Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, which lacks effective biomarkers for prognosis. Therefore, it is urgent to explore new potential molecular markers to disc...
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Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 play important roles in glioma angiogenesis. Thus, the...
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An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour...
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Topoisomerase inhibitors (TI) can inhibit cell proliferation by preventing DNA replication, stimulating DNA damage and inducing cell cycle arrest. Although these agents have been commonly used in the chemother...
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Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of surv...
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In the publication of this article [1], there is an error in Fig. 5C (panel 4, group of InmiR-26a + silinc01296 in SW620). The revised Fig. 5 which includes 5C has now been included in this correction. (Source: Journal of Experimental and Clinical Cancer Research)
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Publication date: Available online 21 August 2019Source: Journal of Infection and ChemotherapyAuthor(s): Zheng Guanghui, Liu Jing, Zhang Guojun, Lv HongAbstractObjectivesThis is a retrospective observational study conducted in one of the largest clinical center of neurosurgery in China. Our aim was to determine the epidemiological characteristics of carbapenem-resistant Enterobacteriaceae (CRE) related meningitis/encephalitis and to elucidate the risk factors for CRE neurosurgical infections.Patients...
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Publication date: Available online 21 August 2019Source: Journal of Infection and ChemotherapyAuthor(s): Kaoru Ikejiri, Kei Suzuki, Asami Ito, Kazunari Yasuda, Akihiro Shindo, Ken Ishikura, Hiroshi ImaiAbstractNon-typhoidal Salmonella usually manifests as a self-limited acute gastroenteritis but may also cause severe invasive infections almost exclusively among children or immunosuppressed patients. A previously healthy 22-year-old man developed high fever with coma, multiple organ failure and shock....
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Abstract Background In Japan, with the rapid increase of breast cancer patients, there has been increasing demand for breast cancer treatment. As the main workforce for breast cancer treatment, women physicians are thought to be in key positions, since the number of women physicians has recently been increasing. Methods To clarify the current statuses and...
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Abstract Background Immune checkpoint inhibitors (ICI) have demonstrated remarkable efficacy as cancer therapeutics, however, their use remains limited due to the development of immune related adverse events (irAEs). Immune related enterocolitis (irEC) is among the most common severe irAEs leading to the discontinuation of ICIs. Inhibitors of tumor necrosis factor alpha (anti-TNFα) have been used to treat irEC. Recent animal studies...
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Abstract Background The safety, efficacy, pharmacokinetics, and pharmacodynamics of the anti-programmed cell death-1 antibody MEDI0680 were evaluated in a phase I, multicenter, dose-escalation study in advanced solid malignancies. Methods MEDI0680 was administered intravenously once every 2 weeks (Q2W) or once every 3 weeks at 0.1, 0.5, 2.5,...
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Abstract Immunotherapy has led to a paradigm shift in the treatment of many advanced malignancies. Despite the success in treatment of tumors like non-small cell lung cancer (NSCLC) and melanoma, checkpoint inhibition-based immunotherapy has limitations. Many tumors, such as pancreatic cancer, are less responsive to checkpoint inhibitors, where patients tend to have a limited duration of benefit and where clinical responses are more robust in patients who are positive for predictive...
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Abstract Purpose Few population-based studies have examined the prevalence of cardiovascular disease (CVD) and risk factors, quality of life (QOL), and health behaviors of cancer survivors and their spouses. This case-control study aimed to fill this gap using the data from a set of large-scale surveys of individuals and families across the USA. Methods Data...
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Abstract The inclusion of diverse populations in clinical trial research is a social justice imperative. Creating the communicative tools that can support cancer patients across varied cultural backgrounds in processing complex clinical trial information, to achieve informed consent, has been a challenge. This study sought to evaluate specific clinical trial multimedia—a website, four animations, and a decision aid—to meet the decision-making and informational needs of Hispanic...
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The goal of this study was to evaluate combination of a novel taxoid, DHA-SBT-1214 chemotherapy in modulating immune checkpoint marker expression and ultimately in improving antibody-based checkpoint blockade therapy in pancreatic adenocarcinoma (PDAC). DHA-SBT-1214 was encapsulated in an oil-in-water nanoemulsion and administered systemically in Panc02 syngeneic PDAC-bearing C57BL/6 mice. Following treatment with DHA-SBT-1214, PD-L1 expression levels were measured and anti-PD-L1 antibody was administered...
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KRAS, an oncogene mutated in nearly one-third of human cancers, remains a pharmacological challenge for direct inhibition except for recent advances in selective inhibitors targeting the G12C variant. Here, we report that selective inhibition of the protein tyrosine phosphatase, SHP2, can impair the proliferation of KRAS mutant cancer cells in vitro and in vivo using cell line xenografts and primary human tumors. In vitro, sensitivity of KRAS mutant cells towards the allosteric SHP2 inhibitor, SHP099,...
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Activation of PI3K/Akt/mTOR pathway is an important signaling mechanism involved in the development and the progression of liver cancer stem cell (LCSC) population during acquired Sorafenib resistance in advanced Hepatocellular carcinoma (HCC). Therefore, identification of novel therapeutic targets involving this pathway and acting on LCSCs are highly essential. Here, we analyzed the bioactivities and the molecular pathways involved in the action of small molecule PI3K/Akt/mTOR pathway inhibitors...
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Nature Reviews Cancer, Published online: 22 August 2019; doi:10.1038/s41568-019-0200-2Taylor et al. demonstrate a causative role for XPO1 mutations in cancer through changing nuclear export signal recognition.
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Facial numbness can occur when nerves in the face become damaged or inflamed. Find out which conditions can cause right sided facial numbness, and learn about the treatment options.
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By constructing 3D semantic maps, scientists have shown that the brain activity of comprehension is largely similar for listening and reading.
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Understanding chronic pain is challenging. A recent study examined the interplay between sociological, psychological, and neurological factors.
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Pre-Surgical Nutrition Support Reduces the Incidence of Surgical Wound Complications in Oncological Patients. Nutr Cancer. 2019 Aug 21;:1-7 Authors: Mudarra García N, Naranjo Peña I, Olivares Pizarro SP, Riquelme Oliveira A, Granizo Martínez JJ, Rodríguez Prieto I, Pérez Muñoz R Abstract Patients who suffer from cancer are at a higher risk of complications when they experience malnutrition. Evidence shows that oral nutritional supplements favor the healing...
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Serum Nutritional Markers as Prognostic Factors for Hepatic and Extrahepatic Carcinogenesis in Japanese Patients with Nonalcoholic Fatty Liver Disease. Nutr Cancer. 2019 Aug 21;:1-8 Authors: Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Toyoda H, Kumada T, Fujishiro M Abstract Serum zinc (Zn) levels and the branched chain amino acid/tyrosine molar ratio (BTR) were reported to decrease with the progression of various chronic liver diseases....
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Pereskia bleo Leaves Extract Induces Cell Death via Cell Cycle Arrest and Apoptosis in Cervical Cancer Cells HeLa. Nutr Cancer. 2019 Aug 21;:1-9 Authors: Mohd-Salleh SF, Wan-Ibrahim WS, Ismail N Abstract Introduction: Pereskia bleo is a leafy and edible plant, locally known as "Pokok Jarum Tujuh Bilah" which has anticancer properties. This study purposed to determine the cytotoxic effects of P. bleo leaves extracts on several well-known cancer cells...
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ObjectivesHealthcare workers, in the course of their professional activity, are potentially exposed to chemical, physical and above all biological risks. The aims of our study were to investigate the extent and distribution of needle-stick and sharp injuries (NSIs) in healthcare students, the behaviours and circumstances most frequently associated with NSIs, the frequency of NSI reporting and the adherence to the post-exposure protocols.MethodsThis study involved, through an interviewer-administered...
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ObjectivesExperimental studies suggested that bisphenol A (BPA) exposure increased the risk of metabolic syndrome (MetS) through the mechanism of insulin resistance. All previous epidemiological studies of BPA and MetS were cross-sectional studies, and their findings were mixed. This study aims to provide further evidence on the association between urinary BPA and risk of MetS using a prospective cohort study in China.MethodsThe study population was from the Shenzhen Night shift workers’ cohort....
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Abstract Background Ultrasonography (US) has been widely applied and has validated efficacy in the diagnosis of colonic polyps in children. However, little attention has been paid to improving the detection rate of polyps, optimizing the ultrasonic examination process and reducing misdiagnosis. Objective To investigate the diagnostic performance of the colonic...
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Abstract Computed tomography (CT) has a well-established diagnostic role in the assessment of coronary arteries in adults. However, its application in a pediatric setting is still limited and often impaired by several technical issues, such as high heart rates, poor patient cooperation, and radiation dose exposure. Nonetheless, CT is becoming crucial in the noninvasive approach of children affected by coronary abnormalities and congenital heart disease. In some circumstances, CT...
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Design, synthesis and DNA interaction studies of new fluorescent platinum complex containing anti HIV drug didanosine. J Biomol Struct Dyn. 2019 Aug 21;:1-19 Authors: Shahabadi N, Abbasi AR, Moshtkob A, Hadidi S Abstract Forming coordination complexes with nucleoside analogues may be helpful in studying antitumor activity of them. Therefore, in order to improve the clinical efficacy of nucleoside analogue and design new ones, a new fluorescent platinum...
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Radiation dose and pathological response in oesophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by surgery: a multi-institutional analysis. Acta Oncol. 2019 Aug 21;:1-8 Authors: Thomas M, Borggreve AS, van Rossum PSN, Perneel C, Moons J, Van Daele E, van Hillegersberg R, Deng W, Pattyn P, Mook S, Boterberg T, Ruurda JP, Nafteux P, Lin SH, Haustermans K Abstract Purpose: To explore whether a higher neoadjuvant radiation dose...
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Pembrolizumab in lung cancer: current evidence and future perspectives. Future Oncol. 2019 Aug 21;: Authors: Palumbo G, Carillio G, Manzo A, Montanino A, Sforza V, Costanzo R, Sandomenico C, Manna C, Luca G, Piccirillo MC, Daniele G, Cecio R, Botti G, Totaro G, Muto P, Picone C, Esposito G, Normanno N, Morabito A Abstract Pembrolizumab is a humanized monoclonal antibody against PD-1 capable of enhancing antitumor immune activity. The KEYNOTE-001 study...
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Related ArticlesTannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis. Oncol Rep. 2019 Aug 16;: Authors: Geng N, Zheng X, Wu M, Yang L, Li X, Chen J Abstract Cisplatin (cis‑dichlorodiamine platinum, CDDP) is a potent antitumor agent. However, its clinical application is limited by its side effects and the development of drug resistance. Tannic acid (TA) has previously been...
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Primary Cutaneous Acral CD8+ T-Cell Lymphoma-A Single Center Review of 3 Cases and Recent Literature Review. Am J Dermatopathol. 2019 Sep;41(9):644-648 Authors: Tjahjono LA, Davis MDP, Witzig TE, Comfere NI Abstract The recently published 2016 revision of the WHO classification of lymphoid neoplasms includes primary cutaneous acral CD8-positive T-cell lymphoma (PCATCL) as a provisional entity. This is a rare indolent lymphoma characterized by papules...
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Low-grade Appendiceal Mucinous Neoplasm and Endometriosis: Incidental Coincident Pathologies at Cesarean Section. Int J Gynecol Pathol. 2019 Aug 19;: Authors: Yohannes N, Watkins JC, Weeks AG, Osmundson SS, Shi C, Kovach AE Abstract Incidental pathologic findings at the time of Cesarean section are exceedingly uncommon. Similarly, occult low-grade appendiceal mucinous neoplasms and other noninflammatory, non-neoplastic appendiceal pathologies are rare,...
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Related ArticlesRepurposing approved drugs on the pathway to novel therapies. Med Res Rev. 2019 Aug 20;: Authors: Schein CH Abstract The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many "repurposed" drugs, such as derivatives of thalidomide, antibiotics, and antivirals have had clinical success in treatment areas well beyond their original...
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Related ArticlesMetachronous or synchronous male breast and prostate cancers a duality to lookout for. F1000Res. 2018;7:1825 Authors: Mukendi AM, Van Den Berg E, Pather S, Padayachee RS Abstract Introduction: Breast cancer is well known as the stereotypical women's cancer, and prostate cancer represents the well-known stereotypical male counterpart. While prostate cancer carries the potential to metastasize to the breast, the synchronous or metachronous...
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Related ArticlesIncidence and patterns of retropharyngeal lymph node involvement in oropharyngeal carcinoma. Radiother Oncol. 2019 Aug 17;: Authors: Iyizoba-Ebozue Z, Murray LJ, Arunsingh M, Vaidyanathan S, Scarsbrook AF, Prestwich RJD Abstract INTRODUCTION: The aim was to evaluate in oropharyngeal carcinoma the: (1) incidence and predictors of retropharyngeal (RP) lymph node (LN) involvement, (2) pattern of ipsilateral/bilateral/contralateral-only RP...
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Related ArticlesSurgical treatment of intraperitoneal metastases from lung cancer: two case reports and a review of the literature. J Med Case Rep. 2019 Aug 21;13(1):262 Authors: Sibio S, Sica GS, Di Carlo S, Cardi M, Di Giorgio A, Sollazzo BM, Sammartino P Abstract BACKGROUND: Peritoneal metastases are often reported in several abdominal tumors. Peritoneal diffusion from extra-abdominal tumors is thought to be rare. Lung cancer is one of the most common...
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Related Articles[Recurrent ataxia and respiratory failure with probable paraneoplastic syndrome responsive to plasma exchange therapy]. Rinsho Shinkeigaku. 2019 Jun 22;59(6):339-344 Authors: Kondo T, Igari R, Sato H, Iseki C, Ishizawa K, Suzuki K Abstract An 80-year-old male with prostatic adenocarcinoma who was treated with orchiectomy presented dysarthria and difficulty in walking. His symptoms subacutely progressed. Seven days later, he was non-ambulatory...
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Related ArticlesBilateral pseudocyst of the auricles in a 4-week neonate-case report and world literature review. Int J Pediatr Otorhinolaryngol. 2019 Jul;122:1-5 Authors: Dutsch-Wicherek M, Trzebuniak I, Szymońska I, Młynarski D, Kobos J, Wicherek Ł, Kwinta P Abstract Pseudocyst of the auricle is a rare, idiopathic disease clinically manifesting as a painless edema of the upper-lateral parts of the auricle. Due to the rarity of the disease, auricular...
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Related ArticlesTransudative myelomatous pleurisy revealing pleural localization of primary plasma cell leukemia. Ann Biol Clin (Paris). 2019 Apr 01;77(2):187-190 Authors: Bouayadi O, Id M'barek A, Lyagoubi A, Taghlaoui R, Aarab A, Kouismi H, Seddik R Abstract Primary plasma cell leukemia (PPCL) is an aggressive and rare variant of multiple myeloma (MM), with frequent extramedullary involvement, mainly liver and splenic lesions. Pleuropulmonary involvement...
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Related ArticlesUrachal cancer-current concepts of a rare cancer. Pathologe. 2019 Jun;40(Suppl 1):31-39 Authors: Reis H, Szarvas T Abstract Urachal cancer is a rare but aggressive disease. In addition to the non-glandular tumors, non-cystic urachal adenocarcinomas are nowadays distinguished from the primary cystic variant. (Immunohistochemical) markers are only of minor differential diagnostic value and, therefore, the diagnosis is primarily established...
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Related ArticlesGallbladder carcinoma. Surgical management of gallblad-der carcinoma. An analysis of 37 cases. Ann Ital Chir. 2018;89:501-506 Authors: Graur F, Mois E, Margarit S, Hagiu C, Al Hajjar N Abstract BACKGROUND & AIMS: Gallbladder carcinoma is a rare yet very aggressive cancer. In this study we evaluate the presentation, staging, procedures, complications and survival of patients with gallbladder carcinoma. MATERIAL AND METHODS:...
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Related ArticlesDNA damage repair alterations are frequent in prostatic adenocarcinomas with focal pleomorphic giant-cell features. Histopathology. 2019 May;74(6):836-843 Authors: Lotan TL, Kaur HB, Alharbi AM, Pritchard CC, Epstein JI Abstract AIMS: Prostatic adenocarcinomas with focal pleomorphic giant-cell features constitute a rare tumour subtype with abysmal clinical outcomes. More than one-third of patients with this histology die within a year...
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Related ArticlesALK and EGFR expression by immunohistochemistry are associated with Merkel cell polyomavirus status in Merkel cell carcinoma. Histopathology. 2019 May;74(6):829-835 Authors: Veija T, Kero M, Koljonen V, Böhling T Abstract AIMS: Merkel cell carcinoma, a rare cutaneous neuroendocrine tumour of the skin, can be categorised into two groups according to Merkel cell polyomavirus (MCV) presence. MCV-negative tumours are more aggressive and...
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Related ArticlesMaxillary Sinus Mass as First Presentation of Silent Metastatic Renal Cell Carcinoma. J Craniofac Surg. 2019 Mar/Apr;30(2):e135-e137 Authors: Moffa A, Casale M, Moffa AP, Grilli G, Grilli G, Macarini L, Cassano M Abstract Renal cell carcinoma accounts for more than 3% of all malignant diseases. Metastatic disease to the head and neck ranges from 15% to 30%. The 5-year survival rate after nephrectomy is 60% to 75%, but with multiorgan...
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Related ArticlesInferior survival for patients with malignant peripheral nerve sheath tumors defined by aberrant TP53. Mod Pathol. 2018 11;31(11):1694-1707 Authors: Høland M, Kolberg M, Danielsen SA, Bjerkehagen B, Eilertsen IA, Hektoen M, Mandahl N, van den Berg E, Smeland S, Mertens F, Sundby Hall K, Picci P, Sveen A, Lothe RA Abstract Malignant peripheral nerve sheath tumor is a rare and aggressive disease with poor treatment response, mainly affecting...
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Related ArticlesClinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation. Mod Pathol. 2018 11;31(11):1708-1716 Authors: Renaudin K, Smati S, Wargny M, Al Ghuzlan A, Aubert S, Leteurtre E, Patey M, Sibony M, Sturm N, Tissier F, Amar L, Bertherat J, Berthozat C, Chabre O, Do Cao C, Haissaguerre M, Pierre P, Briet C, Vezzosi D, Lifante JC, Pattou F, Mirallie E, Baudin E, Cariou B, Libe R, Drui D, for Comete-Cancer...
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Related ArticlesTreatment Approaches and Outcomes for Primary Mediastinal Sarcoma: Analysis of 976 Patients. Ann Thorac Surg. 2018 08;106(2):333-339 Authors: Engelhardt KE, DeCamp MM, Yang AD, Bilimoria KY, Odell DD Abstract BACKGROUND: Primary mediastinal sarcomas are rare and deadly. Our objective was to describe the clinicopathological features, treatment strategies, and overall survival outcomes for a contemporary cohort of patients diagnosed with...
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Prothrombin complex concentrate and fatal thrombotic adverse events: A complication to keep in mind.
Related ArticlesProthrombin complex concentrate and fatal thrombotic adverse events: A complication to keep in mind. Drug Discov Ther. 2018 May 13;12(2):104-107 Authors: Tabet R, Shammaa Y, Karam B, Yacoub H, Lafferty J Abstract Thromboembolic events such as deep vein thrombosis and pulmonary embolism are well-known complications that can occur after prothrombin complex concentrate therapy. However, acute myocardial infarction is a very rare but potentially...
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Related ArticlesVenous Malformation of the Esophagus. Ann Thorac Surg. 2018 08;106(2):e69-e71 Authors: Cano Busnelli V, Medici J, Duro A, Castellaro P, Wright F, Cavadas D, Beskow A Abstract Venous malformations are an extremely infrequent condition in the gastrointestinal tract, particularly in the esophagus. We report a rare case of an adult with an asymptomatic mass located in the mediastinum and in whom the diagnosis and treatment of a venous malformation...
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Related ArticlesGiant Cell Tumor of Bone Presenting as Left Posteromedial Chest Wall Tumor. Ann Thorac Surg. 2018 08;106(2):e89-e91 Authors: Nasser H, Dhanekula A, Abdulhak M, Mott M, Hammoud ZT Abstract Giant cell tumor is a relatively uncommon bone tumor rarely originating from the chest wall. Given its proximity to vital structures in the thoracic cavity, treatment options may be challenging. We report the case of a patient with a giant cell tumor...
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Primary cutaneous peripheral T-cell lymphoma not otherwise specified a rare and aggressive lymphoma.
Related ArticlesPrimary cutaneous peripheral T-cell lymphoma not otherwise specified a rare and aggressive lymphoma. J Eur Acad Dermatol Venereol. 2018 Oct;32(10):e373-e376 Authors: Pileri A, Agostinelli C, Fuligni F, Broccoli A, Gunnella S, Sabattini E, Grandi V, Guglielmo A, Zinzani PL, Patrizi A, Pimpinelli N PMID: 29573477 [PubMed - indexed for MEDLINE]
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Related ArticlesSynchronous Presentation of Pheochromocytoma and Epidermoid Lung Carcinoma. Ann Thorac Surg. 2018 08;106(2):e99 Authors: Gregory J, Bennani S, Freche G, Mansuet-Lupo A, Revel MP, Chassagnon G PMID: 29551630 [PubMed - indexed for MEDLINE]
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Related ArticlesVerrucous carcinoma of the esophagus: A rare entity with a difficult diagnosis. Cir Esp. 2018 Aug - Sep;96(7):453-455 Authors: Paseiro Crespo G, Nebreda MG, Barceló López M, Marqués Medina E, Gimeno Aranguez M PMID: 29452967 [PubMed - indexed for MEDLINE]
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Related Articles[Vascular Cutaneous Abnormalities in Togo: a 120-Case Study]. Bull Soc Pathol Exot. 2018;111(5):278-282 Authors: Akakpo AS, Saka B, Téclessou JN, Djalogue L, Mahamadou G, Mouhari-Touré A, Gottara WS, Kombaté K, Tchangai-Walla K, Pitché P Abstract The purpose of this study was to describe the epidemio-clinical profile, and treatment of vascular cutaneous abnormalities in Togo. It was a retrospective study of patients recorded in dermatology...
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Related ArticlesA Retrospective Multicentric Study of Ewing Sarcoma Family of Tumors in Patients Older Than 50: Management and Outcome. Sci Rep. 2017 12 20;7(1):17917 Authors: Rochefort P, Italiano A, Laurence V, Penel N, Lardy-Cleaud A, Mir O, Chevreau C, Bertucci F, Bompas E, Chaigneau L, Levy D, Ryckewaert T, Dumont S, Meeus P, Ranchere D, Blay JY, Cassier PA Abstract Ewing's sarcoma family of tumors (EFTs) is a group of rare and aggressive tumors....
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Publication date: October 2019Source: Cancer Epidemiology, Volume 62Author(s): Nele Brusselaers, Jesper Lagergren, Lars EngstrandAbstractBackgroundThere is increasing interest in the potential association between proton pump inhibitors (PPIs) and the risk of gastric and oesophageal cancer, yet the effect of duration of treatment needs clarification.MethodsThis Swedish population-based cohort study assessed the influence of time since initiation of PPI treatment on the risk of gastric and oesophageal...
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Publication date: Available online 21 August 2019Source: Cancer Treatment ReviewsAuthor(s): Anne W.M. Lee, Wai Tong Ng, Jimmy Y.W. Chan, June Corry, Antti Mäkitie, William M. Mendenhall, Alessandra Rinaldo, Juan P. Rodrigo, Nabil F. Saba, Primož Strojan, Carlos Suárez, Jan B. Vermorken, Sue S. Yom, Alfio FerlitoAbstractAs a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal...
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Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Ping Yuan, Sha Huang, Fei-Chao Bao, Jin-Lin Cao, Hong-Xu Sheng, Liang Shi, Wang Lv, Jian HuAbstractBackgroundThe role of epidermal growth factor receptor (EGFR) pathways in regulating telomerase is increasingly being recognised. We analysed the impact of rs2853669 single nucleotide polymorphism (SNP) on telomere parameters and its prognostic value for non-small cell lung cancer (NSCLC) with or without EGFR mutation.MethodsThe...
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Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Xavier Pivot, Mark Pegram, Javier Cortes, Diana Lüftner, Gary H. Lyman, Giuseppe Curigliano, Igor Bondarenko, Ye Chan Yoon, Younsoo Kim, Chul KimAbstractBackgroundWe assessed long-term cardiac safety and efficacy in patients with human epidermal growth factor receptor 2–positive early breast cancer treated with a trastuzumab biosimilar (SB3) or its reference product, trastuzumab (TRZ), in a phase 3 study.MethodsPatients...
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Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Paul Nathan, Paolo A. Ascierto, John Haanen, Enrique Espinosa, Lev Demidov, Claus Garbe, Michele Guida, Paul Lorigan, Vanna Chiarion-Sileni, Helen Gogas, Michele Maio, Maria Teresa Fierro, Christoph Hoeller, Patrick Terheyden, Ralf Gutzmer, Tormod K. Guren, Dimitrios Bafaloukos, Piotr Rutkowski, Ruth Plummer, Ashita WaterstonAbstractBackgroundNivolumab has been widely studied in non-acral cutaneous melanoma;...
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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Btissame El Hassouni, Carlotta Granchi, Andrea Vallés-Martí, I Gede Putu Supadmanaba, Giulia Bononi, Tiziano Tuccinardi, Niccola Funel, Connie R. Jimenez, Godefridus J. Peters, Elisa Giovannetti, Filippo MinutoloAbstractCancer metastasis to distant organs is initiated by tumor cells that disseminate from primary heterogeneous tumors. The subsequent growth and survival of tumor metastases depend on different...
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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Yue Zhao, Jiahui Li, Dai Li, Zhefang Wang, Jiangang Zhao, Xiaolin Wu, Qiye Sun, Peter Ping Lin, Patrick Plum, Menglong Zhou, Zhen Zhang, Hans Schlösser, Peter J. Nelson, Christiane J. BrunsAbstractMore than 70% of gastrointestinal (GI) cancers are diagnosed with metastases, leading to poor prognosis. For some cancer patients with limited sites of metastatic tumors, the term oligometastatic disease (OMD)...
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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Francesco Spagnolo, Andrea Boutros, Enrica Tanda, Paola QueiroloAbstractThe past 5 years have witnessed the results of many practice-changing studies that have dramatically improved the landscape of adjuvant therapy in patients with resected, high-risk melanoma. After a 20-year era of adjuvant interferon, the anti-CTLA-4 and anti-PD-1 immune-checkpoint inhibitors, and MAPK-directed targeted therapy brought...
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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Carlos S. MorenoAbstractSOX4 is an essential developmental transcription factor that regulates stemness, differentiation, progenitor development, and multiple developmental pathways including PI3K, Wnt, and TGFβ signaling. The SOX4 gene is frequently amplified and overexpressed in over 20 types of malignancies, and multiple lines of evidence support that notion that SOX4 is an oncogene. Its overexpression...
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The eminent and influential climate scientist passed away in early August -- Read more on ScientificAmerican.com
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Bacteria-killing viruses could protect livestock without the risk of creating resistant microbes -- Read more on ScientificAmerican.com
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After decades of promises that they “may work” to reduce cardiovascular disease, the lack of a demonstrated benefit leads me to conclude that consumers are wasting their money [ED: Please... -- Read more on ScientificAmerican.com
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Dr Michael Diaz discusses how the #OncologyCareModel aims to improve #patientcare in the #oncology community. Watc… https://t.co/M4jZMiPT5A
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New #therapy found effective for refractory #multiplemyeloma patients with no treatment options. Read more here:… https://t.co/JMsilZHvF0
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