In two independent microarray studies involving primary airway epithelial cells, the relative gene expression of TMEM178 decreases with the progression of asthma severity. Our manuscript creates a paradigm for fu...
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Desensitization in immediate type hypersensitivity reactions (HRs) due to chemotherapeutics is well described and standardized for many drugs. However, there are no standardized protocols in non-immediate HRs.
Hypersensitivity reactions to fruit, particularly apples, stone fruits and bananas, are commonly reported.1 One fruit less frequently described in the literature causes adverse reactions in many patients: pineapple (Ananas comosus). Pineapple is best known in developed countries for its sweet and tangy coalesced berries, but its anti-inflammatory properties and enzymatic activity have been used for centuries.2 Despite its pleasant taste and putative salutary effects, pineapple has been implicated...
Tryptase is produced primarily by mast cells. Mast cell degranulation results in release of tryptase and anaphylaxis may result in elevated tryptase levels, with return to normal levels over a few hours.1 Persistent or episodic elevation of tryptase levels can be indicative of increased body mast cell burden or mast cell activation, typically seen in mastocytosis and mast cell activation disorder (MCAD).2 Elevated serum tryptase levels represent a significant risk factor for severe anaphylaxis to...
While the major morbidity from mosquito bites is from transmission of infections, several types of clinical hypersensitivity reactions have been described, mediated through both non-immune and a variety of immune mechanisms including IgE, IgG, immune complex and T cell1 The most common reactions are local cutaneous including both minor immediate reactions and more disturbing large local reactions. Delayed local reactions may persist for days to weeks and include large firm painful induration or even...
Drug-induced hypersensitivity reactions are of major medical concern. Approximately 45% of all the adverse drug reactions are manifested in the skin, which occur in 2%-3% hospitalized patients upon drug administration1. Drug hypersensitivity reactions can be categorized into immediate reactions and delayed reactions. Immediate reactions occur within minutes or hours of drug exposure 2. The manifestations of immediate-type reactions range from pruritus, urticaria, angioedema to anaphylaxis. The delayed-type...
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Abstract Background Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this longitudinal study, we investigated the causal relationship between pubertal maturation and asthma through Mendelian randomization (MR) and explored the joint effect of overweightness and early pubertal maturation on asthma. Methods We used data from the Taiwan Children Health Study with longitudinal follow‐ups of 2991 children aged 11–17 years....
Abstract Background miRNAs are master regulators of signalling pathways critically involved in asthma and are transferred between cells in extracellular vesicles (EV). We aimed to investigate if the miRNA content of EV secreted by primary normal human bronchial epithelial cells (NHBE) is altered upon asthma development. Methods NHBE cells were cultured at air‐liquid interface and treated with Interleukin (IL)‐13 to induce an asthma‐like phenotype. EV isolations by precipitation from basal...
Abstract Background A new approach targeting aeroallergen sensing in the early events of mucosal immunity could have greater benefit. The CSF1‐CSF1R pathway has a critical role in trafficking allergens to regional lymph nodes through activating dendritic cells. Intervention in this pathway could prevent allergen sensitization and subsequent Th2 allergic inflammation. Objective To examine the therapeutic effectiveness of CSF1 and CSF1R inhibition for blocking the dendritic cell function...
Abstract Background New insights into immune cells could contribute to treatment and monitoring of atopic disease. Because non‐genetic factors shape the human immune system, we here studied these immune cells in a large cohort with atopic children with adjustment for prenatal and postnatal confounders. Methods Information on atopic dermatitis, inhalant and food allergic sensitization, asthma lung function scores were obtained from 855 10‐year old children within the Generation R cohort....
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Abstract Acute food protein induced enterocolitis syndrome (FPIES) is a non‐IgE mediated food allergy that typically presented with repetitive protracted vomiting that begins 1 to 4 hours after ingestion of the culprit food [1]. OFC is extremely useful for determining whether FPIES has been outgrown 12 to 18 months after the last episode. According to the International Guidelines [1], the OFC protocol entails the administering of the challenge food at a dose of 0.06 to 0.6 grams per kilogram of...
The cover image is based on the Original Article Hsa_circ_0005519 increases IL‐13/IL‐6 by regulating hsa‐let‐7a‐5p in CD4+ T cells to affect asthma by Zhenli Huang et al, DOI: 10.1111/cea.13445.
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