Related ArticlesProbing the Colorectal Cancer Incidence in Lebanon: an 11-Year Epidemiological Study. J Gastrointest Cancer. 2019 Aug 17;: Authors: Khachfe HH, Salhab HA, Fares MY, Khachfe HM Abstract BACKGROUND AND OBJECTIVES: Lebanon has witnessed an increase in the rates of several cancer sub-types over the past couple of years. The aim of our study is to investigate the incidence rates of colorectal cancer over 11 years in Lebanon and compare them...
Related ArticlesSafety of Combined Yttrium-90 Radioembolization and Immune Checkpoint Inhibitor Immunotherapy for Hepatocellular Carcinoma. J Vasc Interv Radiol. 2019 Aug 14;: Authors: Zhan C, Ruohoniemi D, Shanbhogue KP, Wei J, Welling TH, Gu P, Park JS, Dagher NN, Taslakian B, Hickey RM Abstract PURPOSE: To investigate the safety of yttrium-90 radioembolization in combination with checkpoint inhibitor immunotherapy for the treatment of hepatocellular...
Related ArticlesCost-utility analysis of genetic polymorphism universal screening in colorectal cancer prevention by detection of high-risk individuals. Dig Liver Dis. 2019 Aug 14;: Authors: Pereira C, Areia M, Dinis-Ribeiro M Abstract BACKGROUND: In the past 15 years numerous studies have been published on the involvement of low-penetrance susceptibility genes on the risk for developing colorectal cancer (CRC). AIM: To perform an economic analysis...
Related ArticlesImpact of combined selective internal radiation therapy and sorafenib on survival in advanced hepatocellular carcinoma. J Hepatol. 2019 Aug 14;: Authors: Ricke J, Klumpen HJ, Amthauer H, Bargellini I, Bartenstein P, de Toni E, Gasbarrini A, Pech M, Peck-Radosavljevic M, Popovič P, Rosmorduc O, Schott E, Seidensticker M, Verslype C, Sangro B, Malfertheiner P Abstract BACKGROUND: Sorafenib is the recommended treatment for patients with...
Pathophysiologic Characterization of a Novel Rabbit Model of Biliary Tract Infection-Derived Sepsis.
Related ArticlesPathophysiologic Characterization of a Novel Rabbit Model of Biliary Tract Infection-Derived Sepsis. Sci Rep. 2019 Aug 16;9(1):11947 Authors: Hu L, Chai Y, Xi R, Zhu H, Wang Y, Ren F, Zhang J, Xue Z, Zhang H, Wu R, Lv Y Abstract Biliary tract infection (BTI)-derived sepsis remains a serious problem with significant morbidity and mortality in the modern era of critical care management. Current animal models of BTI have relied mostly on...
Related ArticlesBodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies. Lancet Haematol. 2019 Aug 13;: Authors: Monagle P, Lensing AWA, Thelen K, Martinelli I, Male C, Santamaría A, Samochatova E, Kumar R, Holzhauer S, Saracco P, Simioni P, Robertson J, Grangl G, Halton J, Connor P, Young G, Molinari AC, Nowak-Göttl U, Kenet G, Kapsa S, Willmann S, Pap AF, Becka M, Twomey T, Beyer-Westendorf...
Related ArticlesRole of Cyclin-Dependent Kinase Inhibitors in Endometrial Cancer. Int J Mol Sci. 2019 May 12;20(9): Authors: Giannone G, Tuninetti V, Ghisoni E, Genta S, Scotto G, Mittica G, Valabrega G Abstract Endometrial Cancer (EC) is an important cause of death in women worldwide. Despite early diagnosis and optimal treatment of localized disease, relapsed patients have few therapeutic options because after first line therapy, currently no standard...
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Related ArticlesFurther isolation and identification of anti-diabetic principles from root bark of Myrianthus arboreus P. Beauv.: The ethyl acetate fraction contains bioactive phenolic compounds that improve liver cell glucose homeostasis. J Ethnopharmacol. 2019 Aug 15;:112167 Authors: Kasangana PB, Eid HM, Nachar A, Stevanovic T, Haddad PS Abstract ETHNOPHARMACOLOGICAL RELEVANCE: We recently reported that ethanol extract of Myrianthus arboreus P. Beauv....
Related ArticlesVasoconstrictor stimulus determines the functional contribution of myoendothelial feedback to mesenteric arterial tone. J Physiol. 2018 04 01;596(7):1181-1197 Authors: Wei R, Lunn SE, Tam R, Gust SL, Classen B, Kerr PM, Plane F Abstract KEY POINTS: In isolated resistance arteries, endothelial modulation of vasoconstrictor responses to α1 -adrenoceptor agonists occurs via a process termed myoendothelial feedback: localized inositol...
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Related ArticlesDifferential response of SHH-expressing adult medulloblastomas to the sonic hedgehog inhibitor vismodegib: whole-genome analysis. Cancer Biol Ther. 2019 Aug 18;:1-5 Authors: Lou E, Nelson AC, Kool M Abstract Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is more common in children than in adults. In the past decade, advances in understanding the molecular drivers of medulloblastoma have identified...
Related ArticlesOccurrence of acute myeloid leukemia in hydroxyurea-treated sickle cell disease patient. Cancer Biol Ther. 2019 Aug 18;:1-9 Authors: Regan S, Yang X, Finnberg NK, El-Deiry WS, Pu JJ Abstract Hydroxyurea (HU) has been widely used in sickle cell disease. Its potential long-term risk for carcinogenesis or leukemogenic risk remains undefined. Here, we report a 26 y old African-American female with Sickle Cell Disease (SCD) who developed refractory/relapsed...
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Related ArticlesPhenobarbitone versus phenytoin monotherapy for epilepsy: an individual participant data review. Cochrane Database Syst Rev. 2019 Jul 31;7:CD002217 Authors: Nevitt SJ, Tudur Smith C, Marson AG Abstract BACKGROUND: This is an update of a Cochrane Review first published in 2001, and last updated in 2013. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition...
Related ArticlesFelbamate add-on therapy for drug-resistant focal epilepsy. Cochrane Database Syst Rev. 2019 Aug 01;8:CD008295 Authors: Shi LL, Bresnahan R, Martin-McGill KJ, Dong J, Ni H, Geng J Abstract BACKGROUND: This is an updated version of the Cochrane Review previously published in 2017.Epilepsy is a chronic and disabling neurological disorder, affecting approximately 1% of the population. Up to 30% of people with epilepsy have seizures that...
Related ArticlesBi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy. Am J Hum Genet. 2019 Aug 07;: Authors: van Karnebeek CDM, Ramos RJ, Wen XY, Tarailo-Graovac M, Gleeson JG, Skrypnyk C, Brand-Arzamendi K, Karbassi F, Issa MY, van der Lee R, Drögemöller BI, Koster J, Rousseau J, Campeau PM, Wang Y, Cao F, Li M, Ruiter J, Ciapaite J, Kluijtmans LAJ, Willemsen MAAP, Jans JJ, Ross CJ, Wintjes LT, Rodenburg RJ, Huigen MCDG, Jia Z,...
Related ArticlesPrognostic factors in epileptic encephalopathies at onset in the first 2 years of life: The experience of a tertiary healthcare center in Italy. Epilepsy Behav. 2019 Aug 14;99:106465 Authors: Pellino G, Chiavarino F, Fiumana E, Boni A, Russo A, Faggioli R Abstract INTRODUCTION: The aim of this retrospective cohort study was to identify some prognostic factors in anamnestic/clinical/instrumental data at the onset of epileptic encephalopathy...
Related ArticlesDevelopment of a patient-reported outcome measure for psychotherapeutic interventions in people with seizures: A mixed methods study. Epilepsy Behav. 2019 Aug 14;99:106464 Authors: Michaelis R, Meyer S, Reuber M, Schöne C Abstract BACKGROUND: Generic or even disease-specific quality of life measures are unlikely to be equally responsive to different epilepsy treatment modalities, such as pharmacotherapy, surgery, or psychotherapy. The...
Related ArticlesThe anesthetic drug treatment of refractory and super-refractory status epilepticus around the world: Results from a global audit. Epilepsy Behav. 2019 Aug 13;:106449 Authors: Ferlisi M, Hocker S, Trinka E, Shorvon S, International Steering Committee of the StEp Audit Abstract Multinational and multicenter registries collecting cases of refractory and super-refractory status epilepticus help to understand what the current practice in...
Related ArticlesElectrographic seizure burden and outcomes following pediatric status epilepticus. Epilepsy Behav. 2019 Aug 13;:106409 Authors: Lalgudi Ganesan S, Hahn CD Abstract Pediatric status epilepticus carries a substantial risk for morbidity and mortality, but the relationship between seizure burden, treatment, and outcome remains incompletely understood. This review summarizes the evidence linking seizure burden and outcomes among critically...
Related ArticlesSuccessful treatment of seizure disorder by evaluating phenobarbital clearance in a paediatric patient undergoing continuous haemodiafiltration. J Clin Pharm Ther. 2019 Jun;44(3):479-481 Authors: Suzuki T, Suzuki T, Takatsuka H, Yamazaki S, Ishii I Abstract WHAT IS KNOWN AND OBJECTIVE: Determination of phenobarbital (PB) dosing during continuous haemodiafiltration (CHDF) requires evaluation of both the patient's own clearance and CHDF...
Related ArticlesHLA-B*5701 and HLA-B*5801 in an Indian patient with anti-epileptics induced cutaneous adverse drug reactions. Eur J Clin Pharmacol. 2019 Apr;75(4):599-601 Authors: Manoharan A, Kumar AS, Sreedevi A, Sathishkannan AD, Gaddam BK PMID: 30607451 [PubMed - indexed for MEDLINE]
Related ArticlesCo-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy. Can J Neurol Sci. 2019 01;46(1):64-70 Authors: Datta AN, Wallbank L, Wong PKH Abstract OBJECTIVE: Benign epilepsy of childhood with central temporal spikes (BECTS) and absence epilepsy are common epilepsy syndromes in children with similar age of onset and favorable prognosis. However, the co-existence of the electrocardiogram (EEG) findings of rolandic...
Related Articlesh-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex. Neuron. 2018 12 05;100(5):1194-1208.e5 Authors: Kalmbach BE, Buchin A, Long B, Close J, Nandi A, Miller JA, Bakken TE, Hodge RD, Chong P, de Frates R, Dai K, Maltzer Z, Nicovich PR, Keene CD, Silbergeld DL, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Koch C, Anastassiou CA, Lein ES, Ting JT Abstract Gene...
Related ArticlesDoes epilepsy increase the risk of needing to return to the hospital due to mood disorders? Neurology. 2018 08 28;91(9):e890-e893 Authors: McCaskill M, Karceski S PMID: 30150276 [PubMed - indexed for MEDLINE]
Related ArticlesMedical and Research Consent Decision-Making Capacity in Patients with Alzheimer's Disease: A Systematic Review. J Alzheimers Dis. 2018;65(3):917-930 Authors: van Duinkerken E, Farme J, Landeira-Fernandez J, Dourado MC, Laks J, Mograbi DC Abstract The capacity to make decisions is an important feature of daily living, which is closely linked to proper cognitive functioning. In conditions in which cognitive functioning becomes compromised,...
Related ArticlesIncreased risk of hospital admission for mood disorders following admission for epilepsy. Neurology. 2018 08 28;91(9):e800-e810 Authors: Kim AM, Rossi KC, Jetté N, Yoo JY, Hung K, Dhamoon MS Abstract OBJECTIVE: To determine if epilepsy admissions, compared to admissions for other medical causes, are associated with a higher readmission risk for mood disorders. METHODS: The Nationwide Readmissions Database is a nationally representative...
Related ArticlesVerbal abilities in children of mothers with epilepsy: Association to maternal folate status. Neurology. 2018 08 28;91(9):e811-e821 Authors: Husebye ESN, Gilhus NE, Riedel B, Spigset O, Daltveit AK, Bjørk MH Abstract OBJECTIVE: To examine the effect of maternal folic acid supplementation and maternal plasma folate and antiepileptic drug (AED) concentrations on language delay in AED-exposed children of mothers with epilepsy. ...
Related ArticlesRegulation of kynurenine metabolism by a ketogenic diet. J Lipid Res. 2018 06;59(6):958-966 Authors: Heischmann S, Gano LB, Quinn K, Liang LP, Klepacki J, Christians U, Reisdorph N, Patel M Abstract Ketogenic diets (KDs) are increasingly utilized as treatments for epilepsy, other neurological diseases, and cancer. Despite their long history in suppressing seizures, the distinct molecular mechanisms of action of KDs are still largely...
Related ArticlesPediatric Neurocysticercosis. Indian J Pediatr. 2019 Jan;86(1):76-82 Authors: Singhi P, Saini AG Abstract Neurocysticercosis is the most common helminth infection of nervous system in humans caused by the encysted larvae of Taenia solium. It is a major cause of epilepsy in tropical areas and the most common cause of focal-onset seizures in North Indian children. Children with neurocysticercosis have pleomorphic manifestations depending...
Related ArticlesStatPearls Book. 2019 01 Authors: Abstract Hypothalamic hamartomas are benign congenital tumors that arise from the ventral hypothalamus.[1][2] Research ash identified two clinical phenotypes of hypothalamic hamartoma, namely parahypothalamic and intrahypothalamic hamartoma.[3] Parahypothalmic hamartoma, also known as pedunculated, are attached to the anterior hypothalamus. Parahypothalamic hamartomas are highly associated with central precocious puberty,...
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Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Silvia Diez-Fernández, Hugo Jaegler, Carole Bresson, Frédéric Chartier, Olivier Evrard, Amélie Hubert, Anthony Nonell, Fabien Pointurier, Hélène IsnardAbstractThe 236U/238U isotope ratio is a widely used tracer, which provides information on source identification for safeguard purposes, nuclear forensic studies and environmental monitoring. This paper describes an original approach to determine 236U/238U ratios, below 10−8, in...
Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Yaolan Lin, Chao Han, Qiqi Xu, Wenli Wang, Lingnan Li, Dongrong Zhu, Jianguang Luo, Lingyi KongAbstractThe ability to separate bioactive compounds from herbal medicines, which contain abundant components, is crucial for drug discovery. Conventional Countercurrent chromatography (CCC) methods for separating bioactive compounds are labor intensive and show low efficiency. Here, we present a novel integrative CCC method for separating...
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Publication date: Available online 19 August 2019Source: Clinical TherapeuticsAuthor(s): Susan Minear, Elisha M. WachmanABSTRACTThe prevalence of newborns with neonatal abstinence syndrome (NAS) is rising sharply. To respond to this crisis, our institution re-examined our policies and procedures regarding our approach to the management of newborns with prenatal opioid exposure. Our 6-pronged approach included: (1) a commitment to nonpharmacologic care as first-line treatment; (2) a simplified function-based...
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Related ArticlesAmyloidosis of the bladder and association with urothelial carcinoma: report of 29 cases. Hum Pathol. 2019 Aug 16;: Authors: Sirohi D, Gandhi J, Amin MB, Luthringer DJ Abstract The association of amyloidosis with certain neoplastic processes is well known. Amyloid uncommonly occurs in relationship with other epithelial neoplasms including urothelial carcinoma. Herein, we report 29 cases of amyloidosis in the bladder, 14 of which were...
Related ArticlesThe functional role of the EZH2 gene in controlling breast cancer stem cells. J BUON. 2019 May-Jun;24(3):1060-1066 Authors: Wang FW, Ao X, Fu SM Abstract PURPOSE: Breast cancer is caused by rare populations of self-renewing cancer stem cells that might also play a role in tumor relapse. Genes that regulate cancer stem cells are, therefore, of great interest in controlling cancer. EZH2 gene expression is reported to be elevated during...
Related ArticlesGenetic epidemiology of colorectal cancer and associated cancers. Mutagenesis. 2019 Aug 19;: Authors: Yu H, Hemminki K Abstract We review here data on familial risk in colorectal cancer (CRC) generated from the Swedish Family-Cancer Database, the largest resource of its kind in the world. Although the concordant familial risk for CRC (i.e. CRC risk in families of CRC patients) has been reasonably well established, the studies on discordant...
Related ArticlesPrimary pulmonary lymphoepithelioma-like carcinoma: a potential source of misdiagnosis on radial probe endobronchial ultrasound guided transbronchial aspiration cytology. Cytopathology. 2019 Aug 19;: Authors: Yoon JY, Pal P, Ko HM Abstract Primary pulmonary LELC is a rare variant of lung cancer, accounting for approximately 0.9% of all primary lung cancers. It shares morphologic similarities to undifferentiated nasopharyngeal carcinoma...
Related ArticlesA rare case of generalized tonic-clonic seizure related to paclitaxel infusion. J Clin Pharm Ther. 2019 Aug 18;: Authors: Ajiboye O, Renu N, Ezegwu O, Vohra I, Ayub MT Abstract WHAT IS KNOWN AND OBJECTIVE: Paclitaxel (Taxol) is an antineoplastic agent approved in the United States for the treatment of lung, breast, cervical, pancreatic cancers and Kaposi sarcoma. Paclitaxel does not cross the blood brain barrier, so central nervous system...
Related ArticlesLeft colonic metastasis from primary hepatocellular carcinoma: A case report. World J Clin Cases. 2019 Aug 06;7(15):2044-2048 Authors: Tagliabue F, Burati M, Chiarelli M, Marando A, Simone M, Cioffi U Abstract BACKGROUND: Hepatocellular carcinoma (HCC) accounts for 5-6% of all human cancers. Considering the extrahepatic metastasis, the main organs involved are lymphnodes, lung, bone and adrenal gland. Usually colon metastasis is very...
Related ArticlesPrimary Desmoid Tumor of the Small Bowel: A Case Report and Literature Review. Cureus. 2019 Jun 17;11(6):e4915 Authors: Ebeling PA, Fun T, Beale K, Cromer R, Kempenich JW Abstract Desmoid tumors, also known as aggressive fibromatosis, are fibromuscular neoplasms that arise from mesenchymal cell lines. They may occur in almost all soft tissue compartments. Primary desmoids of the small bowel are rare but potentially serious tumors presenting...
Related ArticlesUndifferentiated endometrial carcinoma: a National Cancer Database analysis of prognostic factors and treatment outcomes. Int J Gynecol Cancer. 2019 Aug 17;: Authors: AlHilli M, Elson P, Rybicki L, Amarnath S, Yang B, Michener CM, Rose PG Abstract BACKGROUND: Undifferentiated endometrioid endometrial carcinoma of the uterus is a rare, highly aggressive, and under-recognized subtype of endometrial cancer. OBJECTIVE: This study...
Related ArticlesCurrent perspectives on the origin theory of juvenile nasopharyngeal angiofibroma. Discov Med. 2019 Jun;27(150):245-254 Authors: Li W, Ni Y, Lu H, Hu L, Wang D Abstract Juvenile nasopharyngeal angiofibroma (JNA) is a histopathologically benign and highly vascular neoplasm, which is mainly seen in young adolescent men. It is a rare tumor, accounting for 0.05% of all head and neck neoplasms. The etiology of JNA has always been a controversial...
Pulmonary tumour thrombotic microangiopathy: a rare but underappreciated complication of malignancy.
Related ArticlesPulmonary tumour thrombotic microangiopathy: a rare but underappreciated complication of malignancy. Med J Aust. 2019 Aug 16;: Authors: Siriratnam P, Boolell V PMID: 31420874 [PubMed - as supplied by publisher]
Related Articles[Sebaceous carcinoma in situ in extraocular skin : Case report and discussion of the new entity]. Hautarzt. 2019 Aug 16;: Authors: Hrudka J, Bezvodová A, Arenbergerová M, Sticová E, Bandke D Abstract Sebaceous carcinoma in situ (SCIS) is a rare intraepidermal neoplasia, mostly occurring on the eyelid and the face. Despite abundant literature on invasive sebaceous carcinoma, there are relatively few articles about SCIS. We report the case...
Related ArticlesCurrent thinking in the management of adenoid cystic carcinoma of the head and neck. Br J Oral Maxillofac Surg. 2019 Aug 14;: Authors: Garg M, Tudor-Green B, Bisase B Abstract Adenoid cystic carcinoma (ACC) is an aggressive, rare, malignant tumour that accounts for about 1% of all head and neck neoplasms and 10% of all salivary gland tumours. It is characterised by frequent local recurrences and distant metastases. Growth is slow but...
Related Articles[Philadelphia chromosome-positive acute lymphoblastic leukemia with basophilic blast features]. Rinsho Ketsueki. 2019;60(7):773-778 Authors: Sato K, Sakai T, Kikuchi T, Obata M, Goto A, Konuma Y Abstract A 62-year-old man was referred to our hospital due to pancytopenia and abnormal leukocyte fraction in December 2016. Bone marrow aspiration showed a massive proliferation of blast cells (96%) with rich myeloperoxidase-negative basophilic...
Related Articles[Molecular analysis of the BCR-ABL1 fusion gene in a chronic myeloid leukemia patient with BCR-ABL1 International Scale-undetectable disease]. Rinsho Ketsueki. 2019;60(7):767-772 Authors: Kawamata N, Watanabe R Abstract BCR-ABL1 International Scale (IS) measurement is an important technique used to monitor chronic myeloid leukemia (CML) when patients are treated with tyrosine kinase inhibitors. In very rare cases, the BCR-ABL1 IS measurement...
Related Articles[BCL2, BCL6, and MYC-positive intravascular large B-cell lymphoma presenting with bilateral adrenal gland lesions]. Rinsho Ketsueki. 2019;60(6):570-576 Authors: Ogasawara T, Ebata N, Hamasaki J, Marshall S, Kawauchi K, Ohshima K, Mori N, Sakura H Abstract Primary adrenal lymphoma is a rare lymphoma, accounting for <0.2% of non-Hodgkin lymphoma. The leading histopathological subtype of adrenal lymphoma is diffuse large B-cell lymphoma,...
Related Articles[Recurring Sweet syndrome in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia]. Rinsho Ketsueki. 2019;60(6):565-569 Authors: Aoki T, Urata S, Ishihara D, Umeno T, Kamimura T Abstract Sweet syndrome is a rare inflammatory disease with rapid onset of painful, edematous skin eruptions, and neutrophilia. Concerning hematological disorders, Sweet syndrome often presents in patients with myeloid diseases, but it...
Related Articles[Hairy cell leukemia complicated by bone marrow necrosis following cladribine administration]. Rinsho Ketsueki. 2019;60(6):559-564 Authors: Terao T, Yuda J, Yamauchi N, Miyamoto K, Minami M, Kojima M, Sugano M, Kuwata T, Minami Y Abstract Classic hairy cell leukemia (classic HCL) is a rare disease associated with indolent mature B-cell lymphoma. A 50-year-old man presented with pancytopenia for 3 years and was diagnosed with classic...
Related ArticlesGiant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases. J Surg Oncol. 2019 Sep;120(3):359-365 Authors: Tang H, Moro A, Feng W, Lai Y, Xiao Z, Liu Y, Wang K Abstract PURPOSE: The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature....
Related ArticlesSurgical management of primary colonic lymphoma: Big data for a rare problem. J Surg Oncol. 2019 Sep;120(3):431-437 Authors: Maguire LH, Geiger TM, Hardiman KM, Regenbogen SE, Hopkins MB, Muldoon RL, Ford MM, Hawkins AT Abstract BACKGROUND AND OBJECTIVES: Primary colonic lymphoma (PCL) is rare, heterogeneous, and presents a therapeutic challenge for surgeons. Optimal treatment strategies are difficult to standardize, leading to variation...
Related ArticlesIntraocular medulloepithelioma - A review of clinical features, DICER 1 mutation, and management. Indian J Ophthalmol. 2019 06;67(6):755-762 Authors: Tadepalli SH, Shields CL, Shields JA, Honavar SG Abstract Intraocular medulloepithelioma is a nonhereditary neoplasm of childhood arising from primitive medullary epithelium. It most often involves the ciliary body. Most patients present between 2 and 10 years of age with loss of vision,...
Related ArticlesSimulation of UV power absorbed by follicular stem cells during sun exposure and possible implications for melanoma development. J Opt Soc Am A Opt Image Sci Vis. 2019 Apr 01;36(4):628-635 Authors: Huang X, Protheroe MD, Al-Jumaily AM, Chalmers AN, Paul SP, Fu X Abstract The incidence of melanoma in children is extremely rare. However, there is convincing evidence supporting a higher risk of developing melanoma in individuals who have...
Related ArticlesSmall Cell Carcinoma: a Rare Subtype of Thyroid Cancer with Unanticipated Prognosis. Curr Med Sci. 2019 Apr;39(2):265-269 Authors: Shi W, Zhao QY, Liu ZM, Wang ST, Liu CP Abstract The prognosis of small cell thyroid carcinoma (SCTC) in a large cohort has not been well reported in the literature. In this study, we analyzed the mortality of SCTC, in comparison to medullary thyroid cancer (MTC) and anaplastic thyroid cancer (ATC), based...
Related ArticlesA rare case of salivary gland choristoma in the middle ear with pharyngeal hamartoma. Chin Med J (Engl). 2019 Apr 20;132(8):1000-1002 Authors: Su QY, Hao SJ, Wang L, Ye FL PMID: 30958449 [PubMed - indexed for MEDLINE]
Related ArticlesOrthokeratinized odontogenic cyst (OOC): Clinicopathological and radiological features of a series of 10 cases. Diagn Pathol. 2019 Apr 04;14(1):28 Authors: Uddin N, Zubair M, Abdul-Ghafar J, Khan ZU, Ahmad Z Abstract BACKGROUND: Orthokeratinized Odontogenic Cyst (OOC) is a rare, developmental odontogenic cyst which was considered in the past to be a variant of Odontogenic keratocyst (OKC) later renamed as keratocystic odontogenic tumor...
Related ArticlesIntradural Extramedullary Epidermoid Cyst at the Conus Medullaris Level with Thoracic Syringomyelia: A Case Report. Acta Medica (Hradec Kralove). 2019;62(1):39-42 Authors: Akgun B, Ergun AC, Ozercan IH, Kok S Abstract Spinal epidermoid cysts are benign tumors. Syringomyelia secondary to intramedullary tumors are frequently observed. However, the association between syringomyelia and spinal intradural extramedullary epidermoid cyst in...
Related ArticlesRare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass. Diagn Pathol. 2019 Mar 28;14(1):26 Authors: Bao H, Gao J, Chen YH, Altman JK, Frankfurt O, Wilson AL, Sukhanova M, Chen Q, Lu X Abstract BACKGROUD: Myeloid sarcoma (MS) is a rare neoplasm of immature myeloid precursors that form tumor mass outside the bone marrow. The diagnosis of de novo MS can be challenging, particularly in patients with no prior...
Related ArticlesAmeloblastic Fibro-Odontoma. J Dent Child (Chic). 2018 Sep 15;85(3):143-146 Authors: Kalra A, Pajpani M, Webb R Abstract The ameloblastic fibro-odontoma (AFO) is a rare, mixed odontogenic tumor exhibiting the histological characters of the ameloblastic fibroma and complex odontoma. It is comprised of proliferating ectodermal and mesenchymal components of odontogenic tissue as well as enamel and dentin. AFO normally presents as an asymptomatic...
Related ArticlesA Rare Case of Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gastroesophageal Junction with HER2/neu Overexpression and Distinct Orbital and Optic Nerve Toxicity after Intravenous Administration of Cisplatin. Oncol Res Treat. 2019;42(3):123-127 Authors: Golombek T, Henker R, Rehak M, Quäschling U, Lordick F, Knödler M Abstract BACKGROUND: Mixed adenoneuroendocrine carcinomas (MANECs) are rare malignancies with both neuroendocrine...
Related ArticlesNon-Clear Cell Renal Cell Carcinoma - Pathology and Treatment Options. Oncol Res Treat. 2019;42(3):128-135 Authors: Ahrens M, Scheich S, Hartmann A, Bergmann L, IAG-N Interdisciplinary Working Group Kidney Cancer of the German Cancer Society Abstract Non-clear cell renal cell carcinomas (nccRCC) are rare diseases with heterogeneous histopathologically and genetically defined entities. The clinical data on optimal systemic treatments...
Related ArticlesReconstruction of Deep Circumflex Iliac Artery Free Flap for Multiple Recurrent Ameloblastoma in Mandible. J Craniofac Surg. 2019 Mar/Apr;30(2):557-562 Authors: Hu Y, Cao R, Wang Z, Hong W, Zheng C Abstract Ameloblastoma is the most common odontogenic tumor of epithelial origin. These tumors are benign in nature but have a high rate of recurrence and possible malignant development when treated inadequately. However, recurrent ameloblastomas...
Related ArticlesGodot syndrome: A rare presentation of anxiety in a young male with Glioblastoma Multiforme. Asian J Psychiatr. 2019 Feb;40:68-70 Authors: Pal A, Gondwal R, Saxena V, Avinash PR PMID: 30753967 [PubMed - indexed for MEDLINE]
Related ArticlesSpontaneous Regression of Recurrent Undifferentiated Carcinoma of the Endometrium. Intern Med. 2019 Jun 01;58(11):1649-1653 Authors: Ishii T, Takayama S, Abe M, Kuroda H, Tanaka J, Numata T, Kikuchi A, Ohsawa M, Kaneko S, Saito N, Arita R, Itakura Y Abstract We herein report a very rare case of spontaneous regression of recurrent undifferentiated carcinoma of the endometrium. An 80-year-old woman had undergone total hysterectomy with...
Related ArticlesEfficacy of gamma knife radiosurgery in brain metastases of primary gynecological tumors. J Neurooncol. 2019 Apr;142(2):283-290 Authors: Sadik ZHA, Beerepoot LV, Hanssens PEJ Abstract OBJECTIVE: Gynecological brain metastases (BM) are rare and usually develop as part of widespread disseminated disease. Despite treatment, the majority of these patients do not survive > 1 year due to advanced extracranial disease. The use of Gamma Knife...
Related ArticlesMetformin delays AKT/c-Met-driven hepatocarcinogenesis by regulating signaling pathways for de novo lipogenesis and ATP generation. Toxicol Appl Pharmacol. 2019 02 15;365:51-60 Authors: Zhang C, Hu J, Sheng L, Yuan M, Wu Y, Chen L, Zheng G, Qiu Z Abstract Hepatocellular carcinoma (HCC) is a lethal malignancy with few effective options for therapeutic treatment in its advanced stages. Metformin, a first-line oral agent used in the treatment...
Related ArticlesSyringotropic Lichen Planus: A Potential Histopathologic Mimicker of Syringotropic Mycosis Fungoides. Am J Dermatopathol. 2019 May;41(5):e50-e53 Authors: Mazzeo M, Saggini A, Rocco T, Fargnoli MC, Cerroni L Abstract Perieccrine inflammation may be observed in several different dermatoses, but true permeation of the secretory coil by lymphocytes (lymphocytic syringotropism) is a rather uncommon finding, usually observed in mycosis fungoides...
Related ArticlesA Stab in the Back: An Unusual Case of Cutaneous Neural Infiltration as a Manifestation of Chronic Lymphoproliferative Disorder of Natural Killer Cells. Am J Dermatopathol. 2019 May;41(5):378-381 Authors: Ní Mhaolcatha S, Flynn A, Hayes B, OʼShea D, Bennett M, Fitzgibbon J Abstract Chronic lymphoproliferative disorder of natural killer cells (CLPDNK) is a rare heterogenous indolent disorder comprising a persistent peripheral blood cell...
Related ArticlesPenile cancer information on the internet: a needle in a haystack. BJU Int. 2018 11;122 Suppl 5:22-26 Authors: Teh J, Op't Hoog S, Nzenza T, Duncan C, Wang J, Radojcic M, Feng C, Lawrentschuk N Abstract INTRODUCTION: Penile cancer is a disease with high morbidity and mortality and is rare in developed countries. In the developing world, the incidence is significantly higher, and accounts for 1-2% of malignant disease in men. Penile cancer...
Related ArticlesUterine Adenosarcoma. Oncol Res Treat. 2018;41(11):693-696 Authors: Ulrich UA, Denschlag D Abstract Uterine adenosarcoma is a rare malignancy. It is defined as a biphasic tumor composed of both sarcomatous stroma and benign epithelium. While the sarcomatous component usually is a low-grade homologous uterine sarcoma, the epithelium most often consists of endometrium-like cells. If the sarcomatous part occupies more than 25% of the tumor...
Related ArticlesUterine Leiomyosarcoma. Oncol Res Treat. 2018;41(11):680-686 Authors: Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP Abstract Uterine leiomyosarcoma (uLMS) is a rare entity among malignant gynecologic tumors with a very unfavorable prognosis and the highest prevalence in the pre- and peri-menopause. Only early-stage tumors have an acceptable prognosis, provided the patient has been treated without injuring the...
Related ArticlesLow-Grade Endometrial Stromal Sarcoma - a Review. Oncol Res Treat. 2018;41(11):687-692 Authors: Thiel FC, Halmen S Abstract Like other uterine sarcomas, low-grade endometrial stromal sarcomas (LG-ESS) are a very rare tumor entity. In the past, research studies therefore discussed the various different types of the disease in combination. In addition, the classification of endometrial stromal tumors presented difficulties for quite some...
Related ArticlesUterine Carcinosarcomas - Diagnosis and Management. Oncol Res Treat. 2018;41(11):675-679 Authors: Denschlag D, Ulrich UA Abstract Uterine carcinosarcomas are rare tumors that account for less than 5% of all uterine malignancies. These tumors (previously called malignant mixed Müllerian tumors) are dedifferentiated carcinomas that comprise carcinomatous and sarcomatous elements and arise from a single malignant clone. They are considered...
Related ArticlesPrimary sphenoid lymphoma: Focus on imaging. Tumori. 2018 Dec;104(6):NP42-NP45 Authors: Facchinelli D, Boninsegna E, Barillari M, Mansueto G, Krampera M, Veneri D Abstract Primary lymphoma of the sphenoid is an extremely rare pathology, therefore it is difficult to hypothesize and the imaging characteristics are not well-known. Here we report the imaging features in computed tomography (CT), magnetic resonance imaging (MRI), and positron...
Related ArticlesAre thyroid nodules with spongiform morphology always benign? Cytopathology. 2019 01;30(1):46-50 Authors: Aydoğan Bİ, Ceyhan K, Şahin M, Çorapçıoğlu D Abstract OBJECTIVE: Fine needle aspiration (FNA) biopsy for evaluation of spongiform nodules ≥20 mm or observation without FNA was recommended by American Thyroid Association. However, this was a weak recommendation supported by moderate quality evidence. We aimed to assess malignancy...
Related ArticlesSelf-Assembled Nanomicelles as Curcumin Drug Delivery Vehicles: Impact on Solitary Fibrous Tumor Cell Protein Expression and Viability. Mol Pharm. 2018 10 01;15(10):4689-4701 Authors: Dagrada G, Rupel K, Zacchigna S, Tamborini E, Pilotti S, Cavalleri A, Fechner LE, Laurini E, Smith DK, Brich S, Pricl S Abstract Solitary fibrous tumors (SFTs) are rare soft tissue sarcomas that rely on several epithelial-mesenchymal transition (EMT) protein...
Related ArticlesPseudochylothorax: An unusual mode of revelation of pleural metastasis from solid tumor. Tumori. 2018 Dec;104(6):NP46-NP49 Authors: Streit A, Guerrera F, Kouki M, Siat J, Lyberis P, Filosso PL, Renaud S Abstract INTRODUCTION: Pseudochylothorax is a rare cause of pleural effusion. Sometimes confounded with chylothorax, firm diagnosis relies on analysis of the pleural liquid: exudative liquid (protein >30 g/L, lactate dehydrogenase...
Related ArticlesGenomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations. Am J Hematol. 2018 11;93(11):1358-1367 Authors: Mi X, Griffin G, Lee W, Patel S, Ohgami R, Ok CY, Wang S, Geyer JT, Xiao W, Roshal M, Garcia JS, Silverman LB, Sallan SE, Aster JC, Harris MH, Weinberg OK Abstract The B/T subtype of mixed phenotype acute leukemia (B/T MPAL) is defined by co-expression of antigens...
Related ArticlesAcquired Haemophilia A Associated with Subsequent Hepatocellular Carcinoma. Hamostaseologie. 2019 Feb;39(1):95-99 Authors: Pacholczak R, Bazan-Socha S, Zdziarska J, Iwaniec T, Walocha JA, Musiał J, Dropiński J Abstract Acquired haemophilia A (AHA) is a rare autoimmune disease caused by antibodies directed against clotting factor VIII. About half of cases are idiopathic, but AHA may also be secondary to autoimmune, dermatologic, or oncologic...
Related Articles[Ectopic tissue of the thyroid gland and the parathyroid glands]. Pathologe. 2018 Sep;39(5):379-389 Authors: Theurer S, Siebolts U, Lorenz K, Dralle H, Schmid KW Abstract Ectopic thyroid tissue results from developmental defects of the early stages of thyroid embryogenesis, in which the median thyroid anlage descends from the floor of the mouth to its final pre-tracheal position. The most common sites of ectopic thyroid tissue are accordingly...
Related ArticlesCytology smears for DNA extraction: Practical approach for selecting the best slide. Cytopathology. 2019 01;30(1):68-73 Authors: Gupta N, Brenkert R, Lee JW, Klein M, Spitzer S, Chau K, Das K Abstract BACKGROUND: Next generation sequencing (NGS) to detect actionable genetic abnormalities is standard of care in advanced stage lung adenocarcinoma. Many studies have shown that the molecular results obtained from fine needle aspiration cytology...
Related Articles[Ectopia of the adrenal]. Pathologe. 2018 Sep;39(5):409-414 Authors: Saeger W Abstract Ectopia of nodular adrenocortical tissue is very frequently found in the periadrenal region. It corresponds to accessory adrenal tissue and is a normal variant. Ectopia in more distant regions are found in inner male or female genitalia. Strong long-lasting hyperstimultions induce hyperplasia and simulate true tumors ("adrenal rest tumors"). Real autonomic...
Related Articles[H3F3A mutated multicentric giant cell tumor of bone : A very rare primary bone disease]. Pathologe. 2018 Sep;39(5):451-456 Authors: Giesche JP, von Baer A, Breining T, Marienfeld R, Mellert K, Lüke J, Schultheiss M, Möller P, Barth TFE Abstract This article presents the case of a metachronic multicentric giant cell tumor of bone (GCTB). The patient obtained his first diagnosis of GCTB in the left humerus at the age of 47 years. Furthermore,...
Related ArticlesPeripheral neuroblastic tumor of the kidney: case report and review of literature. Tumori. 2018 Dec;104(6):NP34-NP37 Authors: Moscheo C, Campari A, Podda MG, Riccipetitoni G, Collini P, Renne SL, Vella C, Napolitano M, Luksch R Abstract INTRODUCTION: Peripheral neuroblastic tumors (PNTs) account for 8%-10% of all pediatric tumors. Adrenal glands and sympathetic ganglia are the commonest site of tumor growth. In the clinicopathologic...
Related ArticlesGiant intercostal nerve schwannoma in a patient with neurofibromatosis type 2. Tumori. 2018 Dec;104(6):NP17-NP21 Authors: Ampollini L, Ventura L, Gnetti L, Carbognani P, Silini EM, Rusca M Abstract PURPOSE: To describe a case of giant intercostal nerve schwannoma successfully resected in a patient with neurofibromatosis type 2. METHODS: A 44-year-old woman, with a history of neurofibromatosis type 2, presented with chest discomfort...
Related ArticlesInorganic mercury in human astrocytes, oligodendrocytes, corticomotoneurons and the locus ceruleus: implications for multiple sclerosis, neurodegenerative disorders and gliomas. Biometals. 2018 10;31(5):807-819 Authors: Pamphlett R, Kum Jew S Abstract Neurotoxic metals have been implicated in the pathogenesis of multiple sclerosis, neurodegenerative disorders and brain tumours but studies of the location of heavy metals in human brains...
Related ArticlesKaposi sarcoma of the upper eyelid: a rare occurrence. Clin Exp Ophthalmol. 2018 12;46(9):1097-1098 Authors: Curragh DS, Chang S, Selva D PMID: 29888854 [PubMed - indexed for MEDLINE]
Related ArticlesManagement of thyroid cytological material, preanalytical procedures and bio-banking. Cytopathology. 2019 01;30(1):7-16 Authors: Bode-Lesniewska B, Cochand-Priollet B, Straccia P, Fadda G, Bongiovanni M Abstract Thyroid nodules are common and are increasingly detected due to recent advances in imaging techniques. However, clinically relevant thyroid cancer is rare and the mortality from aggressive thyroid cancer remains constant. Fine...
Related ArticlesAbdominal lymphatic malformations. Radiologe. 2018 Nov;58(Suppl 1):29-33 Authors: Wohlgemuth WA, Brill R, Dendl LM, Stangl F, Stoevesandt D, Schreyer AG Abstract BACKGROUND: Abdominal lymphatic malformations (LM) are relatively rare findings in the differential diagnosis of focal abdominal lesions; however, they represent a challenge especially in younger patients. The aim of this review article is to provide up-to-date information about...
Related ArticlesThe added value of chemical shift MRI in the preoperative diagnosis of thymolipoma. Tumori. 2018 Dec;104(6):NP57-NP60 Authors: Calandriello L, Larici AR, Sica G, Ciliberto M, Manfredi R Abstract Thymolipoma is a rare tumor of the thymus. Classic radiologic findings of thymolipoma include fatty masses of the anterior mediastinum in conjunction with the thymus. Differential diagnosis with other more aggressive entities like liposarcoma...
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