Cells, Vol. 8, Pages 979: Neutrophil Extracellular Traps: Current Perspectives in the Eye Cells doi: 10.3390/cells8090979 Authors: Gibrán Alejandro Estúa-Acosta Rocío Zamora-Ortiz Beatriz Buentello-Volante Mariana García-Mejía Yonathan Garfias Neutrophil extracellular traps (NETs) have been the subject of research in the field of innate immunity since their first description more than a decade ago. Neutrophils are the first cells recruited at sites of inflammation, where...
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Contributors : Peiwei Chai ; Xianqun FanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identified aberrant CTCF binding lead to a 3D chromosomal interactional driver in NTS locus that accelerates tumorigenesis of uveal melanoma. Both enhancer deletion and abolishing CTCF binding lead to the loss of chromosomal looping and triggered therapeutic efficacy in inhibiting tumorigenesis. Our study shed light on a functional chromosomal architecture induced enhancer...
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Contributors : Walton Ashley ; Gryder Berkley ; Xinyu Wen ; Javed KhanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensActivation of identity determining transcription factors (TFs), or core regulatory TFs, is governed by cell-type specific enhancers, an important subset of these being super enhancers (SEs). This mechanism is distinct from constitutive expression of housekeeping genes. The characterization of drug-like small molecules to selectively inhibit...
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Contributors : Peiwei Chai ; Xianqun FanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe identified aberrant CTCF binding lead to a 3D chromosomal interactional driver in NTS locus that accelerates tumorigenesis of uveal melanoma. Both enhancer deletion and abolishing CTCF binding lead to the loss of chromosomal looping and triggered therapeutic efficacy in inhibiting tumorigenesis. Our study shed light on a functional chromosomal architecture...
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Contributors : Bo Lv ; Chaojie LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe adopt mouse pre-implantation embryos to evaluate the effects of different exposure time and illumination intensity. The damage-causing time and intensity is chosen to treat embryos at 2-cell stage. Single-cell transcriptomes from 2-cell to blastocyst stage are analyzed under both control and high-intensity light conditions. These data show that embryo cells at each embryonic...
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Contributor : Debasish SinhaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe study was aimed at understanding the expression of known neutrophil regulating factors in the retinal pigment epithelium (RPE) cells with increasing age in a mouse model (Cryba1 cKO, mice lacking gene which codes for beta A3/A1-crystallin protein only in the RPE cells) of age-related macular degeneration
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Contributors : Paul Yan ; Athma A Pai ; Julia F Alterman ; Anastasia KhvorovaSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca fascicularisExamine potential off-target effects of HTT targeting siRNA in cynomologus macaque brains.
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Contributor : Marc-André SirardSeries Type : Methylation profiling by high throughput sequencingOrganism : Bos taurusComparison of mitochondrial DNA (mtDNA) methylation patterns in oocytes, blastocysts and ovarian granulosa cells indicates hitherto unsuspected dynamics. Oocytes and blastocysts recovered from animals subjected to ovarian stimulation and from abattoir ovaries were analyzed using bisulphite transformation of DNA followed by whole genome sequencing. The number of mtDNA copies is quite...
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Contributors : Clifton L Dalgard ; Harvey B PollardSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusWe have previously reported that the cardenolide drug digitoxin blocks TNFα/NFκB-driven proinflammatory signaling. We therefore hypothesized that digitoxin might break the collaborative process between NFκB and TGFβ by also inhibiting expression of TGFBR2. We therefore tested whether TGFβ-driven EMT and resulting metastases would be suppressed.
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Contributors : J E Fish ; N KhyzhaSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensThe purpose of this study was to identify long noncoding RNAs (lncRNAs) that are dysregulated during vascular inflammation and contribute to mRNA regulation. Previous studies have suggested that many lncRNAs interact with protein complexes to regulate their neighboring mRNAs. Therefore, we performed the Human LncRNA Expression Microarray V3.0 (Arraystar) to simultaneously profile the expression...
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Contributors : Marcus W Butler ; Neil R Hackett ; Jacqueline Salit ; Yael Strulovici-Barel ; Ronald G CrystalSeries Type : Expression profiling by array ; Genome variation profiling by SNP arrayOrganism : Homo sapiensThe glutathione S-transferase (GST) gene family codes for enzymes that detoxify xenobiotics by catalyzing the conjugation of xenobiotics to glutathione. Based on reports that inherited copy number variations (CNV) in the genome modulate some GST expression levels and with the knowledge...
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Contributors : Natasha L Pacheco ; Michelle OlsenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAstrocytic morphogenesis and maturation are critical steps in CNS development. The time window of astrocyte morphological development is well defined, but the molecular underpinnings are still unclear. BDNF is a critical growth factor involved in the development of the CNS, including synapse refinement. Here we demonstrate the BDNF receptor at Ntrk2 is enriched...
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Contributors : Tyler A Allen ; Jeffrey AYoder ; Xinxia PengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood. A pivotal step in the metastasis process is the exiting of tumor cells from the circulation, a process known as extravasation. However, it is unclear how tumor cells extravasate, and if multicellular clusters of tumor cells posses the ability to exit...
11h
Contributors : Adeline Berger ; Nicholas J Brady ; David S RickmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusDespite recent advances in highly effective androgen receptor (AR)-directed therapies for the treatment of prostate cancer, a significant subset of patients with resistant disease develop AR-null, androgen signaling-indifferent neuroendocrine prostate cancer (NEPC). A majority of these NEPC cases that arise following anti-androgen...
12h
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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Contributors : Adeline Berger ; Nicholas J Brady ; David S RickmanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDespite recent advances in highly effective androgen receptor (AR)-directed therapies for the treatment of prostate cancer, a significant subset of patients with resistant disease develop AR-null, androgen signaling-indifferent neuroendocrine prostate cancer (NEPC). A majority of these NEPC cases that arise following anti-androgen...
12h
Contributors : Sander Lambo ; Marcel KoolSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensETMRs are aggressive pediatric embryonal brain tumors with universally dismal outcome. We collected 193 ETMR samples and an additional 23 matched relapses to investigate the genomic landscape of this distinct entity. We found that patients having tumors without C19MC amplification, the proposed driver, frequently harbor DICER1 germline mutations or other miRNA-related aberrations...
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Contributors : Sander Lambo ; Marcel KoolSeries Type : Expression profiling by arrayOrganism : Homo sapiensETMRs are aggressive pediatric embryonal brain tumors with universally dismal outcome. We collected 193 ETMR samples and an additional 23 matched relapses to investigate the genomic landscape of this distinct entity. We found that patients having tumors without C19MC amplification, the proposed driver, frequently harbor DICER1 germline mutations or other miRNA-related aberrations such as somatic...
13h
Contributors : Fei Li ; Jihye Paik ; Hongwu ZhengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this experiment is to determine the effect of ATRX depletion on telomeric chromatin compaction. We adapted the ATAC-seq to quantify telomere chromatin accessibility. By scoring the ratio of sequence reads that contained 3 - 12 tandem telomeric repeats over the total number of reads in wild-type and ATRX deplted cells, our analysis revealed...
15h
ABSTRACT The excessive sun exposure, coupled with lack of sun protection represents one of the biggest risks to the occurrence of skin cancer and photoaging. Recent strategies for photoprotection have included the incorporation of natural antioxidant and anti-inflammatory compounds, into sunscreens, and the oral administration of natural antioxidant extracts. In this work, we use Brazilian red propolis extract because its antioxidant and anti-inflammatory activities. The aim of this work was to evaluate...
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Contributors : Alison Hirukawa ; Willliam Muller ; Jarey WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMonoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proportion of patients exhibits de novo resistance. Here, by comparing matched Trastuzumab-na ïve and post-treatment patient...
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DERMATOLOGIC CLINICS (Source: Dermatologic Clinics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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present with characteristic findings on the skin, central or peripheral nervous system, and tumors. Neurofibromatosis type 1 is the most common syndrome and is characterized by Caf é-au-lait macules, intertriginous freckling, Lisch nodules, and tumors including neurofibromas, malignant peripheral nerve sheath tumors, and gliomas. Tuberous Sclerosis Complex is characterized by benign hamartomas presenting with hypomelanotic macules, shagreen patches, angiofibromas, confetti le sions and tumors including...
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Skin cancers are relatively rare in patients with skin of color; however, they are an important public health concern because of disparities in patient outcomes. Gaps in skin cancer knowledge exist because of lack of large-scale studies involving people of color, and limitations in data collection methods and skin classification paradigms. Additional research is needed to address questions regarding risk and reasons for disparate skin cancer outcomes in these patients. We summarize the clinical and...
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Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer associated with the Merkel cell Polyomavirus. Its incidence and mortality are increasing. There have been many advances in the last several decades in the etiology, detection, and management of MCC, but much about its natural history and most effective treatment remains unknown. Surgical excision with margins of 1 to 2 cm remains first-line therapy for early-stage MCC, but robust evidence supporting immunotherapy for patients with advanced...
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Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
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This study identifies mechanisms of response to immune checkpoint inhibition in mouse models of triple negative breast cancer. (Source: GEO: Gene Expression Omnibus)
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In this study, we use in vivo zebrafish and mouse models to elucidate the mechanism tumor cells use to extravasate. We found that circulating tumor cells exit the circulation using the recently identified extravasation mechanism, angiopellosis, and do as both clusters and individual cells. We further show that when melanoma and cervical cancer cells utilize this extravasation method to exit as clusters, they exhibit an increased ability to form tumor at distant sites through the expression of unique...
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Contributors : Guillermo Mart ín-Serrano ; Osvaldo Graña-Castro ; Cristina Montero-Conde ; Mercedes RobledoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe explored alternative splicing events upon hsa-miR-139-5p/HNRNPF axis regulation in our cell system using the Multivariate Analysis of Transcript Splicing (rMATS) computational tool (https://doi.org/10.1073/pnas.1419161111). Differential analysis of major splicing outcomes (skipped exon, alternative 5 ’/3’...
1h
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00540 (Source: Molecular Pharmaceutics)
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Contributors : Adeline Berger ; Nicholas J Brady ; David S RickmanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDespite recent advances in highly effective androgen receptor (AR)-directed therapies for the treatment of prostate cancer, a significant subset of patients with resistant disease develop AR-null, androgen signaling-indifferent neuroendocrine prostate cancer (NEPC). A majority of these NEPC cases that arise following anti-androgen therapy...
1h
Contributors : Clifton L Dalgard ; Harvey B PollardSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusWe have previously reported that the cardenolide drug digitoxin blocks TNF α/NFκB-driven proinflammatory signaling. We therefore hypothesized that digitoxin might break the collaborative process between NFκB and TGFβ by also inhibiting expression of TGFBR2. We therefore tested whether TGFβ-driven EMT and resulting metastases would be suppressed. (Source: GEO:...
1h
Contributors : Adeline Berger ; Nicholas J Brady ; David S RickmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusDespite recent advances in highly effective androgen receptor (AR)-directed therapies for the treatment of prostate cancer, a significant subset of patients with resistant disease develop AR-null, androgen signaling-indifferent neuroendocrine prostate cancer (NEPC). A majority of these NEPC cases that arise following anti-androgen...
1h
Contributors : Sven Beyes ; Geoffroy Andrieux ; Monika Schrempp ; David Aicher ; Janna Wenzel ; Melanie Boerries ; Andreas HechtSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAt the molecular level, epithelial-to-mesenchymal transition (EMT) necessitates extensive transcriptional reprogramming which is orchestrated by a small group of gene regulatory proteins. The transcription factor SNAIL1 is a zinc-finger DNA-binding protein and well-known...
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We read with interest the letter to the Editor by Gagat et al. on the ambiguous role of special AT-rich sequence-binding protein-1 (SATB1) expression in malignant tumors (Gagat et al., 2019). The authors make a strong point that miR-155/SATB1 axis contributes to apoptosis resistance not only in malignant T cells, but is also critical in regulating cell death in wide range of cell lines from hematologic malignancies to solid tumors. Among other findings, the authors report that low SATB1 expression...
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Eric A. Gehrie and Edward L. Snyder (Source: Hematology/Oncology Clinics of North America)
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HEMATOLOGY/ONCOLOGY CLINICS OF NORTH AMERICA (Source: Hematology/Oncology Clinics of North America)
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GEORGE P. CANELLOS, MD (Source: Hematology/Oncology Clinics of North America)
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