My CACM blog post this month (see link here) is a retraction of the term “language-independent” in our work on the FCS1 and SCS1: There is no language independence here. The FCS1 and SCS1 are multi-lingual which is a remarkable achievement. We might also call them pseudcode-based assessments, which is how they can be multi-lingual, but since a pseudocode-based test isn’t necessarily validated across other languages, “multi-lingual” is a stronger claim than “pseudocode-based.” We do not cover all of...
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CONCLUSION: In this study, elective neck dissection did not appear to alter survival outcomes or complication rates during salvage laryngectomy. Given the small but significant risk of occult neck metastases, its true value remains unclear. PMID: 31434593 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any...
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CONCLUSIONS: Knowledge of these physiological and pathological conditions in the oral cavity of the older people is essential for early diagnosis and preventive and therapeutic measures when necessary. PMID: 31433386 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
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CONCLUSIONS: This is the first time that oral exfoliative cytology is validated in a study of the alterations of the expression of microRNAs in OLD. The alteration of miR-146a and miR-7 compared to controls was validated. These microRNAs are associated with both inflammatory and carcinogenic phenomena that are involved in the etiopathogenesis of this potentially malignant oral disorder. PMID: 31433395 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
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Publication date: 1 November 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 183Author(s): Jian-Tao Lin, Hua Chen, Dan Wang, Liang Xiong, Jia-Zhu Li, Gui-hong Chen, Guang-Bin ChenAbstractThe nucleus is one of the most important cellular organelles. Chitosan-grafted poly-(N-3-carbobenzyloxy-lysine) (CCL) decorated with human immunodeficiency virus-1 transactivator of transcription (TAT) can co-deliver p53 and doxorubicin into the nucleus simultaneously, such that their antitumor functions...
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The objective of this study was to evaluate the anticancer activity on cancer cell models of a drug delivery system consisting of poly (l-lactic) acid/Pluronic® F-127 (PLLA/PF127) loaded with the new N-butylpyridoquinoxaline 1,4-dioxide (NBPQD) or 2-amino-3-cyano-6-methylquinoxaline 1,4-dioxide (ACMQD) that was synthesized using an electrospinning process compared to free NBPQD and ACMQD. PLLA/PF127-NBPQD and PLLA/PF127-ACMQD nanofibers were prepared, and their shape, size, Fourier-transform infrared...
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Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC05859A, CommunicationGuangping Sun, Zhimei He, Min Hao, Zuqiang Xu, Xiao-Yu Hu, Jun-Jie Zhu, Leyong Wang Bifunctional supramolecular prodrug nanocarriers have been successfully constructed for efficient anticancer drug delivery and tumor diagnosis and therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest...
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The drug-delivery system mimics dietary fatty acids and tricks tumor cells into taking up the conjugate (Source: Chemical and Engineering News)
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Publication date: Available online 22 August 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Jaber Beik, Mohamadreza Asadi, Samideh Khoei, Sophie Laurent, Ziaeddin Abed, Mehri Mirrahimi, Ali Farashahi, Reza Hashemian, Habib Ghaznavi, Ali Shakeri-ZadehAbstractDespite the immense benefits of nanoparticle-assisted photothermal therapy (NPTT) in cancer treatment, the limited method and device for detecting temperature during heat operation significantly hinder its overall...
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Publication date: Available online 22 August 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Stanislav V. Rodkin, Vera D. Kovaleva, Elena V. Berezhnaya, Maria A. Neginskaya, Anatoly B. UzdenskyAbstractPhotodynamic therapy (PDT) is used for killing of malignant cells in tumors including brain cancer. It can also damage normal neurons and glial cells. Nitric oxide (NO) is known to control PDT-induced cell death. To study the mechanisms that regulate NO generation in photosensitized...
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ConclusionsePLND is more likely to predict undetectable PSA at third month after radical prostatectomy, irrespective of disease characteristics.ResumenObjetivosAnalizar la probabilidad de PSA indetectable (<0.01 ng/mL) tras(DGLP-ampliada) versus disección estándar de los ganglios linfáticos pélvicos (DGLP-estándar) en pacientes pN+.Materiales y métodosSe realizó investigación en la base de datos institucional de cáncer de próstata para obtener información sobre pacientes que se sometieron a PR...
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ConclusionsThis study demonstrated the association of high NLR value with T1 tumor, high grade, multiple tumor,>3 cm tumor and EORTC high risk group in NMIBC patients. There was also a positive correlation between NLR and EORTC recurrence and progression scores.ResumenObjetivosEl objetivo del presente estudio es evaluar la correlación entre la puntuación de riesgo de la Organización Europea para la Investigación y Tratamiento del Cáncer (EORTC, por sus siglas en inglés) y el índice neutrófilo/linfocito...
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ConclusionsInfiltration of both fats increases the risk of overall and local relapse in pT3a RCC. In the same way, it is associated with a lower cancer-specific survival and should be considered as a factor of poor prognosis.ResumenIntroducción y objetivosEl objetivo de este estudio es evaluar las tasas de sobrevida global (OS), la sobrevida específica del cáncer (CSS), la sobrevida libre de recaída global (RFS), la sobrevida libre de recaída local (LRFS) y la sobrevida libre de recaída a distancia...
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ConclusionsMen with mHNPC gain treatment benefit from ADT + AAP irrespective of risk stratification for “risk” or “volume”.Patient summaryCoadministration of abiraterone acetate and prednisolone with androgen deprivation therapy (ADT) is associated with prolonged overall survival and disease control, compared with ADT alone, in all men with metastatic disease starting hormone therapy for the first time. (Source: European Urology)MedWorm Message: Have you tried our new medical search engine? More...
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This article describes a framework that covers the significant stages of conceptual development and campaign design to promote oral cancer awareness in Germany. Solution: The challenges of the development, as well as evaluation of an oral cancer awareness campaign are shared in this article. Four key stages of the campaign are defined: (1) mass media, (2) target groups, (3) health care professionals, and (4) epidemiology. For each section, the following levels of assessment are proposed: (a) campaign...
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AbstractIn the U.S. there is an epidemic of sexually transmitted diseases (STIs). One of the most prevalent STIs is the Human Papillomavirus (HPV). Certain high risk strains of HPV are believed to cause virtually all cervical cancers, over 90% of anal cancers, 70% of oropharyngeal cancers, and the majority of anal genital warts. HPV is preventable through vaccination and is available for both men and women. Several educational interventions have been employed, yet baseline awareness and knowledge...
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AbstractRecruitment in research can be challenging, particularly for racial/ethnic minorities and immigrants. There remains a dearth of research identifying the health and sociocultural needs of these populations related to recruitment. To describe our experiences and lessons learned in recruiting African immigrant (AI) women for the AfroPap study, a community-based study examining correlates of cervical cancer screening behaviors. We developed several recruitment strategies in collaboration with...
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ConclusionUltrasound guided infiltration allows accurate placement of large volume of diluted local anaesthetic solution safely and provides effective anaesthesia. (Source: The Surgeon)
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CONCLUSION: LINC00665 was involved in cell viability, apoptosis, and autophagy in HCC via miR-186-5p/MAP4K3 axis, which may provide a new approach for HCC treatment. PMID: 31433582 [PubMed - in process] (Source: Yonsei Medical Journal)
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CONCLUSION: LESS surgery using an angiocatheter needle, with leaving only a small postoperative scar, was deemed feasible for the management of huge ovarian cysts. PMID: 31433584 [PubMed - in process] (Source: Yonsei Medical Journal)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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CONCLUSION: These results support a prominent role for RLX in scar remodeling and suggest that gel/Ad-RLX may have therapeutic effects on scar formation. PMID: 31433583 [PubMed - in process] (Source: Yonsei Medical Journal)
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Publication date: Available online 22 August 2019Source: Pathology - Research and PracticeAuthor(s): Weihong Shi, Qian Wang, Yonghua Bian, Yanxin Fan, Yang Zhou, Tingting Feng, Zhouxiao Li, Xiufeng CaoAbstractEsophageal squamous cell carcinoma (ESCC) is one of the major global health problems, especially in Asia. Long non-coding RNAs (lncRNAs) have been increasingly identified and characterized in almost every aspect of biology, especially in cancer biology. This research desires to explore the regulatory...
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Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Shohei Matsuo, Emiko Tomita, Kenjiro Fukuhara, Akinori Akashi, Yoshitane TsukamotoAbstractWe experienced two cases of poorly differentiated synovial sarcoma (PDSS) arising from the chest wall. The first 42-year-old female patient was asymptomatic, but incidental chest roentgenogram showed a chest wall mass about 5-cm in maximal diameter with extrapleural sign. The chest wall mass was removed at other hospital....
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Meningiomas are one of the most frequently encountered tumor types in the spinal cord, accounting for 20-25% of all spine tumors. Treatment strategies may include observation (active surveillance), surgical excision, radiotherapy/radiosurgery or combination of modalities. Surgery continues to be the most frequently utilized treatment modality, but radiotherapy is also an available treatment option most commonly reserved for high grade or recurrent lesions. Moreover, recent studies have reported on...
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Despite our inability to accurately predict survival in cancer patients, a life expectancy of at least three months is historically considered necessary for patients to be considered for surgical treatment of spinal metastases. With a wealth of new surgical and radiation technologies available, why would someone with incapacitating mechanical pain and/or progressive neurological deficit be denied treatment because their life expectancy is believed to be less than 3 months? (Source: The Spine Journal)
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As the survival of cancer patients increases, so has the incidence of metastatic spine disease (MSD). While surgical stabilization has demonstrated improved outcomes for some patients, there is also increased perioperative morbidity. The Spine Instability Neoplastic Score (SINS) assigns values to clinical and radiographic findings, providing recommendations for surgical stabilization. Scores12 are best treated with surgical stabilization. (Source: The Spine Journal)
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The spine is a common site of metastasis from non-small cell lung cancer (NSCLC), a disease hallmarked by heterogeneity in molecular alterations. Traditional spine radiation treatment (RT) with conventionally fractionated external beam radiation therapy (cEBRT) is associated with high local failure (LF) rates in patients surviving more than 12 months. Treatment with advanced techniques including stereotactic body radiation therapy (SBRT) significantly reduces LF. We hypothesized that specific genomic...
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ConclusionAlthough history and clinical examination provided few elements, diagnosis was made based on imaging and histopathological examination. (Source: Neurological Sciences)
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ConclusionsSeveral metabolites of biological interest were discovered from this proof-of-principle dataset. Augmenting these findings is essential to accelerate the development of urinary metabolic markers in CCA. (Source: Journal of Clinical and Experimental Hepatology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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ConclusionThe present meta-analysis demonstrated that IBD was associated with an increased diagnosis of PC. In addition, large scale prospective studies are essential to determine whether IBD increase the PC risk. (Source: Clinics and Research in Hepatology and Gastroenterology)
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Gastrointestinal polyps are mucosal overgrowths that, if unchecked, can undergo malignant transformation. Although relatively uncommon in the pediatric age group, they can be the harbingers of multiorgan cancer risk and require close management and follow-up. Additionally, as many polyposis syndromes are inherited, appropriate genetic testing and management of relatives is vital for the health of the entire family. In this review, we discuss both common and uncommon childhood gastrointestinal polyposis...
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Publication date: Available online 22 August 2019Source: Pharmacological ResearchAuthor(s): Chuanhong Luo, Xiaorong Xu, Xichuan Wei, Wuwen Feng, Haozhou Huang, Haiyan Liu, Runchun Xu, Junzhi Lin, Li Han, Dingkun ZhangAbstractIt is a common phenomenon that people are in a sub-health condition and facing “unexplained fatigue”, which seriously affects their health, work efficiency and quality of life. Meanwhile, fatigue is also a common symptom of many serious diseases such as HIV/AIDS, cancer, and...
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ConclusionsOverall, both molecular and phenotypic assays showed that CCE has potential in the treatment of breast cancer, especially for the treatment of breast cancer metastasis. CCE-derived sesquiterpene lactone substances are the foundation for the tumour inhibitory effect of CCE.Graphical abstract (Source: Phytomedicine)
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CONCLUSIONS These findings reveal MNX1 as a novel oncogene of cervical cancer and indicate MNX1 is a promising therapeutic and prognostic biomarker. PMID: 31436258 [PubMed - in process] (Source: Medical Science Monitor)
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CONCLUSIONS This study was the first to demonstrate that SUCO was overexpressed in HCC-tissues, and that high expression of SUCO was significantly related to poor overall survival in HCC patients. SUCO might be a potential diagnostic biomarker for HCC patients, which promotes the tumorigenesis and progression of HCC. PMID: 31434866 [PubMed - in process] (Source: Medical Science Monitor)
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In conclusion, this study demonstrated that Salidroside possessed anti-GC effects through regulating miR-99a/IGF1R axis and inhibiting MAPK/ERK and PI3K/AKT pathways. PMID: 31432697 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)
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Conclusion: UCA1-relieved OGD-aroused H9c2 cell injury might be achieved via declining miR-122 and then promoting AKT/mTOR pathway and suppressing JNK/p38MAPK pathway. PMID: 31432699 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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In this study, we developed dequalinium (DQA) modified paclitaxel plus ligustrazine micelles to destroy vasculogenic mimicry (VM) channels and inhibit tumour metastasis. In vitro assays showed that the targeting micelles with centralized particle size distribution showed not only vigoroso cytotoxicity on A549 cells but also strong inhibition on VM channels and tumour metastasis. Mechanism studies indicated that the DQA modified paclitaxel plus ligustrazine micelles could down-regulate the expressions...
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Patients with metastatic colorectal cancer who have a BRAF mutation have improved survival after treatment with three targeted therapies instead of standard chemotherapy, results from a phase III trial have shown. (Source: Clinical Pharmacist)
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