Background: The management of the moderate and severe forms of acute pancreatitis (AP) with necrosis and multiorgan failure remains a challenge. To predict the severity and mortality of AP multiple clinical, laboratory-, and imaging-based scoring systems are available. Aim: To investigate, if the computed tomography severity index (CTSI) can predict the outcomes of AP better than other scoring systems. Methods: A systematic search was performed in 3 databases: Pubmed, Embase, and the Cochrane...
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Considering the predicted rising temperatures under current climate change and heat waves scenarios, organisms are expected to suffer more intense and more frequent thermal stress. Induced heat is accumulated by organisms and can cause a variety of physiological stress responses. Ophraella communa is a known effective biological control agent of common ragweed, Ambrosia artemisiifolia, but the responses of this agent to heat stress have not been fully elucidated and, therefore, its potential responses...
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The combined effects of mechanical loading and maturation during adolescence are still not well understood. The purpose of the study was to investigate the development of the quadriceps femoris muscle-tendon unit from early adolescence (EA), late adolescence (LA) to young adulthood (YA) and examine how it is influenced by athletic training in a cross-sectional design. Forty-one male athletes and forty male non-athletes from three different age groups (EA: 12-14 y, n=28; LA: 16-18y, n=27; YA:...
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Objective: Mitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal protein thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) to scavenge H2O2 in mitochondria. It has been widely reported that Trx2 deletion in cells or mice generates massive reactive oxygen species (ROS) which have been implicated in many pathological processes. On the contrary, how ROS regulate Trx2 expression and activity remains to be elucidated. Approach and Results:...
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Exosomes are 40–150nm extracellular vesicles with a size of 40–150 nm that are released from a multitude of cell types, and are present in biological fluids, which that are particularly rich in membrane proteins. These vesicles are present in the bile, where they function as a are special regulator of the digestive system; however,, but their source and characteristic in normal gallbladders have never been discovered. Bile, liver, and gallbladder were obtained from healthy turtles after starvation...
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Aims: Patient-to-patient anatomical differences are an important source of variability in the electrocardiogram, and they may compromise the identification of pathological electrophysiological abnormalities. This study aims at quantifying the contribution of variability in ventricular and torso anatomies to differences in QRS complexes of the 12-lead ECG using computer simulations. Methods: A computational pipeline is presented that enables computer simulations using human torso/biventricular...
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Primary Sjögren's syndrome (pSS) is an autoimmune disease affecting exocrine glands and extra-glandular organs. There are conflicting reports on the presence of autonomic dysfunction in pSS and no data are available on the functional status of sympathetic outflow to the vessels and baroreceptor (BRS) control mechanisms. We investigated the cardiac (cBRS) and sympathetic (sBRS) baroreceptor modulation in both time and frequency domains and the cardiovascular autonomic profile in pSS patients compared...
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Objective: Although the important role of respiratory modulation of the cardiovascular system in the development of hypertension has been demonstrated in animal studies, little research has assessed this modulation in essential hypertensive patients. We aimed to explore whether respiratory-related variations in cardiovascular variables are changed in hypertensive patients and their potential relationships with the respiratory pattern. Methods: Respiration, ECG, and beat-to-beat blood pressure...
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Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift and cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR, with or without countermeasures, affect cerebral autoregulation (CA). Twelve men (at selection: 34±7 years; 176±7 cm; 70±7 kg) underwent three interventions of a 21-day HDBR: a control condition without countermeasure (CON), a condition with resistance vibration...
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A total of 3,782 performance results for male and female weightlifters, ages 14 to 30 from 123 countries, from Youth, Junior, and Senior World Championships and Olympic Games 2013 to 2017 were used to estimate the age at peak performance in Olympic weightlifting and quantify performance development from adolescence to adulthood. The age at peak performance was estimated for men and women globally and for different geographic regions. Overall male and female weightlifters achieve their peak...
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Atezolizumab is an immune-checkpoint inhibitor, which has been approved by the US Food and Drug Administration (FDA) in various combinations for a number of cancer types in recent years. (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Prostate cancer is the most frequent cancer found in American men, and the second leading cause of cancer death in this population. Currently, scores of reputable clinical trials are underway and recruiting patients. (Source: CancerNetwork)
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[Ghanaian Times] The Child Health Department of the Korle Bu Teaching Hospital in Accra needs Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scan machine at its Paediatric Oncology Unit (POU) where childhood cancers are treated. (Source: AllAfrica News: Health and Medicine)
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The genetic condition is one of the most common in the UK and may be a leading cause of infertility in men. Why does it so often go untreated?Three years ago, Paul (not his real name), now 31, went to the doctor with stomach pains. His blood test came back with low testosterone levels. “We went to see a urologist and he said bluntly that we wouldn’t have any options to have kids with my sperm – we would have to use a donor or adopt,” he says. “My wife immediately burst into tears.” The couple had...
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Has genomic medicine realized all its potential over the past decade? Yes and no, says Dr David Kerr.Medscape Oncology (Source: Medscape Today Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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When most people think about sun-related damage, they probably worry about their skin. But the sun’s ultraviolet rays also pose a threat to a person’s eyes. According to a 2014 study funded by the U.S. National Eye Institute, part of the National Institutes of Health, UV radiation can damage proteins in the eye’s lens. Over time, this damage can raise a person’s risk for cataracts, which impair vision. “When you don’t wear protection, ultraviolet radiation you cannot see is penetrating the eye,...
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When Robert Fuller found out he had throat cancer, he decided to finish out his life and then end it with fatal drugs (Source: ABC News: Health)
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Freddie Burgess-Shardlow has an ectomesenchymoma, a rare and fast-growing tumour of the nervous system or soft tissue. He is receiving treatment in Nottingham. (Source: the Mail online | Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Artificial intelligence (AI) may create new opportunities to improve outcomes...Read more on AuntMinnie.comRelated Reading: Data biases for AI could worsen healthcare disparities Preparing healthcare IT architecture for AI: Part 2 Preparing healthcare IT architecture for AI: Part 1 AI can improve reproducibility of radiomics in CT AI, radiomics can help predict chemotherapy response (Source: AuntMinnie.com Headlines)
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Contributors : Lina Zhang ; Wang Ying ; Mingxi Deng ; Yan YanSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterInvestigation of intratumor heterogeneity in the scrib¹ mutant wing imaginal discs.Method: Staged scrib¹ wing imaginal discs were dissected and transferred to DPBS. The wing imaginal discs were dissociated in 0.25% Trypsin-EDTA solution at 37 ℃ for 10 min. Cells were then washed in DPBS and passed through 35μm filter before library preparation....
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Cells, Vol. 8, Pages 978: The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine Cells doi: 10.3390/cells8090978 Authors: Shiina Blancher Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still...
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Cells, Vol. 8, Pages 976: Physiology, Pathology and Regeneration of Salivary Glands Cells doi: 10.3390/cells8090976 Authors: Porcheri Mitsiadis Salivary glands are essential structures in the oral cavity. A variety of diseases, such as cancer, autoimmune diseases, infections and physical traumas, can alter the functionality of these glands, greatly impacting the quality of life of patients. To date, no definitive therapeutic approach can compensate the impairment of salivary glands,...
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Cells, Vol. 8, Pages 977: A Novel Computational Model for Predicting microRNA–Disease Associations Based on Heterogeneous Graph Convolutional Networks Cells doi: 10.3390/cells8090977 Authors: Li Liu Hu Que Yao Identifying the interactions between disease and microRNA (miRNA) can accelerate drugs development, individualized diagnosis, and treatment for various human diseases. However, experimental methods are time-consuming and costly. So computational approaches to predict...
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Cells, Vol. 8, Pages 975: Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics Cells doi: 10.3390/cells8090975 Authors: Ong Tan Ler Gunaratne Choi Seet Chow During influenza pneumonia, the alveolar epithelial cells of the lungs are targeted by the influenza virus. The distal airway stem cells (DASCs) and proliferating alveolar type II (AT2) cells are reported to...
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Contributors : Xiaowei Zhang ; Hanzhong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study finds that EV71 has oncolytic activity against experimental human malignant gliomas. RNA-seq analysis of infected glioma cells reveals transcriptional up-regulation, notably genes in apoptosis pathways. Application of virus targeting based on brain-specific microRNA-124 enhances the safety profile. Oncolysis with EV71 may be a potentially novel treatment...
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Contributors : Josyf C Mychaleckyj ; Alessandro DoriaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed RNA-Seq whole transcriptome analysis of H716 cells grown in two glucose concentrations.
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Contributors : Berkley E Gryder ; Xinyu Wen ; Javed KhanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWith emerging methods recently developed to capture protein-anchored 3D epigenome folding we herein report an experimental advance yielding a fundamental and systematic improvement in understanding the 3D genome: integrated normalization of orthologous chromatin for measurement of absolute changes in the landscape. With Absolute...
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Contributors : Idit Hazan ; Rami AqeilanSeries Type : OtherOrganism : Homo sapiensMapping physiological double strand breaks (DSBs) in cancer cells uncovers transcription-coupled repair mechanism at oncogenic super-enhancers in which RAD51 of the homologous recombination pathway plays a key role supporting the hyper-transcription of related oncogenes.
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Contributors : Yuanjun Guo ; Jennifer Y Sui ; Kyungsoo Kim ; Zhentao Zhang ; Xiaoyan A Qu ; Young-Jae Nam ; Robert N Willette ; Joey V Barnett ; Bjorn C Knollmann ; Thomas Force ; Hind LalSeries Type : Expression profiling by arrayOrganism : Mus musculusBackground: Cardiac kinases play a critical role in the development of heart failure, and represent potential tractable therapeutic targets. However, only a very small fraction of the cardiac kinome has been investigated. To identify novel cardiac...
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Contributors : Xiaohui Liu ; Donge TangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOne of the most common congenital disorders of male infertility is Klinefelter syndrome. Because of its extreme heterogeneity in clinical and genetic presentation, the relationship between transcriptome and the clinical phenotype and the associated co-morbidities seen in KS has not been fully clarified yet. We reported here a 47 XXY karyotype Chinese male (KS) with infertility...
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Contributor : Li-Fang ChuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLittle is known about human segmentation clock during somitogenesis. Human embryonic stem (ES) cell differentiation towards PSM and somite cells provide a window of opportunity to probe for the dynamics of oscillatory gene expression. Using high temporal RNA-seq, we captured a transcriptional signature highly reminiscent of segmentation clock during somite differentiation. Our study provides...
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Contributors : Laith Al-Eitan ; Amneh H Tarkhan ; Mansour A Alghamdi ; Firas A Al-Qarqaz ; Hadeel S Al-KofahiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe main purpose of this study is to investigate the differences between the gene expression profiles of common warts and healthy skin in HPV-positive individuals by RNA sequencing on the Illumina HiSeq 2500. After obtaining shave biopsies of common warts and healthy skin from twelve Arab males, we were...
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Contributor : Daniele M GilkesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe designed a novel approach to fate-map hypoxic cells in order to determine their cellular response to physiological O2 gradients. Our system causes a change in the expressing fluorescent protein upon hypoxic exposure (DsRed -> GFP). We generated hypoxia fate-mapping tumors using MDA-MB-231 cells expressing our system. Metastatic lungs were resected 2 weeks after primary tumor...
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Contributors : Xin-Yu Shi ; Kan Zhai ; Huan-Zhong ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe interactions between tumor cells and the host vasculature and immune cells results in increased net fluid production via enhanced plasma extravasation into the pleural space.Understanding the regulatory mechanism of IL-10 in MPE formation is essential both for deciphering how IL-10 acts in regulating tumor immunity and for discovering key molecular targets...
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Contributors : Hanns L Ksstsch ; Reinhard UllmannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we describe a potential novel gene expression biomarker for early post-irradiation biodosimetry purposes in BARD1 and we portray the practicability of the established gene expression biomarkers AEN, FDXR and DDB2 after exposure to low dose radiation. Future in-vivo experiments and the inclusion of novel examination procedures present promising approaches...
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Contributors : Wenbiao Chen ; Hongyan DiaoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo explore the lncRNAs and mRNA expression profiles in CHB and asymptomatic HBsAg carriers (ASC) and construct mRNA-lncRNA co-expression profile and ceRNA networks to identify the potential targets of diagnosis and treatment in CHB.
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Contributors : Cuidong Wang ; Nathaniel HeintzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTRAP translational profiling is a method that allows investigators to genetically characterize specific cell types in complex tissues such as mouse brain. Using this technique we obtained RNA-Seq data from actively translating transcripts present in neurons in the cortex-amygdala transition zone (CxA) of adult Lypd1-EGFP/Rpl10a (OI82) mice. This work was supported...
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Contributors : Luyi Tian ; Daniela Amann-Zalcenstein ; Jaring Schreuder ; Shalin H NaikSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA classical view of blood cell development is that multipotent haematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. The Lin–c-kit+Sca1+Flt3+ stage, termed lymphoid-primed multipotent progenitors (LMPPs), have lost megakaryocyte and erythroid potential but are heterogeneous in their...
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Contributors : Marine Adlanmerini ; Bryce J Carpenter ; Jarrett R Remsberg ; Yann Aubert ; Lindey C Peed ; Hannah J Richter ; Mitchell A LazarSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIdentification of temperature-selective RevErba binding sites in mice brown adipose tissue.
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