Contemporary Topics in Radiation Medicine, Part I: Current Issues and Techniques (Source: Hematology/Oncology Clinics of North America)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(Source: OncoTargets and Therapy)
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In this study, the immune infiltrate of 49 primary tumors and 38 corresponding lesions in the omentum (n = 23) and the peritoneum (n = 15) was immunohistochemically analyzed and correlated with clinicopathological factors and platinum-sensitivity. Immune heterogeneity was observed between paired primary and metastatic lesions for all immune cell phenotypes. The stromal immune infiltrate was higher in the omental lesions than in the primary tumors, which was reflected by CD45 (p=0.007), CD3 (p=0.005),...
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This study reviews the literature about CRbCs and analyzes the clinicopathological andmolecular profiles of seven CRbCs characterized by large discohesive cells with abundanteosinophilic cytoplasm, showing hyaline inclusions and large rounded to bean-shaped nuclei. Forcomparison, we included four poorly differentiated medullary carcinomas (PDMCs) with focalaspects mimicking rhabdoid features. Overall survival was poor in both subsets, with 78% ofpatients dying of disease within 2–11 months. The main...
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Authors: Sarah Santiloni Cury Diogo de Moraes Paula Paccielli Freire Grasieli de Oliveira Douglas Venâncio Pereira Marques Geysson Javier Fernandez Maeli Dal-Pai-Silva Érica Nishida Hasimoto Patricia Pintor dos Reis Silvia Regina Rogatto Robson Francisco Carvalho Cachexia is a syndrome characterized by an ongoing loss of skeletal muscle mass associated with poor patient prognosis in non-small cell lung cancer (NSCLC). However, prognostic cachexia biomarkers...
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The authors regret that a funding statement is missing from this article. The Authors also received funding from the National Natural Science Foundation of China (No.71904033). (Source: European Journal of Oncology Nursing)
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We appreciate the interest and comments for our manuscript titled “Impact of KRAS mutation subtype and concurrent pathogenic mutations on non-small cell lung cancer outcomes” [1]. (Source: Lung Cancer)
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Lung cancer is the leading cause of cancer-related deaths worldwide and can be broadly classified into two types: non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). The former represents 85% of all lung cancer [1]. (Source: Lung Cancer)
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Lung cancer is the leading cause of cancer-related death worldwide [1]. In Taiwan, epidermal growth factor receptor (EGFR) mutations are the most common driver mutations and can be found in 55.7% of patients with lung adenocarcinoma [2]. In addition to the discovery of several important driver mutations, a number of agents targeting mutations in genes including EGFR, anaplastic lymphoma kinase (ALK), ROS1, MET, and RET, have been developed, with some demonstrating impressive clinical responses [3...
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Meta-analysis of trial data suggests that in primary cardiovascular disease (CVD) prevention bodyweight modifies low-dose aspirin's effects on colorectal cancer (CRC) and major bleeding. We sought to investigate whether these effects are seen in patients with or without CVD in routine clinical practice by undertaking sub-analyses of data from two cohort studies with nested-case-control analyses. (Source: International Journal of Cardiology)
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This article provides an overview of the most common presentations and their management strategies. (Source: Cardiology Clinics)
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Authors: Peppicelli Ruzzolini Andreucci Bianchini Kontos Yamada Ferrone Calorini Besides playing a crucial role in immune surveillance, human leukocyte antigens (HLA) possess numerous non-immune functions involved in cell communication. In the present study, screening of a panel of HLA class I- and HLA class II-specific monoclonal antibodies (mAbs) for their effects on the metabolism of human melanoma cells showed for the first time that the HLA-B,C-specific...
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Authors: Russi Calice Ruggieri Laurino Rocca Amendola Lapadula Compare Nardone Musto Felice Falco Zoppoli Gastric cancer (GC) is a leading cause of cancer-related deaths in the world. Molecular heterogeneity is a major determinant for the clinical outcomes and an exhaustive tumor classification is currently missing. Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in cancer studies, nevertheless a recently...
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We report a rare case of leiomyosarcoma arising from the left adrenal gland in a 27-year-old male who presented with left side back ache. It was a solid mass of\({9} \times 6.5 \times 7\) cms situated superior to the left kidney. Left adrenalectomy was done and microscopic examination revealed a primary adrenal leiomyosarcoma. (Source: International Cancer Conference Journal)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
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ACS NanoDOI: 10.1021/acsnano.9b01740 (Source: ACS Nano)
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ConclusionIn contrast to traditional therapy, DC-CIK immunotherapy not only shows improved short-term effect, long-term effect and immunologic function, but also reduces mortality and negative immunoregulatory index, and shows mild adverse reactions. This is the first study to evaluate the clinical effect and safety of DC-CIK immunotherapy for PC, and it indicated that DC-CIK immunotherapy may be suitable for patients with advanced PC or intolerance to radiotherapy and chemotherapy. (Source: Cytotherapy)
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Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
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ConclusionsThe toxicokinetic data provided by this study will help forensic and clinical toxicologists to reliably identify these substances in case of abuse and/or intoxication and will allow them a thorough risk assessment. (Source: Forensic Toxicology)
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Viruses, Vol. 11, Pages 785: Combinatorial Avidity Selection of Mosaic Landscape Phages Targeted at Breast Cancer Cells—An Alternative Mechanism of Directed Molecular Evolution Viruses doi: 10.3390/v11090785 Authors: Valery A. Petrenko James W. Gillespie Hai Xu Tiffany O’Dell Laura M. De Plano Low performance of actively targeted nanomedicines required revision of the traditional drug targeting paradigm and stimulated the development of novel phage-programmed, self-navigating...
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. (Source: Cell Cycle)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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. (Source: Cell Cycle)
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ConclusionsGRP78-targeted PET imaging with [68Ga]DOTA-VAP provided an effective approach for the noninvasive accurate classification of TNBC from other breast cancer subtypes comparing with [18F]FDG. GRP78 may be a potential target for the diagnosis and treatment of TNBC. For clinical transformation, efforts should be made to overcome deficiencies of [68Ga]DOTA-VAP such as relative high uptake in normal tissues. (Source: Molecular Imaging and Biology)
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This study was aimed to explore the promotion effect of patient-derived CAFs on the proliferation and migration of prostate cancer cells.Main methodsCAFs were isolated from tumor tissues of PCa patients. The promotion effect of CAFs on the proliferation and migration of PC-3 and LNCaP cells were evaluated in vitro and in vivo. The concentration of TGF-β1 was measured by Luminex assay. The blocking activity of LY2109761 on the promotion effect of CAFs was also evaluated.Key findingsCAFs could significantly...
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Publication date: Available online 25 August 2019Source: Carbohydrate PolymersAuthor(s): Sungchul Shin, Hojung Kwak, Jinho HyunAbstractCarboxymethylated hydrophilic CNF (Hphil-CNF) was modified with methyltrimethoxysilane into hydrophobic CNF (Hphob-CNF) and used as a printing matrix. The Hphil-CNF hydrogel was printed at the surface of the Hphob-CNF hydrogel, forming an immiscible, distinct 3D structure. Fabrication of channel systems in the CNF platform was performed by matrix-assisted 3D printing...
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Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b00024 (Source: Journal of Medicinal Chemistry)
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Authors: Xuan Li Zhang Zhang Song Identifying disease-associated microRNAs (disease miRNAs) contributes to the understanding of disease pathogenesis. Most previous computational biology studies focused on multiple kinds of connecting edges of miRNAs and diseases, including miRNA–miRNA similarities, disease–disease similarities, and miRNA–disease associations. Few methods exploited the node attribute information related to miRNA family and cluster. The previous methods do...
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by Morgan Craig, Kamran Kaveh, Alec Woosley, Andrew S. Brown, David Goldman, Elliot Eton, Ravindra M. Mehta, Andrew Dhawan, Kazuya Arai, M. Mamunur Rahman, Sidi Chen, Martin A. Nowak, Aaron Goldman Understanding intrinsic and acquired resistance is crucial to overcoming cancer chemotherapy failure. While it is well-established that intratumor, subclonal genetic and phenotypic heterogeneity significantly contribute to resistance, it is not fully understood how tumor sub-clones interact with e ach...
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This study has good research value for improving the biological and economic value of tartary buckwheat. (Source: Molecules)
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AbstractAntioxidant based drug preparations are used in the prevention and management of complex diseases which include atherosclerosis, stroke, diabetes, alzheimer ’s disease and cancer. Diabetes mellitus is a metabolic disorder of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this ailment, which may be achieved through the use of oral hypoglycemic drugs such as biguanides, insulin secretagogues, and 𝛼-amyla se and glucosidase inhibitors. Although...
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Authors: Marie-Pier Bergeron-Boucher Jim Oeppen Niels Vilstrup Holm Hanne Melgaard Nielsen Rune Lindahl-Jacobsen Maarten Jan Wensink Large variations in cancer survival have been recorded between populations, e.g., between countries or between regions in a country. To understand the determinants of cancer survival differentials between populations, researchers have often applied regression analysis. We here propose the use of a non-parametric decomposition method to quantify...
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. (Source: Epigenetics)
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ConclusionsFuture studies that examine co-morbid health conditions among African –American women living with HIV should consider the impact of HIV-related stigma on attitudes and beliefs related to co-morbid conditions. (Source: Journal of Racial and Ethnic Health Disparities)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Nature, Published online: 26 August 2019; doi:10.1038/d41586-019-02521-8Two reports examine how a protein complex that adds transcription-repressing marks to histone proteins is potently inhibited by the protein EZHIP during the maturation of sperm and egg cells and in a type of brain cancer. (Source: Nature AOP)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate...
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ConclusionsThe more recent LDLT series compared favorably to our DDLT series in the treatment of secondary liver malignancies. The absence of portal hypertension and the use of smaller left grafts make recipient and donor surgeries safe. The safety of the procedures and lack of interference with the scarce allograft pool are expected to lead to a more frequent use of LDLT in the field of transplant oncology. (Source: Hepatobiliary and Pancreatic Diseases International)MedWorm Message: Have you tried...
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AbstractGenitourinary syndrome of menopause is a condition comprising the atrophic symptoms and signs women may experience in the vulvovaginal and bladder-urethral areas as a result of the loss of sex steroids that occurs with menopause. It is a progressive condition that does not resolve without treatment and can adversely affect a woman ’s quality of life. For a variety of reasons, many symptomatic women do not seek treatment and, of those who do, many are unhappy with their options. Additionally,...
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AbstractIntelligent medical diagnosis and computing system faces many challenges in complex object recognition, large-scale data imaging and real-time diagnosis, such as poor real-time computing, low efficiency of data storage and low recognition rate of lesions. In order to solve the above problems, this paper proposes a medical intelligent computing system and a series of algorithms for the clinical pathology of cervical cancer based on the multi-scale imaging and transfer learning framework. Firstly,...
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Publication date: Available online 25 August 2019Source: Canadian Journal of DiabetesAuthor(s): Sanam Zeib Khan, Nida Ajmal, Rozeena ShaikhAbstractDiabetic Retinopathy (DR) is microvascular complication of retina of eye and regarded as one of the major source of blindness around the globe. It is complex disorder that is characterized by both genetic & environmental factors. Vascular Endothelial Growth Factor (VEGF) gene is one of the main candidate gene for DR; also it is involved in several...
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Publication date: Available online 26 August 2019Source: International Journal of PharmaceuticsAuthor(s): Elisabete Fernandes, Dylan Ferreira, Andreia Peixoto, Rui Freitas, Marta Relvas-Santos, Carlos Palmeira, Gabriela Martins, Anabela Barros, Lúcio Lara Santos, Bruno Sarmento, José Alexandre FerreiraAbstractGastric cancer is the third leading cause of cancer-related death worldwide, with half of patients developing metastasis within 5 years after curative treatment. Moreover, many patients cannot...
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ConclusionrhGH and GnRH analogues therapy, when indicated, though failing to induce catch-up growth, prevented further height loss leading to a FH within the normal range but still below MPH, this latter being statistically significant in children who received craniospinal and TBI. (Source: Journal of Endocrinological Investigation)
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