IJMS, Vol. 20, Pages 4176: FOXG1-Related Syndrome: From Clinical to Molecular Genetics and Pathogenic Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms20174176 Authors: Lee-Chin Wong Shekhar Singh Hsin-Pei Wang Chia-Jui Hsu Su-Ching Hu Wang-Tso Lee Individuals with mutations in forkhead box G1 (FOXG1) belong to a distinct clinical entity, termed “FOXG1-related encephalopathy”. There are two clinical phenotypes/syndromes identified...
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IJMS, Vol. 20, Pages 4177: Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription International Journal of Molecular Sciences doi: 10.3390/ijms20174177 Authors: Ming-Chun Hsieh Hsien-Yu Peng Yu-Cheng Ho Cheng-Yuan Lai Jen-Kun Cheng Gin-Den Chen Tzer-Bin Lin Diverse transcriptional controls in the dorsal horn have been observed in pain hypersensitivity. However, the understanding of the...
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IJMS, Vol. 20, Pages 4175: FKRR-MVSF: A Fuzzy Kernel Ridge Regression Model for Identifying DNA-Binding Proteins by Multi-View Sequence Features via Chou’s Five-Step Rule International Journal of Molecular Sciences doi: 10.3390/ijms20174175 Authors: Yi Zou Yijie Ding Jijun Tang Fei Guo Li Peng DNA-binding proteins play an important role in cell metabolism. In biological laboratories, the detection methods of DNA-binding proteins includes yeast one-hybrid methods, bacterial...
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IJMS, Vol. 20, Pages 4173: Biopolymeric Films of Amphiphilic Derivatives of Chitosan: A Physicochemical Characterization and Antifungal Study International Journal of Molecular Sciences doi: 10.3390/ijms20174173 Authors: Anna Carolina Rodrigues Santos Alves Aline Margarete Furuyama Lima Marcio José Tiera Vera Aparecida de Oliveira Tiera The chemical modification of chitosan has been an active subject of research in order to improve the physicochemical and antifungal properties...
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IJMS, Vol. 20, Pages 4174: Identification of a Potential Founder Effect of a Novel PDZD7 Variant Involved in Moderate-to-Severe Sensorineural Hearing Loss in Koreans International Journal of Molecular Sciences doi: 10.3390/ijms20174174 Authors: Sang-Yeon Lee Jin Hee Han Bong Jik Kim Seung Ha Oh Seungmin Lee Doo-Yi Oh Byung Yoon Choi PDZD7, a PDZ domain-containing scaffold protein, is critical for the organization of Usher syndrome type 2 (USH2) interactome. Recently,...
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IJMS, Vol. 20, Pages 4172: Structural Analysis and Dynamic Processes of the Transmembrane Segment Inside Different Micellar Environments—Implications for the TM4 Fragment of the Bilitranslocase Protein International Journal of Molecular Sciences doi: 10.3390/ijms20174172 Authors: Kosma Szutkowski Emilia Sikorska Iulia Bakanovych Amrita Roy Choudhury Andrej Perdih Stefan Jurga Marjana Novič Igor Zhukov The transmembrane (TM) proteins are gateways for molecular transport...
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IJMS, Vol. 20, Pages 4171: Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions International Journal of Molecular Sciences doi: 10.3390/ijms20174171 Authors: Tadayuki Shimada Shin Yasuda Hiroko Sugiura Kanato Yamagata Syntenin is an adaptor-like molecule that has two adjacent tandem postsynaptic density protein 95/Discs large protein/Zonula occludens 1 (PDZ) domains. The PDZ domains of syntenin recognize multiple peptide motifs with low to moderate affinity....
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IJMS, Vol. 20, Pages 4170: Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses International Journal of Molecular Sciences doi: 10.3390/ijms20174170 Authors: Yue Gao Zhengying Bian Wenyao Xue Qianwen Li Yu Zeng Yimeng Wang Lei Tang Tiejun Tang Xiangdong Gao Wei Guo Interleukin (IL)-23 is considered an effective therapeutic target for the treatment of psoriasis because...
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IJMS, Vol. 20, Pages 4168: Wnt Binding Affinity Prediction for Putative Frizzled-Type Cysteine-Rich Domains International Journal of Molecular Sciences doi: 10.3390/ijms20174168 Authors: Mark Agostino Sebastian Öther-Gee Pohl Several proteins other than the frizzled receptors (Fzd) and the secreted Frizzled-related proteins (sFRP) contain Fzd-type cysteine-rich domains (CRD). We have termed these domains “putative Fzd-type CRDs”, as the relevance of Wnt signalling...
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IJMS, Vol. 20, Pages 4167: Use of the Secreted Proteome of Trametes versicolor for Controlling the Cereal Pathogen Fusarium langsethiae International Journal of Molecular Sciences doi: 10.3390/ijms20174167 Authors: Alessia Parroni Agnese Bellabarba Marzia Beccaccioli Marzia Scarpari Massimo Reverberi Alessandro Infantino Fusarium langsethiae is amongst the most recently discovered pathogens of small grains cereals. F. langsethiae is the main producer, in Europe, of T2...
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IJMS, Vol. 20, Pages 4169: Epigenetics and Neurological Disorders in ART International Journal of Molecular Sciences doi: 10.3390/ijms20174169 Authors: Marina La Rovere Marica Franzago Liborio Stuppia About 1–4% of children are currently generated by Assisted Reproductive Technologies (ART) in developed countries. These babies show only a slightly increased risk of neonatal malformations. However, follow-up studies have suggested a higher susceptibility to multifactorial,...
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IJMS, Vol. 20, Pages 4166: Identifying Common Features in the Activation of Melanocortin-2 Receptors: Studies on the Xenopus tropicalis Melanocortin-2 Receptor International Journal of Molecular Sciences doi: 10.3390/ijms20174166 Authors: Perry E. Davis Emily C. Wilkinson Robert M. Dores The interaction between the pituitary hormone, adrenocorticotropin (ACTH), and melanocortin-2 receptor (MC2R) orthologs involves the H6 F7 R8 W9 and R/K15 K16 R17 R18 motifs in ACTH making contact...
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IJMS, Vol. 20, Pages 4164: β-Glucose-1,6-Bisphosphate Stabilizes Pathological Phophomannomutase2 Mutants In Vitro and Represents a Lead Compound to Develop Pharmacological Chaperones for the Most Common Disorder of Glycosylation, PMM2-CDG International Journal of Molecular Sciences doi: 10.3390/ijms20174164 Authors: Maria Monticelli Ludovica Liguori Mariateresa Allocca Giuseppina Andreotti Maria Vittoria Cubellis A large number of mutations causing PMM2-CDG, which is the...
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IJMS, Vol. 20, Pages 4163: Sex, Age, and Bodyweight as Determinants of Extracellular DNA in the Plasma of Mice: A Cross-Sectional Study International Journal of Molecular Sciences doi: 10.3390/ijms20174163 Authors: Ľubica Janovičová Barbora Konečná Lenka Vokálová Lucia Lauková Barbora Vlková Peter Celec Extracellular DNA (ecDNA) is studied as a possible biomarker, but also as a trigger of the immune responses important for the pathogenesis of several diseases. Extracellular...
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IJMS, Vol. 20, Pages 4165: Reaction of 1-propanol with Ozone in Aqueous Media International Journal of Molecular Sciences doi: 10.3390/ijms20174165 Authors: Erika Reisz Agnes Tekle-Röttering Sergej Naumov Winfried Schmidt Torsten C. Schmidt The main aim of this work is to substantiate the mechanism of 1-propanol oxidation by ozone in aqueous solution when the substrate is present in large excess. Further goals are assessment of the products, their formation yields as well...
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IJMS, Vol. 20, Pages 4159: Discovery of Novel Angiotensin-Converting Enzyme Inhibitory Peptides from Todarodes pacificus and Their Inhibitory Mechanism: In Silico and In Vitro Studies International Journal of Molecular Sciences doi: 10.3390/ijms20174159 Authors: Dingyi Yu Cong Wang Yufeng Song Junxiang Zhu Xiaojun Zhang In order to rapidly and efficiently excavate antihypertensive ingredients in Todarodes pacificus, its myosin heavy chain was hydrolyzed in silico and the...
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IJMS, Vol. 20, Pages 4158: Tumor Metabolism as a Regulator of Tumor–Host Interactions in the B-Cell Lymphoma Microenvironment—Fueling Progression and Novel Brakes for Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20174158 Authors: Anna C. Beielstein Christian P. Pallasch Tumor metabolism and its specific alterations have become an integral part of understanding functional alterations leading to malignant transformation and maintaining cancer progression. Here,...
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IJMS, Vol. 20, Pages 4161: Glucobrassicin Metabolites Ameliorate the Development of Portal Hypertension and Cirrhosis in Bile Duct-Ligated Rats International Journal of Molecular Sciences doi: 10.3390/ijms20174161 Authors: Ting Chang Hsin-Ling Ho Shao-Jung Hsu Ching-Chih Chang Ming-Hung Tsai Teh-Ia Huo Hui-Chun Huang Fa-Yauh Lee Ming-Chih Hou Shou-Dong Lee Patients suffering from liver cirrhosis are often complicated with the formation of portosystemic collateral...
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IJMS, Vol. 20, Pages 4160: Rett Syndrome and Other Neurodevelopmental Disorders Share Common Changes in Gut Microbial Community: A Descriptive Review International Journal of Molecular Sciences doi: 10.3390/ijms20174160 Authors: Elisa Borghi Aglaia Vignoli In this narrative review, we summarize recent pieces of evidence of the role of microbiota alterations in Rett syndrome (RTT). Neurological problems are prominent features of the syndrome, but the pathogenic mechanisms modulating...
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IJMS, Vol. 20, Pages 4162: SILAC-Based Quantification of TGFBR2-Regulated Protein Expression in Extracellular Vesicles of Microsatellite Unstable Colorectal Cancers International Journal of Molecular Sciences doi: 10.3390/ijms20174162 Authors: Fabia Fricke Malwina Michalak Uwe Warnken Ingrid Hausser Martina Schnölzer Jürgen Kopitz Johannes Gebert Microsatellite unstable (MSI) colorectal cancers (CRCs) are characterized by mutational inactivation of Transforming Growth...
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IJMS, Vol. 20, Pages 4157: Local Growth Hormone Therapy for Pressure Ulcer Healing on a Human Skin Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms20174157 Authors: Lara Cristóbal Nerea de los Reyes Miguel A. Ortega Melchor Álvarez-Mon Natalio García-Honduvilla Julia Buján Andrés A. Maldonado The growth hormone is involved in skin homeostasis and wound healing. We hypothesize whether it is possible to improve pressure ulcer (PU) healing by locally...
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IJMS, Vol. 20, Pages 4156: The Role of SATB1 in Tumour Progression and Metastasis International Journal of Molecular Sciences doi: 10.3390/ijms20174156 Authors: Glatzel-Plucińska Piotrowska Dzięgiel Podhorska-Okołów Carcinogenesis is a long-drawn, multistep process, in which metastatic spread is an unequivocal hallmark of a poor prognosis. The progression and dissemination of epithelial cancers is commonly thought to rely on the epidermal-mesenchymal transition (EMT) process....
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IJMS, Vol. 20, Pages 4155: Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20174155 Authors: Sally Temraz Farah Nassar Rihab Nasr Maya Charafeddine Deborah Mukherji Ali Shamseddine Research has been driven towards finding therapy predictive biomarkers for colorectal cancer (CRC) with a special interest in studying the gut microbiome. Gut microbiome acts not only as a barrier to prevent...
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IJMS, Vol. 20, Pages 4154: Role of Cancer Stem Cells in Cholangiocarcinoma and Therapeutic Implications International Journal of Molecular Sciences doi: 10.3390/ijms20174154 Authors: Hsing-Ju Wu Pei-Yi Chu Cholangiocarcinoma (CCA) is the second most common type of liver cancer, and is highly aggressive with very poor prognosis. CCA is classified into intrahepatic cholangiocarcinoma (iCCA) and extra-hepatic cholangiocarcinoma (eCCA), which is further stratified into perihilar (pCCA)...
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IJMS, Vol. 20, Pages 4151: Formation of α-Farnesene in Tea (Camellia sinensis) Leaves Induced by Herbivore-Derived Wounding and Its Effect on Neighboring Tea Plants International Journal of Molecular Sciences doi: 10.3390/ijms20174151 Authors: Xuewen Wang Lanting Zeng Yinyin Liao Jianlong Li Jinchi Tang Ziyin Yang Herbivore-induced plant volatiles (HIPVs) play important ecological roles in defense against stresses. In contrast to model plants, reports on HIPV formation...
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IJMS, Vol. 20, Pages 4152: Diagnostic and Prognostic Role of Blood and Cerebrospinal Fluid and Blood Neurofilaments in Amyotrophic Lateral Sclerosis: A Review of the Literature International Journal of Molecular Sciences doi: 10.3390/ijms20174152 Authors: Delia Gagliardi Megi Meneri Domenica Saccomanno Nereo Bresolin Giacomo Pietro Comi Stefania Corti Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting upper and lower motor neurons (MNs)...
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IJMS, Vol. 20, Pages 4153: ERK1,2 Signalling Pathway along the Nephron and Its Role in Acid-base and Electrolytes Balance International Journal of Molecular Sciences doi: 10.3390/ijms20174153 Authors: Giovanna Capolongo Yoko Suzumoto Mariavittoria D’Acierno Mariadelina Simeoni Giovambattista Capasso Miriam Zacchia Mitogen-activated protein kinases (MAPKs) are intracellular molecules regulating a wide range of cellular functions, including proliferation, differentiation,...
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IJMS, Vol. 20, Pages 4149: Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment
IJMS, Vol. 20, Pages 4149: Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment International Journal of Molecular Sciences doi: 10.3390/ijms20174149 Authors: Vo Van Giau Eva Bagyinszky Seong Soo A. An Mild cognitive impairment (MCI) is characterized by a level of cognitive impairment that is lower than normal for a person’s age, but a higher function than that that observed in a demented person. MCI represents a transitional state between normal...
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IJMS, Vol. 20, Pages 4150: Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies International Journal of Molecular Sciences doi: 10.3390/ijms20174150 Authors: Dina C. Simes Carla S. B. Viegas Nuna Araújo Catarina Marreiros Vitamin K is a multifunctional micronutrient implicated in age-related diseases such as cardiovascular diseases, osteoarthritis and osteoporosis. Although vitamin K-dependent proteins (VKDPs) are described...
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IJMS, Vol. 20, Pages 4148: Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity International Journal of Molecular Sciences doi: 10.3390/ijms20174148 Authors: Toshiaki Matsui Endang Nuryadi Shuichiro Komatsu Yuka Hirota Atsushi Shibata Takahiro Oike Takashi Nakano Photon radiation therapy is a major curative treatment for cancer. However, the lack of robust predictive biomarkers for radiosensitivity precludes personalized radiation therapy....
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IJMS, Vol. 20, Pages 4147: Radical Stress Is More Cytotoxic in the Nucleus than in Other Organelles International Journal of Molecular Sciences doi: 10.3390/ijms20174147 Authors: Laurent M. Paardekooper Ellen van Vroonhoven Martin ter Beest Geert van den Bogaart Cells are exposed to reactive oxygen species (ROS) as a by-product of mitochondrial metabolism, especially under hypoxia. ROS are also enzymatically generated at the plasma membrane during inflammation. Radicals cause...
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IJMS, Vol. 20, Pages 4146: Oral Bacteria and Intestinal Dysbiosis in Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20174146 Authors: Ioannis Koliarakis Ippokratis Messaritakis Taxiarchis Konstantinos Nikolouzakis George Hamilos John Souglakos John Tsiaoussis The human organism coexists with its microbiota in a symbiotic relationship. These polymicrobial communities are involved in many crucial functions, such as immunity, protection against...
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IJMS, Vol. 20, Pages 4145: The Clinical Link between Human Intestinal Microbiota and Systemic Cancer Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20174145 Authors: Romy Aarnoutse Janine Ziemons John Penders Sander S. Rensen Judith de Vos-Geelen Marjolein L. Smidt Clinical interest in the human intestinal microbiota has increased considerably. However, an overview of clinical studies investigating the link between the human intestinal microbiota...
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IJMS, Vol. 20, Pages 4144: Cytosolic Copper Binding by a Bacterial Storage Protein and Interplay with Copper Efflux International Journal of Molecular Sciences doi: 10.3390/ijms20174144 Authors: Jaeick Lee Christopher Dennison Escherichia coli has a well-characterized copper (Cu) transporting ATPase (CopA) that removes this potentially toxic metal ion from the cytosol. Growth of the strain lacking CopA (ΔcopA) is inhibited above 0.5 mM Cu, whilst a similar effect does not...
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IJMS, Vol. 20, Pages 4143: Nuclear Disposition of Alien Chromosome Introgressions into Wheat and Rye Using 3D-FISH International Journal of Molecular Sciences doi: 10.3390/ijms20174143 Authors: Veronika Koláčková Kateřina Perničková Jan Vrána Martin Duchoslav Glyn Jenkins Dylan Phillips Edina Turkosi Olga Šamajová Michaela Sedlářová Jozef Šamaj Jaroslav Doležel David Kopecký During interphase, the chromosomes of eukaryotes decondense and they occupy distinct...
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IJMS, Vol. 20, Pages 4142: Molecular-Level Interactions between Engineered Materials and Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174142 Authors: Yoon-ha Jang Xuelin Jin Prabakaran Shankar Jung Heon Lee Kyubong Jo Kwang-il Lim Various recent experimental observations indicate that growing cells on engineered materials can alter their physiology, function, and fate. This finding suggests that better molecular-level understanding of the interactions...
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IJMS, Vol. 20, Pages 4140: Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity International Journal of Molecular Sciences doi: 10.3390/ijms20174140 Authors: Yuki Narita Kana Hamamura Mami Kashiyama Sara Utsumi Yutaka Kakizoe Yuki Kondo Yoichi Ishitsuka Hirofumi Jono Tetsumi Irie Masashi Mukoyama Hideyuki Saito Daisuke Kadowaki Sumio Hirata Kenichiro Kitamura The interplay between oxidative stress, inflammation,...
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IJMS, Vol. 20, Pages 4139: Development of Substrate Degradation Enzyme Therapy for Mucopolysaccharidosis IVA Murine Model International Journal of Molecular Sciences doi: 10.3390/ijms20174139 Authors: Kazuki Sawamoto Shunji Tomatsu Mucopolysaccharidosis IVA (MPS IVA) is caused by a deficiency of the lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS). Conventional enzyme replacement therapy (ERT) is approved for MPS IVA. However, the fact that the infused enzyme cannot...
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