endothelial stimulus. We assessed the ED by measuring the reactive hyperaemia index (RHI) and the flow-mediated dilation (FMD) in a cohort of pediatric patients affected by inflammatory bowel disease (IBD) and comparing these parameters to a group of healthy controls (HC). Methods: Forty-one patients were consecutive...
8h
No abstract available
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Background: Several studies have demonstrated a reduced wound complication rate when immediate soft tissue reconstruction is performed after complex spine instrumentations in high-risk patients; however, the cost-effectiveness of this technique is not known. We hypothesized that immediate soft tissue reconstruction of oncologic spine wounds would be a cost-effective strategy compared to the standard of care (oncologic spine surgery with conventional primary wound closure). Methods: We employed...
11h
Background: When gastric pull-up is unsuccessful or unsuitable for total esophageal reconstruction, a supercharged pedicled jejunum (SPJ) can be used to re-establish gastrointestinal continuity. We reviewed our technique and outcomes of the SPJ for total esophageal reconstruction. Methods: A retrospective review of a prospectively maintained database was performed of 100 patients who underwent SPJ for total esophageal reconstruction between 2000 and 2017 at the Texas Medical Center. Patient...
11h
Background: Acellular dermal matrices (ADM) are commonly used to support implant-based breast reconstruction. Meshing may enhance integration, reduce drain time and seroma, and decrease surgical costs. Methods: This was a retrospective, single-center analysis of 83 adult women (115 breasts) undergoing one-stage (84.3%) or two-stage (15.7%) immediate breast reconstruction with bovine-derived ADM (SurgiMend) meshed at 2:1 ratio. Outcomes were compared with previously published data from a control...
11h
Background: Loss of elbow flexion commonly occurs following acute brachial plexus injury. The double fascicular transfer (DFT) is often used in acute C5-C6 and C5-C7 root injuries, but rarely applied in cases involving concomitant C8 or T1 root injury. We designed a rat model using varying severities of lower trunk (LT) injury to determine whether partial injury to the LT affects nerve transfers for elbow flexion. Methods: There were four different rat groups in which 0%, 25%, 75% or 100%...
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by Jamie L. Wilson, Lizhen Wang, Zeyu Zhang, Nicholas S. Hill, Peter Polgar Vascular smooth muscle cells from the pulmonary arteries (HPASMC) of subjects with pulmonary arterial hypertension (PAH) exhibit hyperplastic growth. The PAH HPASMC display an increased sensitivity to fetal bovine serum (FBS) and undergo growth at a very low, 0.2%, FBS concentration. On the other hand, normal HPASMC (obtained from non-PAH donors) do not proliferate at low FBS (0.2%). A previous genomic study suggested...
12h
by David Cordova, Frania Mendoza Lua, Jaime Muñoz-Velázquez, Katie Street, Jose A. Bauermeister, Kathryn Fessler, Nicole Adelman, Youth Leadership Council , Torsten B. Neilands, Cherrie B. Boyer Background Drug abuse and sexually transmitted infections (STIs), including the human immunodeficiency virus (HIV), remain significant public health concerns in the United States. Youth are at disproportionate risk of drug use and STIs/HIV, yet interventions aimed at improving STI and HIV testing and reducing...
12h
by Susan C. Kleiman, Emily C. Bulik-Sullivan, Elaine M. Glenny, Stephanie C. Zerwas, Eun Young Huh, Matthew C. B. Tsilimigras, Anthony A. Fodor, Cynthia M. Bulik, Ian M. Carroll
12h
by Rosemeire Cobo Zanella, Maria Cristina de Cunto Brandileone, Samanta Cristine Grassi Almeida, Ana Paula Silva de Lemos, Claudio Tavares Sacchi, Claudia R. Gonçalves, Maria Gisele Gonçalves, Lucila Okuyama Fukasawa, Marcos Daniel Saraiva, Luís Fernando Rangel, Julia Lusis Lassance Cunha, Thereza Cristina Ariza Rotta, Christian Douradinho, Wilson Jacob-Filho, Ruth Minamisava, Ana Lúcia Andrade We aimed to investigate the nasopharyngeal colonization (NPC) by Streptococcus pneumoniae, Haemophilus...
12h
Correction: The protective role of family structure for adolescent development in sub-Saharan Africa
by Oluwaseyi Dolapo Somefun, Clifford Odimegwu
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by Lan Kong, Yuanlin Duan, Yanfang Ye, Zhengzheng Cai, Feng Wang, Xiaojie Qu, Ronghua Qiu, Chunyan Wu, Weiren Wu OsMADS16, a class B floral organ identity gene, plays a pivotal role in stamen formation in rice. To date, little is known about the interacting partners of OsMADS16 except for several MADS-box proteins. In this study, we constructed a high-quality cDNA library of young panicles (
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by Adib Mehrabi, Simon Dixon, Mark Sandler
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by Bryan A. Sisk, Ginny L. Schulz, Jennifer W. Mack, Lauren Yaeger, James DuBois Background Improving communication requires that clinicians and patients change their behaviors. Interventions might be more successful if they incorporate principles from behavioral change theories. We aimed to determine which behavioral domains are targeted by communication interventions in oncology. Methods Systematic search of literature indexed in Ovid Medline, Embase, Scopus, Cochrane Database of Systematic Reviews,...
12h
by Qin Huang, Dan Sun, Muhammad Zubair Hussain, Yonggang Liu, Ludmilla A. Morozova-Roche, Ce Zhang
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by Pavel Marozik, Vidmantas Alekna, Ema Rudenko, Marija Tamulaitiene, Alena Rudenka, Asta Mastaviciute, Volha Samokhovec, Andrejus Cernovas, Katsiaryna Kobets, Irma Mosse Introduction Long-term treatment is used in patients with osteoporosis, and bisphosphonates (BPs) are the most commonly prescribed medications. However, in some patients this therapy is not effective, cause different side effects and complications. Unfortunately, at least one year is needed to identify and confirm an ineffectiveness...
12h
by Maria Simak, Chen-Hsiang Yeang, Henry Horng-Shing Lu
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by Claude Marchand, Guy Lemay, Denis Archambault The lentiviral Rev protein, which is a regulatory protein essential for virus replication, has been first studied in the human immunodeficiency virus type 1 (HIV-1). The main function of Rev is to mediate the nuclear exportation of viral RNAs. To fulfill its function, Rev shuttles between the cytoplasm and the nucleus. The Jembrana disease virus (JDV), a lentivirus, is the etiologic agent of the Jembrana disease which was first described in Bali...
12h
by Beatriz Alonso, María Jesús Pérez-Granda, María Consuelo Latorre, Carmen Rodríguez, Carlos Sánchez-Carrillo, Patricia Muñoz, María Guembe
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by Alberto Domínguez-Vicent, Rune Brautaset, Abinaya Priya Venkataraman Purpose To evaluate the repeatability of the new spectral domain optical coherence tomography (HOCT-1F), and also to evaluate the agreement between vertical and horizontal scan protocols. In addition, we also evaluated the relation between the repeatability and age. Methods Three consecutive measurements of the inner limiting membrane–retinal pigment epithelium (ILM-RPE), inner limiting membrane–inner plexiform layer (ILM-IPL)...
12h
by Jin A. Choi, Ju-Eun Kim, Hyun-hee Ju, Jiyoung Lee, Donghyun Jee, Chan Kee Park, Soon-young Paik
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by Rudy Patrick, Jennifer Jain, Alicia Harvey-Vera, Shirley J. Semple, Gudelia Rangel, Thomas L. Patterson, Heather A. Pines Background Given the slow uptake of PrEP among cisgender men who have sex with men (MSM) in high-income countries, efforts to roll-out PrEP in low- and middle-income countries (LMIC) should address barriers to PrEP use to facilitate its more rapid uptake. To inform PrEP programs in LMIC, we examined patterns of perceived barriers to PrEP use among HIV-negative MSM in Tijuana,...
12h
by Rebecca Deek, Jason Nasser, Anthony Ghanem, Marc Mardelli, Georges Khazen, Angelique K. Salloum, Antoine Abchee, Michella Ghassibe-Sabbagh, Pierre Zalloua
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by Annabelle Cesaro, Joan Defrêne, Asmaa Lachhab, Nathalie Pagé, Mélanie R. Tardif, Amin Al-Shami, Tamas Oravecz, Paul R. Fortin, Jean-François Daudelin, Nathalie Labrecque, Fawzi Aoudjit, Martin Pelletier, Philippe A. Tessier Expressed strongly by myeloid cells, damage-associated molecular pattern (DAMP) proteins S100A8 and S100A9 are found in the serum of patients with infectious and autoimmune diseases. Compared to S100A9, the role of S100A8 is controversial. We investigated its biological...
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by Benny Abraham Kaipparettu, Yewei Ma, Jun Hyoung Park, Tin-Lap Lee, Yiqun Zhang, Patricia Yotnda, Chad J. Creighton, Wai-Yee Chan, Lee-Jun C. Wong
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by Alexander Leonardo Silva-Junior, Fabíola Silva Alves, Marlon Wendell Athaydes Kerr, Lilyane Amorim Xabregas, Fábio Magalhães Gama, Maria Gabriela Almeida Rodrigues, Alexandre Santos Torres, Andréa Monteiro Tarragô, Vanderson Souza Sampaio, Maria Perpétuo Socorro Sampaio Carvalho, Nelson Abrahim Fraiji, Adriana Malheiro, Allyson Guimarães Costa Introduction Leukemia is the most common cancer in children and has the highest rates of incidence in industrialized countries, followed by developing...
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by Tine Steenhoff, Anne Tharner, Mette Skovgaard Væver Parenting behavior is a key factor in children’s socio-emotional development. However, little is known about similarities and differences in maternal and paternal parenting behavior, as most studies have focused on mothers. The present study investigated similarities and differences in mothers’ and fathers’ parenting behavior during observed free play with their preschool children, in a Danish well-resourced sample. We examined differences...
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by Sandra Isabel Calderon-Rodríguez, María Carolina Sanabria-Salas, Adriana Umaña-Perez Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Owing to the incorporation of risk-adapted therapy and the arrival of new directed agents, the cure rate and survival of patients with ALL have improved dramatically, get near to 90%. In Latin American countries, the mortality rates of ALL are high, for example in Colombia, during the last decade, ALL has been the most prevalent cancer...
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by Sung-Hsi Huang, Yu-Chung Chuang, Yi-Chien Lee, Chien-Ching Hung, Wang-Huei Sheng, Jen Jen Su, Hsin-Yun Sun, Yee-Chun Chen, Shan-Chwen Chang Background The indications for lumbar puncture in non-HIV-infected, non-transplant (NHNT) patients with cryptococcosis without meningeal signs need to be more fully defined. Objectives This study was designed to determine the optimal predictors of central nervous system (CNS) involvement in adult NHNT patients with cryptococcosis. Methods The study population...
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by Alessandro Bosco, Laura Paulauskaite, Ian Hall, Jason Crabtree, Sujata Soni, Asit Biswas, Vivien Cooper, Michaela Poppe, Michael King, Andre Strydom, Michael J. Crawford, Angela Hassiotis Background Positive Behaviour Support (PBS) for challenging behaviour is a complex intervention. Process evaluation is pivotal in fully understanding the mechanisms and contextual factors that impact on participant outcomes. Aims To conduct a process evaluation of a national clinical trial investigating the...
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by Craig S. Jabaley, Robert F. Groff, Theresa J. Barnes, Mark E. Caridi-Scheible, James M. Blum, Vikas N. O’Reilly-Shah Raising public awareness of sepsis, a potentially life-threatening dysregulated host response to infection, to hasten its recognition has become a major focus of physicians, investigators, and both non-governmental and governmental agencies. While the internet is a common means by which to seek out healthcare information, little is understood about patterns and drivers of these...
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by Wen Jeat Ang, Embong Zunaina, Abdul Jalil Norfadzillah, Raja Omar Raja-Norliza, Muhammed Julieana, Siti Azrin Ab-Hamid, Mohamed Mahaneem Objective Detection of vascular endothelial growth factor (VEGF) levels in ocular tissue may perhaps provide insight into the role of VEGF in the pathogenesis and progression of diabetic retinopathy (DR). The aim of this study was to evaluate the levels of VEGF in tears and serum amongst type 2 diabetes mellitus (DM) patients. Methods A comparative cross-sectional...
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by Won Seok Gwak, See Nae Lee, Jae Bang Choi, Hyun Soo Kim, Beom Ku Han, Sung Min Bae, Yeon Ho Je, Soo Dong Woo It is generally accepted that ORF1629 is essential for baculovirus replication, which has enabled isolation of recombinant viruses in a baculovirus expression system using linearized viral DNA. ORF1629-defective viruses cannot replicate in insect cells; only recombinant virus with complete ORF1629 restoration by recombination can propagate, allowing for pure isolation and the development...
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by Naruomi Jinno, Yasuki Hori, Itaru Naitoh, Katsuyuki Miyabe, Michihiro Yoshida, Makoto Natsume, Akihisa Kato, Go Asano, Hitoshi Sano, Kazuki Hayashi Background and aims The revised Atlanta classification is widely used for the evaluation of acute pancreatitis (AP) severity. However, this classification cannot be used within 48 hours of AP onset. The aim of this study was to investigate the predictive factors of mortality in patients with AP on admission. Methods We evaluated the association between...
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by Shaghayegh Sadr Karimi, Nelly Pante The transport of macromolecules into the cell nucleus occurs through nuclear pore complexes (NPCs) and is mediated by cellular receptors. Recently, a novel mechanism of nuclear entry, in which actin polymerization provides a propulsive force driving the transport through the NPC, has been proposed. This mechanism is used by the nucleocapsid from baculovirus, one of the largest viruses to replicate in the nucleus of their host cells, which crosses the NPC...
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by Fabrizio Carbone, Leonardo Bruno, Gaetano Perrotta, Maria B. Bitonti, Innocenzo Muzzalupo, Adriana Chiappetta Background The ripening process of olive fruits is associated with chemical and/or enzymatic specific transformations, making them particularly attractive to animals and humans. In olive drupes, including ‘Cassanese’ ones, ripening is usually accompanied by progressive chromatic change, resulting in a final red-brown colourization of both epidermis and mesocarp. This event has an exception...
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Related ArticlesNeurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia. Neurology. 2018 07 31;91(5):e436-e443 Authors: Merluzzi AP, Carlsson CM, Johnson SC, Schindler SE, Asthana S, Blennow K, Zetterberg H, Bendlin BB Abstract OBJECTIVE: To test the hypothesis that cognitively unimpaired individuals with Alzheimer disease (AD) neuropathology differ from individuals with AD dementia on biomarkers of neurodegeneration,...
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Related ArticlesA Roma founder BIN1 mutation causes a novel phenotype of centronuclear myopathy with rigid spine. Neurology. 2018 07 24;91(4):e339-e348 Authors: Cabrera-Serrano M, Mavillard F, Biancalana V, Rivas E, Morar B, Hernández-Laín A, Olive M, Muelas N, Khan E, Carvajal A, Quiroga P, Diaz-Manera J, Davis M, Ávila R, Domínguez C, Romero NB, Vílchez JJ, Comas D, Laing NG, Laporte J, Kalaydjieva L, Paradas C Abstract OBJECTIVE: To describe a large...
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Validation and utilization of amended diagnostic criteria in Creutzfeldt-Jakob disease surveillance.
Related ArticlesValidation and utilization of amended diagnostic criteria in Creutzfeldt-Jakob disease surveillance. Neurology. 2018 07 24;91(4):e331-e338 Authors: Hermann P, Laux M, Glatzel M, Matschke J, Knipper T, Goebel S, Treig J, Schulz-Schaeffer W, Cramm M, Schmitz M, Zerr I Abstract OBJECTIVE: To validate an amended protocol for clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) including real-time quaking-induced conversion (RT-QuIC)...
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Related ArticlesDrug reaction with eosinophilia and systemic symptoms after daclizumab therapy. Neurology. 2018 07 24;91(4):e359-e363 Authors: Rauer S, Stork L, Urbach H, Stathi A, Marx A, Süß P, Prinz M, Brück W, Metz I Abstract OBJECTIVE: To report on 2 women with multiple sclerosis (MS) who developed severe neurologic deterioration and a drug reaction with eosinophilia and systemic symptoms (DRESS) after treatment with 2 and 4 subcutaneous injections...
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Publication date: Available online 21 August 2019Source: Advanced Drug Delivery ReviewsAuthor(s): Leslie Frapin, Johann Clouet, Vianney Delplace, Marion Fusellier, Jérôme Guicheux, Catherine Le VisageAbstractIntervertebral disc (IVD) degeneration has been associated with low back pain, which is a major musculoskeletal disorder and socio-economic problem that affects as many as 600 million patients worldwide. Here, we first review the current knowledge of IVD physiology and physiopathological processes...
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Publication date: December 2019Source: Current Opinion in Immunology, Volume 61Author(s): Bui Thi Cuc, Jelka Pohar, Simon FillatreauThe suppressive function of B cells is mediated mostly through their provision of cytokines with anti-inflammatory properties, in particular interleukin-10. This B cell activity has been convincingly described in mice with autoimmune, infectious, as well as malignant diseases, and evidence is accumulating of its relevance in human. This review provides a personal view...
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Publication date: Available online 21 August 2019Source: DNA RepairAuthor(s): Marc Drolet, Julien BrochuAbstractDNA replication, the faithful copying of genetic material, must be tightly regulated to produce daughter cells with intact copies of the chromosome(s). This regulated replication is initiated by binding of specific proteins at replication origins, such as DnaA to oriC in bacteria. However, unregulated replication can sometimes be initiated at other sites, which can threaten genomic stability....
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Rosai-Dorfman disease (RDD) is an uncommon disorder, characterized by an atypical expansion of histiocytes which classically shows emperipolesis and immunoreactivity with S-100 protein. RDD affects the lymph nodes as well as extranodal sites; however, RDD of the breast is exceptionally rare. Herein, we describe the histopathologic features of 22 cases of RDD occurring in the breast, with an emphasis on the differential diagnosis. All cases were notable for an exuberant lymphocytic infiltrate with...
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Recent discussions have suggested expanding the inclusion criteria for active prostate cancer surveillance to include cases with a Gleason score (GS) of 3+4=7. In this study, we examined this proposed use of a limited percent Gleason pattern 4 (%GP4) to identify candidates of active surveillance among 315 patients who underwent radical prostatectomy for prostate cancer with a GS of 6 or 3+4=7 via needle biopsy. The latter cases were divided into 4 groups using highest or overall %GP4 cut-off values...
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