Nature Cell Biology, Published online: 26 August 2019; doi:10.1038/s41556-019-0373-7Kim et al. demonstrate neutrophil- and macrophage-enriched subtypes in triple-negative breast cancer and how these immune profiles affect therapeutic responses to immune checkpoint blockade.
12h
Nature Cell Biology, Published online: 26 August 2019; doi:10.1038/s41556-019-0386-2Tumours elicit an immune attack that can stifle their growth, but they can also recruit inflammatory immune cells that suppress this response. A new study identifies distinct immune subtypes of triple-negative breast cancer with two different inflammatory cell types: macrophages or neutrophils. The immune subtype dictates the response to immunotherapy.
12h
Nature Cell Biology, Published online: 26 August 2019; doi:10.1038/s41556-019-0377-3Wallroth et al. uncover a mechanism by which protein kinase N activates mTORC1 nutrient signalling at the lysosome by inhibiting PI3KC2-β-mediated PtdIns(3,4)P2 synthesis downstream of mTORC2.
12h
PHOENIX, Ariz. — Aug. 26, 2019 — In just a few weeks this spring, hundreds of Wendy’s restaurants in ten states across the West and Midwest sold Jr. Frosty donation coupons for 835,000 of the mini ice cream treats, helping raise funds for colon cancer research at the Translational Genomics Research Institute (TGen) , an affiliate of City of Hope . The $167,000 in Jr. Frosty coupon sales — $1 for a coupon worth 5 Jr. Frosties — plus the proceeds from an annual golf tournament, enabled the Bernice...
12h
Nature Medicine, Published online: 26 August 2019; doi:10.1038/s41591-019-0575-3Modifiable lifestyle risk factors are able to reduce dementia risk only in people with low genetic risk.
12h
Nature Medicine, Published online: 26 August 2019; doi:10.1038/s41591-019-0547-7Genetic predispositions and lifestyle factors can interact to either confer protection against, or elevate risk for, development of clinical dementia in a prospective cohort of over 6,000 individuals from the population-based Rotterdam Study.
12h
Conditions: Breast Cancer; Non-small Cell Lung Cancer; Prostate Cancer; Ovarian Cancer; Head and Neck Cancer; Gastric Cancer; Esophageal CancerIntervention: Sponsor: Samyang Biopharmaceuticals CorporationNot yet recruiting
12h
Toxins, Vol. 11, Pages 492: Gallic Acid Triggers Iron-Dependent Cell Death with Apoptotic, Ferroptotic, and Necroptotic Features Toxins doi: 10.3390/toxins11090492 Authors: Ho Man Tang Peter Chi Keung Cheung Gallic acid (GA) is a natural anti-cancer compound that can be found in many food sources, including edible mushrooms, fruits, and vegetables. Studies generally attribute the anti-cancer activity of GA to the induction of apoptosis. Here, we reported that GA activated iron-dependent...
12h
Abstract Purpose There is currently no effective noninvasive method for accurate molecular typing of triple negative breast cancer (TNBC) except needle biopsy. Glucoregulated Protein 78 (GRP78) is overexpressed in TNBC cells and tumors which closely related to the invasion, metastasis, and drug resistance of cancer. Meanwhile, it has been verified that VAP peptide bind specifically to GRP78 in vitro and in vivo. In this study, we constructed...
12h
Study in African - American children shows symptom - based adjustment of inhaled corticosteroids is feasible (Source: Pulmonary Medicine News - Doctors Lounge)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
12h
Conditions: Cancer; Cancer Cachexia; Inflammation; Muscular Atrophy Interventions: Other: WB-EMS (Sham-intervention); Other: WB-EMS; Other: Free WB-EMS; Other: Flexi band resistance training Sponsor: University of Erlangen-Nürnberg Medical School Recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps...
12h
Conditions: Childhood Cancer; Survivorship; Sexual Dysfunction Intervention: Other: Interviews Sponsors: University of Colorado, Denver; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
12h
Condition: Classical Hodgkin Lymphoma Interventions: Drug: Camrelizumab; Drug: Epirubicin; Drug: Vincristine; Drug: Dacarbazine Sponsor: Henan Cancer Hospital Not yet recruiting (Source: ClinicalTrials.gov)
12h
Conditions: Breast Cancer; Non-small Cell Lung Cancer; Prostate Cancer; Ovarian Cancer; Head and Neck Cancer; Gastric Cancer; Esophageal Cancer Intervention: Sponsor: Samyang Biopharmaceuticals Corporation Not yet recruiting (Source: ClinicalTrials.gov)
12h
Conditions: Chemotherapy-induced Peripheral Neuropathy; Breast Cancer Female; Gynecologic Cancer Intervention: Device: Acupuncture Sponsors: University of Utah; Annie Budhathoki, DAOM, LAc; Anna Beck, MD; Jeff Anderson, MD, PhD; Lynn Henry, MD Not yet recruiting (Source: ClinicalTrials.gov)
12h
Conditions: Breast Cancer; Ovarian Cancer; Pancreatic Cancer; Prostate Cancer Interventions: Other: Chatbot; Other: Video Education; Other: In Person Genetic Counseling Sponsor: Dana-Farber Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)
12h
Conditions: Fecal Incontinence; Low Anterior Resection Syndrome; Malignant Anal Neoplasm; Malignant Bladder Neoplasm; Malignant Cervical Neoplasm; Malignant Ovarian Neoplasm; Malignant Pelvic Neoplasm; Malignant Prostate Neoplasm; Malignant Uterine Neoplasm; Mali gnant Vaginal Neoplasm; Malignant Vulvar Neoplasm; Rectal Adenocarcinoma; Stage III Rectal Cancer AJCC v8; Stage IIIA Rectal Cancer AJCC v8; Stage IIIB Rectal Cancer AJCC v8; Stage IIIC Rectal Cancer AJCC v8;...
12h
Conditions: Biliary Tract Cancer; Cholangiocarcinoma; Gallbladder Cancer Interventions: Drug: M7824; Drug: Placebo; Drug: Gemcitabine; Drug: Cisplatin Sponsors: EMD Serono Research & Development Institute, Inc.; Merck KGaA, Darmstadt, Germany Not yet recruiting (Source: ClinicalTrials.gov)
12h
Condition: Advanced Malignant Neoplasm Intervention: Drug: KO-539 Sponsor: Kura Oncology, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
12h
Condition: Basal Cell Carcinoma Intervention: Drug: sonidegib Sponsor: Sun Pharmaceutical Industries Limited Recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
12h
Condition: Metastatic Prostate Cancer Intervention: Sponsors: University College, London; Epic Sciences Not yet recruiting (Source: ClinicalTrials.gov)
12h
Condition: Refractory Ventricular Tachycardia Intervention: Procedure: SBRT Sponsors: Centro Cardiologico Monzino; Istituto Europeo di Oncologia Recruiting (Source: ClinicalTrials.gov)
12h
Conditions: Cancer; Kidney Diseases; Heart Failure; Neurologic Disorder; Liver Diseases; Pulmonary Disease; Side Effect; Quality of Life; Physical Disorder Intervention: Sponsor: Rigshospitalet, Denmark Enrolling by invitation (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
12h
Condition: Carcinoma, Hepatocellular Interventions: Device: TACE; Drug: Anlotinib Hydrochloride Sponsor: Zhejiang Cancer Hospital Recruiting (Source: ClinicalTrials.gov)
12h
Condition: Triple Negative Breast Cancer Interventions: Drug: Albumin bound (nab)-paclitaxel combined with carboplatin followed by epirubicin and cyclophosphamide; Drug: paclitaxel combined with carboplatin followed by epirubicin and cyclophosphamide Sponsor: Hebei Medical University Fourth Hospital Recruiting (Source: ClinicalTrials.gov)
12h
Condition: Urothelial Carcinoma Intervention: Drug: Cabozantinib Sponsors: Johannes Gutenberg University Mainz; Interdisciplinary Center Clinical Trials (IZKS), University Medical Center Mainz Not yet recruiting (Source: ClinicalTrials.gov)
12h
Conditions: Radiodermatitis; Injury, Radiation Interventions: Other: Spray skin protector; Other: moisturizer containing in its composition calendula officinalis Sponsor: Instituto Nacional de Cancer, Brazil Not yet recruiting (Source: ClinicalTrials.gov)
12h
Condition: Advanced Hepatocellular Carcinoma Interventions: Dietary Supplement: Oligo Fucoidan; Dietary Supplement: Placebo Sponsor: Hi-Q Marine Biotech International, Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
12h
Conditions: Neoplasms; Neoplasm Malignant Intervention: Other: Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Sponsor: Imperial College London Recruiting (Source: ClinicalTrials.gov)
12h
Condition: Breast Cancer Interventions: Drug: Pyrotinib; Drug: nab-Paclitaxel; Drug: Trastuzumab; Drug: EC chemotherapy; Procedure: Surgery Sponsors: Shanghai Jiao Tong University School of Medicine; Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
12h
Conditions: SBRT; Radical Prostatectomy Intervention: Radiation: SBRT Sponsor: Sunnybrook Health Sciences Centre Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
12h
Conditions: Colo-rectal Cancer; Colon Cancer; Diet Habit Intervention: Other: Walnuts Sponsors: UConn Health; American Institute for Cancer Research; California Walnut Commission; The Jackson Laboratory Recruiting (Source: ClinicalTrials.gov)
12h
Conditions: Pediatric Cancer; Palliative Intervention: Other: Palliative home visit Sponsor: Indonesia University Active, not recruiting (Source: ClinicalTrials.gov)
12h
Condition: Cancer Interventions: Other: Patient-reported outcomes assessment; Other: CTCAE rating; Other: PRO data is displayed Sponsors: Medical University Innsbruck; Complejo Hospitalario de Navarra; Centre Hospitalier Universitaire de Besancon; University of Leeds; VU University Medical Center; The Leeds Teaching Hospitals NHS Trust Not yet recruiting (Source: ClinicalTrials.gov)
12h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου