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Τετάρτη 7 Αυγούστου 2019


Gene expression of TMEM178, which encodes a negative regulator of NFATc1, decreases with the progression of asthma severity
In two independent microarray studies involving primary airway epithelial cells, the relative gene expression of TMEM178 decreases with the progression of asthma severity. Our manuscript creates a paradigm for fu...
Allergy
2h
A practical 16-day Desensitization Protocol in Lenalidomide induced Non-immediate Hypersensitivity Reactions
Desensitization in immediate type hypersensitivity reactions (HRs) due to chemotherapeutics is well described and standardized for many drugs. However, there are no standardized protocols in non-immediate HRs.
Annals of Allergy, Asthma & Immunology
7h
The Many Flavors of Pineapple Reactions
Hypersensitivity reactions to fruit, particularly apples, stone fruits and bananas, are commonly reported.1 One fruit less frequently described in the literature causes adverse reactions in many patients: pineapple (Ananas comosus). Pineapple is best known in developed countries for its sweet and tangy coalesced berries, but its anti-inflammatory properties and enzymatic activity have been used for centuries.2 Despite its pleasant taste and putative salutary effects, pineapple has been implicated...
Annals of Allergy, Asthma & Immunology
7h
Utility of measuring tryptase levels in children and young adults
Tryptase is produced primarily by mast cells. Mast cell degranulation results in release of tryptase and anaphylaxis may result in elevated tryptase levels, with return to normal levels over a few hours.1 Persistent or episodic elevation of tryptase levels can be indicative of increased body mast cell burden or mast cell activation, typically seen in mastocytosis and mast cell activation disorder (MCAD).2 Elevated serum tryptase levels represent a significant risk factor for severe anaphylaxis to...
Annals of Allergy, Asthma & Immunology
7h
Superficial Allergic Lymphangitis with a Cutaneous Recall Reaction to a Mosquito Bite
While the major morbidity from mosquito bites is from transmission of infections, several types of clinical hypersensitivity reactions have been described, mediated through both non-immune and a variety of immune mechanisms including IgE, IgG, immune complex and T cell1 The most common reactions are local cutaneous including both minor immediate reactions and more disturbing large local reactions. Delayed local reactions may persist for days to weeks and include large firm painful induration or even...
Annals of Allergy, Asthma & Immunology
7h
Drug-Induced Severe Cutaneous Adverse Reactions (SCARs): Determine the Cause and Prevention.
Drug-induced hypersensitivity reactions are of major medical concern. Approximately 45% of all the adverse drug reactions are manifested in the skin, which occur in 2%-3% hospitalized patients upon drug administration1. Drug hypersensitivity reactions can be categorized into immediate reactions and delayed reactions. Immediate reactions occur within minutes or hours of drug exposure 2. The manifestations of immediate-type reactions range from pruritus, urticaria, angioedema to anaphylaxis. The delayed-type...
Annals of Allergy, Asthma & Immunology
7h
Early Pubertal Maturation and Risk of Childhood Asthma: A Mendelian Randomization and Longitudinal Study
Abstract Background Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this longitudinal study, we investigated the causal relationship between pubertal maturation and asthma through Mendelian randomization (MR) and explored the joint effect of overweightness and early pubertal maturation on asthma. Methods We used data from the Taiwan Children Health Study with longitudinal follow‐ups of 2991 children aged 11–17 years....
Allergy
20h
Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development
Abstract Background miRNAs are master regulators of signalling pathways critically involved in asthma and are transferred between cells in extracellular vesicles (EV). We aimed to investigate if the miRNA content of EV secreted by primary normal human bronchial epithelial cells (NHBE) is altered upon asthma development. Methods NHBE cells were cultured at air‐liquid interface and treated with Interleukin (IL)‐13 to induce an asthma‐like phenotype. EV isolations by precipitation from basal...
Allergy
20h
Colony stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma
Abstract Background A new approach targeting aeroallergen sensing in the early events of mucosal immunity could have greater benefit. The CSF1‐CSF1R pathway has a critical role in trafficking allergens to regional lymph nodes through activating dendritic cells. Intervention in this pathway could prevent allergen sensitization and subsequent Th2 allergic inflammation. Objective To examine the therapeutic effectiveness of CSF1 and CSF1R inhibition for blocking the dendritic cell function...
Allergy
20h
Associations of Th2, Th17, Treg cells and IgA+ memory B cells with atopic disease in children: the Generation R Study
Abstract Background New insights into immune cells could contribute to treatment and monitoring of atopic disease. Because non‐genetic factors shape the human immune system, we here studied these immune cells in a large cohort with atopic children with adjustment for prenatal and postnatal confounders. Methods Information on atopic dermatitis, inhalant and food allergic sensitization, asthma lung function scores were obtained from 855 10‐year old children within the Generation R cohort....
Allergy
20h
A modified oral food challenge in children with food protein induced enterocolitis syndrome
Abstract Acute food protein induced enterocolitis syndrome (FPIES) is a non‐IgE mediated food allergy that typically presented with repetitive protracted vomiting that begins 1 to 4 hours after ingestion of the culprit food [1]. OFC is extremely useful for determining whether FPIES has been outgrown 12 to 18 months after the last episode. According to the International Guidelines [1], the OFC protocol entails the administering of the challenge food at a dose of 0.06 to 0.6 grams per kilogram of...
Clinical & Experimental Allergy
20h
Issue Information
Clinical & Experimental Allergy
20h
Forthcoming meetings
Clinical & Experimental Allergy
20h
T cell responses, diagnosing peanut allergy and group clinic consultations
Clinical & Experimental Allergy
20h
Cover Image
The cover image is based on the Original Article Hsa_circ_0005519 increases IL‐13/IL‐6 by regulating hsa‐let‐7a‐5p in CD4+ T cells to affect asthma by Zhenli Huang et al, DOI: 10.1111/cea.13445.
Clinical & Experimental Allergy
20h
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Clinical & Experimental Allergy
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