- GSK-3β Inhibitor Induces Expression of the TLR4/MyD88/NF-κB Signaling Pathway to Protect Against Renal Ischemia-Reperfusion Injury During Rat Kidney TransplantationAbstract Ischemia-reperfusion injury (IRI) is an inevitable consequence of kidney transplantation (KT). The aim of our study was to investigate the protective effect of a glycogen synthase kinase 3β (GSK-3β) inhibitor against cold IRI in a rat renal transplantation (RT) model and a rat cold-IRI model through the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nucle
- MMP-9 Inhibition Suppresses Interferon-γ-Induced CXCL10 Production in Human Salivary Gland Ductal CellsAbstract Gene expression profiling of lip salivary gland (LSG) has shown that C-X-C motif chemokine 10 (CXCL10) and matrix metalloproteinase 9 (MMP9) expression is upregulated in primary Sjögren’s syndrome (pSS) patients. Although CXCL10 and MMP-9 are both associated with pSS pathogenesis, the potential relationship between these two factors has not been investigated. In this study, we used LSG sections from pSS patients and hu
- Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-α-Induced CXCL10 Expression in Cultured HuH-7 and HLE CellsAbstract The molecular mechanisms of innate immunity are closely associated with the development of non-alcoholic fatty liver disease (NAFLD). TNF-α is a key cytokine involved in the pathogenesis of metabolic inflammation like NAFLD. Melanoma differentiation-associated gene 5 (MDA5) is a member of the intracellular RNA helicase family proteins that play a pivotal role in an antiviral im
- Relationship between Radiographic Misfit and Clinical Outcomes in Immediately Loaded Complete‐arch Fixed Implant Supported Prostheses in Edentulous PatientsAbstract Purpose : To examine if an uncorrected radiographically detected immediate post‐operative misfit (implant level or abutment level) in an immediately loaded conversion prosthesis plays a significant role in early implant or prosthesis failure. In addition, clinical characteristics related to type of arch, implant position, type of implant, implant orientation, type of connection and type of surgery were analyzed relative to their rela
- A Systematic Review of Clinical Outcomes on Patients Rehabilitated with Complete‐arch Fixed Implant‐Supported Prostheses According to the Time of LoadingAbstract Purpose : To perform a systematic review on studies assessing clinical outcomes in patients rehabilitated with complete‐arch fixed implant‐supported prostheses according to the time of loading. Materials and Methods : Data obtained from patient and clinical outcomes, as implant failure, success rate, survival rate, biological complications, technical complications, mechanical complications, and marginal bone loss, were included
- Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational studyAbstract Purpose Uncertainties exist about the predictors of the severity of the clinical picture of GH deficiency (GHD) syndrome. Aim of the study was to evaluate, in adult patients with GHD, the predictors of the development of hypercholesterolemia, hypertension, diabetes mellitus, and osteoporosis. Methods
- Genetic Diversity in Alveolar Soft Part Sarcoma: A Subset Contain Variant Fusion Genes, Highlighting Broader Molecular Kinship with Other MiT Family TumorsABSTRACT Alveolar soft part sarcoma (ASPS) is a rare malignancy that, since its initial description, remains a neoplasm of uncertain histogenesis. The disease‐defining molecular event characterizing the diagnosis of ASPS is the ASPSCR1‐TFE3 fusion gene. Following identification of an index case of ASPS with a novel TFE3 fusion partner, we performed a retrospective review to determine whether this represents an isolated event. We identified two a
- MSH2 c.1022T>C, p.Leu341Pro is a founder pathogenic variation and a major cause of Lynch syndrome in the North of FranceAbstract Interpretation of missense variants remains a major challenge for genetic diagnosis, even in well‐known genes such as the DNA‐mismatch repair (MMR) genes involved in Lynch syndrome. We report the characterization of a variant in MSH2: c.1022T>C, which was identified in 20 apparently unrelated families living in the North of France. A total of 150 patients from 20 families were included in this study. Family segregation studies, tumor
- Αυτό το λίπος κρατά μακριά την παχυσαρκίαΑναρίθμητες μελέτες έχουν γίνει για τις αρνητικές συνέπειες του λίπους στην αν&the
- Η έλλειψη αυτής της βιταμίνης προμηνύει «δύσκολη» εφηβείαΗ ανεπάρκεια βιταμίνης D στα παιδιά Δημοτικού μπορεί να συντελεί σε επιθετική συμπεριφορά καθώς και άγχος και καταθλιπτική διάθεση κατά την εφηβεία, υποστηρίζουν ερευνητές από το Πανεπιστήμιο του Μίσιγκαν. Σύμφωνα με άρθρο του Journal of Nutrition, οι ερευνητές το 2006 εστίασαν σε 3.202 παιδιά, ηλικίας 5-12 ετών από την Μπογκοτά της Κολομβίας, τα οποία φοιτούσαν σε δημόσια δημοτικά σχολεία. Συνέλεξαν πληροφορίες για τις καθημερινές τους συνήθειε
- Τεστ προβλέπει αν θα είστε ζωντανοί σε δέκα χρόνια – Θα το κάνετε;Θα τολμούσατε να κάνετε μια αιματολογική εξέταση για να μάθετε αν θα είστε ζωντανοί μετά από δέκα χρόνια; Ερευνητές από το Ινστιτούτο Βιολογίας της Γήρανσης Max Planck ανακάλυψαν 14 βιοδείκτες στο αίμα που φαίνεται να επηρεάζουν τον κίνδυνο θανάτου. Οι ειδικοί ανέλυσαν δείγματα αίματος 44.000 ατόμων, 18-109 ετών, όλοι ευρωπαϊκής καταγωγής, και παρατήρησαν ότι οι 14 βιοδείκτες σχετίζονταν με οτιδήποτε, από την ανοσία και τον έλεγχο της γλυκόζης
- Διαβήτης: Κι, όμως, σε αυτό το σημείο του σώματος κάνει καλό!Για τον διαβήτη τύπου 2 και τις επιπτώσεις του στην υγεία μας έχουν γίνει αναρίθμητες μελέτες που τεκμηριώνουν όντως τις επιπλοκές που προκαλεί στους πάσχοντες. Μια κινεζική μελέτη, όμως, που δημοσιεύθηκε στο Menopause υποστηρίζει ότι το οικογενειακό ιστορικό διαβήτη τύπου 2 σχετίζεται με αυξημένη οστική πυκνότητα. Η σχέση μεταξύ διαβήτη τύπου 2 και αυξημένου κινδύνου κατάγματος είναι ήδη καλά τεκμηριωμένη από τις μέχρι σήμερα διαθέσιμες επιστη
- Έμφραγμα: Με ποια συμπτώματα εκδηλώνεται στις γυναίκες;Οι γυναίκες που έχουν υποστεί έμφραγμα έχουν τα ίδια ακριβώς χαρακτηριστικά συμπτώματα με τους άνδρες, αποφαίνεται νέα μελέτη που δημοσιεύεται στο Journal of the American Heart Association. Η έρευνα αμφισβητεί έναν παλιό ιατρικό μύθο που θέλει τις γυναίκες να έχουν ασυνήθιστα ή μη τυπικά συμπτώματα του εμφράγματος και δίνει έμφαση στην ανάγκη και τα δύο φύλα να αναγνωρίζουν και να δρουν άμεσα για την αντιμετώπιση της συμπτωματολογίας. Η λανθασμ
- Penoscrotal reconstruction with superficial circumflex iliac artery perforator propeller flapAbstract Background Successful penoscrotal reconstruction requires proper resurfacing of the defect and maintenance of the original shape of the penis and scrotum. We examined the feasibility of using the superficial circumflex iliac artery perforator (SCIP) propeller flap to effectively reconstruct penoscrotal defects. Methods Eleven male patients with an average age of 62.2 years were retrospectively evaluated. The average defect size
- Cancers, Vol. 11, Pages 1225: Key Role of Obesity in Genitourinary Tumors with Emphasis on Urothelial and Prostate CancersCancers, Vol. 11, Pages 1225: Key Role of Obesity in Genitourinary Tumors with Emphasis on Urothelial and Prostate Cancers Cancers doi: 10.3390/cancers11091225 Authors: Matteo Santoni Alessia Cimadamore Francesco Massari Francesco Piva Gaetano Aurilio Angelo Martignetti Marina Scarpelli Vincenzo Di Nunno Lidia Gatto Nicola Battelli Liang Cheng Antonio Lopez-Beltran Rodolfo Montironi Background: In
- Discovery of a New Light–Molecule Interaction: Supracence Reveals What Is Missing in Fluorescence ImagingBond, loaded bond: Molecular dynamics between equilibrium and non‐equilibrium structures resembles a loaded bow and arrow. When triggered at the right time, the potential energy stored in the molecular strain can be transferred to an emitted photon. This principle, named supracence, was used to enhance the imaging of actin fibers by complementing fluorescence (see picture). Abstract The currently understood principles about light&nda
- Isolating contiguous Pt atoms and forming Pt-Zn intermetallic nanoparticles to regulate selectivity...Isolating contiguous Pt atoms and forming Pt-Zn intermetallic nanoparticles to regulate selectivity in 4-nitrophenylacetylene hydrogenationNature Communications, Published online: 22 August 2019; doi:10.1038/s41467-019-11794-6Noble metals play a momentous role in heterogeneous catalysis but still face a huge challenge in selectivity control. Herein, the authors demonstrate that isolating contiguous Pt atoms and forming Pt-Zn intermetallic nanopa
- The epidemiology of syphilis in Ethiopia: a protocol for systematic review and meta-analysis covering the last three decadesSeveral individual epidemiological studies in Ethiopia suggest that syphilis is a public health problem. However, to the best of our knowledge, there is no synthesized and meta-analysis data on the epidemiolog...
- Outpatient kidney recovery after acute kidney injury requiring dialysis: a systematic review protocolAcute kidney injury requiring dialysis (AKI-D) during hospitalization is associated with both in-hospital and post-discharge mortality. Its incidence has risen over time in Canada and the USA. While the majori...
- Patient-related risk factors for unplanned 30-day readmission following total knee arthroplasty: a protocol for a systematic review and meta-analysisOsteoarthritis is a debilitating condition as well as a growing global health problem, and total knee arthroplasty is an effective treatment for advanced stages of disease. Unplanned 30-day hospital readmissio...
- Doctors’ attitudes to, beliefs about, and experiences of the regulation of professional competence: a scoping review protocolHistorically, individual doctors were responsible for maintaining their own professional competence. More recently, changing patient expectations, debate about the appropriateness of professional self-regulati...
- The prevalence of insufficient iodine intake in pregnancy in Africa: protocol for a systematic review and meta-analysisInsufficient iodine intake in pregnancy is associated with many adverse pregnancy outcomes. About 90% of African countries are at risk of iodine deficiency due to poor soils and dietary goitrogens. Pregnancy p...
- Stable 2D Heteroporous Covalent Organic Frameworks for Efficient Ionic Conduction2D covalent organic frameworks (COFs) feature open and ordered 1D column nanochannels which offer immense possibilities for incorporation of various guests for specific functions. However, the relatively low chemical stability of most COFs originated from the dynamic covalent linkages hindered their practical applications. In this work, a highly crystalline and heteroporous dibenzo[g,p]chrysene based COF (DBC‐2P), was synthesized and served as ho
- Metallocages for Metal Anions: Highly Charged [Co@Ge9]5− and [Ru@Sn9]6− Clusters Featuring Spherically Encapsulated Co1− and Ru2− AnionsAttraction despite repulsion: A formally two‐fold negatively charged anion, Ru2−, is encapsulated inside the cavity of the anionic metallocage [Sn9]4−. The highly charged [Ru@Sn9]6− anion can be crystallized in salts from liquid ammonia solutions of a K‐Ru‐Sn alloy. The encapsulated atoms lead to characteristic Raman modes which allow the detection of filled clusters in the respective alloys. Abstract En
- Electrophilic Iron Catalyst Paired with a Lithium Cation Enables Selective Functionalization of Non‐Activated Aliphatic C−H Bonds via Metallocarbene IntermediatesLi and Fe pairing: Pairing a strong Lewis‐acidic iron catalyst with the lithium salt LiAl(ORF)4 [ORF=(OC(CF3)3], for pre‐activation of diazo reagents, leads to electrophilic iron‐carbene species capable of insertion into non‐activated aliphatic C−H bonds. Reactions occur at 25 °C via α‐alkyl‐metallocarbene intermediates and the lithium cation plays a crucial role in the rate‐determ
- Diversity‐Oriented Synthesis of α‐Functionalized Acylborons and Borylated Heteroarenes by Nucleophilic Ring Opening of α‐ChloroepoxyboronatesThe nucleophilic ring‐opening reactions of N‐methyliminodiacetyl (MIDA) α‐chloroepoxyboronates, a new synthon prepared by a two‐step procedure from alkenyl MIDA boronates, lead to the facile synthesis of α‐functionalized acylboronates and borylated heteroarenes in a divergent manner. Some of the products are difficult to access by alternative methods. Abstract The ring‐opening reactions of N&
- RhI‐Catalyzed PIII‐Directed C−H Bond Alkylation: Design of Multifunctional Phosphines for Carboxylation of Aryl Bromides with Carbon DioxideMultifunctional phosphines bearing flexible pendant groups, such as ester, amide, pyridine, aryl, or cyano groups, were synthesized through RhI‐catalyzed C−H alkylation of biarylphosphines with functionalized alkenes (40 examples). An unprecedented CO2‐responsive surfactant was prepared that exhibits high catalytic activity in the Pd‐catalyzed carboxylation of aryl bromides in aqueous media. Abstract We report the C
- Metal‐Modified Nucleic Acids: Metal‐Mediated Base Pairs, Triples, and TetradsMetal‐modified DNA: Topical research trends in this field at the border of bioinorganic chemistry and supramolecular coordination chemistry are identified and highlighted. The Minireview illustrates how ligand‐based nucleoside surrogates have been used to introduce metal ions site‐specifically into double‐, triple‐, and tetra‐stranded DNA structures. Abstract The incorporation of metal ions into nucleic
- Atomic Layer Deposition of ZnO on CuO Enables Selective and Efficient Electroreduction of Carbon Dioxide to Liquid FuelsElectrochemical reduction of carbon dioxide, if powered by renewable electricity, could serve as a sustainable technology for carbon recycling and energy storage. Among all the products, ethanol is an attractive liquid fuel. However, the maximum faradaic efficiency of ethanol is only ~10% on polycrystalline Cu. Here, CuZn bimetallic catalysts were synthesized by in situ electrochemical reduction of ZnO‐shell/CuO‐core bi‐metal‐oxide. Dynamic evolu
- Redox‐Inert Fe3+ in Octahedral Sites of Co‐Fe Spinel Oxides with Enhanced Oxygen Catalytic Activity for Rechargeable Zn‐Air BatteriesIn the hybrid spinel Co2FeO4, the Fe3+ ions can effectively activate the Co3+ ions through 3d electron delocalization and spin‐state transition. As Z.‐Q. Liu, T. Ma, and co‐workers report in their Communication (DOI: https://doi.org/10.1002/anie.20190759510.1002/anie.201907595), a bifunctional electrode composed of these Co2FeO4 nanoparticles grown on N‐doped carbon nanotubes is a promising candidate for zinc–air ba
- Boosting Hydrogen Oxidation Activity of Ni in Alkaline Media through Oxygen‐Vacancy‐Rich CeO2/Ni HeterostructuresAn abundance of vacancies: An oxygen‐vacancy‐rich CeO2/Ni catalyst was designed to accelerate the hydrogen oxidation reaction in alkaline electrolyte. Electron transfer between CeO2 and Ni leads to thermoneutral adsorption free energies of H* (ΔG H*), and the abundance of oxygen vacancies in the CeO2 species promotes OH* adsorption. Abstract The search for highly efficient platinum group metal (PGM)‐free electrocat
- Scanning Electrochemical Cell Microscopy Investigation of Single ZIF‐Derived Nanocomposite Particles as Electrocatalysts for Oxygen Evolution in Alkaline MediaThe oxygen evolution reaction (OER) activity of single and multiple ZIF‐derived Co/N−C nanocomposite particles was examined by high‐throughput scanning electrochemical cell microscopy. Through the use of an Os complex as internal reference standard, the intrinsic activity of the catalyst with respect to the OER activity as well as the turnover frequency could be determined. Abstract “Single entity” measurement
- In‐situ electrochemical X‐ray diffraction: A rigorous method to navigate within phase diagrams reveals β‐Fe1+xSe as superconductor for all xWe report the precise postsynthetic control of the composition of β‐Fe1+xSe by electrochemistry with simultaneous tracking of the associated structural changes via in‐situ synchrotron X‐ray diffraction. We access the full phase width of 0.01 < x < 0.04 and identify the superconducting state below 8 K, which in contrast to earlier reports is independent of the composition. However, in a second set of in‐situ X‐ray diffraction experiments,
- Spontaneous Crystallization of Perovskite Nanocrystals in Nonpolar Organic Solvents: A Versatile Approach for their Shape‐controlled SynthesisThe growing demand of perovskite nanocrystals (NCs) for various applications has stimulated great research interest in the development of facile synthetic methods. They have often been synthesized by either ligand assisted reprecipitation (LARP) at room temperature or by hot‐injection at high temperatures and inert atmosphere. However, the use of polar solvents in LARP effects their stability. Herein, we report on the spontaneous crystallization
- 1,3‐Difunctionalization of Aminocyclopropanes via Dielectrophilic IntermediatesChoose your nucleophiles: We report an oxidative ring‐opening strategy to transform aminocyclopropanes into 1,3‐dielectrophilic halogenated N,O‐acetals. Substitution of either the alkoxy group of the N,O‐acetal or the halide by a series of nucleophiles then generates a broad range of 1,3‐difunctionalized propylamines. Abstract We report an oxidative ring‐opening strategy to transform acyl, sulfonyl or ca
- Electrochemical Arylation of Electron‐Deficient Arenes through Reductive ActivationAn electrochemical protocol has been developed to achieve arylation of electron‐deficient arenes through reductive activation. Various electro‐deficient arenes and aryl diazonium tetrafluoroborate have been examined in this transformation under the conditions of undivided cell, providing the desired products up to 92% yield. Instead of preparing diazonium reagents, these reactions could also be carried from anilines in a one‐pot fashion. EPR stud
- Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)The directed evolution of enzymes is now routinely used to develop new catalysts with various applications, such as in environmentally friendly production of chemicals and renewable fuels. In her Nobel lecture, F. Arnold describes how lessons from nature inspired the development of methods for directed evolution.
- An Unprecedented Knot‐like G‐Quadruplex Peripheral MotifTie the knot: A knot‐like DNA secondary structure is formed by 7‐nt sequence DL7, d(TGTTGGT) next to a G‐quadruplex. Six out of the seven nucleobases in the knot‐like structure participate in compact base‐pairing interactions. The compatibility of DL7 with various G‐quadruplexes and the resulting stabilizing effects could prove useful in DNA engineering. Abstract A knot‐like G‐quadruplex peri
- Ren‐Gen Xiong“My greatest achievement has been to find ways to push the boundaries of material design in molecular ferroelectric systems. My biggest motivation is to see real applications of molecular ferroelectrics in the near future …” Find out more about Ren‐Gen Xiong in his Author Profile.
- Direct Visualization of Single Nuclear Pore Complex Proteins Using Genetically‐Encoded Probes for DNA‐PAINTGenetically‐encoded self‐labeling enzymes such as SNAP‐tag and HaloTag are combined with DNA‐PAINT microscopy, enabling studies of multicomponent complexes on the level of single proteins in cells. Abstract The nuclear pore complex (NPC) is one of the largest and most complex protein assemblies in the cell and, among other functions, serves as the gatekeeper of nucleocytoplasmic transport. Unraveling its molecular a
- The Dual‐Stereocontrol Mechanism: Heteroselective Polymerization of rac‐Lactide and Syndioselective Polymerization of meso‐Lactide by Chiral Aluminum Salan CatalystsMake me a match: An intricate cooperation between the stereogenic metal site of the catalyst and the stereogenic center of the last inserted monomer unit is perfect for syndioselective polymerization of meso‐lactide. In this way, meso‐lactide, a byproduct of the industrial production of l‐lactide, can be transformed into easily melt‐crystallizable, and high‐melting syndiotactic poly(lactic acid). Abstract We d
- Design Strategies for Vanadium‐based Aqueous Zinc‐Ion BatteriesVanadium‐based compounds are widely implemented as cathodes for aqueous zinc‐ion batteries (ZIBs) because of their low cost and high theoretical capacity. This Minireview presents a comprehensive overview of the energy storage mechanisms and structural features of various vanadium‐based cathodes in ZIBs. Strategies for improving the electrochemical performance of vanadium‐based cathodes are discussed. Abstract Aqueo
- Mechanical Control of the Kinetic Propylene/Propane Separation by Zeolitic Imidazolate Framework‐8Yielding to pressure: A significant enhancement in the kinetic separation of C3H6/C3H8 has been achieved by mechanically fine‐tuning the pore architecture of the flexible zeolitic imidazolate framework ZIF‐8. The increased selectivity was achieved by controlling the gate size and the ligand flip/libration modes of the imidazole linker during adsorption through the application of pressure. Abstract One intriguing feature of many
- Perquinolines A–C: Unprecedented Bacterial Tetrahydroisoquinolines Involving an Intriguing BiosynthesisAs easy as A,B,C: A new biosynthetic pathway for the tetrahydroisoquinolines perquinolines A–C, starts with the condensation of succinyl‐CoA and l‐phenylalanine catalyzed by the AONS‐like enzyme PqrA. The second condensation and cyclization events are mediated by the PqrG enzyme. An ATP‐grasp RimK‐type ligase PqrI completes the synthesis by transfer of a γ‐aminobutyric acid or β‐alanine
- Regulating Transition‐Metal Catalysis through Interference by Short RNAsGood as gold: A DNA hairpin containing a C‐T mismatch complexes with AuI, forming a novel, catalytically inactive, metal‐mediated base pair. Upon addition of the complement strand, this AuI species mediates a hydroamination reaction of a pro‐fluorescent BODIPY substrate. This system presents excellent complement sequence specificity, even when challenged with extraneous biological material. Abstract Herein we report the d
- Stereochemical Determination of Tuscolid/Tuscorons and Total Synthesis of Tuscoron D and E: Insights into the Tuscolid/Tuscoron RearrangementUnprecedented rearrangement: The stereochemistry of the myxobacterial polyketides tuscolid/tuscorons was determined by high‐field NMR studies, molecular modeling, and chemical derivatization and confirmed by a modular total synthesis of tuscorons D and E. These findings provide detailed insight into the chemically unprecedented tuscolid/tuscoron rearrangement cascade. Abstract The stereochemistry of the structurally unique myxo
- Shape Rememorization of an Organosuperelastic Crystal through Superelasticity–Ferroelasticity InterconversionIn recent memory… The permanent shape of a mechanically twinned 1,4‐dicyanobenzene crystal was rememorized through superelasticity (SE)/ferroelasticity (FE) interconversion when the crystal was bent and held in the new shape without heating (see picture). The shape‐rememorization ability of the organosuperelastic crystal indicates the intrinsic workability of organic crystalline materials capable of recovering their crystal fu
- Ligand‐Enabled PdII‐Catalyzed Iterative γ‐C(sp3)−H Arylation of Free Aliphatic AcidA ligand enabled palladium catalyzed protocol was developed for regioselective γ‐C(sp3)−H arylation of aliphatic carboxylic acid without incorporating any directing group. The multifaceted aspects of this transformation have been illustrated through: 1) Synthesis of various γ‐C(sp3)−H arylated acids. 2) Incorporation of complex organic molecules into the acid. 3) Iterative heteroarylation. 4) synthesis of subs
- Preferred Formation of Minority Concomitant Polymorphs in 2D Self‐Assembly under Lateral NanoconfinementNanocorrals created in situ can selectively induce the formation of one of two concomitant polymorphs, which otherwise appear simultaneously at the interface of 1‐phenyloctane/highly‐oriented pyrolytic graphite. Abstract Control over polymorph formation in the crystallization of organic molecules remains a huge scientific challenge. Now, preferential formation is presented of one polymorph, formed by chiral molecules, in
- Quantitation of Femtomolar‐Level Protein Biomarkers Using a Simple Microbubbling Digital Assay and Bright‐Field Smartphone ImagingBlowing bubbles: Labeling target proteins with microbubbles enables the highly sensitive detection of protein biomarkers (femtomolar level) in a digital assay at the point‐of‐care. The microbubbling readout can be detected using a smartphone camera and analyzed using a smartphone application for automated image analysis, developed using machine learning. Abstract Quantitating ultra‐low concentrations of protein biomarkers
- Partnered status and receipt of guideline‐concordant adjuvant chemotherapy among patients with colon cancerBackground Partnered status is an independent predictor of clinical outcomes, including overall survival, among patients with cancer. However, the mechanisms by which partnered status impacts survival are not fully understood and to the authors' knowledge the associations between partnered status and the specific attributes of chemotherapy have not been studied to date. Methods The current study was an observational study of patients with
- Targeted therapy for colorectal cancer metastases: A review of current methods of molecularly targeted therapy and the use of tumor biomarkers in the treatment of metastatic colorectal cancerDespite recent advances in the management of colorectal cancer, metastatic disease remains challenging, and patients are rarely cured. However, a better understanding of the pathways implicated in the evolution and proliferation of cancer cells has led to the development of targeted therapies, that is, agents with action directed at these pathways/features. This approach is more specific to cells within which these pathways, such as epidermal gro
- Transplantation in adults with relapsed/refractory acute lymphoblastic leukemia who are treated with blinatumomab from a phase 3 studyBackground Blinatumomab, a bispecific T‐cell‐engaging (BiTE®) immuno‐oncology therapy, demonstrated superior overall survival versus standard‐of‐care chemotherapy (SOC) in adults with relapsed/refractory B‐cell precursor acute lymphoblastic leukemia (R/R ALL) in the phase 3 TOWER study. Herein, the authors reported clinical features and outcomes for those patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) after trea
- Development of a multiplex RT-PCR assay for simultaneous detection of Cucumber green mottle mosaic virus and Acidovorax citrulli in watermelonWatermelon (Citrullus lanatus Thunb.) is considered as a popular and nutritious fruit crop worldwide. Watermelon blood flesh disease caused by Cucumber green mottle mosaic virus (CGMMV) and bacterial fruit blotch caused by Acidovorax citrulli, are two major quarantine diseases of watermelon and result in considerable losses to global watermelon production. In this study, a multiplex reverse-transcription polymerase chain reaction (RT-PCR) method
- Revision of the Tanzanian dicynodont Dicynodon huenei (Therapsida: Anomodontia) from the Permian Usili FormationA single species of the dicynodontoid dicynodont Dicynodon is currently recognized from the late Permian Usili Formation of Tanzania: Dicynodon huenei Haughton, 1932. Restudy of the known Tanzanian materials of D. huenei demonstrates that they represent two distinct morphotypes, here considered separate taxa. The holotype of D. huenei is not referable to Dicynodon and instead is transferred to the genus Daptocephalus (but retained as a valid spe
- Estimating the phylogeny of geoemydid turtles (Cryptodira) from landmark data: an assessment of different methodsBackground In the last 20 years, a general picture of the evolutionary relationships between geoemydid turtles (ca. 70 species distributed over the Northern hemisphere) has emerged from the analysis of molecular data. However, there is a paucity of good traditional morphological characters that correlate with the phylogeny, which are essential for the robust integration of fossil and molecular data. Part of this problem might be due to intrinsic
- Characterisation of bacteria isolated from the stingless bee, Heterotrigona itama, honey, bee bread and propolisBacteria are present in stingless bee nest products. However, detailed information on their characteristics is scarce. Thus, this study aims to investigate the characteristics of bacterial species isolated from Malaysian stingless bee, Heterotrigona itama, nest products. Honey, bee bread and propolis were collected aseptically from four geographical localities of Malaysia. Total plate count (TPC), bacterial identification, phenotypic profile and
- Root tolerance and biochemical response of Chinese lettuce (Lactuca sativa L.) genotypes to cadmium stressThis study was conducted to determine the root tolerance and biochemical responses of four Chinese Lactuca sativa L. genotypes (Lüsu, Lümeng, Yidali and Anyan) to cadmium (Cd2+) stress. Twenty-eight days old seedlings were exposed to Hoagland’s nutrient solution supplied with or without 100 µM CdCl2 and monitored for seven days in a climate controlled room. The 100 µM CdCl2 significantly (P
- Phylogenomic analyses confirm a novel invasive North American Corbicula (Bivalvia: Cyrenidae) lineageThe genus Corbicula consists of estuarine or freshwater clams native to temperate/tropical regions of Asia, Africa, and Australia that collectively encompass both sexual species and clonal (androgenetic) lineages. The latter have become globally invasive in freshwater systems and they represent some of the most successful aquatic invasive lineages. Previous studies have documented four invasive clonal lineages, Forms A, B, C, and Rlc, with varyi
- Perceptual load modulates contour integration in conscious and unconscious statesPrevious research has documented that contour detection and integration may either be affected by local features such as the distances between elements or by high-level cognitive factors such as attention in our visual system. Less is known about how low and high level factors interact to influence contour integration. In this paper, we investigated how attention modulates contour integration through saliency (different element spacing) and topo
- Seasonal dynamics of microbial diversity in the rhizosphere of Ulmus pumila L. var. sabulosa in a steppe desert area of Northern ChinaThe seasonal dynamics of microbial diversity within the rhizosphere of Ulmus pumila L. var. sabulosa in the hinterland of the Otindag Sandy Land of China were investigated using high-throughput sequencing of bacterial 16S rRNA genes and fungal ITS region sequences. A significant level of bacterial and fungal diversity was observed overall, with detection of 7,676 bacterial Operational Taxonomic Units (OTUs) belonging to 40 bacteria phyla and 3,5
- Fine‐needle aspiration cytology of the apocrine variant of epithelial‐myoepithelial carcinomaAbstract Epithelial‐myoepithelial carcinoma (EMCa) is a rare neoplasm that most frequently afflicts the parotid gland. Histologically, a dual layer of inner, luminal epithelial cells and outer myoepithelial cells with associated background hyalinization characterize these tumors. Several variants of EMCa have been described, including the more recent description of the apocrine variant. We present here a case of a 71‐year‐old male with a parotid
- Physical activity, dietary calcium to magnesium intake, and mortality in the National Health and Examination Survey 1999–2006 cohortCalcium and magnesium affect muscle mass and function. Magnesium and calcium are also important for optimal vitamin D status. Vitamin D status modifies the associations between physical activity and risk of incident cardiovascular disease (CVD) and CVD mortality. However, no study examined whether levels of magnesium and calcium and the ratio of dietary calcium to magnesium (Ca:Mg) intake modify the relationship between physical activity and mort
- Genetic variants in glutamine metabolic pathway genes predict cutaneous melanoma‐specific survivalAbstract Glutamine dependence is a unique metabolic defect seen in cutaneous melanoma (CM), directly influencing the treatment and prognosis. Here, we investigated the associations between 6025 common single‐nucleotide polymorphisms (SNPs) in 77 glutamine metabolic pathway genes with CM‐specific survival (CMSS) using genotyping datasets from two published genome‐wide association studies (GWASs). In the single‐locus analysis, 76 SNPs were found t
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- Middle East Respiratory Syndrome Coronavirus and the One Health conceptMiddle East Respiratory Syndrome Coronavirus (MERS-CoV) is one of the major threats to the healthcare systems in some countries, especially in the Arabian Peninsula. MERS-CoV is considered an ideal example of the One Health concept. This is due to the animals, especially dromedary camels, play important roles in the transmission and sustainability of the virus, and the virus can be transmitted through aerosols of infected patients into the envir
- Ida Institute Convenes Inaugural Meeting or Person-Centered Hearing CareThe Ida Institute will convene the inaugural meeting of the Person-Centered Hearing Network (PCHN) on August 27-28 in Skodsborg, Denmark. The meeting will bring together representatives of leading patient organizations, educational institutions, professional organizations, and care providers from around the world to exchange knowledge and ideas and discuss concrete collaboration opportunities."The purpose of the initiative is to advance person-ce
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Πέμπτη 22 Αυγούστου 2019
- YESTERDAY
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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