Condition: Cancer Interventions: Other: Patient-reported outcomes assessment; Other: CTCAE rating; Other: PRO data is displayed Sponsors: Medical University Innsbruck; Complejo Hospitalario de Navarra; Centre Hospitalier Universitaire de Besancon; University of Leeds; VU University Medical Center; The Leeds Teaching Hospitals NHS Trust Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Ewing Sarcoma Interventions: Drug: Trabectedin 1 MG [Yondelis]; Drug: Irinotecan; Diagnostic Test: tumor biopsy; Other: 3'-Deoxy-3'-18F Fluorothymidine (18F-FLT) Imaging Sponsors: Sarcoma Alliance for Research through Collaboration; Janssen Scientific Affairs, LLC; National Institutes of Health (NIH); National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Parkinson Disease Intervention: Diagnostic Test: Blood Assayed for CTCs Sponsor: NYU Langone Health Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Oral Cavity Cancer; Mouth Neoplasm; Precancerous Conditions Intervention: Drug: Sintilimab Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Condition: Gastric Cancer Interventions: Drug: Sintilimab; Drug: Oxaliplatin; Drug: Capecitabine Sponsor: First Affiliated Hospital of Zhejiang University Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Multiple Myeloma; Relapsed Refractory Multiple Myeloma Interventions: Drug: Elotuzumab, pomalidomide, dexamethasone; Drug: Anti-LAG-3 Monoclonal Antibody BMS-986016, pomalidomide, dexamethasone; Drug: Anti-TIGIT Monoclonal Antibody BMS-986207, pomalidomide, dexamethasone Sponsors: Multiple Myeloma Research Consortium; Bristol-Myers Squibb Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Ovarian Cancer Interventions: Drug: Ropivacaine; Drug: Saline Solution Sponsors: Karolinska Institutet; Karolinska University Hospital Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Head and Neck Cancer Intervention: Drug: TAK-981 Sponsors: Presage Biosciences; Takeda Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Gynaecological Cancers Interventions: Drug: AZD6738; Drug: Olaparib Sponsors: Institute of Cancer Research, United Kingdom; Cancer Research UK; AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Conditions: Breast Cancer; Quality of Life; Physical Activity Intervention: Behavioral: Exercise Intervention Sponsors: University of California, San Diego; Haus of Volta Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Small Intestinal NET; Carcinoid Heart Disease Interventions: Drug: Telotristat Ethyl; Drug: Lanreotide Sponsors: European Organisation for Research and Treatment of Cancer - EORTC; Ipsen Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Condition: Breast Neoplasms Interventions: Procedure: PET-CT examination; Procedure: Peripheral blood detection Sponsor: Shengjing Hospital Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Child; Determinants of Health; Qualitative Research; Cancer Intervention: Sponsors: University Hospital, Clermont-Ferrand; Université d'Auvergne Recruiting (Source: ClinicalTrials.gov)
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Conditions: Cancer; Cancer Cachexia; Inflammation Interventions: Other: Resistance Training; Other: WB-EMS; Other: High-intensity interval training (HIIT); Other: Combined HIIT and Resistance Training (Combi) Sponsor: University of Erlangen-Nürnberg Medical School Recruiting (Source: ClinicalTrials.gov)
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Conditions: Gastric Adenocarcinoma; Cancer Metastatic; Chemotherapy Effect Interventions: Drug: Pressurized intraperitoneal aerosol chemotherapy (PIPAC); Drug: Standard chemotherapy Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Rectal Cancer; Colorectal Cancer; Colon Cancer; Colo-rectal Cancer; Sarcopenia; Sarcopenic Obesity; Advanced Cancer; Recurrent Rectal Cancer Intervention: Device: Microstim 2v2 Stimulator Sponsor: London North West Healthcare NHS Trust Recruiting (Source: ClinicalTrials.gov)
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Condition: Lung Cancer Interventions: Other: Bronchoscopy; Other: Research Procedures Sponsors: NYU Langone Health; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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BackgroundThe 15q11.2 deletion is frequently identified in the neurodevelopmental clinic. Case–control studies have associated the 15q11.2 deletion with neurodevelopmental disorders, and clinical case series have attempted to delineate a microdeletion syndrome with considerable phenotypic variability. The literature on this deletion is extensive and confusing, which is a challenge for genetic counselling. The aim of this study was to estimate the effect size of the 15q11.2 deletion and quantify its...
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Abstract Purpose Autoimmune thyroid events (ATEs) are common side effects after alemtuzumab (ALZ) therapy in patients with multiple sclerosis (MS). Our purpose was to reach more robust evidence on prevalence and outcome of the spectrum of alemtuzumab-induced autoimmune thyroid events in patients with multiple sclerosis. Methods PubMed and Scopus were systematically...
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Abstract Purpose Growth hormone deficiency (GHD) is the most prevalent hypothalamic–pituitary (HP) disorder found in childhood cancer survivors (CCS). The published studies assessing GHD in CCS concluded that recombinant human GH (rhGH) does not restore final height (FH) to that predicted from mid-parental height (MPH). Thus, wider analyses on final height outcomes after rhGH in CCS are needed. ...
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Publication date: November 2019Source: Brain and Language, Volume 198Author(s): Nicola Del Maschio, Davide Fedeli, Simone Sulpizio, Jubin AbutalebiAbstractNeuroimaging evidence suggests that bilingualism may act as a source of neural plasticity. However, prior work has mostly focused on bilingualism-induced alterations in gray matter volume and white matter tract microstructure, with additional effects related to other neurostructural indices that might have remained undetected. The degree of cortical...
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Study in African - American children shows symptom - based adjustment of inhaled corticosteroids is feasible (Source: Pulmonary Medicine News - Doctors Lounge)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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We have learned that earlier this year, 18 patients in our student clinic may have been treated with dental equipment that was not properly sterilized. These patients are being notified directly by letter. More information is available at the following link. The post Notice to our patients appeared first on UW School of Dentistry.
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A 20-year-old woman was referred to our hospital due to the presence of a nasopharyngeal tumour, throat pain, left nasal obstruction and bleeding in the sputum. Indirect endoscopic examination revealed a mass on the left pharyngeal wall (figure 1). A biopsy of the nasopharyngeal tumour indicated the presence of inflammatory cells (figure 2). She was previously treated for uteritis at another gynaecological clinic after her last menstruation. Immunohistochemical study of the nasopharyngeal biopsy...
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Abstract Multiple myeloma (MM) is a plasma cell neoplasm which is characterized by widespread genetic heterogeneity. The MMs with t(4;14) translocation exhibit poor outcomes. However, the mechanism underlying has not been well dissected. Our study aimed to identify key microRNA involved in the oncogenesis of t(4;14) MM. We here performed an integrated analysis to screen important regulators in the pathogenesis of t(4;14) MM. We used real-time quantitative polymerase chain reaction...
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Genes, Vol. 10, Pages 646: Patterns, Mechanisms and Genetics of Speciation in Reptiles and Amphibians Genes doi: 10.3390/genes10090646 Authors: Wollenberg Valero Marshall Bastiaans Caccone Camargo Morando Niemiller Pabijan Russello Sinervo Werneck Sites Jr. Wiens Steinfartz In this contribution, the aspects of reptile and amphibian speciation that emerged from research performed over the past decade are reviewed. First, this study...
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Genes, Vol. 10, Pages 645: Molecular Characterization and Functional Study of Insulin-Like Androgenic Gland Hormone Gene in the Red Swamp Crayfish, Procambarus clarkii Genes doi: 10.3390/genes10090645 Authors: Linlin Shi Shuxin Han Jiamin Fei Long Zhang Jonathan W Ray Weimin Wang Yanhe Li The androgenic gland (AG) is a male-specific endocrine organ that controls the primary and secondary sexual characteristics in male crustaceans. More evidence indicates that the insulin-like...
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Genes, Vol. 10, Pages 644: Identification of TCP13 as an Upstream Regulator of ATHB12 during Leaf Development Genes doi: 10.3390/genes10090644 Authors: Yoon-Sun Hur Jiyoung Kim Sunghan Kim Ora Son Woo-Young Kim Gyung-Tae Kim Masaru Ohme-Takagi Choong-Ill Cheon Leaves grow by distinct phases controlled by gene regulatory networks including many transcription factors. Arabidopsis thaliana homeobox 12 (ATHB12) promotes leaf growth especially during the cell expansion...
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PHOENIX, Ariz. — Aug. 26, 2019 — In just a few weeks this spring, hundreds of Wendy’s restaurants in ten states across the West and Midwest sold Jr. Frosty donation coupons for 835,000 of the mini ice cream treats, helping raise funds for colon cancer research at the Translational Genomics Research Institute (TGen) , an affiliate of City of Hope . The $167,000 in Jr. Frosty coupon sales — $1 for a coupon worth 5 Jr. Frosties — plus the proceeds from an annual golf tournament, enabled the Bernice...
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JCDD, Vol. 6, Pages 31: Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd6030031 Authors: Ozkan Ozcelik Yildiz Budak Calcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental andgenetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying frommild valve thickening to severe valve calcification and stenosis....
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Journal of Medicinal Food, Ahead of Print.
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Abstract Purpose Neurogenic orthostatic hypotension is a prominent and disabling manifestation of autonomic dysfunction in patients with hereditary transthyretin (TTR) amyloidosis affecting an estimated 40–60% of patients, and reducing their quality of life. We reviewed the epidemiology and pathophysiology of neurogenic orthostatic hypotension in patients with hereditary TTR amyloidosis, summarize non-pharmacologic and pharmacological...
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Abstract Purpose To review the management of gastrointestinal symptoms in patients with hereditary transthyretin amyloidosis, discussing diagnostic evaluations, assessment of disease progression and therapeutic strategies that could be implemented in routine practice. Methods Literature review. Key search terms included “gastrointestinal symptoms”, “autonomic...
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Abstract Amyloidosis describes a family of related disease states associated with the extracellular tissue deposition of fibrils composed of low-molecular-weight subunits of a variety of proteins circulating as constituents of plasma. Depending on the disease subtype, fibrillar deposits in a several organs including the heart, kidney, liver, and peripheral nerves cause organ dysfunction and associated morbidity and mortality. The most common amyloid fibril deposits associated with...
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Abstract Purpose We aimed to review the current knowledge on the epidemiology, diagnosis, and management of urinary and sexual dysfunction in patients with TTR amyloidosis (ATTR). Methods We performed a review of the literature, screening for randomized controlled trials, prospective and retrospective series, position papers, and guidelines on urinary and...
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Publication date: Available online 26 August 2019Source: Gait & PostureAuthor(s): Sizhong Wang, Roy T.H. Cheung
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