Meat consumption has been postulated to increase the risk of breast cancer, but this association has not been consistently seen. We examined the association between consumption of different types of meat, meat mutagens and incident invasive breast cancer. Information on consumption of different meat categories and meat cooking practice behaviors was obtained from 42,012 Sister Study participants who completed a Block 1998 Food Frequency Questionnaire at enrollment (2003–2009) and satisfied eligibility...
Publication date: Available online 7 August 2019Source: Surgical Oncology Clinics of North AmericaAuthor(s): Sebastian Mondaca, Hooman Yarmohammadi, Nancy E. Kemeny
Cancers, Vol. 11, Pages 1132: HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target Cancers doi: 10.3390/cancers11081132 Authors: Souri Wierenga Mulder Jochemsen Jager Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and gives rise to metastases in 50% of cases. The presence of an inflammatory phenotype is a well-known risk factor for the development of metastases. This inflammatory phenotype...
Cancers, Vol. 11, Pages 1130: MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation Cancers doi: 10.3390/cancers11081130 Authors: Daozhi Xu Peixin Dong Ying Xiong Junming Yue Kei Ihira Yosuke Konno Noriko Kobayashi Yukiharu Todo Hidemichi Watari MicroRNA-361-5p (miR-361) expression frequently decreases or is lost in different types of cancers, and contributes to tumor suppression by repressing the expression of...
Cancers, Vol. 11, Pages 1129: High Level Expression of MHC-II in HPV+ Head and Neck Cancers Suggests that Tumor Epithelial Cells Serve an Important Role as Accessory Antigen Presenting Cells Cancers doi: 10.3390/cancers11081129 Authors: Steven F. Gameiro Farhad Ghasemi John W. Barrett Anthony C. Nichols Joe S. Mymryk High-risk human papillomaviruses (HPVs) are responsible for a subset of head and neck squamous cell carcinomas (HNSCC). Expression of class II major histocompatibility...
Cancers, Vol. 11, Pages 1131: Isoliquiritigenin Suppresses E2-Induced Uterine Leiomyoma Growth through the Modulation of Cell Death Program and the Repression of ECM Accumulation Cancers doi: 10.3390/cancers11081131 Authors: Po-Han Lin Hsiang-Lin Kung Hsin-Yuan Chen Ko-Chieh Huang Shih-Min Hsia Uterine leiomyomas, also known as fibroids, are common and prevalent in women of reproductive age. In this study, the effect of Isoliquiritigenin (ISL), a licorice flavonoid, on the...
Cancers, Vol. 11, Pages 1128: CSCs in Breast Cancer—One Size Does Not Fit All: Therapeutic Advances in Targeting Heterogeneous Epithelial and Mesenchymal CSCs Cancers doi: 10.3390/cancers11081128 Authors: Andrew Sulaiman Sarah McGarry Xianghui Han Sheng Liu Lisheng Wang Unlike other breast cancer subtypes, triple-negative breast cancer (TNBC) has no specific targets and is characterized as one of the most aggressive subtypes of breast cancer that disproportionately accounts...
Cancers, Vol. 11, Pages 1127: Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma? Cancers doi: 10.3390/cancers11081127 Authors: Christiaan van Weeghel Annemijn P. A. Wierenga Mieke Versluis Thorbald van Hall Pieter A. van der Velden Wilma G. M. Kroes Ulrich Pfeffer Gregorius P. M. Luyten Martine J. Jager Inflammation, characterized by high numbers of infiltrating leukocytes and a high HLA Class I expression, is associated...
Cancers, Vol. 11, Pages 1126: The Hedgehog Signaling Pathway: A Viable Target in Breast Cancer? Cancers doi: 10.3390/cancers11081126 Authors: Priyanka Bhateja Mathew Cherian Sarmila Majumder Bhuvaneswari Ramaswamy The hedgehog (Hh) pathway plays a key role in embryonic development and stem cell programs. Deregulation of the Hh pathway is a key driver of basal cell carcinoma, and therapeutic targeting led to approval of Hh inhibitor, vismodegib, in the management of this cancer....
Cancers, Vol. 11, Pages 1125: Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference Cancers doi: 10.3390/cancers11081125 Authors: Sara Charmsaz Denis Collins Antoinette Perry Maria Prencipe While conventional cancer treatments, such as surgery, radiotherapy and chemotherapy, have been combined for decades in an effort to treat cancer patients, the emergence of novel fields of cancer research have led to a renewed interest in combining conventional...
RNA kissing complexes are essential for genomic RNA dimerization and regulation of gene expression, and their structures and stability are critical to their biological functions. In this work, we employed our previously developed coarse-grained model with an implicit structure-based electrostatic potential to predict 3D structures and stability of RNA kissing complexes in salt solutions. For extensive RNA kissing complexes, our model shows great reliability in predicting 3D structures from their...
TCF3, also known as E2A, is a well-studied transcription factor that plays an important role in stem cell maintenance and hematopoietic development. The TCF3 gene encodes two related proteins, E12 and E47, which arise from mutually exclusive alternative splicing (MEAS). Since these two proteins have different DNA binding and dimerization domains, this AS event must be strictly regulated to ensure proper isoform ratios. Previously, we found that heterogeneous nuclear ribonucleoprotein (hnRNP) H1/F...
Epithelial ovarian cancer (EOC) is the malignant tumor of the female reproductive system with the highest fatality rate. Tolerance of chemotherapeutic drugs like cisplatin (DDP) occurring in very early stage i...
Accumulated evidences have demonstrated that long non-coding RNAs (lncRNAs) are dysregulated and correlate with the pathophysiological basis of malignant tumors. The objective of this research is to uncover th...
Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression and biological role in KIRC remained unc...
Abstract Translational multidisciplinary research is important for the CDRH's efforts for utilizing real‐world data (RWD) to enhance predictive evaluation of medical device performance in patient subpopulations. As part of our efforts for developing new RWD‐based evidentiary approaches, including in silico discovery of device‐related risk predictors and biomarkers, this study aims to characterize the sex/race‐related trends in hip replacement outcomes and identify corresponding candidate SNPs. Adverse...
Abstract As with other psychiatric disorders, development of drugs to treat binge eating disorder (BED) has been hampered by high placebo response and dropout rates in randomized controlled trials (RCTs). Though not approved for use in BED, several RCTs have suggested that topiramate is efficacious for BED in obese individuals. Using data from a positive investigator‐initiated RCT of topiramate in 61 obese individuals with BED, the objective of the present study is (1) develop a quantitative disease‐drug‐trial...
Abstract Objective Surgical procedures intended to treat breast cancer or reduce risk of developing the disease typically result in changes to appearance and scarring of the breast area, and any donor sites. The longer‐term impact of these changes on body image and quality of life are well documented, but research in this field has failed to explore women's initial experiences of their appearance after surgery. This study used a qualitative approach to gain insight and better understand the experiences...
Purpose: Paclitaxel is an integral component of primary therapy for breast and epithelial ovarian cancers, but less than half of these cancers respond to the drug. Enhancing the response to primary therapy with paclitaxel could improve outcomes for women with both diseases.Experimental Design: Twelve kinases that regulate metabolism were depleted in multiple ovarian and breast cancer cell lines to determine whether they regulate sensitivity to paclitaxel in Sulforhodamine B assays. The effects of...
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