- Isolating contiguous Pt atoms and forming Pt-Zn intermetallic nanoparticles to regulate selectivity in 4-nitrophenylacetylene hydrogenationNature Communications, Published online: 22 August 2019; doi:10.1038/s41467-019-11794-6Noble metals play a momentous role in heterogeneous catalysis but still face a huge challenge in selectivity control. Herein, the authors demonstrate that isolating contiguous Pt atoms and forming Pt-Zn intermetallic nanoparticles is an effective strategy to optimize the selectivity of Pt catalysts.
- Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchinsNature Communications, Published online: 22 August 2019; doi:10.1038/s41467-019-11560-8Micromeres in a sea urchin embryo are formed by asymetric cleavage but what molecular mechanisms regulate their formation is unclear. Here, the authors show that sea urchins modify an evolutionarily conserved AGS-dependent mechanism to induce asymmetric cell divisions in the early embryo.
- Octahedral gold-silver nanoframes with rich crystalline defects for efficient methanol oxidation manifesting a CO-promoting effectNature Communications, Published online: 22 August 2019; doi:10.1038/s41467-019-11766-wDirect methanol fuel cells are promising for clean, sustainable energy, but catalysts should be optimized. Here the authors construct ultrathin nanoframes with rich crystalline defects to increase electrocatalytic activity of gold for methanol oxidation, which is surprisingly promoted by carbon monoxide.
- Cognitive control of complex motor behavior in marmoset monkeysNature Communications, Published online: 22 August 2019; doi:10.1038/s41467-019-11714-8Whether marmosets can exhibit complex motor tasks in controlled experimental designs has not yet been demonstrated. Here, the authors show that marmoset monkeys can be trained to call on command in controlled operant conditioning tasks.
- Nucleosome and ubiquitin position Set2 to methylate H3K36Nature Communications, Published online: 22 August 2019; doi:10.1038/s41467-019-11726-4Set2 methyltransferase catalyzes the lysine 36 methylation of histone H3 (H3K36me) and the enzyme is mutated in many cancers. The authors provide mechanistic insights into how Set2 methylates nucleosomes by determining the 3.8 Å cryo-EM structure of Set2 bound to a H2B ubiquitinated nucleosome core particle.
- Crystal structure and substrate-induced activation of ADAMTS13Nature Communications, Published online: 22 August 2019; doi:10.1038/s41467-019-11474-5The plasma metalloprotease ADAMTS13 regulates the platelet-tethering function of von Willebrand factor (VWF) in a shear-dependent manner. Here the authors present the ADAMTS13 crystal structure of the 70kDa N-terminal metalloprotease to spacer domains, and using kinetic measurements they identify a substrate binding induced allosteric mechanism for ADAMTS13, w
- Patterns of bone metastases from head and neck squamous cell carcinomaPublication date: Available online 22 August 2019Source: Auris Nasus LarynxAuthor(s): Ayako Suzuki, Nobuo Kashiwagi, Hiroshi Doi, Kazunari Ishii, Katsumi Doi, Mutsukazu Kitano, Takenori Kozuka, Tomoko Hyodo, Masakatsu Tsurusaki, Yukinobu Yagyu, Katsuyuki NakanishiAbstractObjectiveTo report clinical features of bone metastases (BM) from head and neck squamous cell carcinoma (HNSCC).MethodsAmong 772 patients with HNSCC diagnosed at our hospital ov
- Human brain responses to gustatory and food stimuli: A meta-evaluation of neuroimaging meta-analysesPublication date: Available online 22 August 2019Source: NeuroImageAuthor(s): Andy Wa Kani Yeung, Natalie Sui Miu Wong, Hakwan Lau, Simon B. EickhoffAbstractMultiple neuroimaging meta-analyses have been published concerning gustation, food and taste. A meta-evaluation of these meta-analyses was conducted to qualitatively evaluate the presented evidence. A systematic search was done using multiple databases, in which no restriction was placed on
- Agreeableness modulates group member risky decision-making behavior and brain activityPublication date: Available online 22 August 2019Source: NeuroImageAuthor(s): Fang Wang, Xin Wang, Fenghua Wang, Li Gao, Hengyi Rao, Yu PanAbstractWhen facing difficult decisions, people typically believe that “two heads are better than one”. However, findings from previous studies are inconsistent regarding the advantages of decision-making in groups as compared to individual decision-making. We hypothesize that personality traits m
- The sourdough loaves that led two scientists to fame on <i>The Great British Bake Off</i>Nature, Published online: 22 August 2019; doi:10.1038/d41586-019-02533-4The UK television competition, which has spawned spin-offs in 30 other countries, is back for a tenth series, starting on 27 August. The 2018 winner Rahul Mandal and 2017 contestant Chuen-Yan Tsou (‘Yan’) talk cake, failed bakes, imposter syndrome and why science is an advantage in the Bake Off tent.
- Executive Summary of the ARS Appropriate Use Criteria for Local Excision in Rectal CancerPublication date: Available online 22 August 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Suzanne Russo, Christopher J. Anker, May Abdel-Wahab, Nilofer Azad, Prajnan Das, Jadranka Dragovic, Karyn A. Goodman, Joseph M. Herman, William Jones, Timothy Kennedy, Andre Konski, Rachit Kumar, Percy Lee, Nell Maloney Patel, Navesh Sharma, William Small, W.Warren Suh, Salma K. JabbourAbstractThe goal of treatment for e
- The role of the right premotor cortex and temporo-parietal junction in defensive responses to visual threatsPublication date: Available online 22 August 2019Source: CortexAuthor(s): Laura Sagliano, Maria Vela, Luigi Trojano, Massimiliano ConsonAbstractPrevious neuroimaging studies demonstrated that several brain areas are involved in detecting threats and activating defensive responses to threatening stimuli. The right premotor cortex (PM) is mainly activated during freezing, whereas the right temporoparietal junction (TPJ) is involved in attentional
- Northwestern Anagram Test-Italian (Nat-I) For Primary Progressive AphasiaPublication date: Available online 21 August 2019Source: CortexAuthor(s): Elisa Canu, Federica Agosta, Francesca Imperiale, Pilar M. Ferraro, Andrea Fontana, Giuseppe Magnani, Marek-Marsel Mesulam, Cynthia K. Thompson, Sandra Weintraub, Andrea Moro, Stefano F. Cappa, Massimo FilippiAbstractObjectivesTo test the ability of the Northwestern Anagram Test-Italian (NAT-I) to distinguish between the non-fluent/agrammatic (nfv-) and phonological/logope
- Visual Processing Speed as a Marker of Immaturity in Lexical but not Sublexical DyslexiaPublication date: Available online 21 August 2019Source: CortexAuthor(s): Nicole Stefanac, Megan Spencer-Smith, Méadhbh Brosnan, Anne Castles, Mark BellgroveAbstractA visual attention span (VAS) deficit has been widely reported in the Developmental Dyslexia (DD) literature, however, consensus regarding what underlies this problem and the nature of its relationship with reading ability remains elusive. Thirty-two children with DD (15 femal
- How words and space collide: Lexical and sublexical reading are reliant on separable reflexive and voluntary attention regions in hybrid tasksPublication date: Available online 21 August 2019Source: CortexAuthor(s): Chelsea Ekstrand, Josh Neudorf, Shaylyn Kress, Ron BorowskyAbstractReading ability requires the coordination of many cognitive processes to be effective, including spatial attention. Recent functional magnetic resonance imaging (fMRI) evidence from Ekstrand et al. (2019) suggests that lexical reading is more associated with reflexive attentional orienting regions, whereas
- Coverage of radial forearm flap donor site with full thickness skin graft and Matriderm®: An alternative reliable solution?Publication date: Available online 21 August 2019Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): S. Cristofari, Y. Guenane, M. Atlan, A. Hallier, M. Revol, A. StivalaSummaryPurposeAfter harvesting a radial forearm flap (RFF) an optimal aesthetic and functional restitution of the donor site is required. In order to cover the secondary defect of the donor site, several solutions are currently available, but there is still no rea
- Corrections secondaires de la face par implants en titanePublication date: Available online 21 August 2019Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): J.-B. Charrier, N. MoreauRésuméL’augmentation du contour osseux facial — qu’elle soit à visée esthétique ou reconstructrice — fait appel le plus souvent à deux types de techniques chirurgicales : autologues et alloplastiques. À ce titre, diff&ea
- Εγκυμοσύνη: Ο πιο σοβαρός λόγος να μην πίνετε αλκοόλΑλλαγές σε δύο γονίδια στο DNA των γυναικών που καταναλώνουν μέτρια έως υψηλή ποσότητα αλκοόλ κατά τη διάρκεια της κύησης, αλλά και στα παιδιά τους εκτέθηκαν σε αυτά τα επίπεδα αλκοόλ κατά την ενδομήτρια ζωή, εντόπισαν ερευνητές του Πανεπιστημίου Rutgers. Η υψηλή κατανάλωση αλκοόλ στις γυναίκες ορίζεται στα τέσσερα και άνω ποτά σε τουλάχιστον πέντε διαφορετικές περιστάσεις τον μήνα, ενώ η μέτρια κατανάλωση στα τρία ποτά σε ανά περίσταση. Σύμφων
- Vocal Turn-Taking Between Mothers and Their Children With Cochlear ImplantsObjectives: The primary objective of the study was to examine the occurrence and temporal structure of vocal turn-taking during spontaneous interactions between mothers and their children with cochlear implants (CI) over the first year after cochlear implantation as compared with interactions between mothers and children with normal hearing (NH). Design: Mothers’ unstructured play sessions with children with CI (n = 12) were recorded at 2
- Binaural Optimization of Cochlear Implants: Discarding Frequency Content Without Sacrificing Head-Shadow BenefitObjectives: Single-sided deafness cochlear-implant (SSD-CI) listeners and bilateral cochlear-implant (BI-CI) listeners gain near-normal levels of head-shadow benefit but limited binaural benefits. One possible reason for these limited binaural benefits is that cochlear places of stimulation tend to be mismatched between the ears. SSD-CI and BI-CI patients might benefit from a binaural fitting that reallocates frequencies to reduce interaural p
- Violet LED for non-vital tooth bleaching as a new approachPublication date: Available online 21 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Eran Nair Mesquita de Almeida, João Felipe Besegato, Diego Dantas Lopes dos Santos, Alessandra Nara de Souza Rastelli, Vanderlei Salvador BagnatoAbstractDifferent light sources have been used during the dental bleaching procedures. More recently, a violet LED system was introduced as a promising and viable light source, which is capa
- Photodynamic therapy enhancing anti-skin cancer chemotherapy effects through autophagy regulationPublication date: Available online 21 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Lili Zhang, Zhoujing Ji, Jie Zhang, Shengju YangAbstractNon-melanotic cutaneous cancers and melanoma are the main common type skin cancers worldwide, and squamous cell carcinoma (SCC) and melanoma were most serious and high aggressive. Despite many therapeutic options, but the therapeutic efficacy is not satisfied in all patients with advan
- Effect of piezoelectric osteotomy on postoperative edema and ecchymosis after rhinoplasty: a systemic review and meta‐analysisAbstract Objectives This study evaluated the efficacy of piezoelectric osteotomy in reducing edema and ecchymosis during rhinoplasty via a systematic review with meta‐analysis. Data Sources PubMed, Embase, SCOPUS, the Web of Science, the Cochrane library, and Google Scholar. Review Methods Two authors independently searched the referenced databases from inception to January 2019. They included studies that compared piezoelectric o
- Vocal Fold Nodules – A Disorder of Phonation Organs or Auditory Feedback?Abstract Objective Increasing evidence supports that auditory feedback of one's own voice closely relates to real‐time adjustments of vocal control. Previous studies highlighted that the low‐frequency modulations of below 3 Hz (LFM) embedded in vocal fundamental frequency (F0) showed a reflex‐like response to altered auditory inputs. However, the auditory feedback control of different vocal disorders remains unclear. Design A cross‐sect
- Long term swallowing outcomes following transoral surgery and adjuvant radiotherapy versus adjuvant chemoradiotherapy for oropharyngeal carcinoma; Our experience in 37 patientsAbstract Approximately 75% of patients are recommended adjuvant oncological treatment after transoral surgery (TOS) for oropharyngeal squamous cell carcinoma. Radiotherapy and chemoradiotherapy can result in significant long‐term swallowing difficulties, which can negatively impact upon quality of life. This prospective study utilised a comprehensive and complementary set of measures, including a patient reported, clinician‐rated and an object
- Repurposing approved drugs on the pathway to novel therapies. Related ArticlesRepurposing approved...Repurposing approved drugs on the pathway to novel therapies.Related ArticlesRepurposing approved drugs on the pathway to novel therapies. Med Res Rev. 2019 Aug 20;: Authors: Schein CH Abstract The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many "repurposed" drugs, such as derivatives of thalidomide, antibiotics, and antivirals h
- Retrospective analysis of sub mucosal radiofrequency procedure for the treatment of nasal bleeding in forty‐four patients with hereditary hemorrhagic telangiectasiaAbstract No treatment of epistaxis has proved its superiority in hereditary hemorrhagic telangiectasia. Submucosal radiofrequency (SRF) can reduce Epistaxis Severity Score up to 24 months after surgery. SRF is well tolerated under local anesthesia. A unilateral SRF can reduce epistaxis on both nasal sides. Repeated SRF procedures require controlling energy delivery to prevent nasal perforation. This article is protected by
- Antitumor effect of insulin‐like growth factor‐1 receptor inhibition in head and neck squamous cell carcinomaObjectives The insulin‐like growth factor‐1 receptor (IGF1R) has been implicated in therapeutic resistance in head and neck squamous cell carcinoma (HNSCC), and small molecule tyrosine kinase inhibitors (TKIs) of IGF1R activity may have anticancer activity. Therefore, the relationship between survival and IGF1R expression was assessed for oral cavity (OC) cancer, and the antitumor effects of two IGF1R‐TKIs, OSI‐906 and BMS‐754807, were evaluated
- Variability in pathologic interpretation of mandibular invasionObjectives/Hypothesis Our objective was to identify the accuracy, sensitivity, and specificity of pathological interpretation of mandibular invasion by oral cavity squamous cell carcinoma (SCC) and compare the sensitivity of detecting mandibular invasion in the erosive versus the infiltrative patterns of invasion. We also aimed to describe the significance of the terminology the carcinoma “abuts the mandible” in pathologic interpretation of mand
- New open access no-fee journal on rural neurosciencesJournal of Neurosciences in Rural Practice (www.ruralneuropractice.com) is new semi-annual peer-reviewed open access journal to be published from January 2010 on behalf of the Associacion Ayuda Enfermo Neuroquirurgico. The journal would not charge the authors for submission, processing or publication of manuscripts and would provide immediate free access to all its content.September-2009
- Deceptive combined effects of short allele dominance and stuttering: an example with Ixodes scapularis, the main vector of Lyme disease in the U.S.A. [NEW RESULTS]Null alleles, short allele dominance (SAD), and stuttering increase the perceived relative inbreeding of individuals and subpopulations as measured by Wright's FIS and FST. Ascertainment bias, due to such amplifying problems are usually caused by inaccurate primer design (if developed from a different species or a distant population), poor DNA quality, low DNA concentration, or a combination of some or all these sources of inaccuracy. When combin
- Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple MyelomaDespite the availability of proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies for multiple myeloma, most patients will have a relapse and refractory disease will develop. An increasing number of patients have triple-class refractory myeloma, defined as disease refractory to…
- The Comfort of the Ordinary — On Dying as We’ve LivedYears ago, I heard about the death of an old family friend whom I’d loved as a child for her eccentric cooking habits, feeding her parakeets saliva-soaked crumbs from her lips, and letting me rap my knuckles on her wooden leg. Although I wasn’t with her at the end of her colorful life, I can almost…
- Fine needle aspiration (FNA) of subcutaneous lesion: A diagnostic dilemma on cytologyManjari Kishore, Purnima Malhotra, Manju Kaushal, Preeti Singh, Neeti KapurCytoJournal 2019 16(1):17-17
- Transthoracic fine-needle aspiration diagnosis of solid, subsolid, and partially calcified lung nodules: A retrospective study from a single academic centerYangying Zhou, Gary Gong, Haiyan Wang, Zahra Alikhassy Habibabady, Peggy Lang, Russell Hales, Frederic Askin, Ed Gabrielson, Qing Kay LiCytoJournal 2019 16(1):16-16 Background: The large-scale National Lung Cancer Screening Trial demonstrated an increased detection of early-stage lung cancers using low-dose computed tomography scan in the screening population. It also demonstrated a 20% reduction of lung cancer-related deaths in these patien
- New open access no-fee journal on rural neurosciencesJournal of Neurosciences in Rural Practice (www.ruralneuropractice.com) is new semi-annual peer-reviewed open access journal to be published from January 2010 on behalf of the Associacion Ayuda Enfermo Neuroquirurgico. The journal would not charge the authors for submission, processing or publication of manuscripts and would provide immediate free access to all its content.September-2009
- Salvage surgery for recurrent larynx cancerAbstract Background Despite advances in treatment, the recurrence rates for laryngeal cancer range from 16% to 40%. Methods Patients with recurrent laryngeal cancer treated at Memorial Sloan Kettering (MSK) from 1999 to 2016 were reviewed. Survival outcomes were analyzed. Results Of 241 patients, 88% were male; the median age was 67 years; 71% had primary glottic tumors. At initial treatment, 72% of patients were seen with early s
- Prognostic and Predictive Role of DNA Mismatch Repair Status in Stage II‐III Colorectal Cancer: A Systematic Review and Meta‐AnalysisAbstract DNA mismatch repair (MMR) status was considered to be a potential prognostic factor for colorectal cancer (CRC) but with conflicting reports, and varied in terms of TNM stages. Its relationship with prognosis in stage II‐III CRC had not yet been systematically established. Therefore, we retrieved eligible studies published through May 2019, and screened out 51 studies that reported survival data (overall survival [OS] a
- Molecular defects in thyroid dysgenesisAbstract Congenital hypothyroidism (CH) is a neonatal endocrine disorder that might occur as itself or be associated to congenital extra‐thyroidal defects. About 85% of affected subjects experience thyroid dysgenesis (TD), characterized by defect in thyroid gland development. In vivo experiments on null mice paved the way for the identification of genes involved thyroid morphogenesis and development, whose mutation has been str
- Novel variant p.E269K confirms causative role of PLS1 mutations in autosomal dominant hearing lossAbstract Auditory reception relies on the perception of mechanical stimuli by stereocilia and its conversion to electrochemical signal. Mechanosensory stereocilia are abundant in actin, which provides them with structural conformity necessary for perception of auditory stimuli. Out of three major classes of actin bundling proteins, Plastin 1 encoded by PLS1, is highly expressed in stereocilia and is necessary for their regular mainten
- Familial pancreatic adenocarcinoma: A retrospective analysis of germline genetic testing in a French multicentre cohortABSTRACT The rate of genetic diagnosis of French patients with familial pancreatic ductal adenocarcinoma (PDAC) is not known. We report germline genetic testing data from 133 index cases meeting criteria for familial pancreatic cancer (FPC) as well as 87 “FPC‐like” index cases who did not fulfilled strict FPC definition but were evocative for a PDAC predisposition. The overall rate of genetic diagnosis (in BRCA1, BRC
- The effect of olfactory training on odor identification in patients with traumatic anosmiaBackground This study investigates the effect of olfactory training on odor identification in patients with traumatic anosmia. Methods Patients with a clear history of loss of smell after head injury, and whose phenyl ethyl alcohol (PEA) odor detection thresholds remained at –1 after steroid and zinc treatment, were included in this study between July 2016 and July 2018. They were randomly divided into 2 groups, with patients in the 4‐odor
- The inner clock ‐ blue light sets the human rhythmAbstract Visible light synchronizes the human biological clock in the suprachiasmatic nuclei of the hypothalamus to the solar 24‐hour cycle. Short wavelengths, perceived as blue color, are the strongest synchronizing agent for the circadian system that keeps most biological and psychological rhythms internally synchronized. Circadian rhythm is important for optimum function of organisms and circadian sleep‐wake disruptions or chronic misalignm
- Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic ReviewInterleukin-6 (IL-6) is a unique cytokine that can play both pro- and anti-inflammatory roles depending on the anatomical site and conditions under which it has been induced. Specific neurons of the hypothalamus provide important signals to control food intake and energy expenditure. In individuals with obesity, a microglia-dependent inflammatory response damages the neural circuits responsible for maintaining whole-body energy homeostasis, resul
- Effects of Fe3+ on Acute Toxicity and Regeneration of Planarian (Dugesia japonica) at Different TemperaturesObjective. To investigate the effects of different concentrations of Fe3+ on the acute toxicity and regeneration of planarian at different temperatures. Method. The planarians were treated with 40 mg/l, 50 mg/l, 60 mg/l, and 70 mg/l Fe3+ solution and placed in 15°C, 20°C, and 25°C, respectively, to observe the mortality and the poisoning pattern of the planarian. In addition, the planarians were cut into three parts of head, trunk, and tail, then
- Effect of Hypoxia on Gene Expression in Cell Populations Involved in Wound HealingWound healing is a complex process regulated by multiple signals and consisting of several phases known as haemostasis, inflammation, proliferation, and remodelling. Keratinocytes, endothelial cells, macrophages, and fibroblasts are the major cell populations involved in wound healing process. Hypoxia plays a critical role in this process since cells sense and respond to hypoxic conditions by changing gene expression. This study assessed the in v
- FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic MiceThe immune system is involved in the development of diabetes complications and IgG Fc gamma receptors (FcgRs) are key immune receptors responsible for the effective control of both humoral and innate immunity. We investigated the effects of members of the FcgR superfamily into both the streptozotocin plus high fat-induced type 2 diabetes and high fat diet (HFD) models. FcgRIII-/- diabetic mice and FcgRIIb-/- diabetic mice had elevated levels of s
- Effect of piezoelectric osteotomy on postoperative edema and ecchymosis after rhinoplasty: a systemic review and meta‐analysisAbstract Objectives This study evaluated the efficacy of piezoelectric osteotomy in reducing edema and ecchymosis during rhinoplasty via a systematic review with meta‐analysis. Data Sources PubMed, Embase, SCOPUS, the Web of Science, the Cochrane library, and Google Scholar. Review Methods Two authors independently searched the referenced databases from inception to January 2019. They included studies that compared piezoelectric o
- Vocal Fold Nodules – A Disorder of Phonation Organs or Auditory Feedback?Abstract Objective Increasing evidence supports that auditory feedback of one's own voice closely relates to real‐time adjustments of vocal control. Previous studies highlighted that the low‐frequency modulations of below 3 Hz (LFM) embedded in vocal fundamental frequency (F0) showed a reflex‐like response to altered auditory inputs. However, the auditory feedback control of different vocal disorders remains unclear. Design A cross‐sect
- Long term swallowing outcomes following transoral surgery and adjuvant radiotherapy versus adjuvant chemoradiotherapy for oropharyngeal carcinoma; Our experience in 37 patientsAbstract Approximately 75% of patients are recommended adjuvant oncological treatment after transoral surgery (TOS) for oropharyngeal squamous cell carcinoma. Radiotherapy and chemoradiotherapy can result in significant long‐term swallowing difficulties, which can negatively impact upon quality of life. This prospective study utilised a comprehensive and complementary set of measures, including a patient reported, clinician‐rated and an object
- Retrospective analysis of sub mucosal radiofrequency procedure for the treatment of nasal bleeding in forty‐four patients with hereditary hemorrhagic telangiectasiaAbstract No treatment of epistaxis has proved its superiority in hereditary hemorrhagic telangiectasia. Submucosal radiofrequency (SRF) can reduce Epistaxis Severity Score up to 24 months after surgery. SRF is well tolerated under local anesthesia. A unilateral SRF can reduce epistaxis on both nasal sides. Repeated SRF procedures require controlling energy delivery to prevent nasal perforation. This article is protected by
- Somato‐dendritic morphology and axon origin site specify von Economo neurons as a subclass of modified pyramidal neurons in the human anterior cingulate cortexVon Economo neurons (VENs) in the human anterior cingulate cortex have specific somato‐dendritic morphology on Golgi staining. The most notable morphological feature for their reliable identification is the extremely distant position of the axon origin. We suggest that until specific markers for VENs are established, the results of quantitative studies of VENs using Nissl or NeuN staining should be taken with caution as they might not be r
- Issue Cover (September 2019)Front cover: Cover: Cover image by Ayman Alzu’bi: immunofluorescent double labelling for ROBO1 (red) and calretinin (green) in human fetal telencephalon and diencephalon at 8 post‐conceptional weeks (coronal section).
- Decreased Expression of CHST-12, CHST-13, and UST in the Proximal Interphalangeal Joint Cartilage of School-Age Children with Kashin–Beck Disease: an Endemic Osteoarthritis in China Caused by Selenium DeficiencyAbstract The objective of this study is to investigate changes in the expression of enzymes involved in chondroitin sulfate (CS) sulfation in distal articular surface of proximal interphalangeal joint isolated from school-age children patients with Kashin–Beck disease (KBD), using normal children as controls. Articular cartilage samples were collected from four normal and four KBD children (7–12 years old), and these children
- Biosynthesis of Fe 3 O 4 @Ag Nanocomposite and Evaluation of Its Performance on Expression of norA and norB Efflux Pump Genes in Ciprofloxacin-Resistant Staphylococcus aureusAbstract At present, the universal health problem with Staphylococcus aureus is the emergence of multidrug-resistant strains due to the overuse of antibiotics. Drug extrusion through efflux pumps is one of the bacterial mechanisms to neutralize the bactericidal effect of antibiotics. The antibacterial activity of silver nanoparticle as well as Fe3O4 nanoparticle had been previously studied and widely described. Today, the dev
- Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous KidneysAbstract In the body, disorders in the composition and concentration of trace elements, including copper, can lead to the development of various alterations that may result in incorrect functioning of the kidneys. Data on the concentrations of copper in human kidneys are discussed; however, little is known about the concentration of trace elements within rejected renal grafts and kidneys with tumor lesions. The aim of our stu
- Pharmacokinetics of Selenium in Healthy Piglets After Different Routes of Administration: Application of Pharmacokinetic Data to the Risk Assessment of SeleniumAbstract Selenium (Se) is a trace element in the environment. Although it is a necessary trace element for human and animal health, excessive Se can also pollute the environment and show toxic effects on humans and animals. Since the safe dose range of Se is narrow, it is important to study the pharmacokinetics of Se in order to make better use of the biological effects of Se. In the present study, we investigated the pharmac
- Presence of Toxic Heavy Metals in Platelet-Rich Fibrin: a Pilot StudyAbstract Platelet-rich fibrin (PRF) is widely used blood-derived biomaterial which is directly applied to the surgical wounds. Depending on its autologous origin, PRF is thought as a safe material. However, it is not known to what extent the blood-derived toxins can be found in the PRF by considering the systemic exposure rates of the individuals to the toxins. The aim of this pilot study was to test the hypothesis whether PR
- Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-AnalysisAbstract Studies point out that trace elements take vital roles in immunological and inflammatory reactions, such as psoriasis, while the conclusions are controversial. The purpose of this study was to analyze the existing literatures and explore the relationship between the risk of psoriasis and four trace elements zinc (Zn), copper (Cu), iron (Fe), and selenium (Se). We identified 42 studies through the databases PubMed, Em
- The Growth Rate, Immune Status, Duodenal Development, and Cecal Microbial Diversity of 24-Day-Old Offspring of SD Rats Received Bacillus subtilis -Cu or CuSO 4 During Pregnancy and Lactation PeriodsAbstract A total of 108 pregnant and lactation SD rats were divided into six groups, daily and orally dosed with Bacillus subtilis-copper (CuBs) and CuSO4 (CuS) both at three doses equivalent to 1.5 mg (Cu deficiency), 3 mg, and 6 mg Cu per kg diet, and the effects of the Cu source and dosage on the growth rate, immune status, duodenal development, and cecal microbial diversity were examined on 24-day-old offspring rats. The
- Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley RatsAbstract Lead has heavy metal toxicity which endangers human and animal health. Salidroside (SDS) is a natural antioxidant that has extensive pharmacological usage. However, its protective effects on lead-induced oxidative stress and hepatotoxicity has not been reported. In this study, we established an animal model to evaluate the protective effects of SDS on chronic lead exposure induced oxidative stress and hepatotoxicity.
- Intravenous Thrombolysis for Suspected Ischemic Stroke with Seizure at OnsetAbstract Objective Seizure at onset (SaO) has been considered a relative contraindication for intravenous thrombolysis (IVT) in patients with acute ischemic stroke, although this appraisal is not evidence‐based. Here, we investigated the prognostic significance of SaO in patients treated with IVT for suspected ischemic stroke. Methods In this multicenter, IVT‐registry‐based study we assessed the association between SaO and symptomatic i
- Astrocyte subtype vulnerability in stem cell models of Vanishing White MatterAbstract Objective Astrocytes have gained attention as important players in neurological disease. In line with their heterogeneous character, defects in specific astrocyte subtypes have been identified. Leukodystrophy Vanishing White Matter shows selective vulnerability in white matter astrocytes, but the underlying mechanisms remain unclear. Induced pluripotent stem cell technology is extensively being explored in studies of pathophysiology
- GGC repeat expansion of NOTCH2NLC in adult patients with leukoencephalopathyAbstract Leukoencephalopathies comprise a broad spectrum of disorders, but the genetic background of adult leukoencephalopathies has rarely been assessed. In this study, we analyzed 101 Japanese patients with genetically unresolved adult leukoencephalopathy using whole‐exome sequencing and repeat‐primed PCR for detecting GGC expansion in NOTCH2NLC. NOTCH2NLC was recently identified as the cause of neuronal intranuclear inclusion disease. We foun
- Rosai-Dorfman Disease of the Breast With Variable IgG4+ Plasma Cells: A Diagnostic Mimicker of Other Malignant and Reactive EntitiesRosai-Dorfman disease (RDD) is an uncommon disorder, characterized by an atypical expansion of histiocytes which classically shows emperipolesis and immunoreactivity with S-100 protein. RDD affects the lymph nodes as well as extranodal sites; however, RDD of the breast is exceptionally rare. Herein, we describe the histopathologic features of 22 cases of RDD occurring in the breast, with an emphasis on the differential diagnosis. All cases were n
- Cases Having a Gleason Score 3+4=7 With <5% of Gleason Pattern 4 in Prostate Needle Biopsy Show Similar Failure-free Survival and Adverse Pathology Prevalence to Gleason Score 6 Cases in a Radical Prostatectomy CohortRecent discussions have suggested expanding the inclusion criteria for active prostate cancer surveillance to include cases with a Gleason score (GS) of 3+4=7. In this study, we examined this proposed use of a limited percent Gleason pattern 4 (%GP4) to identify candidates of active surveillance among 315 patients who underwent radical prostatectomy for prostate cancer with a GS of 6 or 3+4=7 via needle biopsy. The latter cases were divided into
- Early Neuromuscular Blockade in the Acute Respiratory Distress SyndromeNew England Journal of Medicine, Volume 381, Issue 8, Page 785-788, August 2019.
- Ibrutinib and Venetoclax for First-Line Treatment of CLLNew England Journal of Medicine, Volume 381, Issue 8, Page 788-789, August 2019.
- Ambient Particulate Air Pollution and Daily Mortality in 652 CitiesNew England Journal of Medicine, Volume 381, Issue 8, Page 705-715, August 2019.
- Prescription Drug Monitoring Programs — Friend or Folly in Addressing the Opioid-Overdose Crisis?New England Journal of Medicine, Volume 381, Issue 8, Page 699-701, August 2019.
- Drug Effects on the ThyroidNew England Journal of Medicine, Volume 381, Issue 8, Page 749-761, August 2019.
- Effects of Serelaxin in Patients with Acute Heart FailureNew England Journal of Medicine, Volume 381, Issue 8, Page 716-726, August 2019.
- Fish Bone PerforationNew England Journal of Medicine, Volume 381, Issue 8, Page 762-762, August 2019.
- The Climate Crisis — Health and Care DeliveryNew England Journal of Medicine, Volume 381, Issue 8, August 2019.
- Prioritizing Health in a Changing ClimateNew England Journal of Medicine, Volume 381, Issue 8, Page 773-774, August 2019.
- Emphysematous CholecystitisNew England Journal of Medicine, Volume 381, Issue 8, August 2019.
- Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple MyelomaNew England Journal of Medicine, Volume 381, Issue 8, Page 727-738, August 2019.
- A New Era of Climate Medicine — Addressing Heat-Triggered Renal DiseaseNew England Journal of Medicine, Volume 381, Issue 8, Page 693-696, August 2019.
- Case 26-2019: A 27-Year-Old Woman with Opioid Use Disorder and Suicidal IdeationNew England Journal of Medicine, Volume 381, Issue 8, Page 763-771, August 2019.
- Do We Really Need Another Time-Series Study of the PM2.5–Mortality Association?New England Journal of Medicine, Volume 381, Issue 8, Page 774-776, August 2019.
- Myocardial Viability and Long-Term Outcomes in Ischemic CardiomyopathyNew England Journal of Medicine, Volume 381, Issue 8, Page 739-748, August 2019.
- Human Health on an Ailing Planet — Historical Perspectives on Our FutureNew England Journal of Medicine, Volume 381, Issue 8, Page 778-782, August 2019.
- Fornix-Region Deep Brain Stimulation–Induced Memory Flashbacks in Alzheimer’s DiseaseNew England Journal of Medicine, Volume 381, Issue 8, Page 783-785, August 2019.
- The Comfort of the Ordinary — On Dying as We’ve LivedNew England Journal of Medicine, Volume 381, Issue 8, Page 701-703, August 2019.
- Why Are Physicians So Confused about Acute Heart Failure?New England Journal of Medicine, Volume 381, Issue 8, Page 776-777, August 2019.
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Πέμπτη 22 Αυγούστου 2019
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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